Assessment and Treatment in Autism Spectrum Disorders: A Focus on Genetics and Psychiatry / Merlin G. BUTLER in Autism Research and Treatment, (March 2012)  

Public ISBD [article]  inAutism Research and Treatment > (March 2012) . - 11 p. Titre : Assessment and Treatment in Autism Spectrum Disorders: A Focus on Genetics and Psychiatry Type de document : Texte imprimé et/ou numérique Auteurs : Merlin G. BUTLER, Auteur ; Erin L. YOUNGS, Auteur ; Jennifer L. ROBERTS, Auteur ; Jessica A. HELLINGS, Auteur Année de publication : 2012 Article en page(s) : 11 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are neurobehavioral disorders characterized by abnormalities in three behavioral domains including social interaction, impaired communication, and repetitive stereotypic behaviors. ASD affects approximately 1% of children and is on the rise with significant genetic mechanisms underlying these disorders. We review the current understanding of the role of genetic and metabolic factors contributing to ASD with the use of new genetic technology. Fifty percent is diagnosed with chromosomal abnormalities, small DNA deletions/duplications, single-gene conditions, or metabolic disturbances. Genetic evaluation is discussed along with psychiatric treatment and approaches for selection of medication to treat associated challenging behaviors or comorbidities seen in ASD. We emphasize the importance of prioritizing treatment based on target symptom clusters and in what order for individuals with ASD, as the treatment may vary from patient to patient. En ligne : http://dx.doi.org/10.1155/2012/242537 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Assessment and Treatment in Autism Spectrum Disorders: A Focus on Genetics and Psychiatry [Texte imprimé et/ou numérique] / Merlin G. BUTLER, Auteur ; Erin L. YOUNGS, Auteur ; Jennifer L. ROBERTS, Auteur ; Jessica A. HELLINGS, Auteur . - 2012 . - 11 p. Langues : Anglais (eng) in Autism Research and Treatment > (March 2012) . - 11 p. Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are neurobehavioral disorders characterized by abnormalities in three behavioral domains including social interaction, impaired communication, and repetitive stereotypic behaviors. ASD affects approximately 1% of children and is on the rise with significant genetic mechanisms underlying these disorders. We review the current understanding of the role of genetic and metabolic factors contributing to ASD with the use of new genetic technology. Fifty percent is diagnosed with chromosomal abnormalities, small DNA deletions/duplications, single-gene conditions, or metabolic disturbances. Genetic evaluation is discussed along with psychiatric treatment and approaches for selection of medication to treat associated challenging behaviors or comorbidities seen in ASD. We emphasize the importance of prioritizing treatment based on target symptom clusters and in what order for individuals with ASD, as the treatment may vary from patient to patient. En ligne : http://dx.doi.org/10.1155/2012/242537 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

Loxapine for Reversal of Antipsychotic-Induced Metabolic Disturbances: A Chart Review / Seema JAIN in Journal of Autism and Developmental Disorders, 46-4 (April 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1344-1353 Titre : Loxapine for Reversal of Antipsychotic-Induced Metabolic Disturbances: A Chart Review Type de document : Texte imprimé et/ou numérique Auteurs : Seema JAIN, Auteur ; Rebecca R. ANDRIDGE, Auteur ; Jessica A. HELLINGS, Auteur Article en page(s) : p.1344-1353 Langues : Anglais (eng) Mots-clés : Loxapine  Metabolic side effects  Autism spectrum disorder  Atypical antipsychotics Index. décimale : PER Périodiques Résumé : Loxapine substitution is a promising option for patients with autism spectrum disorder (ASD) who develop antipsychotic-induced metabolic illness. We performed a chart review of 15 adolescents and adults meeting DSM-IV-TR criteria for ASD, all with antipsychotic-associated weight gain, who received low dose loxapine in an attempt to taper or discontinue the weight gain-associated antipsychotic. Mean weight loss was ?5.7 kg, mean BMI reduction was ?1.9, and mean triglyceride reduction was ?33.7 mg/dl. At chart review, 14 of 15 subjects were rated 2 (Much Improved) or 1 (Very Much Improved) on the Clinical Global Impressions-Improvement scale (CGI-I). Low dose loxapine addition in most cases enabled taper of offending antipsychotics, significantly reversed drug-induced metabolic disturbances and improved irritability. En ligne : http://dx.doi.org/10.1007/s10803-015-2675-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284 [article] Loxapine for Reversal of Antipsychotic-Induced Metabolic Disturbances: A Chart Review [Texte imprimé et/ou numérique] / Seema JAIN, Auteur ; Rebecca R. ANDRIDGE, Auteur ; Jessica A. HELLINGS, Auteur . - p.1344-1353. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1344-1353 Mots-clés : Loxapine  Metabolic side effects  Autism spectrum disorder  Atypical antipsychotics Index. décimale : PER Périodiques Résumé : Loxapine substitution is a promising option for patients with autism spectrum disorder (ASD) who develop antipsychotic-induced metabolic illness. We performed a chart review of 15 adolescents and adults meeting DSM-IV-TR criteria for ASD, all with antipsychotic-associated weight gain, who received low dose loxapine in an attempt to taper or discontinue the weight gain-associated antipsychotic. Mean weight loss was ?5.7 kg, mean BMI reduction was ?1.9, and mean triglyceride reduction was ?33.7 mg/dl. At chart review, 14 of 15 subjects were rated 2 (Much Improved) or 1 (Very Much Improved) on the Clinical Global Impressions-Improvement scale (CGI-I). Low dose loxapine addition in most cases enabled taper of offending antipsychotics, significantly reversed drug-induced metabolic disturbances and improved irritability. En ligne : http://dx.doi.org/10.1007/s10803-015-2675-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284

A Retrospective Study of Amitriptyline in Youth with Autism Spectrum Disorders / Irfan BHATTI in Journal of Autism and Developmental Disorders, 43-5 (May 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-5 (May 2013) . - p.1017-1027 Titre : A Retrospective Study of Amitriptyline in Youth with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Irfan BHATTI, Auteur ; Andrew THOME, Auteur ; Patricia OXLER SMITH, Auteur ; Galen COOK-WIENS, Auteur ; Hung Wen YEH, Auteur ; Gary R. GAFFNEY, Auteur ; Jessica A. HELLINGS, Auteur Article en page(s) : p.1017-1027 Langues : Anglais (eng) Mots-clés : Amitriptyline  Autism Spectrum Disorders  Hyperactivity  Impulsivity Index. décimale : PER Périodiques Résumé : We performed a retrospective chart review of 50 youths with Autism Spectrum Disorder (ASD), prescribed amitriptyline (AMI) for hyperactivity and impulsivity. Data was systematically extracted from 50 outpatient clinic charts, including AMI treatment duration, dose, trough levels and adverse events. Mean age was 9.4 years (4.6–17.9); 40 were males and 10 females. 30 % had failed atomoxetine and 40 % had failed ?3 ADHD medications. Mean dose was 1.3 ± 0.6 mg/kg/day, mean trough level 114.1 ± 50.5 ng/ml, mean duration 3.4 years. Clinical Global Impressions Scale-Improvement (CGI-I) was ?2 in 60 % of patients at the final visit, and in 82 % of patients for at least 50 % of follow-ups. Cautious use of low dose AMI shows promise for treatment-resistant youth with ASD accompanied by hyperactivity, impulsivity, aggression and self injury. En ligne : http://dx.doi.org/10.1007/s10803-012-1647-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=195 [article] A Retrospective Study of Amitriptyline in Youth with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Irfan BHATTI, Auteur ; Andrew THOME, Auteur ; Patricia OXLER SMITH, Auteur ; Galen COOK-WIENS, Auteur ; Hung Wen YEH, Auteur ; Gary R. GAFFNEY, Auteur ; Jessica A. HELLINGS, Auteur . - p.1017-1027. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-5 (May 2013) . - p.1017-1027 Mots-clés : Amitriptyline  Autism Spectrum Disorders  Hyperactivity  Impulsivity Index. décimale : PER Périodiques Résumé : We performed a retrospective chart review of 50 youths with Autism Spectrum Disorder (ASD), prescribed amitriptyline (AMI) for hyperactivity and impulsivity. Data was systematically extracted from 50 outpatient clinic charts, including AMI treatment duration, dose, trough levels and adverse events. Mean age was 9.4 years (4.6–17.9); 40 were males and 10 females. 30 % had failed atomoxetine and 40 % had failed ?3 ADHD medications. Mean dose was 1.3 ± 0.6 mg/kg/day, mean trough level 114.1 ± 50.5 ng/ml, mean duration 3.4 years. Clinical Global Impressions Scale-Improvement (CGI-I) was ?2 in 60 % of patients at the final visit, and in 82 % of patients for at least 50 % of follow-ups. Cautious use of low dose AMI shows promise for treatment-resistant youth with ASD accompanied by hyperactivity, impulsivity, aggression and self injury. En ligne : http://dx.doi.org/10.1007/s10803-012-1647-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=195

Training of child and adolescent psychiatry fellows in autism and intellectual disability / Natasha MARRUS in Autism, 18-4 (May 2014)  

Public ISBD [article]  inAutism > 18-4 (May 2014) . - p.471-475 Titre : Training of child and adolescent psychiatry fellows in autism and intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : Natasha MARRUS, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Jessica A. HELLINGS, Auteur ; Kimberly A. STIGLER, Auteur ; Ludwik SZYMANSKI, Auteur ; Bryan H. KING, Auteur ; L. Lee CARLISLE, Auteur ; Edwin H. Jr COOK, Auteur ; THE AMERICAN ACADEMY OF CHILD ADOLESCENT PSYCHIATRY AUTISM,, Auteur ; INTELLECTUAL DISABILITY COMMITTEE,, Auteur ; John R. PRUETT, Auteur Article en page(s) : p.471-475 Langues : Anglais (eng) Mots-clés : autism  intellectual disability  education  fellowship training Index. décimale : PER Périodiques Résumé : Patients with autism spectrum disorders and intellectual disability can be clinically complex and often have limited access to psychiatric care. Because little is known about post-graduate clinical education in autism spectrum disorder and intellectual disability, we surveyed training directors of child and adolescent psychiatry fellowship programs. On average, child and adolescent psychiatry directors reported lectures of 3 and 4 h per year in autism spectrum disorder and intellectual disability, respectively. Training directors commonly reported that trainees see 1–5 patients with autism spectrum disorder or intellectual disability per year for outpatient pharmacological management and inpatient treatment. Overall, 43% of directors endorsed the need for additional resources for training in autism spectrum disorder and intellectual disability, which, coupled with low didactic and clinical exposure, suggests that current training is inadequate. En ligne : http://dx.doi.org/10.1177/1362361313477247 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232 [article] Training of child and adolescent psychiatry fellows in autism and intellectual disability [Texte imprimé et/ou numérique] / Natasha MARRUS, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Jessica A. HELLINGS, Auteur ; Kimberly A. STIGLER, Auteur ; Ludwik SZYMANSKI, Auteur ; Bryan H. KING, Auteur ; L. Lee CARLISLE, Auteur ; Edwin H. Jr COOK, Auteur ; THE AMERICAN ACADEMY OF CHILD ADOLESCENT PSYCHIATRY AUTISM,, Auteur ; INTELLECTUAL DISABILITY COMMITTEE,, Auteur ; John R. PRUETT, Auteur . - p.471-475. Langues : Anglais (eng) in Autism > 18-4 (May 2014) . - p.471-475 Mots-clés : autism  intellectual disability  education  fellowship training Index. décimale : PER Périodiques Résumé : Patients with autism spectrum disorders and intellectual disability can be clinically complex and often have limited access to psychiatric care. Because little is known about post-graduate clinical education in autism spectrum disorder and intellectual disability, we surveyed training directors of child and adolescent psychiatry fellowship programs. On average, child and adolescent psychiatry directors reported lectures of 3 and 4 h per year in autism spectrum disorder and intellectual disability, respectively. Training directors commonly reported that trainees see 1–5 patients with autism spectrum disorder or intellectual disability per year for outpatient pharmacological management and inpatient treatment. Overall, 43% of directors endorsed the need for additional resources for training in autism spectrum disorder and intellectual disability, which, coupled with low didactic and clinical exposure, suggests that current training is inadequate. En ligne : http://dx.doi.org/10.1177/1362361313477247 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232

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