Adaptive trajectories and early risk factors in the autism spectrum: A 15-year prospective study / Amaria BAGHDADLI in Autism Research, 11-11 (November 2018)  

Public ISBD [article]  inAutism Research > 11-11 (November 2018) . - p.1455-1467 Titre : Adaptive trajectories and early risk factors in the autism spectrum: A 15-year prospective study Type de document : texte imprimé Auteurs : Amaria BAGHDADLI, Auteur ; Cécile MICHELON, Auteur ; Eric PERNON, Auteur ; Marie-Christine PICOT, Auteur ; Stéphanie MIOT, Auteur ; Sandrine SONIE, Auteur ; Cécile RATTAZ, Auteur ; Laurent MOTTRON, Auteur Article en page(s) : p.1455-1467 Langues : Anglais (eng) Mots-clés : adaptative level  autism spectrum  developmental trajectories  early adulthood Index. décimale : PER Périodiques Résumé : Little is known about long-term outcomes. We investigate the adaptive trajectories and their risk factors in ASD. Data were obtained from 281 children prospectively followed untill adulthood. The final sample consisted of 106 individuals. Vineland scores were collected at baseline (T1), 3 (T2), 10 (T3), and 15 (T4) years later. A group-based method was used to identify homogeneous patterns of adaptive skills trajectories. Results show that among the children initially categorized as autistic, 82.6% remained over the ADOS diagnostic threshold, 11.9% converted to atypical autism, and 5.4% fell under the ADOS threshold. Most atypical autism diagnoses were unstable. Most (81.7%) autistic participants had an ID at inclusion. At T1, 59.3% were nonverbal, but only 39% at T4. Most changes occurred between 4 and 8 years of age. Approximately 25% of participants exhibited a "high" growth trajectory, in which progress continues throughout adolescence, and 75% a "low" growth trajectory, characterized by greater autistic symptoms, intellectual disability, and lower language abilities reflected by high CARS scores, low apparent DQ, and speech difficulties, which mostly, but not always, predicted low trajectories. Our findings suggest that the adaptive prognosis of autism is mostly poor in this cohort, biased toward intellectual disability. However, changes in diagnostic, speech, and adaptive status are not uncommon, even for indivduals with low measured intelligence or apparent intellectual disability, and are sometimes difficult to predict. Autism Research 2018, 11: 1455-1467. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Most autism diagnoses given before 5 years of age are stable to adulthood, but one-fifth of individuals are no longer considered to be autistic, even in a cohort biased toward apparent intellectual disability. Conversely, atypical autism diagnoses are mostly unstable. One-third of children who are nonverbal at 5 years are verbal within 15 years, mostly before 8 years of age. Concerning adaptive behavior outcomes, only one-fourth of children exhibit a high-growth trajectory through at least 15 years. En ligne : http://dx.doi.org/10.1002/aur.2022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Adaptive trajectories and early risk factors in the autism spectrum: A 15-year prospective study [texte imprimé] / Amaria BAGHDADLI, Auteur ; Cécile MICHELON, Auteur ; Eric PERNON, Auteur ; Marie-Christine PICOT, Auteur ; Stéphanie MIOT, Auteur ; Sandrine SONIE, Auteur ; Cécile RATTAZ, Auteur ; Laurent MOTTRON, Auteur . - p.1455-1467. Langues : Anglais (eng) in Autism Research > 11-11 (November 2018) . - p.1455-1467 Mots-clés : adaptative level  autism spectrum  developmental trajectories  early adulthood Index. décimale : PER Périodiques Résumé : Little is known about long-term outcomes. We investigate the adaptive trajectories and their risk factors in ASD. Data were obtained from 281 children prospectively followed untill adulthood. The final sample consisted of 106 individuals. Vineland scores were collected at baseline (T1), 3 (T2), 10 (T3), and 15 (T4) years later. A group-based method was used to identify homogeneous patterns of adaptive skills trajectories. Results show that among the children initially categorized as autistic, 82.6% remained over the ADOS diagnostic threshold, 11.9% converted to atypical autism, and 5.4% fell under the ADOS threshold. Most atypical autism diagnoses were unstable. Most (81.7%) autistic participants had an ID at inclusion. At T1, 59.3% were nonverbal, but only 39% at T4. Most changes occurred between 4 and 8 years of age. Approximately 25% of participants exhibited a "high" growth trajectory, in which progress continues throughout adolescence, and 75% a "low" growth trajectory, characterized by greater autistic symptoms, intellectual disability, and lower language abilities reflected by high CARS scores, low apparent DQ, and speech difficulties, which mostly, but not always, predicted low trajectories. Our findings suggest that the adaptive prognosis of autism is mostly poor in this cohort, biased toward intellectual disability. However, changes in diagnostic, speech, and adaptive status are not uncommon, even for indivduals with low measured intelligence or apparent intellectual disability, and are sometimes difficult to predict. Autism Research 2018, 11: 1455-1467. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Most autism diagnoses given before 5 years of age are stable to adulthood, but one-fifth of individuals are no longer considered to be autistic, even in a cohort biased toward apparent intellectual disability. Conversely, atypical autism diagnoses are mostly unstable. One-third of children who are nonverbal at 5 years are verbal within 15 years, mostly before 8 years of age. Concerning adaptive behavior outcomes, only one-fourth of children exhibit a high-growth trajectory through at least 15 years. En ligne : http://dx.doi.org/10.1002/aur.2022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

A Call to Action to Implement Effective COVID-19 Prevention and Screening of Individuals with Severe Intellectual Developmental and Autism Spectrum Disorders / Amaria BAGHDADLI in Journal of Autism and Developmental Disorders, 51-7 (July 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2566-2568 Titre : A Call to Action to Implement Effective COVID-19 Prevention and Screening of Individuals with Severe Intellectual Developmental and Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Amaria BAGHDADLI, Auteur ; Marie-Christine PICOT, Auteur ; Stéphanie MIOT, Auteur ; Kerim M. MUNIR, Auteur Article en page(s) : p.2566-2568 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-020-04719-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] A Call to Action to Implement Effective COVID-19 Prevention and Screening of Individuals with Severe Intellectual Developmental and Autism Spectrum Disorders [texte imprimé] / Amaria BAGHDADLI, Auteur ; Marie-Christine PICOT, Auteur ; Stéphanie MIOT, Auteur ; Kerim M. MUNIR, Auteur . - p.2566-2568. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2566-2568 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-020-04719-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Determinants of Inclusion in Mainstream School for Children with Autism Spectrum Disorders from the EpiTED Study: A 10-Year Follow-up Cohort / Charlotte LAFONT in Journal of Autism and Developmental Disorders, 53-1 (January 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-1 (January 2023) . - p.121-131 Titre : Determinants of Inclusion in Mainstream School for Children with Autism Spectrum Disorders from the EpiTED Study: A 10-Year Follow-up Cohort Type de document : texte imprimé Auteurs : Charlotte LAFONT, Auteur ; Henri PANJO, Auteur ; Cécile MICHELON, Auteur ; Bruno FALISSARD, Auteur ; Mario SPERANZA, Auteur ; Marie-Christine PICOT, Auteur ; Amaria BAGHDADLI, Auteur ; Alexandra ROUQUETTE, Auteur Article en page(s) : p.121-131 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Inclusion of students with Autism Spectrum Disorder (ASD) in mainstream schools has a positive impact on their social and daily living behaviors. Our objective was to identify clinical and socio-demographic variables promoting or limiting inclusion in mainstream school through childhood and adolescence. The EpiTED study is a long-term, prospective, multicenter cohort of 281 ASD children included before the age of 7, with a 10-year follow-up in France. Variables significantly linked to inclusion in mainstream school were identified using a mixed-effect logistic regression model: greater autonomy [OR=1.45 (1.29 “1.63)], lesser symptom severity [OR=0.96 (0.92 “0.99)] and fewer siblings [OR=0.86 (0.75 “0.99)]. In the multivariate model, the probability for a child of being included in mainstream school decreased over time [OR=0.91 (0.85 “0.97)], i.e. with age. En ligne : https://doi.org/10.1007/s10803-021-05404-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Determinants of Inclusion in Mainstream School for Children with Autism Spectrum Disorders from the EpiTED Study: A 10-Year Follow-up Cohort [texte imprimé] / Charlotte LAFONT, Auteur ; Henri PANJO, Auteur ; Cécile MICHELON, Auteur ; Bruno FALISSARD, Auteur ; Mario SPERANZA, Auteur ; Marie-Christine PICOT, Auteur ; Amaria BAGHDADLI, Auteur ; Alexandra ROUQUETTE, Auteur . - p.121-131. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-1 (January 2023) . - p.121-131 Index. décimale : PER Périodiques Résumé : Inclusion of students with Autism Spectrum Disorder (ASD) in mainstream schools has a positive impact on their social and daily living behaviors. Our objective was to identify clinical and socio-demographic variables promoting or limiting inclusion in mainstream school through childhood and adolescence. The EpiTED study is a long-term, prospective, multicenter cohort of 281 ASD children included before the age of 7, with a 10-year follow-up in France. Variables significantly linked to inclusion in mainstream school were identified using a mixed-effect logistic regression model: greater autonomy [OR=1.45 (1.29 “1.63)], lesser symptom severity [OR=0.96 (0.92 “0.99)] and fewer siblings [OR=0.86 (0.75 “0.99)]. In the multivariate model, the probability for a child of being included in mainstream school decreased over time [OR=0.91 (0.85 “0.97)], i.e. with age. En ligne : https://doi.org/10.1007/s10803-021-05404-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Developmental Trajectories of Adaptive Behaviors from Early Childhood to Adolescence in a Cohort of 152 Children with Autism Spectrum Disorders / Amaria BAGHDADLI in Journal of Autism and Developmental Disorders, 42-7 (July 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1314-1325 Titre : Developmental Trajectories of Adaptive Behaviors from Early Childhood to Adolescence in a Cohort of 152 Children with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Amaria BAGHDADLI, Auteur ; Brigitte ASSOULINE, Auteur ; Sandrine SONIE, Auteur ; Eric PERNON, Auteur ; Céline DARROU, Auteur ; Cécile MICHELON, Auteur ; Marie-Christine PICOT, Auteur ; Charles AUSSILLOUX, Auteur ; René PRY, Auteur Année de publication : 2012 Article en page(s) : p.1314-1325 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Developmental trajectory  Adaptive behaviors  Cohort Index. décimale : PER Périodiques Résumé : This study examines change in 152 children over an almost 10-year period (T1: 4.9 (±1.3) years; T2: 8.1 (±1.3) years; T3: 15(±1.6) years) using a group-based, semi-parametric method in order to identify distinct developmental trajectories. Important deficits remain at adolescence in the adaptive abilities of children with Autism spectrum disorders, but changes in adaptive skills show two distinct growth rates. The univariate analysis reveals that low growth trajectories for both social and communication outcome are associated with the following characteristics at age 5: low cognitive and language skills, presence of epilepsy, and severity of autism. The multivariate analysis confirms that risk factors at age 5, were low language and severity of autism for both social and communication outcomes 10 years later, and that hours of early intervention was protective factor for communication. En ligne : http://dx.doi.org/10.1007/s10803-011-1357-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] Developmental Trajectories of Adaptive Behaviors from Early Childhood to Adolescence in a Cohort of 152 Children with Autism Spectrum Disorders [texte imprimé] / Amaria BAGHDADLI, Auteur ; Brigitte ASSOULINE, Auteur ; Sandrine SONIE, Auteur ; Eric PERNON, Auteur ; Céline DARROU, Auteur ; Cécile MICHELON, Auteur ; Marie-Christine PICOT, Auteur ; Charles AUSSILLOUX, Auteur ; René PRY, Auteur . - 2012 . - p.1314-1325. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1314-1325 Mots-clés : Autism spectrum disorders  Developmental trajectory  Adaptive behaviors  Cohort Index. décimale : PER Périodiques Résumé : This study examines change in 152 children over an almost 10-year period (T1: 4.9 (±1.3) years; T2: 8.1 (±1.3) years; T3: 15(±1.6) years) using a group-based, semi-parametric method in order to identify distinct developmental trajectories. Important deficits remain at adolescence in the adaptive abilities of children with Autism spectrum disorders, but changes in adaptive skills show two distinct growth rates. The univariate analysis reveals that low growth trajectories for both social and communication outcome are associated with the following characteristics at age 5: low cognitive and language skills, presence of epilepsy, and severity of autism. The multivariate analysis confirms that risk factors at age 5, were low language and severity of autism for both social and communication outcomes 10 years later, and that hours of early intervention was protective factor for communication. En ligne : http://dx.doi.org/10.1007/s10803-011-1357-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166

Factors associated with age of diagnosis in children with autism spectrum disorders: Report from a French cohort / Cécile RATTAZ in Autism, 26-8 (November 2022)  

Public ISBD [article]  inAutism > 26-8 (November 2022) . - p.2108-2116 Titre : Factors associated with age of diagnosis in children with autism spectrum disorders: Report from a French cohort Type de document : texte imprimé Auteurs : Cécile RATTAZ, Auteur ; Julie LOUBERSAC, Auteur ; Cécile MICHELON, Auteur ; Marie-Maude GEOFFRAY, Auteur ; Marie-Christine PICOT, Auteur ; Kerim M. MUNIR, Auteur ; Amaria BAGHDADLI, Auteur Article en page(s) : p.2108-2116 Langues : Anglais (eng) Mots-clés : Child  Adolescent  Humans  Child, Preschool  Autism Spectrum Disorder/diagnosis/epidemiology/complications  Cohort Studies  Intellectual Disability/complications  Early Diagnosis  Social Class  ELENA cohort  age of diagnosis  autism spectrum disorder  children Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is an early onset neurodevelopmental disorder and diagnosis can be made as early as 18 months of age. Early diagnosis of autism spectrum disorder is critical as it leads to early intervention. Age of autism spectrum disorder diagnosis has been linked to the child profile as autism spectrum disorder is characterized by strong heterogeneity, but is also influenced by socio-economic factors. There is paucity of data on age of diagnosis of autism spectrum disorder in France. We therefore examined the age of autism spectrum disorder diagnosis in 554 children and adolescents enrolled in the ELENA cohort study with respect to the influences of child profile, family antecedents, and socio-economic factors. The mean age of diagnosis was 4.9 years (Â+2.8 years). Early diagnosis, before 3 years of age, was related to the co-occurrence of intellectual disability, higher autism spectrum disorder symptom severity, and lower communicative abilities. Children in low socio-economic status families tended to have an earlier diagnosis, but these children also had greater degree of intellectual impairment compared to children in high socio-economic status families. The age of autism spectrum disorder diagnosis was not associated with the presence of an older sibling with autism spectrum disorder. The observed current trend of an inverse relationship between socio-economic status and age of diagnosis of autism spectrum disorder suggests equitable access to autism spectrum disorder services in France where health coverage is universal and free. Better screening of more subtle/less severe forms of autism spectrum disorder is needed, as well as further assessment of the link between the co-occurrence of autism spectrum disorder and intellectual impairment in children in lower socio-economic status families. En ligne : http://dx.doi.org/10.1177/13623613221077724 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Factors associated with age of diagnosis in children with autism spectrum disorders: Report from a French cohort [texte imprimé] / Cécile RATTAZ, Auteur ; Julie LOUBERSAC, Auteur ; Cécile MICHELON, Auteur ; Marie-Maude GEOFFRAY, Auteur ; Marie-Christine PICOT, Auteur ; Kerim M. MUNIR, Auteur ; Amaria BAGHDADLI, Auteur . - p.2108-2116. Langues : Anglais (eng) in Autism > 26-8 (November 2022) . - p.2108-2116 Mots-clés : Child  Adolescent  Humans  Child, Preschool  Autism Spectrum Disorder/diagnosis/epidemiology/complications  Cohort Studies  Intellectual Disability/complications  Early Diagnosis  Social Class  ELENA cohort  age of diagnosis  autism spectrum disorder  children Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is an early onset neurodevelopmental disorder and diagnosis can be made as early as 18 months of age. Early diagnosis of autism spectrum disorder is critical as it leads to early intervention. Age of autism spectrum disorder diagnosis has been linked to the child profile as autism spectrum disorder is characterized by strong heterogeneity, but is also influenced by socio-economic factors. There is paucity of data on age of diagnosis of autism spectrum disorder in France. We therefore examined the age of autism spectrum disorder diagnosis in 554 children and adolescents enrolled in the ELENA cohort study with respect to the influences of child profile, family antecedents, and socio-economic factors. The mean age of diagnosis was 4.9 years (Â+2.8 years). Early diagnosis, before 3 years of age, was related to the co-occurrence of intellectual disability, higher autism spectrum disorder symptom severity, and lower communicative abilities. Children in low socio-economic status families tended to have an earlier diagnosis, but these children also had greater degree of intellectual impairment compared to children in high socio-economic status families. The age of autism spectrum disorder diagnosis was not associated with the presence of an older sibling with autism spectrum disorder. The observed current trend of an inverse relationship between socio-economic status and age of diagnosis of autism spectrum disorder suggests equitable access to autism spectrum disorder services in France where health coverage is universal and free. Better screening of more subtle/less severe forms of autism spectrum disorder is needed, as well as further assessment of the link between the co-occurrence of autism spectrum disorder and intellectual impairment in children in lower socio-economic status families. En ligne : http://dx.doi.org/10.1177/13623613221077724 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Longitudinal change in symptom severity in children with ASD: Results from the ELENA cohort / Florine DELLAPIAZZA in Autism Research, 17-11 (November 2024)  

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Multimorbidity patterns and subgroups among autistic adults with intellectual disability: Results from the EFAAR study / Stéphanie MIOT in Autism, 27-3 (April 2023)  

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School Inclusion in Children and Adolescents with Autism Spectrum Disorders in France: Report from the ELENA French Cohort Study / Cécile RATTAZ in Journal of Autism and Developmental Disorders, 50-2 (February 2020)  

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SRS-2 : Echelle de réciprocité sociale / John N. CONSTANTINO

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The French Version of the Revised Ritvo Autism and Asperger Diagnostic Scale: A Psychometric Validation and Diagnostic Accuracy Study / Marie-Christine PICOT in Journal of Autism and Developmental Disorders, 51-1 (January 2021)  

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The Impact of Atypical Sensory Processing on Adaptive Functioning and Maladaptive Behaviors in Autism Spectrum Disorder During Childhood: Results From the ELENA Cohort / Florine DELLAPIAZZA in Journal of Autism and Developmental Disorders, 50-6 (June 2020)  

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WISC-V Profiles and Their Correlates in Children with Autism Spectrum Disorder without Intellectual Developmental Disorder: Report from the ELENA Cohort / Lee AUDRAS-TORRENT in Autism Research, 14-5 (May 2021)  

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