Brief Report: A Preliminary Study of Fetal Head Circumference Growth in Autism Spectrum Disorder / Andrew J. O. WHITEHOUSE in Journal of Autism and Developmental Disorders, 41-1 (January 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.122-129 Titre : Brief Report: A Preliminary Study of Fetal Head Circumference Growth in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Andrew J. O. WHITEHOUSE, Auteur ; Martha HICKEY, Auteur ; Fiona J. STANLEY, Auteur ; John P. NEWNHAM, Auteur ; Craig E. PENNELL, Auteur Année de publication : 2011 Article en page(s) : p.122-129 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Brain growth  Head circumference  Fetus  Ultrasound Index. décimale : PER Périodiques Résumé : Fetal head circumference (HC) growth was examined prospectively in children with autism spectrum disorder (ASD). ASD participants (N = 14) were each matched with four control participants (N = 56) on a range of parameters known to influence fetal growth. HC was measured using ultrasonography at approximately 18 weeks gestation and again at birth using a paper tape-measure. Overall body size was indexed by fetal femur-length and birth length. There was no between-groups difference in head circumference at either time-point. While a small number of children with ASD had disproportionately large head circumference relative to body size at both time-points, the between-groups difference did not reach statistical significance in this small sample. These preliminary findings suggest that further investigation of fetal growth in ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-010-1019-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 [article] Brief Report: A Preliminary Study of Fetal Head Circumference Growth in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Andrew J. O. WHITEHOUSE, Auteur ; Martha HICKEY, Auteur ; Fiona J. STANLEY, Auteur ; John P. NEWNHAM, Auteur ; Craig E. PENNELL, Auteur . - 2011 . - p.122-129. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.122-129 Mots-clés : Autism spectrum disorder  Brain growth  Head circumference  Fetus  Ultrasound Index. décimale : PER Périodiques Résumé : Fetal head circumference (HC) growth was examined prospectively in children with autism spectrum disorder (ASD). ASD participants (N = 14) were each matched with four control participants (N = 56) on a range of parameters known to influence fetal growth. HC was measured using ultrasonography at approximately 18 weeks gestation and again at birth using a paper tape-measure. Overall body size was indexed by fetal femur-length and birth length. There was no between-groups difference in head circumference at either time-point. While a small number of children with ASD had disproportionately large head circumference relative to body size at both time-points, the between-groups difference did not reach statistical significance in this small sample. These preliminary findings suggest that further investigation of fetal growth in ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-010-1019-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

Common variation contributes to the genetic architecture of social communication traits / Beate ST POURCAIN in Molecular Autism, (September 2013)  

Public ISBD [article]  inMolecular Autism > (September 2013) Titre : Common variation contributes to the genetic architecture of social communication traits Type de document : Texte imprimé et/ou numérique Auteurs : Beate ST POURCAIN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Wei ANG, Auteur ; Nicole WARRINGTON, Auteur ; Joseph GLESSNER, Auteur ; Kai WANG, Auteur ; Nicholas TIMPSON, Auteur ; David EVANS, Auteur ; John KEMP, Auteur ; Susan RING, Auteur ; Wendy MCARDLE, Auteur ; Jean GOLDING, Auteur ; Hakon HAKONARSON, Auteur ; Craig E. PENNELL, Auteur ; George SMITH, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Social communication difficulties represent an autistic trait that is highly heritable and persistent during the course of development. However, little is known about the underlying genetic architecture of this phenotype. We performed a genome-wide association study on parent-reported social communication problems using items of the children's communication checklist (age 10 to 11 years) studying single and/or joint marker effects. Analyses were conducted in a large UK population-based birth cohort (Avon Longitudinal Study of Parents and their Children, ALSPAC, N = 5,584) and followed-up within a sample of children with comparable measures from Western Australia (RAINE, N = 1364). Two of our seven independent top signals (P-discovery 1.0E-05) were replicated (0.009 P-replication [less than or equal to]0.02) within RAINE and suggested evidence for association at 6p22.1 (rs9257616, meta-P = 2.5E-07) and 14q22.1 (rs2352908, meta-P = 1.1E-06). The signal at 6p22.1 was identified within the olfactory receptor gene cluster within the broader major histocompatibility complex (MHC) region. The strongest candidate locus within this genomic area was TRIM27. This gene encodes an ubiquitin E3 ligase, which is an interaction partner of methyl-CpG-binding domain (MBD) proteins, such as MBD3 and MBD4, and rare protein-coding mutations within MBD3 and MBD4 have been linked to autism. The signal at 14q22.1 was found within a gene-poor region.Single-variant findings were complemented by estimations of the narrow-sense heritability in ALSPAC suggesting that approximately a fifth of the phenotypic variance in social communication traits is accounted for by joint additive effects of genotyped single nucleotide polymorphisms throughout the genome (h2(SE) = 0.18(0.066), P = 0.0027). Overall, our study provides both joint and single-SNP-based evidence for the contribution of common polymorphisms to variation in social communication phenotypes. En ligne : http://dx.doi.org/10.1186/2040-2392-4-34 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Common variation contributes to the genetic architecture of social communication traits [Texte imprimé et/ou numérique] / Beate ST POURCAIN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Wei ANG, Auteur ; Nicole WARRINGTON, Auteur ; Joseph GLESSNER, Auteur ; Kai WANG, Auteur ; Nicholas TIMPSON, Auteur ; David EVANS, Auteur ; John KEMP, Auteur ; Susan RING, Auteur ; Wendy MCARDLE, Auteur ; Jean GOLDING, Auteur ; Hakon HAKONARSON, Auteur ; Craig E. PENNELL, Auteur ; George SMITH, Auteur. Langues : Anglais (eng) in Molecular Autism > (September 2013) Index. décimale : PER Périodiques Résumé : Social communication difficulties represent an autistic trait that is highly heritable and persistent during the course of development. However, little is known about the underlying genetic architecture of this phenotype. We performed a genome-wide association study on parent-reported social communication problems using items of the children's communication checklist (age 10 to 11 years) studying single and/or joint marker effects. Analyses were conducted in a large UK population-based birth cohort (Avon Longitudinal Study of Parents and their Children, ALSPAC, N = 5,584) and followed-up within a sample of children with comparable measures from Western Australia (RAINE, N = 1364). Two of our seven independent top signals (P-discovery 1.0E-05) were replicated (0.009 P-replication [less than or equal to]0.02) within RAINE and suggested evidence for association at 6p22.1 (rs9257616, meta-P = 2.5E-07) and 14q22.1 (rs2352908, meta-P = 1.1E-06). The signal at 6p22.1 was identified within the olfactory receptor gene cluster within the broader major histocompatibility complex (MHC) region. The strongest candidate locus within this genomic area was TRIM27. This gene encodes an ubiquitin E3 ligase, which is an interaction partner of methyl-CpG-binding domain (MBD) proteins, such as MBD3 and MBD4, and rare protein-coding mutations within MBD3 and MBD4 have been linked to autism. The signal at 14q22.1 was found within a gene-poor region.Single-variant findings were complemented by estimations of the narrow-sense heritability in ALSPAC suggesting that approximately a fifth of the phenotypic variance in social communication traits is accounted for by joint additive effects of genotyped single nucleotide polymorphisms throughout the genome (h2(SE) = 0.18(0.066), P = 0.0027). Overall, our study provides both joint and single-SNP-based evidence for the contribution of common polymorphisms to variation in social communication phenotypes. En ligne : http://dx.doi.org/10.1186/2040-2392-4-34 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Erratum - Prenatal stress and risk of behavioral morbidity from age 2 to 14 years: The influence of the number, type, and timing of stressful life events / Monique ROBINSON in Development and Psychopathology, 24-1 (January 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-1 (January 2012) . - p.333 Titre : Erratum - Prenatal stress and risk of behavioral morbidity from age 2 to 14 years: The influence of the number, type, and timing of stressful life events Type de document : Texte imprimé et/ou numérique Auteurs : Monique ROBINSON, Auteur ; Eugen MATTES, Auteur ; Wendy H. ODDY, Auteur ; Craig E. PENNELL, Auteur ; Anke VAN EEKELEN, Auteur ; Neil J. MCLEAN, Auteur ; Peter JACOBY, Auteur ; Jianghong LI, Auteur ; Nicholas H. DE KLERK, Auteur ; Stephen R. ZUBRICK, Auteur ; Fiona J. STANLEY, Auteur ; John P. NEWNHAM, Auteur Année de publication : 2012 Article en page(s) : p.333 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579411000861 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Erratum - Prenatal stress and risk of behavioral morbidity from age 2 to 14 years: The influence of the number, type, and timing of stressful life events [Texte imprimé et/ou numérique] / Monique ROBINSON, Auteur ; Eugen MATTES, Auteur ; Wendy H. ODDY, Auteur ; Craig E. PENNELL, Auteur ; Anke VAN EEKELEN, Auteur ; Neil J. MCLEAN, Auteur ; Peter JACOBY, Auteur ; Jianghong LI, Auteur ; Nicholas H. DE KLERK, Auteur ; Stephen R. ZUBRICK, Auteur ; Fiona J. STANLEY, Auteur ; John P. NEWNHAM, Auteur . - 2012 . - p.333. Langues : Anglais (eng) in Development and Psychopathology > 24-1 (January 2012) . - p.333 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579411000861 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

Prenatal stress and risk of behavioral morbidity from age 2 to 14 years: The influence of the number, type, and timing of stressful life events / Monique ROBINSON in Development and Psychopathology, 23-2 (May 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-2 (May 2011) . - p.507-520 Titre : Prenatal stress and risk of behavioral morbidity from age 2 to 14 years: The influence of the number, type, and timing of stressful life events Type de document : Texte imprimé et/ou numérique Auteurs : Monique ROBINSON, Auteur ; Eugen MATTES, Auteur ; Wendy H. ODDY, Auteur ; Craig E. PENNELL, Auteur ; Anke VAN EEKELEN, Auteur ; Neil J. MCLEAN, Auteur ; Peter JACOBY, Auteur ; Jianghong LI, Auteur ; Nicholas H. DE KLERK, Auteur ; Stephen R. ZUBRICK, Auteur ; Fiona J. STANLEY, Auteur ; John P. NEWNHAM, Auteur Année de publication : 2011 Article en page(s) : p.507-520 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The maternal experience of stressful events during pregnancy has been associated with a number of adverse consequences for behavioral development in offspring, but the measurement and interpretation of prenatal stress varies among reported studies. The Raine Study recruited 2900 pregnancies and recorded life stress events experienced by 18 and 34 weeks' gestation along with numerous sociodemographic data. The mother's exposure to life stress events was further documented when the children were followed-up in conjunction with behavioral assessments at ages 2, 5, 8, 10, and 14 years using the Child Behavior Checklist. The maternal experience of multiple stressful events during pregnancy was associated with subsequent behavioral problems for offspring. Independent (e.g., death of a relative, job loss) and dependent stress events (e.g., financial problems, marital problems) were both significantly associated with a greater incidence of mental health morbidity between age 2 and 14 years. Exposure to stressful events in the first 18 weeks of pregnancy showed similar associations with subsequent total and externalizing morbidity to events reported at 34 weeks of gestation. These results were independent of postnatal stress exposure. Improved support for women with chronic stress exposure during pregnancy may improve the mental health of their offspring in later life. En ligne : http://dx.doi.org/10.1017/S0954579411000241 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 [article] Prenatal stress and risk of behavioral morbidity from age 2 to 14 years: The influence of the number, type, and timing of stressful life events [Texte imprimé et/ou numérique] / Monique ROBINSON, Auteur ; Eugen MATTES, Auteur ; Wendy H. ODDY, Auteur ; Craig E. PENNELL, Auteur ; Anke VAN EEKELEN, Auteur ; Neil J. MCLEAN, Auteur ; Peter JACOBY, Auteur ; Jianghong LI, Auteur ; Nicholas H. DE KLERK, Auteur ; Stephen R. ZUBRICK, Auteur ; Fiona J. STANLEY, Auteur ; John P. NEWNHAM, Auteur . - 2011 . - p.507-520. Langues : Anglais (eng) in Development and Psychopathology > 23-2 (May 2011) . - p.507-520 Index. décimale : PER Périodiques Résumé : The maternal experience of stressful events during pregnancy has been associated with a number of adverse consequences for behavioral development in offspring, but the measurement and interpretation of prenatal stress varies among reported studies. The Raine Study recruited 2900 pregnancies and recorded life stress events experienced by 18 and 34 weeks' gestation along with numerous sociodemographic data. The mother's exposure to life stress events was further documented when the children were followed-up in conjunction with behavioral assessments at ages 2, 5, 8, 10, and 14 years using the Child Behavior Checklist. The maternal experience of multiple stressful events during pregnancy was associated with subsequent behavioral problems for offspring. Independent (e.g., death of a relative, job loss) and dependent stress events (e.g., financial problems, marital problems) were both significantly associated with a greater incidence of mental health morbidity between age 2 and 14 years. Exposure to stressful events in the first 18 weeks of pregnancy showed similar associations with subsequent total and externalizing morbidity to events reported at 34 weeks of gestation. These results were independent of postnatal stress exposure. Improved support for women with chronic stress exposure during pregnancy may improve the mental health of their offspring in later life. En ligne : http://dx.doi.org/10.1017/S0954579411000241 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121

A Prospective Ultrasound Study of Prenatal Growth in Infant Siblings of Children With Autism / Lisa M. UNWIN in Autism Research, 9-2 (February 2016)  

Public ISBD [article]  inAutism Research > 9-2 (February 2016) . - p.210-216 Titre : A Prospective Ultrasound Study of Prenatal Growth in Infant Siblings of Children With Autism Type de document : Texte imprimé et/ou numérique Auteurs : Lisa M. UNWIN, Auteur ; Murray T. MAYBERY, Auteur ; Anthony MURPHY, Auteur ; Wendy LILJE, Auteur ; Michelle BELLESINI, Auteur ; Anna M. HUNT, Auteur ; Joanna GRANICH, Auteur ; Peter JACOBY, Auteur ; Cheryl DISSANAYAKE, Auteur ; Craig E. PENNELL, Auteur ; Martha HICKEY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.210-216 Langues : Anglais (eng) Mots-clés : infants  pediatrics  developmental psychology  prenatal  ultrasound Index. décimale : PER Périodiques Résumé : Numerous studies have observed that a proportion of infants later diagnosed with autism spectrum disorder (ASD) experience accelerated head growth during the first years of life. An emerging methodology for examining the developmental trajectory prior to a diagnosis of ASD is to investigate siblings of affected individuals. The current study is the first prospective investigation of fetal growth in siblings of children with ASD. Two groups of pregnant women were recruited as part of the PRegnancy Investigation of Siblings and Mothers of children with autism cohort in Perth, Western Australia. The “high risk” group (n?=?23) comprised pregnant women who have an existing child with a diagnosis of ASD and the “low risk” group (n?=?36) comprised pregnant mothers who have an existing child who has developed typically. Prenatal ultrasounds were procured at multiple time-points throughout the second- and third-trimesters, enabling an examination of growth trajectories. Growth measurements were then compared for the high- and low-risk fetuses. Mixed linear regression models identified no significant differences between the high- and low-risk fetuses in the rate of prenatal head and body growth throughout the second- and third-trimester (all P-values >0.05). Similarly, there were no significant differences observed when comparing high and low risk groups on a ratio of head circumference relative to body size (??=??0.019, P = 0.75). Future studies may consider looking beyond the macro architecture of the prenatal brain and examine the growth of brain subregions that have been implicated in the presentation of ASD symptoms. En ligne : http://dx.doi.org/10.1002/aur.1518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] A Prospective Ultrasound Study of Prenatal Growth in Infant Siblings of Children With Autism [Texte imprimé et/ou numérique] / Lisa M. UNWIN, Auteur ; Murray T. MAYBERY, Auteur ; Anthony MURPHY, Auteur ; Wendy LILJE, Auteur ; Michelle BELLESINI, Auteur ; Anna M. HUNT, Auteur ; Joanna GRANICH, Auteur ; Peter JACOBY, Auteur ; Cheryl DISSANAYAKE, Auteur ; Craig E. PENNELL, Auteur ; Martha HICKEY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.210-216. Langues : Anglais (eng) in Autism Research > 9-2 (February 2016) . - p.210-216 Mots-clés : infants  pediatrics  developmental psychology  prenatal  ultrasound Index. décimale : PER Périodiques Résumé : Numerous studies have observed that a proportion of infants later diagnosed with autism spectrum disorder (ASD) experience accelerated head growth during the first years of life. An emerging methodology for examining the developmental trajectory prior to a diagnosis of ASD is to investigate siblings of affected individuals. The current study is the first prospective investigation of fetal growth in siblings of children with ASD. Two groups of pregnant women were recruited as part of the PRegnancy Investigation of Siblings and Mothers of children with autism cohort in Perth, Western Australia. The “high risk” group (n?=?23) comprised pregnant women who have an existing child with a diagnosis of ASD and the “low risk” group (n?=?36) comprised pregnant mothers who have an existing child who has developed typically. Prenatal ultrasounds were procured at multiple time-points throughout the second- and third-trimesters, enabling an examination of growth trajectories. Growth measurements were then compared for the high- and low-risk fetuses. Mixed linear regression models identified no significant differences between the high- and low-risk fetuses in the rate of prenatal head and body growth throughout the second- and third-trimester (all P-values >0.05). Similarly, there were no significant differences observed when comparing high and low risk groups on a ratio of head circumference relative to body size (??=??0.019, P = 0.75). Future studies may consider looking beyond the macro architecture of the prenatal brain and examine the growth of brain subregions that have been implicated in the presentation of ASD symptoms. En ligne : http://dx.doi.org/10.1002/aur.1518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

The impact of life stress on adult depression and anxiety is dependent on gender and timing of exposure / Carly E. HERBISON in Development and Psychopathology, 29-4 (October 2017)  

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