Acoustic Properties of Cries in 12-Month Old Infants at High-Risk of Autism Spectrum Disorder / Lisa M. UNWIN in Journal of Autism and Developmental Disorders, 47-7 (July 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2108-2119 Titre : Acoustic Properties of Cries in 12-Month Old Infants at High-Risk of Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Lisa M. UNWIN, Auteur ; Ildiko BRUZ, Auteur ; Murray T. MAYBERY, Auteur ; Victoria REYNOLDS, Auteur ; Natalie CICCONE, Auteur ; Cheryl DISSANAYAKE, Auteur ; Martha HICKEY, Auteur ; Andrew J.O. WHITEHOUSE, Auteur Article en page(s) : p.2108-2119 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Crying  Infant siblings  Acoustic properties Index. décimale : PER Périodiques Résumé : There is preliminary evidence that infant siblings of children with Autism Spectrum Disorder (ASD) have an atypical pattern of cry, characterized by higher fundamental frequency and increased dysphonation. This prospective study collected multiple cry samples of 12-month old siblings of children with ASD (n = 22, ‘high-risk’ group) and 12-month olds with no family history of ASD (n = 27, ‘low risk’ group). While there was no difference between groups in the fundamental frequency or degree of phonation of the cry samples, the duration of each cry unit was significantly shorter in the high-risk siblings (p < .05). The six infant siblings who received a diagnosis of ASD at age two had amongst the shortest recorded cry durations. En ligne : https://doi.org/10.1007/s10803-017-3119-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314 [article] Acoustic Properties of Cries in 12-Month Old Infants at High-Risk of Autism Spectrum Disorder [texte imprimé] / Lisa M. UNWIN, Auteur ; Ildiko BRUZ, Auteur ; Murray T. MAYBERY, Auteur ; Victoria REYNOLDS, Auteur ; Natalie CICCONE, Auteur ; Cheryl DISSANAYAKE, Auteur ; Martha HICKEY, Auteur ; Andrew J.O. WHITEHOUSE, Auteur . - p.2108-2119. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2108-2119 Mots-clés : Autism spectrum disorders  Crying  Infant siblings  Acoustic properties Index. décimale : PER Périodiques Résumé : There is preliminary evidence that infant siblings of children with Autism Spectrum Disorder (ASD) have an atypical pattern of cry, characterized by higher fundamental frequency and increased dysphonation. This prospective study collected multiple cry samples of 12-month old siblings of children with ASD (n = 22, ‘high-risk’ group) and 12-month olds with no family history of ASD (n = 27, ‘low risk’ group). While there was no difference between groups in the fundamental frequency or degree of phonation of the cry samples, the duration of each cry unit was significantly shorter in the high-risk siblings (p < .05). The six infant siblings who received a diagnosis of ASD at age two had amongst the shortest recorded cry durations. En ligne : https://doi.org/10.1007/s10803-017-3119-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314

Brief Report: Autistic-Like Traits in Childhood Predict Later Age at Menarche in Girls / Andrew J.O. WHITEHOUSE in Journal of Autism and Developmental Disorders, 41-8 (August 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1125-1130 Titre : Brief Report: Autistic-Like Traits in Childhood Predict Later Age at Menarche in Girls Type de document : texte imprimé Auteurs : Andrew J.O. WHITEHOUSE, Auteur ; Murray T. MAYBERY, Auteur ; Martha HICKEY, Auteur ; Deborah M. SLOBODA, Auteur Année de publication : 2011 Article en page(s) : p.1125-1130 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Menarche  Testosterone  Raine study  Child behavior checklist Index. décimale : PER Périodiques Résumé : We investigated the relationship between autistic-like traits in early childhood and age at menarche in typically developing girls. Autistic-like symptoms were measured at age 2 years using the Child Behaviour Checklist, and age at menarche (AAM) was determined prospectively using self-report questionnaires at age 8, 10, 14 and 17 years. Girls with ‘high’ autistic-like symptoms at age 2 years demonstrated significantly later AAM (n = 70; M = 13.07 years; SD = 1 year) than girls reported to show ‘typical’ (n = 216; M = 12.72 years; SD = 1.1) or ‘low’ (n = 47; M = 12.66 years; SD = 1.13 years) levels of these behaviors. These data further establish a link between the autism phenotype and later AAM and may provide insights into the etiology of the condition. En ligne : http://dx.doi.org/10.1007/s10803-010-1129-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Brief Report: Autistic-Like Traits in Childhood Predict Later Age at Menarche in Girls [texte imprimé] / Andrew J.O. WHITEHOUSE, Auteur ; Murray T. MAYBERY, Auteur ; Martha HICKEY, Auteur ; Deborah M. SLOBODA, Auteur . - 2011 . - p.1125-1130. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1125-1130 Mots-clés : Autism spectrum disorder  Menarche  Testosterone  Raine study  Child behavior checklist Index. décimale : PER Périodiques Résumé : We investigated the relationship between autistic-like traits in early childhood and age at menarche in typically developing girls. Autistic-like symptoms were measured at age 2 years using the Child Behaviour Checklist, and age at menarche (AAM) was determined prospectively using self-report questionnaires at age 8, 10, 14 and 17 years. Girls with ‘high’ autistic-like symptoms at age 2 years demonstrated significantly later AAM (n = 70; M = 13.07 years; SD = 1 year) than girls reported to show ‘typical’ (n = 216; M = 12.72 years; SD = 1.1) or ‘low’ (n = 47; M = 12.66 years; SD = 1.13 years) levels of these behaviors. These data further establish a link between the autism phenotype and later AAM and may provide insights into the etiology of the condition. En ligne : http://dx.doi.org/10.1007/s10803-010-1129-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Brief Report: A Preliminary Study of Fetal Head Circumference Growth in Autism Spectrum Disorder / Andrew J.O. WHITEHOUSE in Journal of Autism and Developmental Disorders, 41-1 (January 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.122-129 Titre : Brief Report: A Preliminary Study of Fetal Head Circumference Growth in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Andrew J.O. WHITEHOUSE, Auteur ; Martha HICKEY, Auteur ; Fiona J. STANLEY, Auteur ; John P. NEWNHAM, Auteur ; Craig E. PENNELL, Auteur Année de publication : 2011 Article en page(s) : p.122-129 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Brain growth  Head circumference  Fetus  Ultrasound Index. décimale : PER Périodiques Résumé : Fetal head circumference (HC) growth was examined prospectively in children with autism spectrum disorder (ASD). ASD participants (N = 14) were each matched with four control participants (N = 56) on a range of parameters known to influence fetal growth. HC was measured using ultrasonography at approximately 18 weeks gestation and again at birth using a paper tape-measure. Overall body size was indexed by fetal femur-length and birth length. There was no between-groups difference in head circumference at either time-point. While a small number of children with ASD had disproportionately large head circumference relative to body size at both time-points, the between-groups difference did not reach statistical significance in this small sample. These preliminary findings suggest that further investigation of fetal growth in ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-010-1019-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 [article] Brief Report: A Preliminary Study of Fetal Head Circumference Growth in Autism Spectrum Disorder [texte imprimé] / Andrew J.O. WHITEHOUSE, Auteur ; Martha HICKEY, Auteur ; Fiona J. STANLEY, Auteur ; John P. NEWNHAM, Auteur ; Craig E. PENNELL, Auteur . - 2011 . - p.122-129. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.122-129 Mots-clés : Autism spectrum disorder  Brain growth  Head circumference  Fetus  Ultrasound Index. décimale : PER Périodiques Résumé : Fetal head circumference (HC) growth was examined prospectively in children with autism spectrum disorder (ASD). ASD participants (N = 14) were each matched with four control participants (N = 56) on a range of parameters known to influence fetal growth. HC was measured using ultrasonography at approximately 18 weeks gestation and again at birth using a paper tape-measure. Overall body size was indexed by fetal femur-length and birth length. There was no between-groups difference in head circumference at either time-point. While a small number of children with ASD had disproportionately large head circumference relative to body size at both time-points, the between-groups difference did not reach statistical significance in this small sample. These preliminary findings suggest that further investigation of fetal growth in ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-010-1019-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study / Andrew J.O. WHITEHOUSE in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.25 Titre : Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study Type de document : texte imprimé Auteurs : Andrew J.O. WHITEHOUSE, Auteur ; Eugen MATTES, Auteur ; Murray T. MAYBERY, Auteur ; Cheryl DISSANAYAKE, Auteur ; Michael G. SAWYER, Auteur ; Rebecca M. JONES, Auteur ; Craig E. PENNELL, Auteur ; Jeff A. KEELAN, Auteur ; Martha HICKEY, Auteur Article en page(s) : p.25 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : UNLABELLED: BACKGROUND: Increased prenatal testosterone exposure has been hypothesized as a mechanism underlying autism spectrum disorders (ASD). However, no studies have prospectively measured prenatal testosterone exposure and ASD. The current study sought to determine whether testosterone concentrations in umbilical cord blood are associated with a clinical diagnosis of ASD in a small number of children and with autistic-like traits in the general population. METHODS: Umbilical cord blood was collected from 707 children. Samples were analyzed for total (TT) and bioavailable (BioT) testosterone concentrations. Parent report indicated that five individuals had a clinical diagnosis of ASD. Those participants without a diagnosis were approached in early adulthood to complete the Autism-Spectrum Quotient (AQ), a self-report measure of autistic-like traits, with 184 males (M = 20.10 years; SD= 0.65 years) and 190 females (M = 19.92 years; SD=0.68 years) providing data. RESULTS: The BioT and TT concentrations of the five children diagnosed with ASD were within one standard-deviation of the sex-specific means. Spearman's rank-order coefficients revealed no significant correlations between TT levels and scores on any AQ scale among males (rho range: -.01 to .06) or females (rho value range: -.07 to .01). There was also no significant association between BioT or TT concentrations and AQ scores among males (rho value range: -.07 to .08) or females (rho value range: -.06 to .12). Males were more likely than females to have 'high' scores (upper decile) on the AQ scale relating pattern and detail processing. However, the likelihood of a high score on this scale was unrelated to BioT and TT concentrations in both males and females. CONCLUSIONS: These findings indicate that testosterone concentrations from umbilical cord blood are unrelated to autistic-like traits in the general population. However, the findings do not exclude an association between testosterone exposure in early intrauterine life and ASD. En ligne : http://dx.doi.org/10.1186/1866-1955-4-25 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344 [article] Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study [texte imprimé] / Andrew J.O. WHITEHOUSE, Auteur ; Eugen MATTES, Auteur ; Murray T. MAYBERY, Auteur ; Cheryl DISSANAYAKE, Auteur ; Michael G. SAWYER, Auteur ; Rebecca M. JONES, Auteur ; Craig E. PENNELL, Auteur ; Jeff A. KEELAN, Auteur ; Martha HICKEY, Auteur . - p.25. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.25 Index. décimale : PER Périodiques Résumé : UNLABELLED: BACKGROUND: Increased prenatal testosterone exposure has been hypothesized as a mechanism underlying autism spectrum disorders (ASD). However, no studies have prospectively measured prenatal testosterone exposure and ASD. The current study sought to determine whether testosterone concentrations in umbilical cord blood are associated with a clinical diagnosis of ASD in a small number of children and with autistic-like traits in the general population. METHODS: Umbilical cord blood was collected from 707 children. Samples were analyzed for total (TT) and bioavailable (BioT) testosterone concentrations. Parent report indicated that five individuals had a clinical diagnosis of ASD. Those participants without a diagnosis were approached in early adulthood to complete the Autism-Spectrum Quotient (AQ), a self-report measure of autistic-like traits, with 184 males (M = 20.10 years; SD= 0.65 years) and 190 females (M = 19.92 years; SD=0.68 years) providing data. RESULTS: The BioT and TT concentrations of the five children diagnosed with ASD were within one standard-deviation of the sex-specific means. Spearman's rank-order coefficients revealed no significant correlations between TT levels and scores on any AQ scale among males (rho range: -.01 to .06) or females (rho value range: -.07 to .01). There was also no significant association between BioT or TT concentrations and AQ scores among males (rho value range: -.07 to .08) or females (rho value range: -.06 to .12). Males were more likely than females to have 'high' scores (upper decile) on the AQ scale relating pattern and detail processing. However, the likelihood of a high score on this scale was unrelated to BioT and TT concentrations in both males and females. CONCLUSIONS: These findings indicate that testosterone concentrations from umbilical cord blood are unrelated to autistic-like traits in the general population. However, the findings do not exclude an association between testosterone exposure in early intrauterine life and ASD. En ligne : http://dx.doi.org/10.1186/1866-1955-4-25 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344

A prospective study of fetal head growth, autistic traits and autism spectrum disorder / Laura M.E. BLANKEN in Autism Research, 11-4 (April 2018)  

Public ISBD [article]  inAutism Research > 11-4 (April 2018) . - p.602-612 Titre : A prospective study of fetal head growth, autistic traits and autism spectrum disorder Type de document : texte imprimé Auteurs : Laura M.E. BLANKEN, Auteur ; Alena DASS, Auteur ; Gail A. ALVARES, Auteur ; Jan VAN DER ENDE, Auteur ; Nikita K. SCHOEMAKER, Auteur ; Hanan EL MARROUN, Auteur ; Martha HICKEY, Auteur ; Craig E. PENNELL, Auteur ; Sarah WHITE, Auteur ; Murray T. MAYBERY, Auteur ; Cheryl DISSANAYAKE, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur ; Will MCINTOSH, Auteur ; Tiffany C. WHITE, Auteur ; Andrew J.O. WHITEHOUSE, Auteur Article en page(s) : p.602-612 Langues : Anglais (eng) Mots-clés : brain growth  head circumference  pregnancy  prenatal  ultrasound Index. décimale : PER Périodiques Résumé : Altered trajectories of brain growth are often reported in Autism Spectrum Disorder (ASD), particularly during the first year of life. However, less is known about prenatal head growth trajectories, and no study has examined the relation with postnatal autistic symptom severity. The current study prospectively examined the association between fetal head growth and the spectrum of autistic symptom severity in two large population-based cohorts, including a sample of individuals with clinically diagnosed ASD. This study included 3,820 children from two longitudinal prenatal cohorts in The Netherlands and Australia, comprising 60 individuals with a confirmed diagnosis of ASD. Latent growth curve models were used to examine the relationship between fetal head circumference measured at three different time points and autistic traits measured in postnatal life using either the Social Responsiveness Scale or the Autism-Spectrum Quotient. While lower initial prenatal HC was weakly associated with increasing autistic traits in the Dutch cohort, this relationship was not observed in the Australian cohort, nor when the two cohorts were analysed together. No differences in prenatal head growth were found between individuals with ASD and controls. This large population-based study identified no consistent association across two cohorts between prenatal head growth and postnatal autistic traits. Our mixed findings suggest that further research in this area is needed. Autism Res 2018, 11: 602-612. (c) 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: It is not known whether different patterns of postnatal brain growth in Autism Spectrum Disorder (ASD) also occurs prenatally. We examined fetal head growth and autistic symptoms in two large groups from The Netherlands and Australia. Lower initial prenatal head circumference was associated with autistic traits in the Dutch, but not the Australian, group. No differences in head growth were found in individuals with ASD and controls when the data was combined. Our mixed findings suggest that more research in this area is needed. En ligne : http://dx.doi.org/10.1002/aur.1921 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358 [article] A prospective study of fetal head growth, autistic traits and autism spectrum disorder [texte imprimé] / Laura M.E. BLANKEN, Auteur ; Alena DASS, Auteur ; Gail A. ALVARES, Auteur ; Jan VAN DER ENDE, Auteur ; Nikita K. SCHOEMAKER, Auteur ; Hanan EL MARROUN, Auteur ; Martha HICKEY, Auteur ; Craig E. PENNELL, Auteur ; Sarah WHITE, Auteur ; Murray T. MAYBERY, Auteur ; Cheryl DISSANAYAKE, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur ; Will MCINTOSH, Auteur ; Tiffany C. WHITE, Auteur ; Andrew J.O. WHITEHOUSE, Auteur . - p.602-612. Langues : Anglais (eng) in Autism Research > 11-4 (April 2018) . - p.602-612 Mots-clés : brain growth  head circumference  pregnancy  prenatal  ultrasound Index. décimale : PER Périodiques Résumé : Altered trajectories of brain growth are often reported in Autism Spectrum Disorder (ASD), particularly during the first year of life. However, less is known about prenatal head growth trajectories, and no study has examined the relation with postnatal autistic symptom severity. The current study prospectively examined the association between fetal head growth and the spectrum of autistic symptom severity in two large population-based cohorts, including a sample of individuals with clinically diagnosed ASD. This study included 3,820 children from two longitudinal prenatal cohorts in The Netherlands and Australia, comprising 60 individuals with a confirmed diagnosis of ASD. Latent growth curve models were used to examine the relationship between fetal head circumference measured at three different time points and autistic traits measured in postnatal life using either the Social Responsiveness Scale or the Autism-Spectrum Quotient. While lower initial prenatal HC was weakly associated with increasing autistic traits in the Dutch cohort, this relationship was not observed in the Australian cohort, nor when the two cohorts were analysed together. No differences in prenatal head growth were found between individuals with ASD and controls. This large population-based study identified no consistent association across two cohorts between prenatal head growth and postnatal autistic traits. Our mixed findings suggest that further research in this area is needed. Autism Res 2018, 11: 602-612. (c) 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: It is not known whether different patterns of postnatal brain growth in Autism Spectrum Disorder (ASD) also occurs prenatally. We examined fetal head growth and autistic symptoms in two large groups from The Netherlands and Australia. Lower initial prenatal head circumference was associated with autistic traits in the Dutch, but not the Australian, group. No differences in head growth were found in individuals with ASD and controls when the data was combined. Our mixed findings suggest that more research in this area is needed. En ligne : http://dx.doi.org/10.1002/aur.1921 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358

A Prospective Ultrasound Study of Prenatal Growth in Infant Siblings of Children With Autism / Lisa M. UNWIN in Autism Research, 9-2 (February 2016)  

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The perinatal androgen to estrogen ratio and autistic-like traits in the general population: a longitudinal pregnancy cohort study / Esha S.L. JAMNADASS in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

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