Altered neural response to rejection-related words in children exposed to maltreatment / Vanessa B. PUETZ in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1165-1173 Titre : Altered neural response to rejection-related words in children exposed to maltreatment Type de document : Texte imprimé et/ou numérique Auteurs : Vanessa B. PUETZ, Auteur ; Essi VIDING, Auteur ; Amy L. PALMER, Auteur ; Philip A. KELLY, Auteur ; Rachael LICKLEY, Auteur ; Iakovina KOUTOUFA, Auteur ; Catherine L. SEBASTIAN, Auteur ; Eamon J. MCCRORY, Auteur Article en page(s) : p.1165-1173 Langues : Anglais (eng) Mots-clés : Child abuse  emotion regulation  fMRI  posttraumatic stress disorder  adolescence Index. décimale : PER Périodiques Résumé : Background Children exposed to maltreatment show neural sensitivity to facial cues signalling threat. However, little is known about how maltreatment influences the processing of social threat cues more broadly, and whether atypical processing of social threat cues relates to psychiatric risk. Methods Forty-one 10- to 14-year-old children underwent a social rejection-themed emotional Stroop task during functional magnetic resonance imaging: 21 children with a documented history of maltreatment (11 F) and 19 comparison children with no maltreatment history (11 F). Groups were matched on age, pubertal status, gender, IQ, socioeconomic status, ethnicity and reading ability. Classic colour Stroop stimuli were also administered in the same paradigm to investigate potential differences in general cognitive control. Results Compared with their peers, children who had experienced maltreatment showed reduced activation in the Rejection versus Neutral condition, across circuitry previously implicated in abuse-related posttraumatic stress disorder (PTSD), including the left anterior insula, extending into left ventrolateral prefrontal cortex/orbitofrontal cortex; left amygdala; left inferior parietal cortex (STS); and bilateral visual association cortex, encompassing the cuneus and lingual gyrus. No group differences in neural or behavioural responses were found for the classic colour Stroop conditions. Significant negative associations between activity in bilateral cuneus and STS during the rejection-themed Stroop and higher self-reported PTSD symptomatology, including dissociation, were observed in children exposed to maltreatment. Conclusion Our findings indicate a pattern of altered neural response to social rejection cues in maltreated children. Compared to their peers, these children displayed relative hypoactivation to rejection cues in regions previously associated with PTSD, potentially reflecting an avoidant coping response. It is suggested that such atypical processing of social threat may index latent vulnerability to future psychopathology in general and PTSD in particular. En ligne : http://dx.doi.org/10.1111/jcpp.12595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Altered neural response to rejection-related words in children exposed to maltreatment [Texte imprimé et/ou numérique] / Vanessa B. PUETZ, Auteur ; Essi VIDING, Auteur ; Amy L. PALMER, Auteur ; Philip A. KELLY, Auteur ; Rachael LICKLEY, Auteur ; Iakovina KOUTOUFA, Auteur ; Catherine L. SEBASTIAN, Auteur ; Eamon J. MCCRORY, Auteur . - p.1165-1173. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1165-1173 Mots-clés : Child abuse  emotion regulation  fMRI  posttraumatic stress disorder  adolescence Index. décimale : PER Périodiques Résumé : Background Children exposed to maltreatment show neural sensitivity to facial cues signalling threat. However, little is known about how maltreatment influences the processing of social threat cues more broadly, and whether atypical processing of social threat cues relates to psychiatric risk. Methods Forty-one 10- to 14-year-old children underwent a social rejection-themed emotional Stroop task during functional magnetic resonance imaging: 21 children with a documented history of maltreatment (11 F) and 19 comparison children with no maltreatment history (11 F). Groups were matched on age, pubertal status, gender, IQ, socioeconomic status, ethnicity and reading ability. Classic colour Stroop stimuli were also administered in the same paradigm to investigate potential differences in general cognitive control. Results Compared with their peers, children who had experienced maltreatment showed reduced activation in the Rejection versus Neutral condition, across circuitry previously implicated in abuse-related posttraumatic stress disorder (PTSD), including the left anterior insula, extending into left ventrolateral prefrontal cortex/orbitofrontal cortex; left amygdala; left inferior parietal cortex (STS); and bilateral visual association cortex, encompassing the cuneus and lingual gyrus. No group differences in neural or behavioural responses were found for the classic colour Stroop conditions. Significant negative associations between activity in bilateral cuneus and STS during the rejection-themed Stroop and higher self-reported PTSD symptomatology, including dissociation, were observed in children exposed to maltreatment. Conclusion Our findings indicate a pattern of altered neural response to social rejection cues in maltreated children. Compared to their peers, these children displayed relative hypoactivation to rejection cues in regions previously associated with PTSD, potentially reflecting an avoidant coping response. It is suggested that such atypical processing of social threat may index latent vulnerability to future psychopathology in general and PTSD in particular. En ligne : http://dx.doi.org/10.1111/jcpp.12595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children / Stephane A. DE BRITO in Journal of Child Psychology and Psychiatry, 54-1 (January 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 105-112 Titre : Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children Type de document : Texte imprimé et/ou numérique Auteurs : Stephane A. DE BRITO, Auteur ; Essi VIDING, Auteur ; Catherine L. SEBASTIAN, Auteur ; Philip A. KELLY, Auteur ; Andrea MECHELLI, Auteur ; Helen MARIS, Auteur ; Eamon J. MCCRORY, Auteur Article en page(s) : 105-112 Langues : Anglais (eng) Mots-clés : maltreatment  child abuse  orbitofrontal cortex  middle temporal gyrus  voxel-based morphometry Index. décimale : PER Périodiques Résumé : Background: Childhood maltreatment is strongly associated with increased risk of psychiatric disorder. Previous neuroimaging studies have reported atypical neural structure in the orbitofrontal cortex, temporal lobe, amygdala, hippocampus and cerebellum in maltreated samples. It has been hypothesised that these structural differences may relate to increased psychiatric vulnerability. However, previous studies have typically recruited clinical samples with concurrent psychiatric disorders, or have poorly characterised the range of maltreatment experiences and levels of concurrent anxiety or depression, limiting the interpretation of the observed structural differences. Methods: We used voxel-based morphometry to compare grey matter volume in a group of 18 children (mean age 12.01 years, SD = 1.4), referred to community social services, with documented and well-characterised experiences of maltreatment at home and a group of 20 nonmaltreated children (mean age 12.6 years, SD = 1.3). Both groups were comparable on age, gender, cognitive ability, ethnicity and levels of anxiety, depression and posttraumatic stress symptoms. We examined five a priori regions of interest: the prefrontal cortex, temporal lobes, amygdala, hippocampus and cerebellum. Results: Maltreated children, compared to nonmaltreated peers, presented with reduced grey matter in the medial orbitofrontal cortex and the left middle temporal gyrus. Conclusions: The medial orbitofrontal cortex and the middle temporal gyrus have been implicated in reinforcement-based decision-making, emotion regulation and autobiographical memory, processes that are impaired in a number of psychiatric disorders associated with maltreatment. We speculate that grey matter disturbance in these regions in a community sample of maltreated children may represent a latent neurobiological risk factor for later psychopathology and heightened risk taking. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02597.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 [article] Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children [Texte imprimé et/ou numérique] / Stephane A. DE BRITO, Auteur ; Essi VIDING, Auteur ; Catherine L. SEBASTIAN, Auteur ; Philip A. KELLY, Auteur ; Andrea MECHELLI, Auteur ; Helen MARIS, Auteur ; Eamon J. MCCRORY, Auteur . - 105-112. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 105-112 Mots-clés : maltreatment  child abuse  orbitofrontal cortex  middle temporal gyrus  voxel-based morphometry Index. décimale : PER Périodiques Résumé : Background: Childhood maltreatment is strongly associated with increased risk of psychiatric disorder. Previous neuroimaging studies have reported atypical neural structure in the orbitofrontal cortex, temporal lobe, amygdala, hippocampus and cerebellum in maltreated samples. It has been hypothesised that these structural differences may relate to increased psychiatric vulnerability. However, previous studies have typically recruited clinical samples with concurrent psychiatric disorders, or have poorly characterised the range of maltreatment experiences and levels of concurrent anxiety or depression, limiting the interpretation of the observed structural differences. Methods: We used voxel-based morphometry to compare grey matter volume in a group of 18 children (mean age 12.01 years, SD = 1.4), referred to community social services, with documented and well-characterised experiences of maltreatment at home and a group of 20 nonmaltreated children (mean age 12.6 years, SD = 1.3). Both groups were comparable on age, gender, cognitive ability, ethnicity and levels of anxiety, depression and posttraumatic stress symptoms. We examined five a priori regions of interest: the prefrontal cortex, temporal lobes, amygdala, hippocampus and cerebellum. Results: Maltreated children, compared to nonmaltreated peers, presented with reduced grey matter in the medial orbitofrontal cortex and the left middle temporal gyrus. Conclusions: The medial orbitofrontal cortex and the middle temporal gyrus have been implicated in reinforcement-based decision-making, emotion regulation and autobiographical memory, processes that are impaired in a number of psychiatric disorders associated with maltreatment. We speculate that grey matter disturbance in these regions in a community sample of maltreated children may represent a latent neurobiological risk factor for later psychopathology and heightened risk taking. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02597.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186

Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: A multilevel investigation / Philip A. KELLY in Development and Psychopathology, 27-4 (Part 2) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1591-1609 Titre : Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: A multilevel investigation Type de document : Texte imprimé et/ou numérique Auteurs : Philip A. KELLY, Auteur ; Essi VIDING, Auteur ; Vanessa B. PUETZ, Auteur ; Amy L. PALMER, Auteur ; Andrea MECHELLI, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Sophie SAMUEL, Auteur ; Eamon J. MCCRORY, Auteur Article en page(s) : p.1591-1609 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While maltreatment is known to impact social and emotional functioning, threat processing, and neural structure, the potentially dimorphic influence of sex on these outcomes remains relatively understudied. We investigated sex differences across these domains in a large community sample of children aged 10 to 14 years (n = 122) comprising 62 children with verified maltreatment experience and 60 well-matched nonmaltreated peers. The maltreated group relative to the nonmaltreated comparison group exhibited poorer social and emotional functioning (more peer problems and heightened emotional reactivity). Cognitively, they displayed a pattern of attentional avoidance of threat in a visual dot-probe task. Similar patterns were observed in males and females in these domains. Reduced gray matter volume was found to characterize the maltreated group in the medial orbitofrontal cortex, bilateral middle temporal lobes, and bilateral supramarginal gyrus; sex differences were observed only in the supramarginal gyrus. In addition, a disordinal interaction between maltreatment exposure and sex was found in the postcentral gyrus. Finally, attentional avoidance to threat mediated the relationship between maltreatment and emotional reactivity, and medial orbitofrontal cortex gray matter volume mediated the relationship between maltreatment and peer functioning. Similar mediation patterns were observed across sexes. This study highlights the utility of combining multiple levels of analysis when studying the “latent vulnerability” engendered by childhood maltreatment and yields tentative findings regarding a neural basis of sex differences in long-term outcomes for maltreated children. En ligne : http://dx.doi.org/10.1017/S0954579415000966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: A multilevel investigation [Texte imprimé et/ou numérique] / Philip A. KELLY, Auteur ; Essi VIDING, Auteur ; Vanessa B. PUETZ, Auteur ; Amy L. PALMER, Auteur ; Andrea MECHELLI, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Sophie SAMUEL, Auteur ; Eamon J. MCCRORY, Auteur . - p.1591-1609. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1591-1609 Index. décimale : PER Périodiques Résumé : While maltreatment is known to impact social and emotional functioning, threat processing, and neural structure, the potentially dimorphic influence of sex on these outcomes remains relatively understudied. We investigated sex differences across these domains in a large community sample of children aged 10 to 14 years (n = 122) comprising 62 children with verified maltreatment experience and 60 well-matched nonmaltreated peers. The maltreated group relative to the nonmaltreated comparison group exhibited poorer social and emotional functioning (more peer problems and heightened emotional reactivity). Cognitively, they displayed a pattern of attentional avoidance of threat in a visual dot-probe task. Similar patterns were observed in males and females in these domains. Reduced gray matter volume was found to characterize the maltreated group in the medial orbitofrontal cortex, bilateral middle temporal lobes, and bilateral supramarginal gyrus; sex differences were observed only in the supramarginal gyrus. In addition, a disordinal interaction between maltreatment exposure and sex was found in the postcentral gyrus. Finally, attentional avoidance to threat mediated the relationship between maltreatment and emotional reactivity, and medial orbitofrontal cortex gray matter volume mediated the relationship between maltreatment and peer functioning. Similar mediation patterns were observed across sexes. This study highlights the utility of combining multiple levels of analysis when studying the “latent vulnerability” engendered by childhood maltreatment and yields tentative findings regarding a neural basis of sex differences in long-term outcomes for maltreated children. En ligne : http://dx.doi.org/10.1017/S0954579415000966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

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