Attentional influences on neural processing of biological motion in typically developing children and those on the autism spectrum / Emily J. KNIGHT in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 33 p. Titre : Attentional influences on neural processing of biological motion in typically developing children and those on the autism spectrum Type de document : texte imprimé Auteurs : Emily J. KNIGHT, Auteur ; Aaron I. KRAKOWSKI, Auteur ; Edward G. FREEDMAN, Auteur ; John S. BUTLER, Auteur ; Sophie MOLHOLM, Auteur ; John J. FOXE, Auteur Article en page(s) : 33 p. Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Autistic Disorder  Child  Cross-Sectional Studies  Electroencephalography  Humans  Social Skills  Asd  Biological motion  Erp  Event-related potentials  Social cognition  Vep  Visual evoked potential Index. décimale : PER Périodiques Résumé : BACKGROUND: Biological motion imparts rich information related to the movement, actions, intentions and affective state of others, which can provide foundational support for various aspects of social cognition and behavior. Given that atypical social communication and cognition are hallmark symptoms of autism spectrum disorder (ASD), many have theorized that a potential source of this deficit may lie in dysfunctional neural mechanisms of biological motion processing. Synthesis of existing literature provides some support for biological motion processing deficits in autism spectrum disorder, although high study heterogeneity and inconsistent findings complicate interpretation. Here, we attempted to reconcile some of this residual controversy by investigating a possible modulating role for attention in biological motion processing in ASD. METHODS: We employed high-density electroencephalographic recordings while participants observed point-light displays of upright, inverted and scrambled biological motion under two task conditions to explore spatiotemporal dynamics of intentional and unintentional biological motion processing in children and adolescents with ASD (n=27), comparing them to a control cohort of neurotypical (NT) participants (n=35). RESULTS: Behaviorally, ASD participants were able to discriminate biological motion with similar accuracy to NT controls. However, electrophysiologic investigation revealed reduced automatic selective processing of upright biologic versus scrambled motion stimuli in ASD relative to NT individuals, which was ameliorated when task demands required explicit attention to biological motion. Additionally, we observed distinctive patterns of covariance between visual potentials evoked by biological motion and functional social ability, such that Vineland Adaptive Behavior Scale-Socialization domain scores were differentially associated with biological motion processing in the N1 period in the ASD but not the NT group. LIMITATIONS: The cross-sectional design of this study does not allow us to definitively answer the question of whether developmental differences in attention to biological motion cause disruption in social communication, and the sample was limited to children with average or above cognitive ability. CONCLUSIONS: Together, these data suggest that individuals with ASD are able to discriminate, with explicit attention, biological from non-biological motion but demonstrate diminished automatic neural specificity for biological motion processing, which may have cascading implications for the development of higher-order social cognition. En ligne : http://dx.doi.org/10.1186/s13229-022-00512-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Attentional influences on neural processing of biological motion in typically developing children and those on the autism spectrum [texte imprimé] / Emily J. KNIGHT, Auteur ; Aaron I. KRAKOWSKI, Auteur ; Edward G. FREEDMAN, Auteur ; John S. BUTLER, Auteur ; Sophie MOLHOLM, Auteur ; John J. FOXE, Auteur . - 33 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 33 p. Mots-clés : Adolescent  Autism Spectrum Disorder  Autistic Disorder  Child  Cross-Sectional Studies  Electroencephalography  Humans  Social Skills  Asd  Biological motion  Erp  Event-related potentials  Social cognition  Vep  Visual evoked potential Index. décimale : PER Périodiques Résumé : BACKGROUND: Biological motion imparts rich information related to the movement, actions, intentions and affective state of others, which can provide foundational support for various aspects of social cognition and behavior. Given that atypical social communication and cognition are hallmark symptoms of autism spectrum disorder (ASD), many have theorized that a potential source of this deficit may lie in dysfunctional neural mechanisms of biological motion processing. Synthesis of existing literature provides some support for biological motion processing deficits in autism spectrum disorder, although high study heterogeneity and inconsistent findings complicate interpretation. Here, we attempted to reconcile some of this residual controversy by investigating a possible modulating role for attention in biological motion processing in ASD. METHODS: We employed high-density electroencephalographic recordings while participants observed point-light displays of upright, inverted and scrambled biological motion under two task conditions to explore spatiotemporal dynamics of intentional and unintentional biological motion processing in children and adolescents with ASD (n=27), comparing them to a control cohort of neurotypical (NT) participants (n=35). RESULTS: Behaviorally, ASD participants were able to discriminate biological motion with similar accuracy to NT controls. However, electrophysiologic investigation revealed reduced automatic selective processing of upright biologic versus scrambled motion stimuli in ASD relative to NT individuals, which was ameliorated when task demands required explicit attention to biological motion. Additionally, we observed distinctive patterns of covariance between visual potentials evoked by biological motion and functional social ability, such that Vineland Adaptive Behavior Scale-Socialization domain scores were differentially associated with biological motion processing in the N1 period in the ASD but not the NT group. LIMITATIONS: The cross-sectional design of this study does not allow us to definitively answer the question of whether developmental differences in attention to biological motion cause disruption in social communication, and the sample was limited to children with average or above cognitive ability. CONCLUSIONS: Together, these data suggest that individuals with ASD are able to discriminate, with explicit attention, biological from non-biological motion but demonstrate diminished automatic neural specificity for biological motion processing, which may have cascading implications for the development of higher-order social cognition. En ligne : http://dx.doi.org/10.1186/s13229-022-00512-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

A Comparative Trial of Occupational Therapy Using Ayres Sensory Integration and Applied Behavior Analysis Interventions for Autistic Children / Roseann C. SCHAAF in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.2120-2134 Titre : A Comparative Trial of Occupational Therapy Using Ayres Sensory Integration and Applied Behavior Analysis Interventions for Autistic Children Type de document : texte imprimé Auteurs : Roseann C. SCHAAF, Auteur ; Elizabeth M. RIDGWAY, Auteur ; Emily A. JONES, Auteur ; Rachel L. DUMONT, Auteur ; John FOXE, Auteur ; Tim CONLY, Auteur ; Catherine SANCIMINO, Auteur ; Misung YI, Auteur ; Zoe MAILLOUX, Auteur ; Joanne M. HUNT, Auteur ; Leon KIRSCHNER, Auteur ; Ben E. LEIBY, Auteur ; Sophie MOLHOLM, Auteur Article en page(s) : p.2120-2134 Langues : Anglais (eng) Mots-clés : applied behavior analysis  autism  autistic  autistic children  Ayres Sensory Integration  occupational therapy Index. décimale : PER Périodiques Résumé : ABSTRACT Many autistic children demonstrate sensory integration differences that impact their participation in daily living activities and tasks. Occupational Therapy using Ayres Sensory Integration (OT-ASI) is an evidence-based intervention for autistic children that addresses the sensory integrative factors impacting daily living skills and participation in a variety of tasks and activities. Applied Behavior Analysis (ABA) is the recommended evidence-based practice for autism to improve a range of developmental domains. This study compared Occupational Therapy using Ayres Sensory Integration, Applied Behavior Analysis, and no treatment on daily living skills and individualized goals for autistic children who also show sensory differences. A parallel arm comparative effectiveness trial design with participants randomized equally to OT-ASI, ABA, or no treatment. Intervention consisted of 30 one-hour sessions. Significant gains in individualized goals, measured by Goal Attainment Scaling, were found in both treatment arms over the no treatment group. Both the OT-ASI and the ABA groups improved in daily living skills measured on the Pediatric Evaluation of Disabilities Inventory; although the improvements over the no treatment group were not significant. Both OT-ASI and ABA improved individualized goals and daily living skills at comparable levels. These findings are discussed in light of their implications for intervention. Trial Registration: NCT02536365 En ligne : https://doi.org/10.1002/aur.70099 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] A Comparative Trial of Occupational Therapy Using Ayres Sensory Integration and Applied Behavior Analysis Interventions for Autistic Children [texte imprimé] / Roseann C. SCHAAF, Auteur ; Elizabeth M. RIDGWAY, Auteur ; Emily A. JONES, Auteur ; Rachel L. DUMONT, Auteur ; John FOXE, Auteur ; Tim CONLY, Auteur ; Catherine SANCIMINO, Auteur ; Misung YI, Auteur ; Zoe MAILLOUX, Auteur ; Joanne M. HUNT, Auteur ; Leon KIRSCHNER, Auteur ; Ben E. LEIBY, Auteur ; Sophie MOLHOLM, Auteur . - p.2120-2134. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.2120-2134 Mots-clés : applied behavior analysis  autism  autistic  autistic children  Ayres Sensory Integration  occupational therapy Index. décimale : PER Périodiques Résumé : ABSTRACT Many autistic children demonstrate sensory integration differences that impact their participation in daily living activities and tasks. Occupational Therapy using Ayres Sensory Integration (OT-ASI) is an evidence-based intervention for autistic children that addresses the sensory integrative factors impacting daily living skills and participation in a variety of tasks and activities. Applied Behavior Analysis (ABA) is the recommended evidence-based practice for autism to improve a range of developmental domains. This study compared Occupational Therapy using Ayres Sensory Integration, Applied Behavior Analysis, and no treatment on daily living skills and individualized goals for autistic children who also show sensory differences. A parallel arm comparative effectiveness trial design with participants randomized equally to OT-ASI, ABA, or no treatment. Intervention consisted of 30 one-hour sessions. Significant gains in individualized goals, measured by Goal Attainment Scaling, were found in both treatment arms over the no treatment group. Both the OT-ASI and the ABA groups improved in daily living skills measured on the Pediatric Evaluation of Disabilities Inventory; although the improvements over the no treatment group were not significant. Both OT-ASI and ABA improved individualized goals and daily living skills at comparable levels. These findings are discussed in light of their implications for intervention. Trial Registration: NCT02536365 En ligne : https://doi.org/10.1002/aur.70099 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium / Roseann SCHAAF ; Karla K. AUSDERAU ; Grace T. BARANEK ; D Jonah BARRETT ; Carissa J. CASCIO ; Rachel L. DUMONT ; Ekomobong E. Eyoh ; Michelle D. FAILLA ; Jacob I. FELDMAN ; Jennifer H. FOSS-FEIG ; Heather L. GREEN ; Shulamite A. GREEN ; Jason L. HE ; Elizabeth A. KAPLAN-KAHN ; Bahar KEÇELI-KAYSILI ; Keren MACLENNAN ; Zoe MAILLOUX ; Elysa J. MARCO ; Lisa E. MASH ; Elizabeth P. MCKERNAN ; Sophie MOLHOLM ; Stewart H. MOSTOFSKY ; Nicolaas A. J. PUTS ; Caroline E. ROBERTSON ; Natalie RUSSO ; Nicole SHEA ; John SIDERIS ; James S. SUTCLIFFE ; Teresa TAVASSOLI ; Mark T. WALLACE ; Ericka L. WODKA ; Tiffany G. WOYNAROSKI in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 31 p. Titre : Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium Type de document : texte imprimé Auteurs : Roseann SCHAAF, Auteur ; Karla K. AUSDERAU, Auteur ; Grace T. BARANEK, Auteur ; D Jonah BARRETT, Auteur ; Carissa J. CASCIO, Auteur ; Rachel L. DUMONT, Auteur ; Ekomobong E. Eyoh, Auteur ; Michelle D. FAILLA, Auteur ; Jacob I. FELDMAN, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Heather L. GREEN, Auteur ; Shulamite A. GREEN, Auteur ; Jason L. HE, Auteur ; Elizabeth A. KAPLAN-KAHN, Auteur ; Bahar KEÇELI-KAYSILI, Auteur ; Keren MACLENNAN, Auteur ; Zoe MAILLOUX, Auteur ; Elysa J. MARCO, Auteur ; Lisa E. MASH, Auteur ; Elizabeth P. MCKERNAN, Auteur ; Sophie MOLHOLM, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nicolaas A. J. PUTS, Auteur ; Caroline E. ROBERTSON, Auteur ; Natalie RUSSO, Auteur ; Nicole SHEA, Auteur ; John SIDERIS, Auteur ; James S. SUTCLIFFE, Auteur ; Teresa TAVASSOLI, Auteur ; Mark T. WALLACE, Auteur ; Ericka L. WODKA, Auteur ; Tiffany G. WOYNAROSKI, Auteur Article en page(s) : 31 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Differences in responding to sensory stimuli, including sensory hyperreactivity (HYPER), hyporeactivity (HYPO), and sensory seeking (SEEK) have been observed in autistic individuals across sensory modalities, but few studies have examined the structure of these "supra-modal" traits in the autistic population. METHODS: Leveraging a combined sample of 3868 autistic youth drawn from 12 distinct data sources (ages 3-18 years and representing the full range of cognitive ability), the current study used modern psychometric and meta-analytic techniques to interrogate the latent structure and correlates of caregiver-reported HYPER, HYPO, and SEEK within and across sensory modalities. Bifactor statistical indices were used to both evaluate the strength of a "general response pattern" factor for each supra-modal construct and determine the added value of "modality-specific response pattern" scores (e.g., Visual HYPER). Bayesian random-effects integrative data analysis models were used to examine the clinical and demographic correlates of all interpretable HYPER, HYPO, and SEEK (sub)constructs. RESULTS: All modality-specific HYPER subconstructs could be reliably and validly measured, whereas certain modality-specific HYPO and SEEK subconstructs were psychometrically inadequate when measured using existing items. Bifactor analyses supported the validity of a supra-modal HYPER construct (?(H)=.800) but not a supra-modal HYPO construct (?(H)=.653), and supra-modal SEEK models suggested a more limited version of the construct that excluded some sensory modalities (?(H)=.800; 4/7 modalities). Modality-specific subscales demonstrated significant added value for all response patterns. Meta-analytic correlations varied by construct, although sensory features tended to correlate most with other domains of core autism features and co-occurring psychiatric symptoms (with general HYPER and speech HYPO demonstrating the largest numbers of practically significant correlations). LIMITATIONS: Conclusions may not be generalizable beyond the specific pool of items used in the current study, which was limited to caregiver report of observable behaviors and excluded multisensory items that reflect many "real-world" sensory experiences. CONCLUSION: Of the three sensory response patterns, only HYPER demonstrated sufficient evidence for valid interpretation at the supra-modal level, whereas supra-modal HYPO/SEEK constructs demonstrated substantial psychometric limitations. For clinicians and researchers seeking to characterize sensory reactivity in autism, modality-specific response pattern scores may represent viable alternatives that overcome many of these limitations. En ligne : http://dx.doi.org/10.1186/s13229-023-00563-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium [texte imprimé] / Roseann SCHAAF, Auteur ; Karla K. AUSDERAU, Auteur ; Grace T. BARANEK, Auteur ; D Jonah BARRETT, Auteur ; Carissa J. CASCIO, Auteur ; Rachel L. DUMONT, Auteur ; Ekomobong E. Eyoh, Auteur ; Michelle D. FAILLA, Auteur ; Jacob I. FELDMAN, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Heather L. GREEN, Auteur ; Shulamite A. GREEN, Auteur ; Jason L. HE, Auteur ; Elizabeth A. KAPLAN-KAHN, Auteur ; Bahar KEÇELI-KAYSILI, Auteur ; Keren MACLENNAN, Auteur ; Zoe MAILLOUX, Auteur ; Elysa J. MARCO, Auteur ; Lisa E. MASH, Auteur ; Elizabeth P. MCKERNAN, Auteur ; Sophie MOLHOLM, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nicolaas A. J. PUTS, Auteur ; Caroline E. ROBERTSON, Auteur ; Natalie RUSSO, Auteur ; Nicole SHEA, Auteur ; John SIDERIS, Auteur ; James S. SUTCLIFFE, Auteur ; Teresa TAVASSOLI, Auteur ; Mark T. WALLACE, Auteur ; Ericka L. WODKA, Auteur ; Tiffany G. WOYNAROSKI, Auteur . - 31 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 31 p. Index. décimale : PER Périodiques Résumé : BACKGROUND: Differences in responding to sensory stimuli, including sensory hyperreactivity (HYPER), hyporeactivity (HYPO), and sensory seeking (SEEK) have been observed in autistic individuals across sensory modalities, but few studies have examined the structure of these "supra-modal" traits in the autistic population. METHODS: Leveraging a combined sample of 3868 autistic youth drawn from 12 distinct data sources (ages 3-18 years and representing the full range of cognitive ability), the current study used modern psychometric and meta-analytic techniques to interrogate the latent structure and correlates of caregiver-reported HYPER, HYPO, and SEEK within and across sensory modalities. Bifactor statistical indices were used to both evaluate the strength of a "general response pattern" factor for each supra-modal construct and determine the added value of "modality-specific response pattern" scores (e.g., Visual HYPER). Bayesian random-effects integrative data analysis models were used to examine the clinical and demographic correlates of all interpretable HYPER, HYPO, and SEEK (sub)constructs. RESULTS: All modality-specific HYPER subconstructs could be reliably and validly measured, whereas certain modality-specific HYPO and SEEK subconstructs were psychometrically inadequate when measured using existing items. Bifactor analyses supported the validity of a supra-modal HYPER construct (?(H)=.800) but not a supra-modal HYPO construct (?(H)=.653), and supra-modal SEEK models suggested a more limited version of the construct that excluded some sensory modalities (?(H)=.800; 4/7 modalities). Modality-specific subscales demonstrated significant added value for all response patterns. Meta-analytic correlations varied by construct, although sensory features tended to correlate most with other domains of core autism features and co-occurring psychiatric symptoms (with general HYPER and speech HYPO demonstrating the largest numbers of practically significant correlations). LIMITATIONS: Conclusions may not be generalizable beyond the specific pool of items used in the current study, which was limited to caregiver report of observable behaviors and excluded multisensory items that reflect many "real-world" sensory experiences. CONCLUSION: Of the three sensory response patterns, only HYPER demonstrated sufficient evidence for valid interpretation at the supra-modal level, whereas supra-modal HYPO/SEEK constructs demonstrated substantial psychometric limitations. For clinicians and researchers seeking to characterize sensory reactivity in autism, modality-specific response pattern scores may represent viable alternatives that overcome many of these limitations. En ligne : http://dx.doi.org/10.1186/s13229-023-00563-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Multisensory processing in children with autism: high-density electrical mapping of auditory–somatosensory integration / Natalie RUSSO in Autism Research, 3-5 (October 2010)  

Public ISBD [article]  inAutism Research > 3-5 (October 2010) . - p.253-267 Titre : Multisensory processing in children with autism: high-density electrical mapping of auditory–somatosensory integration Type de document : texte imprimé Auteurs : Natalie RUSSO, Auteur ; John J. FOXE, Auteur ; Alice B. BRANDWEIN, Auteur ; Ted ALTSCHULER, Auteur ; Hilary GOMES, Auteur ; Sophie MOLHOLM, Auteur Année de publication : 2010 Article en page(s) : p.253-267 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  electrophysiology  multisensory integration  auditory processing  somatosensory processing  development Index. décimale : PER Périodiques Résumé : Successful integration of signals from the various sensory systems is crucial for normal sensory–perceptual functioning, allowing for the perception of coherent objects rather than a disconnected cluster of fragmented features. Several prominent theories of autism suggest that automatic integration is impaired in this population, but there have been few empirical tests of this thesis. A standard electrophysiological metric of multisensory integration (MSI) was used to test the integrity of auditory–somatosensory integration in children with autism (N=17, aged 6–16 years), compared to age- and IQ-matched typically developing (TD) children. High-density electrophysiology was recorded while participants were presented with either auditory or somatosensory stimuli alone (unisensory conditions), or as a combined auditory–somatosensory stimulus (multisensory condition), in randomized order. Participants watched a silent movie during testing, ignoring concurrent stimulation. Significant differences between neural responses to the multisensory auditory–somatosensory stimulus and the unisensory stimuli (the sum of the responses to the auditory and somatosensory stimuli when presented alone) served as the dependent measure. The data revealed group differences in the integration of auditory and somatosensory information that appeared at around 175 ms, and were characterized by the presence of MSI for the TD but not the autism spectrum disorder (ASD) children. Overall, MSI was less extensive in the ASD group. These findings are discussed within the framework of current knowledge of MSI in typical development as well as in relation to theories of ASD. En ligne : http://dx.doi.org/10.1002/aur.152 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] Multisensory processing in children with autism: high-density electrical mapping of auditory–somatosensory integration [texte imprimé] / Natalie RUSSO, Auteur ; John J. FOXE, Auteur ; Alice B. BRANDWEIN, Auteur ; Ted ALTSCHULER, Auteur ; Hilary GOMES, Auteur ; Sophie MOLHOLM, Auteur . - 2010 . - p.253-267. Langues : Anglais (eng) in Autism Research > 3-5 (October 2010) . - p.253-267 Mots-clés : autism spectrum disorders  electrophysiology  multisensory integration  auditory processing  somatosensory processing  development Index. décimale : PER Périodiques Résumé : Successful integration of signals from the various sensory systems is crucial for normal sensory–perceptual functioning, allowing for the perception of coherent objects rather than a disconnected cluster of fragmented features. Several prominent theories of autism suggest that automatic integration is impaired in this population, but there have been few empirical tests of this thesis. A standard electrophysiological metric of multisensory integration (MSI) was used to test the integrity of auditory–somatosensory integration in children with autism (N=17, aged 6–16 years), compared to age- and IQ-matched typically developing (TD) children. High-density electrophysiology was recorded while participants were presented with either auditory or somatosensory stimuli alone (unisensory conditions), or as a combined auditory–somatosensory stimulus (multisensory condition), in randomized order. Participants watched a silent movie during testing, ignoring concurrent stimulation. Significant differences between neural responses to the multisensory auditory–somatosensory stimulus and the unisensory stimuli (the sum of the responses to the auditory and somatosensory stimuli when presented alone) served as the dependent measure. The data revealed group differences in the integration of auditory and somatosensory information that appeared at around 175 ms, and were characterized by the presence of MSI for the TD but not the autism spectrum disorder (ASD) children. Overall, MSI was less extensive in the ASD group. These findings are discussed within the framework of current knowledge of MSI in typical development as well as in relation to theories of ASD. En ligne : http://dx.doi.org/10.1002/aur.152 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115

Neural correlates of audiovisual narrative speech perception in children and adults on the autism spectrum: A functional magnetic resonance imaging study / Lars A. ROSS in Autism Research, 17-2 (February 2024)  

Public ISBD [article]  inAutism Research > 17-2 (February 2024) . - p.280-310 Titre : Neural correlates of audiovisual narrative speech perception in children and adults on the autism spectrum: A functional magnetic resonance imaging study Type de document : texte imprimé Auteurs : Lars A. ROSS, Auteur ; Sophie MOLHOLM, Auteur ; John S. BUTLER, Auteur ; Victor A. DEL BENE, Auteur ; Tufikameni BRIMA, Auteur ; John J. FOXE, Auteur Article en page(s) : p.280-310 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autistic individuals show substantially reduced benefit from observing visual articulations during audiovisual speech perception, a multisensory integration deficit that is particularly relevant to social communication. This has mostly been studied using simple syllabic or word-level stimuli and it remains unclear how altered lower-level multisensory integration translates to the processing of more complex natural multisensory stimulus environments in autism. Here, functional neuroimaging was used to examine neural correlates of audiovisual gain (AV-gain) in 41 autistic individuals to those of 41 age-matched non-autistic controls when presented with a complex audiovisual narrative. Participants were presented with continuous narration of a story in auditory-alone, visual-alone, and both synchronous and asynchronous audiovisual speech conditions. We hypothesized that previously identified differences in audiovisual speech processing in autism would be characterized by activation differences in brain regions well known to be associated with audiovisual enhancement in neurotypicals. However, our results did not provide evidence for altered processing of auditory alone, visual alone, audiovisual conditions or AV- gain in regions associated with the respective task when comparing activation patterns between groups. Instead, we found that autistic individuals responded with higher activations in mostly frontal regions where the activation to the experimental conditions was below baseline (de-activations) in the control group. These frontal effects were observed in both unisensory and audiovisual conditions, suggesting that these altered activations were not specific to multisensory processing but reflective of more general mechanisms such as an altered disengagement of Default Mode Network processes during the observation of the language stimulus across conditions. En ligne : https://doi.org/10.1002/aur.3104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=522 [article] Neural correlates of audiovisual narrative speech perception in children and adults on the autism spectrum: A functional magnetic resonance imaging study [texte imprimé] / Lars A. ROSS, Auteur ; Sophie MOLHOLM, Auteur ; John S. BUTLER, Auteur ; Victor A. DEL BENE, Auteur ; Tufikameni BRIMA, Auteur ; John J. FOXE, Auteur . - p.280-310. Langues : Anglais (eng) in Autism Research > 17-2 (February 2024) . - p.280-310 Index. décimale : PER Périodiques Résumé : Abstract Autistic individuals show substantially reduced benefit from observing visual articulations during audiovisual speech perception, a multisensory integration deficit that is particularly relevant to social communication. This has mostly been studied using simple syllabic or word-level stimuli and it remains unclear how altered lower-level multisensory integration translates to the processing of more complex natural multisensory stimulus environments in autism. Here, functional neuroimaging was used to examine neural correlates of audiovisual gain (AV-gain) in 41 autistic individuals to those of 41 age-matched non-autistic controls when presented with a complex audiovisual narrative. Participants were presented with continuous narration of a story in auditory-alone, visual-alone, and both synchronous and asynchronous audiovisual speech conditions. We hypothesized that previously identified differences in audiovisual speech processing in autism would be characterized by activation differences in brain regions well known to be associated with audiovisual enhancement in neurotypicals. However, our results did not provide evidence for altered processing of auditory alone, visual alone, audiovisual conditions or AV- gain in regions associated with the respective task when comparing activation patterns between groups. Instead, we found that autistic individuals responded with higher activations in mostly frontal regions where the activation to the experimental conditions was below baseline (de-activations) in the control group. These frontal effects were observed in both unisensory and audiovisual conditions, suggesting that these altered activations were not specific to multisensory processing but reflective of more general mechanisms such as an altered disengagement of Default Mode Network processes during the observation of the language stimulus across conditions. En ligne : https://doi.org/10.1002/aur.3104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=522

Neurophysiological Indices of Atypical Auditory Processing and Multisensory Integration are Associated with Symptom Severity in Autism / Alice B. BRANDWEIN in Journal of Autism and Developmental Disorders, 45-1 (January 2015)  

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Sensory Phenotypes in Autism: Making a Case for the Inclusion of Sensory Integration Functions / Zoe MAILLOUX ; Elizabeth RIDGWAY ; Alaina S. BERRUTI ; Rachel L. DUMONT ; Emily A. JONES ; Benjamin E. LEIBY ; Catherine SANCIMINO ; Misung YI ; Sophie MOLHOLM in Journal of Autism and Developmental Disorders, 53-12 (December 2023)  

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Somatosensory temporal sensitivity in adults on the autism spectrum: A high-density electrophysiological mapping study using the mismatch negativity (MMN) sensory memory paradigm / Edward G. FREEDMAN ; Sophie MOLHOLM ; John J. FOXE in Autism Research, 17-9 (September 2024)  

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Susceptibility to Distraction in Autism Spectrum Disorder: Probing the Integrity of Oscillatory Alpha-Band Suppression Mechanisms / Jeremy W. MURPHY in Autism Research, 7-4 (August 2014)  

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