Analysis of Three Coding Region Polymorphisms in Autism: Evidence for an Association with the Serotonin Transporter / Nurit YIRMIYA

Public ISBD contenu dans The Research Basis for Autism Intervention / Eric SCHOPLER Titre : Analysis of Three Coding Region Polymorphisms in Autism: Evidence for an Association with the Serotonin Transporter Type de document : Texte imprimé et/ou numérique Auteurs : Nurit YIRMIYA, Auteur ; Tammy PILOWSKY, Auteur ; Lubov NEMANOV, Auteur ; Shoshana ARBELLE, Auteur ; Temira FEINSILVER, Auteur ; Iris FRIED, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2001 Importance : p.91-101 Langues : Anglais (eng) Index. décimale : APP-D APP-D - Interventions Educatives - Généralités Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=100 contenu dans The Research Basis for Autism Intervention / Eric SCHOPLER Analysis of Three Coding Region Polymorphisms in Autism: Evidence for an Association with the Serotonin Transporter [Texte imprimé et/ou numérique] / Nurit YIRMIYA, Auteur ; Tammy PILOWSKY, Auteur ; Lubov NEMANOV, Auteur ; Shoshana ARBELLE, Auteur ; Temira FEINSILVER, Auteur ; Iris FRIED, Auteur ; Richard P. EBSTEIN, Auteur . - 2001 . - p.91-101. Langues : Anglais (eng) Index. décimale : APP-D APP-D - Interventions Educatives - Généralités Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=100

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Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders / Aisling MULLIGAN in Journal of Autism and Developmental Disorders, 39-2 (February 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.197-209 Titre : Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Aisling MULLIGAN, Auteur ; Herbert ROEYERS, Auteur ; Richard ANNEY, Auteur ; Wai CHEN, Auteur ; Myra O’REGAN, Auteur ; Louise BUTLER, Auteur ; Judith NIJMEIJER, Auteur ; Pieter J. HOEKSTRA, Auteur ; Robert D. OADES, Auteur ; Hanna CHRISTIANSEN, Auteur ; Isabel GABRIELS, Auteur ; Rafaela MARCO, Auteur ; Sheera MEIDAD, Auteur ; Ueli MUELLER, Auteur ; Jacques EISENBERG, Auteur ; Iris MANOR, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Barbara FRANKE, Auteur ; Margaret J. THOMPSON, Auteur ; Ruud B. MINDERAA, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Henrik UEBEL, Auteur ; Joseph A. SERGEANT, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Catharina A. HARTMAN, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur ; Jan K. BUITELAAR, Auteur ; Michael FITZGERALD, Auteur ; Nanda N. ROMMELSE, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Michael GILL, Auteur ; Lamprini PSYCHOGIOU, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2009 Article en page(s) : p.197-209 Langues : Anglais (eng) Mots-clés : ADHD Autism Familiality Oppositional-disorders Motor-disorder Language-disorder Index. décimale : PER Périodiques Résumé : It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2–4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders. En ligne : http://dx.doi.org/10.1007/s10803-008-0621-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=683 [article] Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders [Texte imprimé et/ou numérique] / Aisling MULLIGAN, Auteur ; Herbert ROEYERS, Auteur ; Richard ANNEY, Auteur ; Wai CHEN, Auteur ; Myra O’REGAN, Auteur ; Louise BUTLER, Auteur ; Judith NIJMEIJER, Auteur ; Pieter J. HOEKSTRA, Auteur ; Robert D. OADES, Auteur ; Hanna CHRISTIANSEN, Auteur ; Isabel GABRIELS, Auteur ; Rafaela MARCO, Auteur ; Sheera MEIDAD, Auteur ; Ueli MUELLER, Auteur ; Jacques EISENBERG, Auteur ; Iris MANOR, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Barbara FRANKE, Auteur ; Margaret J. THOMPSON, Auteur ; Ruud B. MINDERAA, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Henrik UEBEL, Auteur ; Joseph A. SERGEANT, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Catharina A. HARTMAN, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur ; Jan K. BUITELAAR, Auteur ; Michael FITZGERALD, Auteur ; Nanda N. ROMMELSE, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Michael GILL, Auteur ; Lamprini PSYCHOGIOU, Auteur ; Richard P. EBSTEIN, Auteur . - 2009 . - p.197-209. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.197-209 Mots-clés : ADHD Autism Familiality Oppositional-disorders Motor-disorder Language-disorder Index. décimale : PER Périodiques Résumé : It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2–4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders. En ligne : http://dx.doi.org/10.1007/s10803-008-0621-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=683

Boys' serotonin transporter genotype affects maternal behavior through self-control: A case of evocative gene–environment correlation / Roni PENER-TESSLER in Development and Psychopathology, 25-1 (February 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-1 (February 2013) . - p.151-162 Titre : Boys' serotonin transporter genotype affects maternal behavior through self-control: A case of evocative gene–environment correlation Type de document : Texte imprimé et/ou numérique Auteurs : Roni PENER-TESSLER, Auteur ; Reut AVINUN, Auteur ; Florina UZEFOVSKY, Auteur ; Shany EDELMAN, Auteur ; Richard P. EBSTEIN, Auteur ; Ariel KNAFO, Auteur Article en page(s) : p.151-162 Index. décimale : PER Périodiques Résumé : Self-control, involving processes such as delaying gratification, concentrating, planning, following instructions, and adapting emotions and behavior to situational requirements and social norms, may have a profound impact on children's adjustment. The importance of self-control suggests that parents are likely to modify their parenting based on children's ability for self-control. We study the effect of children's self-control, a trait partially molded by genetics, on their mothers' parenting, a process of evocative gene–environment correlation. Israeli 3.5-year-old twins (N = 320) participated in a lab session in which their mothers' parenting was observed. DNA was available from most children (N = 228). Mothers described children's self-control in a questionnaire. Boys were lower in self-control and received less positive parenting from their mothers, in comparison with girls. For boys, and not for girls, the serotonin transporter linked polymorphic region gene predicted mothers' levels of positive parenting, an effect mediated by boys' self-control. The implications of this evocative gene–environment correlation and the observed sex differences are discussed. En ligne : http://dx.doi.org/10.1017/S095457941200096X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190 [article] Boys' serotonin transporter genotype affects maternal behavior through self-control: A case of evocative gene–environment correlation [Texte imprimé et/ou numérique] / Roni PENER-TESSLER, Auteur ; Reut AVINUN, Auteur ; Florina UZEFOVSKY, Auteur ; Shany EDELMAN, Auteur ; Richard P. EBSTEIN, Auteur ; Ariel KNAFO, Auteur . - p.151-162. in Development and Psychopathology > 25-1 (February 2013) . - p.151-162 Index. décimale : PER Périodiques Résumé : Self-control, involving processes such as delaying gratification, concentrating, planning, following instructions, and adapting emotions and behavior to situational requirements and social norms, may have a profound impact on children's adjustment. The importance of self-control suggests that parents are likely to modify their parenting based on children's ability for self-control. We study the effect of children's self-control, a trait partially molded by genetics, on their mothers' parenting, a process of evocative gene–environment correlation. Israeli 3.5-year-old twins (N = 320) participated in a lab session in which their mothers' parenting was observed. DNA was available from most children (N = 228). Mothers described children's self-control in a questionnaire. Boys were lower in self-control and received less positive parenting from their mothers, in comparison with girls. For boys, and not for girls, the serotonin transporter linked polymorphic region gene predicted mothers' levels of positive parenting, an effect mediated by boys' self-control. The implications of this evocative gene–environment correlation and the observed sex differences are discussed. En ligne : http://dx.doi.org/10.1017/S095457941200096X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190

Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: the case of conduct and emotional problems in attention deficit/hyperactivity disorder / Edmund J. S. SONUGA-BARKE in Journal of Child Psychology and Psychiatry, 50-9 (September 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1052-1063 Titre : Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: the case of conduct and emotional problems in attention deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Edmund J. S. SONUGA-BARKE, Auteur ; Herbert ROEYERS, Auteur ; Michael GIL, Auteur ; Ana MIRANDA, Auteur ; Robert D. OADES, Auteur ; Wai CHEN, Auteur ; Richard ANNEY, Auteur ; Barbara FRANKE, Auteur ; Margaret J. THOMPSON, Auteur ; Lamprini PSYCHOGIOU, Auteur ; Jan K. BUITELAAR, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Joseph A. SERGEANT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Aribert ROTHENBERGER, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2009 Article en page(s) : p.1052-1063 Langues : Anglais (eng) Mots-clés : ADHD gene-x-environment-interaction conduct-problems behaviour-problems emotional-problems emotional-symptoms expressed-emotion mothers teachers genetics serotonin-transports dopamine-transport Index. décimale : PER Périodiques Résumé : Background: Mothers' positive emotions expressed about their children with attention deficit/hyperactivity disorder (ADHD) are associated with a reduced likelihood of comorbid conduct problems (CP). We examined whether this association with CP, and one with emotional problems (EMO), is moderated by variants within three genes, previously reported to be associated with ADHD and to moderate the impact of environmental risks on conduct and/or emotional problems; the dopamine transporter gene (SLC6A3/DAT1), the dopamine D4 receptor gene (DRD4) and the serotonin transporter gene (SLC6A4/5HTT). Methods: Seven hundred and twenty-eight males between the ages of 5 and 17 with a DSM-IV research diagnosis of combined type ADHD were included in these analyses. Parents and teachers rated children's conduct and emotional problems. Positive maternal expressed emotion (PMEE) was coded by independent observers on comments made during a clinical assessment with the mother based on current or recent medication-free periods. Results: Sensitivity to the effects of PMEE on CP was moderated by variants of the DAT1 and 5HTT genes. Only children who did not carry the DAT1 10R/10R or the 5HTT l/l genotypes showed altered levels of CP when exposed to PMEE. The effect was most marked where the child with ADHD had both these genotypes. For EMO, sensitivity to PMEE was found only with those who carried the DAT1 9R/9R. There was no effect of DRD4 on CP or EMO. Conclusion: The gene–environment interactions observed suggested that genetic make-up can alter the degree of sensitivity an ADHD patients has to their family environment. Further research should focus on distinguishing general sensitivity genotypes from those conferring risk or protective qualities. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02095.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=828 [article] Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: the case of conduct and emotional problems in attention deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Edmund J. S. SONUGA-BARKE, Auteur ; Herbert ROEYERS, Auteur ; Michael GIL, Auteur ; Ana MIRANDA, Auteur ; Robert D. OADES, Auteur ; Wai CHEN, Auteur ; Richard ANNEY, Auteur ; Barbara FRANKE, Auteur ; Margaret J. THOMPSON, Auteur ; Lamprini PSYCHOGIOU, Auteur ; Jan K. BUITELAAR, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Joseph A. SERGEANT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Aribert ROTHENBERGER, Auteur ; Richard P. EBSTEIN, Auteur . - 2009 . - p.1052-1063. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1052-1063 Mots-clés : ADHD gene-x-environment-interaction conduct-problems behaviour-problems emotional-problems emotional-symptoms expressed-emotion mothers teachers genetics serotonin-transports dopamine-transport Index. décimale : PER Périodiques Résumé : Background: Mothers' positive emotions expressed about their children with attention deficit/hyperactivity disorder (ADHD) are associated with a reduced likelihood of comorbid conduct problems (CP). We examined whether this association with CP, and one with emotional problems (EMO), is moderated by variants within three genes, previously reported to be associated with ADHD and to moderate the impact of environmental risks on conduct and/or emotional problems; the dopamine transporter gene (SLC6A3/DAT1), the dopamine D4 receptor gene (DRD4) and the serotonin transporter gene (SLC6A4/5HTT). Methods: Seven hundred and twenty-eight males between the ages of 5 and 17 with a DSM-IV research diagnosis of combined type ADHD were included in these analyses. Parents and teachers rated children's conduct and emotional problems. Positive maternal expressed emotion (PMEE) was coded by independent observers on comments made during a clinical assessment with the mother based on current or recent medication-free periods. Results: Sensitivity to the effects of PMEE on CP was moderated by variants of the DAT1 and 5HTT genes. Only children who did not carry the DAT1 10R/10R or the 5HTT l/l genotypes showed altered levels of CP when exposed to PMEE. The effect was most marked where the child with ADHD had both these genotypes. For EMO, sensitivity to PMEE was found only with those who carried the DAT1 9R/9R. There was no effect of DRD4 on CP or EMO. Conclusion: The gene–environment interactions observed suggested that genetic make-up can alter the degree of sensitivity an ADHD patients has to their family environment. Further research should focus on distinguishing general sensitivity genotypes from those conferring risk or protective qualities. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02095.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=828

Emotional lability in children and adolescents with attention deficit/hyperactivity disorder (ADHD): clinical correlates and familial prevalence / Esther SOBANSKI in Journal of Child Psychology and Psychiatry, 51-8 (August 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-8 (August 2010) . - p.915-923 Titre : Emotional lability in children and adolescents with attention deficit/hyperactivity disorder (ADHD): clinical correlates and familial prevalence Type de document : Texte imprimé et/ou numérique Auteurs : Esther SOBANSKI, Auteur ; Herbert ROEYERS, Auteur ; Barbara FRANKE, Auteur ; Richard ANNEY, Auteur ; Wai CHEN, Auteur ; Robert D. OADES, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Argyris STRINGARIS, Auteur ; Bertram KRUMM, Auteur ; Eric TAYLOR, Auteur ; Michael GILL, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Joseph A. SERGEANT, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jan K. BUITELAAR, Auteur ; Martin HOLTMANN, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2010 Article en page(s) : p.915-923 Langues : Anglais (eng) Mots-clés : Attention-deficit-hyperactivity-disorder emotional-lability affective-lability emotional-dysregulation Index. décimale : PER Périodiques Résumé : Background:  The goal of this study was to investigate the occurrence, severity and clinical correlates of emotional lability (EL) in children with attention deficit/hyperactivity disorder (ADHD), and to examine factors contributing to EL and familiality of EL in youth with ADHD. Methods:  One thousand, one hundred and eighty-six children with ADHD combined type and 1827 siblings (aged 6–18 years) were assessed for symptoms of EL, ADHD, associated psychopathology and comorbid psychiatric disorders with a structured diagnostic interview (PACS) as well as parent and teacher ratings of psychopathology (SDQ; CPRS-R:L; CTRS-R:L). Analyses of variance, regression analyses, χ2-tests or loglinear models were applied. Results:  Mean age and gender-standardized ratings of EL in children with ADHD were >1.5 SD above the mean in normative samples. Severe EL (>75th percentile) was associated with more severe ADHD core symptoms, primarily hyperactive-impulsive symptoms, and more comorbid oppositional defiant, affective and substance use disorders. Age, hyperactive-impulsive, oppositional, and emotional symptoms accounted for 30% of EL variance; hyperactive-impulsive symptoms did not account for EL variance when coexisting oppositional and emotional problems were taken into account, but oppositional symptoms explained 12% of EL variance specifically. Severity of EL in probands increased the severity of EL in siblings, but not the prevalence rates of ADHD or ODD. EL and ADHD does not co-segregate within families. Conclusion:  EL is a frequent clinical problem in children with ADHD. It is associated with increased severity of ADHD core symptoms, particularly hyperactivity-impulsivity, and more symptoms of comorbid psychopathology, primarily symptoms of oppositional defiant disorder (ODD), but also affective symptoms, and substance abuse. EL in ADHD seems to be more closely related to ODD than to ADHD core symptoms, and is only partly explainable by the severity of ADHD core symptoms and associated psychopathology. Although EL symptoms are transmitted within families, EL in children with ADHD does not increase the risk of ADHD and ODD in their siblings. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02217.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Emotional lability in children and adolescents with attention deficit/hyperactivity disorder (ADHD): clinical correlates and familial prevalence [Texte imprimé et/ou numérique] / Esther SOBANSKI, Auteur ; Herbert ROEYERS, Auteur ; Barbara FRANKE, Auteur ; Richard ANNEY, Auteur ; Wai CHEN, Auteur ; Robert D. OADES, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Argyris STRINGARIS, Auteur ; Bertram KRUMM, Auteur ; Eric TAYLOR, Auteur ; Michael GILL, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Joseph A. SERGEANT, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jan K. BUITELAAR, Auteur ; Martin HOLTMANN, Auteur ; Richard P. EBSTEIN, Auteur . - 2010 . - p.915-923. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-8 (August 2010) . - p.915-923 Mots-clés : Attention-deficit-hyperactivity-disorder emotional-lability affective-lability emotional-dysregulation Index. décimale : PER Périodiques Résumé : Background:  The goal of this study was to investigate the occurrence, severity and clinical correlates of emotional lability (EL) in children with attention deficit/hyperactivity disorder (ADHD), and to examine factors contributing to EL and familiality of EL in youth with ADHD. Methods:  One thousand, one hundred and eighty-six children with ADHD combined type and 1827 siblings (aged 6–18 years) were assessed for symptoms of EL, ADHD, associated psychopathology and comorbid psychiatric disorders with a structured diagnostic interview (PACS) as well as parent and teacher ratings of psychopathology (SDQ; CPRS-R:L; CTRS-R:L). Analyses of variance, regression analyses, χ2-tests or loglinear models were applied. Results:  Mean age and gender-standardized ratings of EL in children with ADHD were >1.5 SD above the mean in normative samples. Severe EL (>75th percentile) was associated with more severe ADHD core symptoms, primarily hyperactive-impulsive symptoms, and more comorbid oppositional defiant, affective and substance use disorders. Age, hyperactive-impulsive, oppositional, and emotional symptoms accounted for 30% of EL variance; hyperactive-impulsive symptoms did not account for EL variance when coexisting oppositional and emotional problems were taken into account, but oppositional symptoms explained 12% of EL variance specifically. Severity of EL in probands increased the severity of EL in siblings, but not the prevalence rates of ADHD or ODD. EL and ADHD does not co-segregate within families. Conclusion:  EL is a frequent clinical problem in children with ADHD. It is associated with increased severity of ADHD core symptoms, particularly hyperactivity-impulsivity, and more symptoms of comorbid psychopathology, primarily symptoms of oppositional defiant disorder (ODD), but also affective symptoms, and substance abuse. EL in ADHD seems to be more closely related to ODD than to ADHD core symptoms, and is only partly explainable by the severity of ADHD core symptoms and associated psychopathology. Although EL symptoms are transmitted within families, EL in children with ADHD does not increase the risk of ADHD and ODD in their siblings. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02217.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

Erratum : Autism Symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial Trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders / Aisling MULLIGAN in Journal of Autism and Developmental Disorders, 39-2 (February 2009)  

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Heritability of children's prosocial behavior and differential susceptibility to parenting by variation in the dopamine receptor D4 gene / Ariel KNAFO in Development and Psychopathology, 23-1 (January 2011)  

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Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study / Elad LERER in Autism Research, 3-6 (December 2010)  

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Research Review: Crossing syndrome boundaries in the search for brain endophenotypes / Yonata LEVY in Journal of Child Psychology and Psychiatry, 50-6 (June 2009)  

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The Broad Autism Phenotype Questionnaire: Mothers Versus Fathers of Children with an Autism Spectrum Disorder / Ifat SEIDMAN in Journal of Autism and Developmental Disorders, 42-5 (May 2012)  

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The hierarchical factor model of ADHD: invariant across age and national groupings? / Maggie E. TOPLAK in Journal of Child Psychology and Psychiatry, 53-3 (March 2012)  

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