Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 / David MASON in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1684-1694 Titre : Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 Type de document : texte imprimé Auteurs : David MASON, Auteur ; Angelica RONALD, Auteur ; Antony AMBLER, Auteur ; Avshalom CASPI, Auteur ; Renate HOUTS, Auteur ; Richie POULTON, Auteur ; Sandhya RAMRAKHA, Auteur ; Jasmin WERTZ, Auteur ; Terrie E. MOFFITT, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.1684-1694 Langues : Anglais (eng) Mots-clés : Adult  Aging  Autism Spectrum Disorder  Autistic Disorder  Humans  Middle Aged  Surveys and Questionnaires  aging  autistic traits  intelligence  physical health  socioeconomic status Index. décimale : PER Périodiques Résumé : Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the "pace of aging" was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45 years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self-reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self-, informant-, and interviewer-rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (β = 0.09), facial age (β = 0.08), self- (β = -0.15), informant (β = -0.12), and interviewer-rated (β = -0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. LAY SUMMARY: The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self-reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 [texte imprimé] / David MASON, Auteur ; Angelica RONALD, Auteur ; Antony AMBLER, Auteur ; Avshalom CASPI, Auteur ; Renate HOUTS, Auteur ; Richie POULTON, Auteur ; Sandhya RAMRAKHA, Auteur ; Jasmin WERTZ, Auteur ; Terrie E. MOFFITT, Auteur ; Francesca HAPPE, Auteur . - p.1684-1694. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1684-1694 Mots-clés : Adult  Aging  Autism Spectrum Disorder  Autistic Disorder  Humans  Middle Aged  Surveys and Questionnaires  aging  autistic traits  intelligence  physical health  socioeconomic status Index. décimale : PER Périodiques Résumé : Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the "pace of aging" was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45 years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self-reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self-, informant-, and interviewer-rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (β = 0.09), facial age (β = 0.08), self- (β = -0.15), informant (β = -0.12), and interviewer-rated (β = -0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. LAY SUMMARY: The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self-reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood / Line Jee Hartmann RASMUSSEN in Journal of Child Psychology and Psychiatry, 60-2 (February 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.199-208 Titre : Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood Type de document : texte imprimé Auteurs : Line Jee Hartmann RASMUSSEN, Auteur ; Terrie E. MOFFITT, Auteur ; Jesper EUGEN-OLSEN, Auteur ; Daniel W. BELSKY, Auteur ; Andrea DANESE, Auteur ; Honalee HARRINGTON, Auteur ; Renate HOUTS, Auteur ; Richie POULTON, Auteur ; Karen SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Avshalom CASPI, Auteur Article en page(s) : p.199-208 Langues : Anglais (eng) Mots-clés : Adverse childhood experiences  inflammation  physical health  risk factors  self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP). METHODS: Prospective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood experiences (ACEs), low IQ, and poor self-control. Main adult outcomes were adulthood inflammation measured as suPAR and high-sensitivity CRP (hsCRP). RESULTS: Participants with available plasma samples at age 38 were included (N = 837, 50.5% male). suPAR (mean 2.40 ng/ml; SD 0.91) was positively correlated with hsCRP (r 0.15, p < .001). After controlling for sex, body mass index (BMI), and smoking, children who experienced more ACEs, lower IQ, or had poorer self-control showed elevated adult suPAR. When the five childhood risks were aggregated into a Cumulative Childhood Risk index, and controlling for sex, BMI, and smoking, Cumulative Childhood Risk was associated with higher suPAR (b 0.10; SE 0.03; p = .002). Cumulative Childhood Risk predicted elevated suPAR, after controlling for hsCRP (b 0.18; SE 0.03; p < .001). CONCLUSIONS: Exposure to more childhood risk factors was associated with higher suPAR levels, independent of CRP. suPAR is a useful addition to studies connecting childhood risk to adult inflammatory burden. En ligne : http://dx.doi.org/10.1111/jcpp.12928 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381 [article] Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood [texte imprimé] / Line Jee Hartmann RASMUSSEN, Auteur ; Terrie E. MOFFITT, Auteur ; Jesper EUGEN-OLSEN, Auteur ; Daniel W. BELSKY, Auteur ; Andrea DANESE, Auteur ; Honalee HARRINGTON, Auteur ; Renate HOUTS, Auteur ; Richie POULTON, Auteur ; Karen SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Avshalom CASPI, Auteur . - p.199-208. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.199-208 Mots-clés : Adverse childhood experiences  inflammation  physical health  risk factors  self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP). METHODS: Prospective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood experiences (ACEs), low IQ, and poor self-control. Main adult outcomes were adulthood inflammation measured as suPAR and high-sensitivity CRP (hsCRP). RESULTS: Participants with available plasma samples at age 38 were included (N = 837, 50.5% male). suPAR (mean 2.40 ng/ml; SD 0.91) was positively correlated with hsCRP (r 0.15, p < .001). After controlling for sex, body mass index (BMI), and smoking, children who experienced more ACEs, lower IQ, or had poorer self-control showed elevated adult suPAR. When the five childhood risks were aggregated into a Cumulative Childhood Risk index, and controlling for sex, BMI, and smoking, Cumulative Childhood Risk was associated with higher suPAR (b 0.10; SE 0.03; p = .002). Cumulative Childhood Risk predicted elevated suPAR, after controlling for hsCRP (b 0.18; SE 0.03; p < .001). CONCLUSIONS: Exposure to more childhood risk factors was associated with higher suPAR levels, independent of CRP. suPAR is a useful addition to studies connecting childhood risk to adult inflammatory burden. En ligne : http://dx.doi.org/10.1111/jcpp.12928 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381

Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children / Daniel W. BELSKY in Development and Psychopathology, 24-1 (January 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-1 (January 2012) . - p.251-265 Titre : Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children Type de document : texte imprimé Auteurs : Daniel W. BELSKY, Auteur ; Avshalom CASPI, Auteur ; Louise ARSENEAULT, Auteur ; Wiebke BLEIDORN, Auteur ; Peter FONAGY, Auteur ; Marianne GOODMAN, Auteur ; Renate HOUTS, Auteur ; Terrie E. MOFFITT, Auteur Année de publication : 2012 Article en page(s) : p.251-265 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : It has been reported that borderline personality related characteristics can be observed in children, and that these characteristics are associated with increased risk for the development of borderline personality disorder. It is not clear whether borderline personality related characteristics in children share etiological features with adult borderline personality disorder. We investigated the etiology of borderline personality related characteristics in a longitudinal cohort study of 1,116 pairs of same-sex twins followed from birth through age 12 years. Borderline personality related characteristics measured at age 12 years were highly heritable, were more common in children who had exhibited poor cognitive function, impulsivity, and more behavioral and emotional problems at age 5 years, and co-occurred with symptoms of conduct disorder, depression, anxiety, and psychosis. Exposure to harsh treatment in the family environment through age 10 years predicted borderline personality related characteristics at age 12 years. This association showed evidence of environmental mediation and was stronger among children with a family history of psychiatric illness, consistent with diathesis–stress models of borderline etiology. Results indicate that borderline personality related characteristics in children share etiological features with borderline personality disorder in adults and suggest that inherited and environmental risk factors make independent and interactive contributions to borderline etiology. En ligne : http://dx.doi.org/10.1017/S0954579411000812 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children [texte imprimé] / Daniel W. BELSKY, Auteur ; Avshalom CASPI, Auteur ; Louise ARSENEAULT, Auteur ; Wiebke BLEIDORN, Auteur ; Peter FONAGY, Auteur ; Marianne GOODMAN, Auteur ; Renate HOUTS, Auteur ; Terrie E. MOFFITT, Auteur . - 2012 . - p.251-265. Langues : Anglais (eng) in Development and Psychopathology > 24-1 (January 2012) . - p.251-265 Index. décimale : PER Périodiques Résumé : It has been reported that borderline personality related characteristics can be observed in children, and that these characteristics are associated with increased risk for the development of borderline personality disorder. It is not clear whether borderline personality related characteristics in children share etiological features with adult borderline personality disorder. We investigated the etiology of borderline personality related characteristics in a longitudinal cohort study of 1,116 pairs of same-sex twins followed from birth through age 12 years. Borderline personality related characteristics measured at age 12 years were highly heritable, were more common in children who had exhibited poor cognitive function, impulsivity, and more behavioral and emotional problems at age 5 years, and co-occurred with symptoms of conduct disorder, depression, anxiety, and psychosis. Exposure to harsh treatment in the family environment through age 10 years predicted borderline personality related characteristics at age 12 years. This association showed evidence of environmental mediation and was stronger among children with a family history of psychiatric illness, consistent with diathesis–stress models of borderline etiology. Results indicate that borderline personality related characteristics in children share etiological features with borderline personality disorder in adults and suggest that inherited and environmental risk factors make independent and interactive contributions to borderline etiology. En ligne : http://dx.doi.org/10.1017/S0954579411000812 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts / Jonathan D. SCHAEFER in Development and Psychopathology, 37-5 (December 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-5 (December 2025) . - p.2251-2265 Titre : Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts Type de document : texte imprimé Auteurs : Jonathan D. SCHAEFER, Auteur ; Matthew A. SCULT, Auteur ; Avshalom CASPI, Auteur ; Louise ARSENEAULT, Auteur ; Daniel W. BELSKY, Auteur ; Ahmad R. HARIRI, Auteur ; Honalee HARRINGTON, Auteur ; Renate HOUTS, Auteur ; Sandhya RAMRAKHA, Auteur ; Richie POULTON, Auteur ; Terrie E. MOFFITT, Auteur Article en page(s) : p.2251-2265 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Cognitive impairment has been identified as an important aspect of major depressive disorder (MDD). We tested two theories regarding the association between MDD and cognitive functioning using data from longitudinal cohort studies. One theory, the cognitive reserve hypothesis, suggests that higher cognitive ability in childhood decreases risk of later MDD. The second, the scarring hypothesis, instead suggests that MDD leads to persistent cognitive deficits following disorder onset. We tested both theories in the Dunedin Study, a population-representative cohort followed from birth to midlife and assessed repeatedly for both cognitive functioning and psychopathology. We also used data from the Environmental Risk Longitudinal Twin Study to test whether childhood cognitive functioning predicts future MDD risk independent of family-wide and genetic risk using a discordant twin design. Contrary to both hypotheses, we found that childhood cognitive functioning did not predict future risk of MDD, nor did study members with a past history of MDD show evidence of greater cognitive decline unless MDD was accompanied by other comorbid psychiatric conditions. Our results thus suggest that low cognitive functioning is related to comorbidity, but is neither an antecedent nor an enduring consequence of MDD. Future research may benefit from considering cognitive deficits that occur during depressive episodes from a transdiagnostic perspective. En ligne : https://dx.doi.org/10.1017/S095457941700164X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts [texte imprimé] / Jonathan D. SCHAEFER, Auteur ; Matthew A. SCULT, Auteur ; Avshalom CASPI, Auteur ; Louise ARSENEAULT, Auteur ; Daniel W. BELSKY, Auteur ; Ahmad R. HARIRI, Auteur ; Honalee HARRINGTON, Auteur ; Renate HOUTS, Auteur ; Sandhya RAMRAKHA, Auteur ; Richie POULTON, Auteur ; Terrie E. MOFFITT, Auteur . - p.2251-2265. Langues : Anglais (eng) in Development and Psychopathology > 37-5 (December 2025) . - p.2251-2265 Index. décimale : PER Périodiques Résumé : Cognitive impairment has been identified as an important aspect of major depressive disorder (MDD). We tested two theories regarding the association between MDD and cognitive functioning using data from longitudinal cohort studies. One theory, the cognitive reserve hypothesis, suggests that higher cognitive ability in childhood decreases risk of later MDD. The second, the scarring hypothesis, instead suggests that MDD leads to persistent cognitive deficits following disorder onset. We tested both theories in the Dunedin Study, a population-representative cohort followed from birth to midlife and assessed repeatedly for both cognitive functioning and psychopathology. We also used data from the Environmental Risk Longitudinal Twin Study to test whether childhood cognitive functioning predicts future MDD risk independent of family-wide and genetic risk using a discordant twin design. Contrary to both hypotheses, we found that childhood cognitive functioning did not predict future risk of MDD, nor did study members with a past history of MDD show evidence of greater cognitive decline unless MDD was accompanied by other comorbid psychiatric conditions. Our results thus suggest that low cognitive functioning is related to comorbidity, but is neither an antecedent nor an enduring consequence of MDD. Future research may benefit from considering cognitive deficits that occur during depressive episodes from a transdiagnostic perspective. En ligne : https://dx.doi.org/10.1017/S095457941700164X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

Maternal depression in the intergenerational transmission of childhood maltreatment and its sequelae: Testing postpartum effects in a longitudinal birth cohort / Karmel W. CHOI in Development and Psychopathology, 31-1 (February 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-1 (February 2019) . - p.143-156 Titre : Maternal depression in the intergenerational transmission of childhood maltreatment and its sequelae: Testing postpartum effects in a longitudinal birth cohort Type de document : texte imprimé Auteurs : Karmel W. CHOI, Auteur ; Renate HOUTS, Auteur ; Louise ARSENEAULT, Auteur ; Carmine M. PARIANTE, Auteur ; Kathleen J. SIKKEMA, Auteur ; Terrie E. MOFFITT, Auteur Article en page(s) : p.143-156 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Mothers who have experienced childhood maltreatment are more likely to have children also exposed to maltreatment, a phenomenon known as intergenerational transmission. Factors in the perinatal period may contribute uniquely to this transmission, but timing effects have not been ascertained. Using structural equation modeling with 1,016 mothers and their 2,032 children in the Environmental Risk Longitudinal Twin Study, we tested the mediating role of postpartum depression between maternal childhood maltreatment and a cascade of negative child outcomes, specifically child exposure to maltreatment, internalizing symptoms, and externalizing symptoms: (a) adjusting for later maternal depression, (b) comparing across sex differences, and (c) examining the relative role of maltreatment subtypes. Mothers who had been maltreated as children, especially those who had experienced emotional or sexual abuse, were at increased risk for postpartum depression. In turn, postpartum depression predicted children’s exposure to maltreatment, followed by emotional and behavioral problems. Indirect effects from maternal childhood maltreatment to child outcomes were robust across child sex and supported significant mediation through postpartum depression; however, this appeared to be carried by mothers’ depression beyond the postpartum period. Identifying and treating postpartum depression, and preventing its recurrence, may help interrupt the intergenerational transmission of maltreatment and its sequelae. En ligne : http://dx.doi.org/10.1017/S0954579418000032 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] Maternal depression in the intergenerational transmission of childhood maltreatment and its sequelae: Testing postpartum effects in a longitudinal birth cohort [texte imprimé] / Karmel W. CHOI, Auteur ; Renate HOUTS, Auteur ; Louise ARSENEAULT, Auteur ; Carmine M. PARIANTE, Auteur ; Kathleen J. SIKKEMA, Auteur ; Terrie E. MOFFITT, Auteur . - p.143-156. Langues : Anglais (eng) in Development and Psychopathology > 31-1 (February 2019) . - p.143-156 Index. décimale : PER Périodiques Résumé : Mothers who have experienced childhood maltreatment are more likely to have children also exposed to maltreatment, a phenomenon known as intergenerational transmission. Factors in the perinatal period may contribute uniquely to this transmission, but timing effects have not been ascertained. Using structural equation modeling with 1,016 mothers and their 2,032 children in the Environmental Risk Longitudinal Twin Study, we tested the mediating role of postpartum depression between maternal childhood maltreatment and a cascade of negative child outcomes, specifically child exposure to maltreatment, internalizing symptoms, and externalizing symptoms: (a) adjusting for later maternal depression, (b) comparing across sex differences, and (c) examining the relative role of maltreatment subtypes. Mothers who had been maltreated as children, especially those who had experienced emotional or sexual abuse, were at increased risk for postpartum depression. In turn, postpartum depression predicted children’s exposure to maltreatment, followed by emotional and behavioral problems. Indirect effects from maternal childhood maltreatment to child outcomes were robust across child sex and supported significant mediation through postpartum depression; however, this appeared to be carried by mothers’ depression beyond the postpartum period. Identifying and treating postpartum depression, and preventing its recurrence, may help interrupt the intergenerational transmission of maltreatment and its sequelae. En ligne : http://dx.doi.org/10.1017/S0954579418000032 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

A polygenic score for age-at-first-birth predicts disinhibition / Leah S. RICHMOND-RAKERD in Journal of Child Psychology and Psychiatry, 61-12 (December 2020)  

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Prospective developmental subtypes of alcohol dependence from age 18 to 32 years: Implications for nosology, etiology, and intervention / Madeline H. MEIER in Development and Psychopathology, 25-3 (August 2013)  

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The high societal costs of childhood conduct problems: evidence from administrative records up to age 38 in a longitudinal birth cohort / Joshua G. RIVENBARK in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)  

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