Aspects macroscopiques de la maturation normale et pathologique du cerveau humain de la naissance à l’âge adulte / Stephan ELIEZ

Public ISBD contenu dans Traité de Neuropsychologie de l'Enfant / Martine PONCELET Titre : Aspects macroscopiques de la maturation normale et pathologique du cerveau humain de la naissance à l’âge adulte Type de document : Texte imprimé et/ou numérique Auteurs : Stephan ELIEZ, Auteur ; Marie SCHAER, Auteur Année de publication : 2009 Importance : p.13-27 Langues : Français (fre) Index. décimale : SCI-C SCI-C - Neuropsychologie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=112 contenu dans Traité de Neuropsychologie de l'Enfant / Martine PONCELET Aspects macroscopiques de la maturation normale et pathologique du cerveau humain de la naissance à l’âge adulte [Texte imprimé et/ou numérique] / Stephan ELIEZ, Auteur ; Marie SCHAER, Auteur . - 2009 . - p.13-27. Langues : Français (fre) Index. décimale : SCI-C SCI-C - Neuropsychologie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=112

Exemplaires

Code-barres	Cote	Support	Localisation	Section	Disponibilité
aucun exemplaire

Early trajectories and moderators of autistic language profiles: A longitudinal study in preschoolers / Michel GODEL ; Martina FRANCHINI ; Fiona JOURNAL ; Nada KOJOVIC ; Marie SCHAER in Autism, 28-12 (December 2024)  

Public ISBD [article]  inAutism > 28-12 (December 2024) . - p.3043-3062 Titre : Early trajectories and moderators of autistic language profiles: A longitudinal study in preschoolers Type de document : Texte imprimé et/ou numérique Auteurs : Michel GODEL, Auteur ; Martina FRANCHINI, Auteur ; Fiona JOURNAL, Auteur ; Nada KOJOVIC, Auteur ; Marie SCHAER, Auteur Article en page(s) : p.3043-3062 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  cluster analysis  early intervention  Early Start Denver Model  moderators  precision medicine  prognosis Index. décimale : PER Périodiques Résumé : Both expressive and receptive language difficulties in autism emerge early and significantly have an impact on social functioning and quality of life. Despite their wide heterogeneity, autistic language abilities can be stratified into three distinct profiles. Language unimpaired exhibit near-typical verbal performance, language impaired show significant alterations in language structure, and minimally verbal display limited verbal abilities. However, little is known about the early trajectories and moderators specific to each profile. Here, we used a longitudinal sample of 286 preschoolers with autism and 85 typically developing (aged 1.5-5.7 years old), yielding 1164 visits. Our cluster analysis replicated the three well-established autistic language profiles (language unimpaired, n = 86; language impaired, n = 85; minimally verbal, n = 44) and revealed their specific early trajectories in expressive vocabulary, syntax, and pragmatics. At age 2.4, non-verbal cognition moderated the participants' attribution to each language profile. Moreover, early stereotyped language specifically moderated the later verbal performance of language unimpaired participants, while the language outcome of language impaired participants was moderated by early intensive behavioral intervention. In conclusion, we provided a fine-grained description of language acquisition trajectories and moderators of autistic language profiles in a longitudinal sample exposed to French language, paving the way toward personalized medicine to autistic language difficulties. Lay Abstract Language development can greatly vary among autistic children. Children who struggle with language acquisition often face many challenges and experience lower quality of life. However, little is known about the early language trajectories of autistic preschoolers and their moderators. Autistic language can be stratified into three profiles. Language unimpaired experience little to no language difficulties; language impaired show significant difficulties in language; minimally verbal never develop functional language. In this study, we used a longitudinal sample of preschoolers with autism and with typical development (aged 1.5-5.7?years). We replicated the three language profiles through a data-driven approach. We also found that different factors modulated the language outcome within each group. For instance, non-verbal cognition at age 2.4 moderated the participants' attribution to each language profile. Moreover, early intervention moderated verbal outcome in the language impaired profile. In conclusion, we provided a detailed description of how autistic preschoolers acquire language, and what factors might influence their trajectories. Our findings could inspire more personalized intervention for early autistic language difficulties. En ligne : https://dx.doi.org/10.1177/13623613241253015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=543 [article] Early trajectories and moderators of autistic language profiles: A longitudinal study in preschoolers [Texte imprimé et/ou numérique] / Michel GODEL, Auteur ; Martina FRANCHINI, Auteur ; Fiona JOURNAL, Auteur ; Nada KOJOVIC, Auteur ; Marie SCHAER, Auteur . - p.3043-3062. Langues : Anglais (eng) in Autism > 28-12 (December 2024) . - p.3043-3062 Mots-clés : autism spectrum disorders  cluster analysis  early intervention  Early Start Denver Model  moderators  precision medicine  prognosis Index. décimale : PER Périodiques Résumé : Both expressive and receptive language difficulties in autism emerge early and significantly have an impact on social functioning and quality of life. Despite their wide heterogeneity, autistic language abilities can be stratified into three distinct profiles. Language unimpaired exhibit near-typical verbal performance, language impaired show significant alterations in language structure, and minimally verbal display limited verbal abilities. However, little is known about the early trajectories and moderators specific to each profile. Here, we used a longitudinal sample of 286 preschoolers with autism and 85 typically developing (aged 1.5-5.7 years old), yielding 1164 visits. Our cluster analysis replicated the three well-established autistic language profiles (language unimpaired, n = 86; language impaired, n = 85; minimally verbal, n = 44) and revealed their specific early trajectories in expressive vocabulary, syntax, and pragmatics. At age 2.4, non-verbal cognition moderated the participants' attribution to each language profile. Moreover, early stereotyped language specifically moderated the later verbal performance of language unimpaired participants, while the language outcome of language impaired participants was moderated by early intensive behavioral intervention. In conclusion, we provided a fine-grained description of language acquisition trajectories and moderators of autistic language profiles in a longitudinal sample exposed to French language, paving the way toward personalized medicine to autistic language difficulties. Lay Abstract Language development can greatly vary among autistic children. Children who struggle with language acquisition often face many challenges and experience lower quality of life. However, little is known about the early language trajectories of autistic preschoolers and their moderators. Autistic language can be stratified into three profiles. Language unimpaired experience little to no language difficulties; language impaired show significant difficulties in language; minimally verbal never develop functional language. In this study, we used a longitudinal sample of preschoolers with autism and with typical development (aged 1.5-5.7?years). We replicated the three language profiles through a data-driven approach. We also found that different factors modulated the language outcome within each group. For instance, non-verbal cognition at age 2.4 moderated the participants' attribution to each language profile. Moreover, early intervention moderated verbal outcome in the language impaired profile. In conclusion, we provided a detailed description of how autistic preschoolers acquire language, and what factors might influence their trajectories. Our findings could inspire more personalized intervention for early autistic language difficulties. En ligne : https://dx.doi.org/10.1177/13623613241253015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=543

Phenotyping variability in early socio-communicative skills in young children with autism and its influence on later development / Fiona JOURNAL in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2030-2044 Titre : Phenotyping variability in early socio-communicative skills in young children with autism and its influence on later development Type de document : Texte imprimé et/ou numérique Auteurs : Fiona JOURNAL, Auteur ; Martina FRANCHINI, Auteur ; Michel GODEL, Auteur ; Nada KOJOVIC, Auteur ; Kenza LATRÈCHE, Auteur ; Stefania SOLAZZO, Auteur ; Maude SCHNEIDER, Auteur ; Marie SCHAER, Auteur Article en page(s) : p.2030-2044 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  cluster analysis  deep phenotyping  joint attention  nonverbal communication  phenotype  trajectories Index. décimale : PER Périodiques Résumé : Abstract Children with autism spectrum disorder (ASD) often face challenges in early social communication skills, prompting the need for a detailed exploration of specific behaviors and their impact on cognitive and adaptive functioning. This study aims to address this gap by examining the developmental trajectories of early social communication skills in preschoolers with ASD aged 18?60?months, comparing them to age-matched typically developing (TD) children. Utilizing the early social communication scales (ESCS), the research employs a longitudinal design to capture changes over time. We apply a principal component analysis (PCA) to ESCS variables to identify underlying components, and cluster analysis to identify subgroups based on preverbal communication profiles. The results reveal consistent differences in early social communication skills between ASD and TD children, with ASD children exhibiting reduced skills. PCA identifies two components, distinguishing objects-directed behaviors and social interaction-directed behaviors. Cluster analysis identifies three subgroups of autistic children, each displaying specific communication profiles associated with distinct cognitive and adaptive functioning trajectories. In conclusion, this study provides a nuanced understanding of early social communication development in ASD, emphasizing the importance of low-level behaviors. The identification of subgroups and their unique trajectories contributes to a more comprehensive understanding of ASD heterogeneity. These findings underscore the significance of early diagnosis, focusing on specific behaviors predicting cognitive and adaptive functioning outcomes. The study encourages further research to explore the sequential development of these skills, offering valuable insights for interventions and support strategies. En ligne : https://doi.org/10.1002/aur.3188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Phenotyping variability in early socio-communicative skills in young children with autism and its influence on later development [Texte imprimé et/ou numérique] / Fiona JOURNAL, Auteur ; Martina FRANCHINI, Auteur ; Michel GODEL, Auteur ; Nada KOJOVIC, Auteur ; Kenza LATRÈCHE, Auteur ; Stefania SOLAZZO, Auteur ; Maude SCHNEIDER, Auteur ; Marie SCHAER, Auteur . - p.2030-2044. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2030-2044 Mots-clés : autism spectrum disorders  cluster analysis  deep phenotyping  joint attention  nonverbal communication  phenotype  trajectories Index. décimale : PER Périodiques Résumé : Abstract Children with autism spectrum disorder (ASD) often face challenges in early social communication skills, prompting the need for a detailed exploration of specific behaviors and their impact on cognitive and adaptive functioning. This study aims to address this gap by examining the developmental trajectories of early social communication skills in preschoolers with ASD aged 18?60?months, comparing them to age-matched typically developing (TD) children. Utilizing the early social communication scales (ESCS), the research employs a longitudinal design to capture changes over time. We apply a principal component analysis (PCA) to ESCS variables to identify underlying components, and cluster analysis to identify subgroups based on preverbal communication profiles. The results reveal consistent differences in early social communication skills between ASD and TD children, with ASD children exhibiting reduced skills. PCA identifies two components, distinguishing objects-directed behaviors and social interaction-directed behaviors. Cluster analysis identifies three subgroups of autistic children, each displaying specific communication profiles associated with distinct cognitive and adaptive functioning trajectories. In conclusion, this study provides a nuanced understanding of early social communication development in ASD, emphasizing the importance of low-level behaviors. The identification of subgroups and their unique trajectories contributes to a more comprehensive understanding of ASD heterogeneity. These findings underscore the significance of early diagnosis, focusing on specific behaviors predicting cognitive and adaptive functioning outcomes. The study encourages further research to explore the sequential development of these skills, offering valuable insights for interventions and support strategies. En ligne : https://doi.org/10.1002/aur.3188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Predictors of Treatment Outcome in Preschoolers with Autism Spectrum Disorder: An Observational Study in the Greater Geneva Area, Switzerland / François ROBAIN in Journal of Autism and Developmental Disorders, 50-11 (November 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.3815-3830 Titre : Predictors of Treatment Outcome in Preschoolers with Autism Spectrum Disorder: An Observational Study in the Greater Geneva Area, Switzerland Type de document : Texte imprimé et/ou numérique Auteurs : François ROBAIN, Auteur ; Martina FRANCHINI, Auteur ; Nada KOJOVIC, Auteur ; Hilary WOOD DE WILDE, Auteur ; Marie SCHAER, Auteur Article en page(s) : p.3815-3830 Langues : Anglais (eng) Mots-clés : Community treatment  Early Start Denver Model  Early intervention  Intensity of intervention  Predictors  Social orienting Index. décimale : PER Périodiques Résumé : This study aims to identify predictors of treatment outcome in young children with ASD within a European context, where service provision of intervention remains sporadic. We investigated whether a child's age at baseline, intensity of the intervention provided, type of intervention, child's level of social orienting and cognitive skills at baseline predicted changes in autistic symptoms and cognitive development after 1 year of intervention, in a sample of 60 children with ASD. Our results strongly support early and intensive intervention. We also observed that lower cognitive skills at baseline were related to greater cognitive gains. Finally, we show that a child's interest in social stimuli may contribute to intervention outcome. En ligne : http://dx.doi.org/10.1007/s10803-020-04430-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Predictors of Treatment Outcome in Preschoolers with Autism Spectrum Disorder: An Observational Study in the Greater Geneva Area, Switzerland [Texte imprimé et/ou numérique] / François ROBAIN, Auteur ; Martina FRANCHINI, Auteur ; Nada KOJOVIC, Auteur ; Hilary WOOD DE WILDE, Auteur ; Marie SCHAER, Auteur . - p.3815-3830. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.3815-3830 Mots-clés : Community treatment  Early Start Denver Model  Early intervention  Intensity of intervention  Predictors  Social orienting Index. décimale : PER Périodiques Résumé : This study aims to identify predictors of treatment outcome in young children with ASD within a European context, where service provision of intervention remains sporadic. We investigated whether a child's age at baseline, intensity of the intervention provided, type of intervention, child's level of social orienting and cognitive skills at baseline predicted changes in autistic symptoms and cognitive development after 1 year of intervention, in a sample of 60 children with ASD. Our results strongly support early and intensive intervention. We also observed that lower cognitive skills at baseline were related to greater cognitive gains. Finally, we show that a child's interest in social stimuli may contribute to intervention outcome. En ligne : http://dx.doi.org/10.1007/s10803-020-04430-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Sex differences in cortical volume and gyrification in autism / Marie SCHAER in Molecular Autism, (July 2015)  

Public ISBD [article]  inMolecular Autism > (July 2015) . - p.1-14 Titre : Sex differences in cortical volume and gyrification in autism Type de document : Texte imprimé et/ou numérique Auteurs : Marie SCHAER, Auteur ; John KOCHALKA, Auteur ; Aarthi PADMANABHAN, Auteur ; Kaustubh SUPEKAR, Auteur ; Vinod MENON, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Male predominance is a prominent feature of autism spectrum disorders (ASD), with a reported male to female ratio of 4:1. Because of the overwhelming focus on males, little is known about the neuroanatomical basis of sex differences in ASD. Investigations of sex differences with adequate sample sizes are critical for improving our understanding of the biological mechanisms underlying ASD in females. En ligne : http://dx.doi.org/10.1186/s13229-015-0035-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Sex differences in cortical volume and gyrification in autism [Texte imprimé et/ou numérique] / Marie SCHAER, Auteur ; John KOCHALKA, Auteur ; Aarthi PADMANABHAN, Auteur ; Kaustubh SUPEKAR, Auteur ; Vinod MENON, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (July 2015) . - p.1-14 Index. décimale : PER Périodiques Résumé : Male predominance is a prominent feature of autism spectrum disorders (ASD), with a reported male to female ratio of 4:1. Because of the overwhelming focus on males, little is known about the neuroanatomical basis of sex differences in ASD. Investigations of sex differences with adequate sample sizes are critical for improving our understanding of the biological mechanisms underlying ASD in females. En ligne : http://dx.doi.org/10.1186/s13229-015-0035-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

The effect of emotional intensity on responses to joint attention in preschoolers with an autism spectrum disorder / Martina FRANCHINI in Research in Autism Spectrum Disorders, 35 (March 2017)  

Permalink

---

1 (1 - 6 / 6)