An Initial Examination of Post-Traumatic Stress Disorder in Mothers of Children with Autism Spectrum Disorder: Challenging Child Behaviors as Criterion A Traumatic Stressors / Alexandra SCHNABEL in Autism Research, 13-9 (September 2020)  

Public ISBD [article]  inAutism Research > 13-9 (September 2020) . - p.1527-1536 Titre : An Initial Examination of Post-Traumatic Stress Disorder in Mothers of Children with Autism Spectrum Disorder: Challenging Child Behaviors as Criterion A Traumatic Stressors Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra SCHNABEL, Auteur ; David J. HALLFORD, Auteur ; Michelle STEWART, Auteur ; Jane A. MCGILLIVRAY, Auteur ; David FORBES, Auteur ; David W. AUSTIN, Auteur Article en page(s) : p.1527-1536 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Parenting a child with autism spectrum disorder (ASD) is associated with high levels of stress. Several studies have conceptualized this as a traumatic stress response to challenging child behaviors such as self-harm, suicidal ideation, and physical aggression toward caregivers. In the present study, we explored the relevance of a trauma-based diagnostic framework to a sample of 30 mothers (M age = 42.97, SD = 5.82) of children with ASD (M age = 12.43, SD = 3.15). Participants were interviewed using the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) for post-traumatic stress disorder (PTSD) and an abbreviated Mini International Neuropsychiatric Interview to assess for comorbidity. Three participants were excluded as they met criteria for PTSD from a traumatic event unrelated to their parenting experience. Of the remaining 27 participants, 6 (22.2%) met criteria for PTSD in the context of traumatic parenting experiences. Descriptions of traumatic events experienced are summarized. Results suggest that, for some parents, challenging child behaviors such as physical violence toward the caregiver from the child, self-injurious behaviors, and suicidal behaviors function as traumatic stressors as per Criterion A of PTSD (American Psychiatric Association [2013]. Diagnostic and statistical manual of mental disorders [DSM-5]. Arlington, VA). This has implications for health professionals engaged with parents of children with ASD, who should consider the possibility of PTSD when challenging behaviors of a potentially traumatic nature are present. Autism Res 2020. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This study found that some challenging behaviors exhibited by children with autism spectrum disorder can be traumatic for parents and lead to the development of post-traumatic stress disorder. Some of these behaviors included self-harming behaviors like head banging, expressing suicidal urges, and becoming physically aggressive toward parents during meltdowns. Autism Res 2020, 13: 1527–1536. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2301 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] An Initial Examination of Post-Traumatic Stress Disorder in Mothers of Children with Autism Spectrum Disorder: Challenging Child Behaviors as Criterion A Traumatic Stressors [Texte imprimé et/ou numérique] / Alexandra SCHNABEL, Auteur ; David J. HALLFORD, Auteur ; Michelle STEWART, Auteur ; Jane A. MCGILLIVRAY, Auteur ; David FORBES, Auteur ; David W. AUSTIN, Auteur . - p.1527-1536. Langues : Anglais (eng) in Autism Research > 13-9 (September 2020) . - p.1527-1536 Index. décimale : PER Périodiques Résumé : Abstract Parenting a child with autism spectrum disorder (ASD) is associated with high levels of stress. Several studies have conceptualized this as a traumatic stress response to challenging child behaviors such as self-harm, suicidal ideation, and physical aggression toward caregivers. In the present study, we explored the relevance of a trauma-based diagnostic framework to a sample of 30 mothers (M age = 42.97, SD = 5.82) of children with ASD (M age = 12.43, SD = 3.15). Participants were interviewed using the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) for post-traumatic stress disorder (PTSD) and an abbreviated Mini International Neuropsychiatric Interview to assess for comorbidity. Three participants were excluded as they met criteria for PTSD from a traumatic event unrelated to their parenting experience. Of the remaining 27 participants, 6 (22.2%) met criteria for PTSD in the context of traumatic parenting experiences. Descriptions of traumatic events experienced are summarized. Results suggest that, for some parents, challenging child behaviors such as physical violence toward the caregiver from the child, self-injurious behaviors, and suicidal behaviors function as traumatic stressors as per Criterion A of PTSD (American Psychiatric Association [2013]. Diagnostic and statistical manual of mental disorders [DSM-5]. Arlington, VA). This has implications for health professionals engaged with parents of children with ASD, who should consider the possibility of PTSD when challenging behaviors of a potentially traumatic nature are present. Autism Res 2020. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This study found that some challenging behaviors exhibited by children with autism spectrum disorder can be traumatic for parents and lead to the development of post-traumatic stress disorder. Some of these behaviors included self-harming behaviors like head banging, expressing suicidal urges, and becoming physically aggressive toward parents during meltdowns. Autism Res 2020, 13: 1527–1536. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2301 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? / Kerrie SHANDLEY in Autism Research, 7-5 (October 2014)  

Public ISBD [article]  inAutism Research > 7-5 (October 2014) . - p.535-542 Titre : Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? Type de document : Texte imprimé et/ou numérique Auteurs : Kerrie SHANDLEY, Auteur ; David W. AUSTIN, Auteur ; Jahar L. BHOWMIK, Auteur Article en page(s) : p.535-542 Langues : Anglais (eng) Mots-clés : porphyrins  biomarker  ASD diagnosis  ASD severity  heavy metals  mercury Index. décimale : PER Périodiques Résumé : A fundamental challenge to the timely diagnosis of Autism Spectrum Disorder (ASD) is the reliance on the observation of a set of aberrant behavior. Consequently, the diagnostic process requires that the child reach an age where the behaviors would typically be exhibited. The identification of a reliable biological marker (biomarker) could be of considerable benefit to the diagnostic process. As a diagnostic biomarker, porphyrins present an attractive prospect as previous studies have reported consistent findings of children with ASD showing significant elevations in porphyrin levels in contrast to controls. Furthermore, there is some evidence that ASD severity may be associated with porphyrins, which would be a valuable characteristic of any ASD biomarker. Importantly, for practical use, porphyrins can be tested non-invasively via a sample of urine. The present study sought to investigate whether porphyrin profiles can reliably be used to (a) differentiate ASD cases from healthy controls; and (b) predict ASD severity. The study compared the porphyrin levels of three groups of children aged 2–6 years: Group 1—children diagnosed with ASD (n?=?70); Group 2—healthy, normally developing siblings of children diagnosed with ASD (n?=?36); and Group 3—healthy, normally developing children with no known blood relative diagnosed with ASD (n?=?54). The results of logistic regression analyses failed to find support for the hypotheses that porphyrin levels could be used as a valid tool to detect ASD cases or predict severity. Autism Res 2014, 7: 535–542. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? [Texte imprimé et/ou numérique] / Kerrie SHANDLEY, Auteur ; David W. AUSTIN, Auteur ; Jahar L. BHOWMIK, Auteur . - p.535-542. Langues : Anglais (eng) in Autism Research > 7-5 (October 2014) . - p.535-542 Mots-clés : porphyrins  biomarker  ASD diagnosis  ASD severity  heavy metals  mercury Index. décimale : PER Périodiques Résumé : A fundamental challenge to the timely diagnosis of Autism Spectrum Disorder (ASD) is the reliance on the observation of a set of aberrant behavior. Consequently, the diagnostic process requires that the child reach an age where the behaviors would typically be exhibited. The identification of a reliable biological marker (biomarker) could be of considerable benefit to the diagnostic process. As a diagnostic biomarker, porphyrins present an attractive prospect as previous studies have reported consistent findings of children with ASD showing significant elevations in porphyrin levels in contrast to controls. Furthermore, there is some evidence that ASD severity may be associated with porphyrins, which would be a valuable characteristic of any ASD biomarker. Importantly, for practical use, porphyrins can be tested non-invasively via a sample of urine. The present study sought to investigate whether porphyrin profiles can reliably be used to (a) differentiate ASD cases from healthy controls; and (b) predict ASD severity. The study compared the porphyrin levels of three groups of children aged 2–6 years: Group 1—children diagnosed with ASD (n?=?70); Group 2—healthy, normally developing siblings of children diagnosed with ASD (n?=?36); and Group 3—healthy, normally developing children with no known blood relative diagnosed with ASD (n?=?54). The results of logistic regression analyses failed to find support for the hypotheses that porphyrin levels could be used as a valid tool to detect ASD cases or predict severity. Autism Res 2014, 7: 535–542. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Brief Report: Pregnancy, Birth and Infant Feeding Practices: A Survey-Based Investigation into Risk Factors for Autism Spectrum Disorder / Aleesha WHITELY in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.5072-5078 Titre : Brief Report: Pregnancy, Birth and Infant Feeding Practices: A Survey-Based Investigation into Risk Factors for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Aleesha WHITELY, Auteur ; Kerrie SHANDLEY, Auteur ; Minh HUYNH, Auteur ; Christine M. BROWN, Auteur ; David W. AUSTIN, Auteur ; Jahar BHOWMIK, Auteur Article en page(s) : p.5072-5078 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/etiology  Child  Female  Humans  Infant  Male  Meperidine  Mothers  Pregnancy  Risk Factors  Surveys and Questionnaires  Analgesia  Autism spectrum disorder  Breastfeeding  Labour interventions  Pregnancy complications Index. décimale : PER Périodiques Résumé : A succession of interconnected environmental factors is believed to contribute substantially to the development of autism spectrum disorder (ASD). This exploratory study therefore aims to identify potential risk factors for ASD that are associated with pregnancy, birth and infant feeding. Demographic and health-related data on children aged 3-13 years (N=4306) was collected through an online survey completed by biological mothers. A fitted logistic regression model identified advanced maternal age, prenatal bleeding, pre-eclampsia, perinatal pethidine usage, foetal distress before birth and male sex of child as associated with an increased risk of ASD, whereas longer gestational duration demonstrated a protective effect. These findings highlight potential risk factors and predictor interrelationships which may contribute to overall ASD risk. En ligne : http://dx.doi.org/10.1007/s10803-021-05348-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Brief Report: Pregnancy, Birth and Infant Feeding Practices: A Survey-Based Investigation into Risk Factors for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Aleesha WHITELY, Auteur ; Kerrie SHANDLEY, Auteur ; Minh HUYNH, Auteur ; Christine M. BROWN, Auteur ; David W. AUSTIN, Auteur ; Jahar BHOWMIK, Auteur . - p.5072-5078. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.5072-5078 Mots-clés : Autism Spectrum Disorder/complications/etiology  Child  Female  Humans  Infant  Male  Meperidine  Mothers  Pregnancy  Risk Factors  Surveys and Questionnaires  Analgesia  Autism spectrum disorder  Breastfeeding  Labour interventions  Pregnancy complications Index. décimale : PER Périodiques Résumé : A succession of interconnected environmental factors is believed to contribute substantially to the development of autism spectrum disorder (ASD). This exploratory study therefore aims to identify potential risk factors for ASD that are associated with pregnancy, birth and infant feeding. Demographic and health-related data on children aged 3-13 years (N=4306) was collected through an online survey completed by biological mothers. A fitted logistic regression model identified advanced maternal age, prenatal bleeding, pre-eclampsia, perinatal pethidine usage, foetal distress before birth and male sex of child as associated with an increased risk of ASD, whereas longer gestational duration demonstrated a protective effect. These findings highlight potential risk factors and predictor interrelationships which may contribute to overall ASD risk. En ligne : http://dx.doi.org/10.1007/s10803-021-05348-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

Challenging child behaviours positively predict symptoms of posttraumatic stress disorder in parents of children with Autism Spectrum Disorder and Rare Diseases / Michelle STEWART in Research in Autism Spectrum Disorders, 69 (January 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 69 (January 2020) . - p.101467 Titre : Challenging child behaviours positively predict symptoms of posttraumatic stress disorder in parents of children with Autism Spectrum Disorder and Rare Diseases Type de document : Texte imprimé et/ou numérique Auteurs : Michelle STEWART, Auteur ; Alexandra SCHNABEL, Auteur ; David J. HALLFORD, Auteur ; Jane A. MCGILLIVRAY, Auteur ; David FORBES, Auteur ; Madeline FOSTER, Auteur ; Kerrie SHANDLEY, Auteur ; Madeleine GARDAM, Auteur ; David W. AUSTIN, Auteur Article en page(s) : p.101467 Langues : Anglais (eng) Mots-clés : Autism  ASD  Rare diseases  Traumatic stress  Trauma  PTSD Index. décimale : PER Périodiques Résumé : Background This study investigated the validity of conceptualising elevated stress in parents of children who exhibit challenging behaviour within the framework of posttraumatic stress disorder (PTSD). It was hypothesised that parents of children with autism spectrum disorder (ASD), and parents of children with a rare disease would endorse greater PTSD symptomatology than parents of typically developing (TD) children, and that challenging child behaviours would positively predict PTSD symptomatology. Method The Life Events Checklist for DSM-5, Developmental Behaviour Checklist (Parent) and PTSD Checklist for DSM-5 were administered to 395 parents. Results Significantly more PTSD symptomatology was reported by parents of children with ASD and parents of children with a rare disease than parents of TD children, and challenging child behaviours positively predicted PTSD symptomatology in both groups. Conclusion A PTSD framework may validly explain elevated stress among some parents of children with ASD and parents of children with a rare disease, and has important implications for support delivered to parents by healthcare providers. En ligne : https://doi.org/10.1016/j.rasd.2019.101467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] Challenging child behaviours positively predict symptoms of posttraumatic stress disorder in parents of children with Autism Spectrum Disorder and Rare Diseases [Texte imprimé et/ou numérique] / Michelle STEWART, Auteur ; Alexandra SCHNABEL, Auteur ; David J. HALLFORD, Auteur ; Jane A. MCGILLIVRAY, Auteur ; David FORBES, Auteur ; Madeline FOSTER, Auteur ; Kerrie SHANDLEY, Auteur ; Madeleine GARDAM, Auteur ; David W. AUSTIN, Auteur . - p.101467. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 69 (January 2020) . - p.101467 Mots-clés : Autism  ASD  Rare diseases  Traumatic stress  Trauma  PTSD Index. décimale : PER Périodiques Résumé : Background This study investigated the validity of conceptualising elevated stress in parents of children who exhibit challenging behaviour within the framework of posttraumatic stress disorder (PTSD). It was hypothesised that parents of children with autism spectrum disorder (ASD), and parents of children with a rare disease would endorse greater PTSD symptomatology than parents of typically developing (TD) children, and that challenging child behaviours would positively predict PTSD symptomatology. Method The Life Events Checklist for DSM-5, Developmental Behaviour Checklist (Parent) and PTSD Checklist for DSM-5 were administered to 395 parents. Results Significantly more PTSD symptomatology was reported by parents of children with ASD and parents of children with a rare disease than parents of TD children, and challenging child behaviours positively predicted PTSD symptomatology in both groups. Conclusion A PTSD framework may validly explain elevated stress among some parents of children with ASD and parents of children with a rare disease, and has important implications for support delivered to parents by healthcare providers. En ligne : https://doi.org/10.1016/j.rasd.2019.101467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

Molecular Characterisation of Gastrointestinal Microbiota of Children With Autism (With and Without Gastrointestinal Dysfunction) and Their Neurotypical Siblings / Shakuntla V. GONDALIA in Autism Research, 5-6 (December 2012)  

Public ISBD [article]  inAutism Research > 5-6 (December 2012) . - p.419-427 Titre : Molecular Characterisation of Gastrointestinal Microbiota of Children With Autism (With and Without Gastrointestinal Dysfunction) and Their Neurotypical Siblings Type de document : Texte imprimé et/ou numérique Auteurs : Shakuntla V. GONDALIA, Auteur ; Enzo A. PALOMBO, Auteur ; Simon R. KNOWLES, Auteur ; Stephen B. COX, Auteur ; Denny MEYER, Auteur ; David W. AUSTIN, Auteur Article en page(s) : p.419-427 Mots-clés : faecal microbiota  pyrosequencing  autism spectrum disorder  gastrointestinal dysfunction Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 [article] Molecular Characterisation of Gastrointestinal Microbiota of Children With Autism (With and Without Gastrointestinal Dysfunction) and Their Neurotypical Siblings [Texte imprimé et/ou numérique] / Shakuntla V. GONDALIA, Auteur ; Enzo A. PALOMBO, Auteur ; Simon R. KNOWLES, Auteur ; Stephen B. COX, Auteur ; Denny MEYER, Auteur ; David W. AUSTIN, Auteur . - p.419-427. in Autism Research > 5-6 (December 2012) . - p.419-427 Mots-clés : faecal microbiota  pyrosequencing  autism spectrum disorder  gastrointestinal dysfunction Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187

Professional and Parental Attitudes Toward iPad Application Use in Autism Spectrum Disorder / Megan L. E. CLARK in Focus on Autism and Other Developmental Disabilities, 30-3 (September 2015)  

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Psychopathology in parents of children with autism spectrum disorder: A systematic review and meta-analysis of prevalence / A. SCHNABEL in Autism, 24-1 (January 2020)  

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Reconceptualizing Autism: Moving Beyond the Behavioral to Address Cause, Cure and Prevention / Kerrie SHANDLEY in Autism Insights, 2 ([01/01/2010])  

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