Adaptation of the “ten questions” to screen for autism and other neurodevelopmental disorders in Uganda / Angelina KAKOOZA-MWESIGE in Autism, 18-4 (May 2014)  

Public ISBD [article]  inAutism > 18-4 (May 2014) . - p.447-457 Titre : Adaptation of the “ten questions” to screen for autism and other neurodevelopmental disorders in Uganda Type de document : Texte imprimé et/ou numérique Auteurs : Angelina KAKOOZA-MWESIGE, Auteur ; Keron SSEBYALA, Auteur ; Charles KARAMAGI, Auteur ; Sarah KIGULI, Auteur ; Karen SMITH, Auteur ; Meredith C. ANDERSON, Auteur ; Lisa A. CROEN, Auteur ; Edwin TREVATHAN, Auteur ; Robin HANSEN, Auteur ; Daniel SMITH, Auteur ; Judith K. GRETHER, Auteur Article en page(s) : p.447-457 Langues : Anglais (eng) Mots-clés : autism spectrum disorder screening and assessment  developing countries  low- and middle-income countries  neurodevelopmental disorder screening and assessment  Uganda Index. décimale : PER Périodiques Résumé : Neurodevelopmental disorders are recognized to be relatively common in developing countries but little data exist for planning effective prevention and intervention strategies. In particular, data on autism spectrum disorders are lacking. For application in Uganda, we developed a 23-question screener (23Q) that includes the Ten Questions screener and additional questions on autism spectrum disorder behaviors. We then conducted household screening of 1169 children, 2–9 years of age, followed by clinical assessment of children who screened positive and a sample of those who screened negative to evaluate the validity of the screener. We found that 320 children (27% of the total) screened positive and 68 children received a clinical diagnosis of one or more moderate to severe neurodevelopmental disorders (autism spectrum disorder; cerebral palsy; epilepsy; cognitive, speech and language, hearing, or vision impairment), including 8 children with autism spectrum disorders. Prevalence and validity of the screener were evaluated under different statistical assumptions. Sensitivity of the 23Q ranged from 0.55 to 0.80 and prevalence for ?1 neurodevelopmental disorders from 7.7/100 children to 12.8/100 children depending on which assumptions were used. The combination of screening positive on both autism spectrum disorders and Ten Questions items was modestly successful in identifying a subgroup of children at especially high risk of autism spectrum disorders. We recommend that autism spectrum disorders and related behavioral disorders be included in studies of neurodevelopmental disorders in low-resource settings to obtain essential data for planning local and global public health responses. En ligne : http://dx.doi.org/10.1177/1362361313475848 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232 [article] Adaptation of the “ten questions” to screen for autism and other neurodevelopmental disorders in Uganda [Texte imprimé et/ou numérique] / Angelina KAKOOZA-MWESIGE, Auteur ; Keron SSEBYALA, Auteur ; Charles KARAMAGI, Auteur ; Sarah KIGULI, Auteur ; Karen SMITH, Auteur ; Meredith C. ANDERSON, Auteur ; Lisa A. CROEN, Auteur ; Edwin TREVATHAN, Auteur ; Robin HANSEN, Auteur ; Daniel SMITH, Auteur ; Judith K. GRETHER, Auteur . - p.447-457. Langues : Anglais (eng) in Autism > 18-4 (May 2014) . - p.447-457 Mots-clés : autism spectrum disorder screening and assessment  developing countries  low- and middle-income countries  neurodevelopmental disorder screening and assessment  Uganda Index. décimale : PER Périodiques Résumé : Neurodevelopmental disorders are recognized to be relatively common in developing countries but little data exist for planning effective prevention and intervention strategies. In particular, data on autism spectrum disorders are lacking. For application in Uganda, we developed a 23-question screener (23Q) that includes the Ten Questions screener and additional questions on autism spectrum disorder behaviors. We then conducted household screening of 1169 children, 2–9 years of age, followed by clinical assessment of children who screened positive and a sample of those who screened negative to evaluate the validity of the screener. We found that 320 children (27% of the total) screened positive and 68 children received a clinical diagnosis of one or more moderate to severe neurodevelopmental disorders (autism spectrum disorder; cerebral palsy; epilepsy; cognitive, speech and language, hearing, or vision impairment), including 8 children with autism spectrum disorders. Prevalence and validity of the screener were evaluated under different statistical assumptions. Sensitivity of the 23Q ranged from 0.55 to 0.80 and prevalence for ?1 neurodevelopmental disorders from 7.7/100 children to 12.8/100 children depending on which assumptions were used. The combination of screening positive on both autism spectrum disorders and Ten Questions items was modestly successful in identifying a subgroup of children at especially high risk of autism spectrum disorders. We recommend that autism spectrum disorders and related behavioral disorders be included in studies of neurodevelopmental disorders in low-resource settings to obtain essential data for planning local and global public health responses. En ligne : http://dx.doi.org/10.1177/1362361313475848 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232

Autism and Developmental Screening in a Public, Primary Care Setting Primarily Serving Hispanics: Challenges and Results / Gayle C. WINDHAM in Journal of Autism and Developmental Disorders, 44-7 (July 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1621-1632 Titre : Autism and Developmental Screening in a Public, Primary Care Setting Primarily Serving Hispanics: Challenges and Results Type de document : Texte imprimé et/ou numérique Auteurs : Gayle C. WINDHAM, Auteur ; Karen S. SMITH, Auteur ; Nila ROSEN, Auteur ; Meredith C. ANDERSON, Auteur ; Judith K. GRETHER, Auteur ; Richard B. COOLMAN, Auteur ; Stephen HARRIS, Auteur Article en page(s) : p.1621-1632 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Developmental screening  M-CHAT  ASQ  Hispanics  Children’s health Index. décimale : PER Périodiques Résumé : We implemented screening of children 16–30 months of age (n = 1,760) from a typically under-served, primarily Hispanic, population, at routine pediatric appointments using the modified checklist for autism in toddlers (M-CHAT) and Ages and Stages Questionnaire. Screen positive rates of 26 and 39 %, respectively, were higher than previous reports. Hispanics were more likely to score M-CHAT positive than non-Hispanics (adjusted OR 1.7, 95 % CI 1.2–2.4), as were those screened in Spanish. About 30 % of screen-positive children were referred for further assessment, but only half were seen. Thus screening in this population is feasible, but may require additional resources. Attention to the cultural applicability of screening instruments, as well as to explaining the results or need for additional services to parents, is critical to serve the growing Hispanic population. En ligne : http://dx.doi.org/10.1007/s10803-014-2032-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 [article] Autism and Developmental Screening in a Public, Primary Care Setting Primarily Serving Hispanics: Challenges and Results [Texte imprimé et/ou numérique] / Gayle C. WINDHAM, Auteur ; Karen S. SMITH, Auteur ; Nila ROSEN, Auteur ; Meredith C. ANDERSON, Auteur ; Judith K. GRETHER, Auteur ; Richard B. COOLMAN, Auteur ; Stephen HARRIS, Auteur . - p.1621-1632. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1621-1632 Mots-clés : Autism spectrum disorders  Developmental screening  M-CHAT  ASQ  Hispanics  Children’s health Index. décimale : PER Périodiques Résumé : We implemented screening of children 16–30 months of age (n = 1,760) from a typically under-served, primarily Hispanic, population, at routine pediatric appointments using the modified checklist for autism in toddlers (M-CHAT) and Ages and Stages Questionnaire. Screen positive rates of 26 and 39 %, respectively, were higher than previous reports. Hispanics were more likely to score M-CHAT positive than non-Hispanics (adjusted OR 1.7, 95 % CI 1.2–2.4), as were those screened in Spanish. About 30 % of screen-positive children were referred for further assessment, but only half were seen. Thus screening in this population is feasible, but may require additional resources. Attention to the cultural applicability of screening instruments, as well as to explaining the results or need for additional services to parents, is critical to serve the growing Hispanic population. En ligne : http://dx.doi.org/10.1007/s10803-014-2032-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California / Gayle C. WINDHAM in Journal of Autism and Developmental Disorders, 46-2 (February 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.478-488 Titre : Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California Type de document : Texte imprimé et/ou numérique Auteurs : Gayle C. WINDHAM, Auteur ; Kristen LYALL, Auteur ; Meredith C. ANDERSON, Auteur ; Martin KHARRAZI, Auteur Année de publication : 2016 Article en page(s) : p.478-488 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Steroid hormones  Estrogen  Alpha-fetoprotein  hCG  Prenatal screening  Estriol Index. décimale : PER Périodiques Résumé : We examined prenatal screening markers and offspring autism spectrum disorder (ASD) using California statewide data on singleton births in 1996 and 2002. Second trimester levels of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and maternal serum alpha-fetoprotein (MSAFP) were compared between mothers of children with ASD (n = 2586) and of non-cases (n = 600,103). Adjusted odds ratios (AOR) were calculated by logistic regression. Lower uE3 (AOR for < 10th percentile vs. 25th–74th percentiles = 1.21, 95 % CI 1.06–1.37), and higher MSAFP (AOR = 1.21, 95 % CI 1.07–1.37 for > 90th percentile) were significantly associated with ASD. A U-shaped relationship was seen for hCG (AOR = 1.16, 95 % CI 1.02–1.32 for < 10th percentile; AOR = 1.19, 95 % CI 1.05–1.36 for > 90th percentile). Our results further support prenatal hormone involvement in ASD risk. En ligne : http://dx.doi.org/10.1007/s10803-015-2587-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 [article] Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California [Texte imprimé et/ou numérique] / Gayle C. WINDHAM, Auteur ; Kristen LYALL, Auteur ; Meredith C. ANDERSON, Auteur ; Martin KHARRAZI, Auteur . - 2016 . - p.478-488. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.478-488 Mots-clés : Autism spectrum disorder  Steroid hormones  Estrogen  Alpha-fetoprotein  hCG  Prenatal screening  Estriol Index. décimale : PER Périodiques Résumé : We examined prenatal screening markers and offspring autism spectrum disorder (ASD) using California statewide data on singleton births in 1996 and 2002. Second trimester levels of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and maternal serum alpha-fetoprotein (MSAFP) were compared between mothers of children with ASD (n = 2586) and of non-cases (n = 600,103). Adjusted odds ratios (AOR) were calculated by logistic regression. Lower uE3 (AOR for < 10th percentile vs. 25th–74th percentiles = 1.21, 95 % CI 1.06–1.37), and higher MSAFP (AOR = 1.21, 95 % CI 1.07–1.37 for > 90th percentile) were significantly associated with ASD. A U-shaped relationship was seen for hCG (AOR = 1.16, 95 % CI 1.02–1.32 for < 10th percentile; AOR = 1.19, 95 % CI 1.05–1.36 for > 90th percentile). Our results further support prenatal hormone involvement in ASD risk. En ligne : http://dx.doi.org/10.1007/s10803-015-2587-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280

Birth Prevalence of Autism Spectrum Disorders in the San Francisco Bay Area by Demographic and Ascertainment Source Characteristics / Gayle C. WINDHAM in Journal of Autism and Developmental Disorders, 41-10 (October 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-10 (October 2011) . - p.1362-1372 Titre : Birth Prevalence of Autism Spectrum Disorders in the San Francisco Bay Area by Demographic and Ascertainment Source Characteristics Type de document : Texte imprimé et/ou numérique Auteurs : Gayle C. WINDHAM, Auteur ; Meredith C. ANDERSON, Auteur ; Lisa A. CROEN, Auteur ; Karen S. SMITH, Auteur ; John COLLINS, Auteur ; Judith K. GRETHER, Auteur Année de publication : 2011 Article en page(s) : p.1362-1372 Langues : Anglais (eng) Mots-clés : Autism  ASD  Prevalence  Surveillance  Demographics Index. décimale : PER Périodiques Résumé : Using standardized methods for multi-source surveillance, we calculated the prevalence of autism spectrum disorders (ASD) among children born in a racially diverse region in 1994 or 1996 as 4.7/1000 live births. Children with ASD before age 9 were identified through chart abstraction at health-related sources; three-quarters were being served by the state-wide Department of Developmental Services. In adjusted models, we found a male:female ratio of 6:1, a doubling of ASD prevalence among children of older mothers (40+), and lower prevalence with lower paternal education. Children of Black or Hispanic mothers had lower prevalence than those of White, non-Hispanic mothers, but these differences were attenuated after adjustment. Prevalence in children of Asian mothers was similar to Whites. Potential under-counting is discussed. En ligne : http://dx.doi.org/10.1007/s10803-010-1160-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 [article] Birth Prevalence of Autism Spectrum Disorders in the San Francisco Bay Area by Demographic and Ascertainment Source Characteristics [Texte imprimé et/ou numérique] / Gayle C. WINDHAM, Auteur ; Meredith C. ANDERSON, Auteur ; Lisa A. CROEN, Auteur ; Karen S. SMITH, Auteur ; John COLLINS, Auteur ; Judith K. GRETHER, Auteur . - 2011 . - p.1362-1372. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-10 (October 2011) . - p.1362-1372 Mots-clés : Autism  ASD  Prevalence  Surveillance  Demographics Index. décimale : PER Périodiques Résumé : Using standardized methods for multi-source surveillance, we calculated the prevalence of autism spectrum disorders (ASD) among children born in a racially diverse region in 1994 or 1996 as 4.7/1000 live births. Children with ASD before age 9 were identified through chart abstraction at health-related sources; three-quarters were being served by the state-wide Department of Developmental Services. In adjusted models, we found a male:female ratio of 6:1, a doubling of ASD prevalence among children of older mothers (40+), and lower prevalence with lower paternal education. Children of Black or Hispanic mothers had lower prevalence than those of White, non-Hispanic mothers, but these differences were attenuated after adjustment. Prevalence in children of Asian mothers was similar to Whites. Potential under-counting is discussed. En ligne : http://dx.doi.org/10.1007/s10803-010-1160-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143

Neonatal thyroid hormone levels in association with autism spectrum disorder / Kristen LYALL in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.585-592 Titre : Neonatal thyroid hormone levels in association with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kristen LYALL, Auteur ; Meredith C. ANDERSON, Auteur ; Martin KHARRAZI, Auteur ; Gayle C. WINDHAM, Auteur Article en page(s) : p.585-592 Langues : Anglais (eng) Mots-clés : risk factors  thyroid hormones  autism spectrum disorder  neonatal hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones (TH) are critical in early neurodevelopment, but few studies have examined whether neonatal TH levels influence risk of autism spectrum disorder (ASD). This study linked California neonatal screening data with live birth and Department of Developmental Services records to examine newborn TH levels in relation to ASD. Thyroxine (T4) and thyroid-stimulating hormone (TSH) levels were measured in newborn bloodspots as part of routine screening, in 1996 and 2002, respectively. Mean levels of T4 and TSH were compared between ASD cases and non-cases. Four hundred forty-seven thousand, fifty-nine screened, singleton births from 1996 and 446,424 from 2002 were examined, including 4,818 ASD cases. Binomial regression, using categories of T4 and TSH percentiles was used to calculate crude and adjusted risk ratios (RR). Covariates included maternal and child factors, gestational age, and age at blood draw. No significant associations were found with TSH levels and ASD in crude or adjusted analyses. ASD cases had significantly lower mean T4 levels than non-cases, but this association was no longer significant in adjusted analyses (RR in individuals in lowest 5th percentile of T4 levels?=?1.13, 95% 0.93–1.37). However, this association appeared stronger in certain subgroup analyses, particularly among neonates with blood draw ?48 hr from birth (RR?=?1.67, 95% CI 1.08, 2.60), when TH levels become more stable. Thus, results from this large, population-based study did not suggest strong associations between neonatal TH and ASD, but certain subgroups of newborns with the lowest T4 levels may have modestly increased ASD risk. En ligne : http://dx.doi.org/10.1002/aur.1708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Neonatal thyroid hormone levels in association with autism spectrum disorder [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur ; Meredith C. ANDERSON, Auteur ; Martin KHARRAZI, Auteur ; Gayle C. WINDHAM, Auteur . - p.585-592. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.585-592 Mots-clés : risk factors  thyroid hormones  autism spectrum disorder  neonatal hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones (TH) are critical in early neurodevelopment, but few studies have examined whether neonatal TH levels influence risk of autism spectrum disorder (ASD). This study linked California neonatal screening data with live birth and Department of Developmental Services records to examine newborn TH levels in relation to ASD. Thyroxine (T4) and thyroid-stimulating hormone (TSH) levels were measured in newborn bloodspots as part of routine screening, in 1996 and 2002, respectively. Mean levels of T4 and TSH were compared between ASD cases and non-cases. Four hundred forty-seven thousand, fifty-nine screened, singleton births from 1996 and 446,424 from 2002 were examined, including 4,818 ASD cases. Binomial regression, using categories of T4 and TSH percentiles was used to calculate crude and adjusted risk ratios (RR). Covariates included maternal and child factors, gestational age, and age at blood draw. No significant associations were found with TSH levels and ASD in crude or adjusted analyses. ASD cases had significantly lower mean T4 levels than non-cases, but this association was no longer significant in adjusted analyses (RR in individuals in lowest 5th percentile of T4 levels?=?1.13, 95% 0.93–1.37). However, this association appeared stronger in certain subgroup analyses, particularly among neonates with blood draw ?48 hr from birth (RR?=?1.67, 95% CI 1.08, 2.60), when TH levels become more stable. Thus, results from this large, population-based study did not suggest strong associations between neonatal TH and ASD, but certain subgroups of newborns with the lowest T4 levels may have modestly increased ASD risk. En ligne : http://dx.doi.org/10.1002/aur.1708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Neonatally measured immunoglobulins and risk of autism / Judith K. GRETHER in Autism Research, 3-6 (December 2010)  

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Use of Birth Certificates to Examine Maternal Occupational Exposures and Autism Spectrum Disorders in Offspring / Gayle C. WINDHAM in Autism Research, 6-1 (February 2013)  

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