Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development / Lisa A. CROEN in Autism Research, 12-1 (January 2019)  

Public ISBD [article]  inAutism Research > 12-1 (January 2019) . - p.123-135 Titre : Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development Type de document : texte imprimé Auteurs : Lisa A. CROEN, Auteur ; Yinge QIAN, Auteur ; Paul ASHWOOD, Auteur ; Julie L. DANIELS, Auteur ; M. Daniele FALLIN, Auteur ; Diana SCHENDEL, Auteur ; Laura A. SCHIEVE, Auteur ; Alison B. SINGER, Auteur ; Ousseny ZERBO, Auteur Article en page(s) : p.123-135 Langues : Anglais (eng) Mots-clés : allergy  asthma  autism  autoimmune  pregnancy  prenatal Index. décimale : PER Périodiques Résumé : Numerous studies have reported immune system disturbances in individuals with autism and their family members; however, there is considerable variability in findings with respect to the specific immune conditions involved, their timing, and the family members affected and little understanding of variation by autism subphenotype. Using data from the Study to Explore Early Development (SEED), a multi-site case-control study of children born 2003-2006 in the United States, we examined the role of family history of autoimmune diseases, asthma, and allergies in autism spectrum disorder (ASD) as well as other developmental disorders (DD). We investigated maternal immune conditions during the pregnancy period, as well as lifetime history of these conditions in several family members (mother, father, siblings, and study child). Logistic regression analyses included 663 children with ASD, 984 children with DD, and 915 controls ascertained from the general population (POP). Maternal history of eczema/psoriasis and asthma was associated with a 20%-40% increased odds of both ASD and DD. Risk estimates varied by specific ASD subphenotypes in association with these exposures. In addition, children with ASD were more likely to have a history of psoriasis/eczema or allergies than POP controls. No association was observed for paternal history or family history of these immune conditions for either ASD or DD. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes, and further suggest that associations may differ by ASD phenotype of the child. Autism Research 2019, 12: 123-135. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multi-site study in the US-the Study to Explore Early Development-we found that women with a history of eczema/psoriasis and asthma are more likely to have children with ASD or DD. In addition, children with ASD are more likely to have a history of psoriasis/eczema or allergies than typically developing children. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes. En ligne : http://dx.doi.org/10.1002/aur.1979 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 [article] Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development [texte imprimé] / Lisa A. CROEN, Auteur ; Yinge QIAN, Auteur ; Paul ASHWOOD, Auteur ; Julie L. DANIELS, Auteur ; M. Daniele FALLIN, Auteur ; Diana SCHENDEL, Auteur ; Laura A. SCHIEVE, Auteur ; Alison B. SINGER, Auteur ; Ousseny ZERBO, Auteur . - p.123-135. Langues : Anglais (eng) in Autism Research > 12-1 (January 2019) . - p.123-135 Mots-clés : allergy  asthma  autism  autoimmune  pregnancy  prenatal Index. décimale : PER Périodiques Résumé : Numerous studies have reported immune system disturbances in individuals with autism and their family members; however, there is considerable variability in findings with respect to the specific immune conditions involved, their timing, and the family members affected and little understanding of variation by autism subphenotype. Using data from the Study to Explore Early Development (SEED), a multi-site case-control study of children born 2003-2006 in the United States, we examined the role of family history of autoimmune diseases, asthma, and allergies in autism spectrum disorder (ASD) as well as other developmental disorders (DD). We investigated maternal immune conditions during the pregnancy period, as well as lifetime history of these conditions in several family members (mother, father, siblings, and study child). Logistic regression analyses included 663 children with ASD, 984 children with DD, and 915 controls ascertained from the general population (POP). Maternal history of eczema/psoriasis and asthma was associated with a 20%-40% increased odds of both ASD and DD. Risk estimates varied by specific ASD subphenotypes in association with these exposures. In addition, children with ASD were more likely to have a history of psoriasis/eczema or allergies than POP controls. No association was observed for paternal history or family history of these immune conditions for either ASD or DD. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes, and further suggest that associations may differ by ASD phenotype of the child. Autism Research 2019, 12: 123-135. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multi-site study in the US-the Study to Explore Early Development-we found that women with a history of eczema/psoriasis and asthma are more likely to have children with ASD or DD. In addition, children with ASD are more likely to have a history of psoriasis/eczema or allergies than typically developing children. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes. En ligne : http://dx.doi.org/10.1002/aur.1979 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

Health conditions in autism: Defining the trajectory from adolescence to early adulthood / Beth A. MALOW in Autism Research, 16-7 (July 2023)  

Public ISBD [article]  inAutism Research > 16-7 (July 2023) . - p.1437-1449 Titre : Health conditions in autism: Defining the trajectory from adolescence to early adulthood Type de document : texte imprimé Auteurs : Beth A. MALOW, Auteur ; Yinge QIAN, Auteur ; Jennifer L. AMES, Auteur ; Stacey E. ALEXEEFF, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.1437-1449 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autistic adults, as compared to non-autistic adults, have increased rates of nearly all medical and psychiatric conditions. Many of these conditions begin in childhood, although few longitudinal studies have been conducted to examine prevalence rates of these conditions from adolescence into early adulthood. In this study, we analyze the longitudinal trajectory of health conditions in autistic youth, compared to age and sex-matched non-autistic youth, transitioning from adolescence into early adulthood in a large integrated health care delivery system. The percent and modeled prevalence of common medical and psychiatric conditions increased from age 14 to 22 years, with autistic youth having a higher prevalence of most conditions than non-autistic youth. The most prevalent conditions in autistic youth at all ages were obesity, neurological disorders, anxiety, and ADHD. The prevalence of obesity and dyslipidemia rose at a faster rate in autistic youth compared to non-autistic youth. By age 22, autistic females showed a higher prevalence of all medical and psychiatric conditions compared to autistic males. Our findings emphasize the importance of screening for medical and psychiatric conditions in autistic youth, coupled with health education targeted at this population, to mitigate the development of adverse health outcomes in autistic adults. En ligne : https://doi.org/10.1002/aur.2960 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] Health conditions in autism: Defining the trajectory from adolescence to early adulthood [texte imprimé] / Beth A. MALOW, Auteur ; Yinge QIAN, Auteur ; Jennifer L. AMES, Auteur ; Stacey E. ALEXEEFF, Auteur ; Lisa A. CROEN, Auteur . - p.1437-1449. Langues : Anglais (eng) in Autism Research > 16-7 (July 2023) . - p.1437-1449 Index. décimale : PER Périodiques Résumé : Abstract Autistic adults, as compared to non-autistic adults, have increased rates of nearly all medical and psychiatric conditions. Many of these conditions begin in childhood, although few longitudinal studies have been conducted to examine prevalence rates of these conditions from adolescence into early adulthood. In this study, we analyze the longitudinal trajectory of health conditions in autistic youth, compared to age and sex-matched non-autistic youth, transitioning from adolescence into early adulthood in a large integrated health care delivery system. The percent and modeled prevalence of common medical and psychiatric conditions increased from age 14 to 22 years, with autistic youth having a higher prevalence of most conditions than non-autistic youth. The most prevalent conditions in autistic youth at all ages were obesity, neurological disorders, anxiety, and ADHD. The prevalence of obesity and dyslipidemia rose at a faster rate in autistic youth compared to non-autistic youth. By age 22, autistic females showed a higher prevalence of all medical and psychiatric conditions compared to autistic males. Our findings emphasize the importance of screening for medical and psychiatric conditions in autistic youth, coupled with health education targeted at this population, to mitigate the development of adverse health outcomes in autistic adults. En ligne : https://doi.org/10.1002/aur.2960 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

Health Services Utilization Among Children With and Without Autism Spectrum Disorders / Janet R. CUMMINGS in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.910-920 Titre : Health Services Utilization Among Children With and Without Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Janet R. CUMMINGS, Auteur ; Frances L. LYNCH, Auteur ; Kristal C. RUST, Auteur ; Karen J. COLEMAN, Auteur ; Jeanne M. MADDEN, Auteur ; Ashli A. OWEN-SMITH, Auteur ; Vincent M. YAU, Auteur ; Yinge QIAN, Auteur ; Kathryn A. PEARSON, Auteur ; Phillip M. CRAWFORD, Auteur ; Maria L. MASSOLO, Auteur ; Virginia P. QUINN, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.910-920 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Health care utilization  Preventive services  Children  Adolescents Index. décimale : PER Périodiques Résumé : Using data from multiple health systems (2009–2010) and the largest sample to date, this study compares health services use among youth with and without an autism spectrum disorder (ASD)—including preventive services not previously studied. To examine these differences, we estimated logistic and count data models, controlling for demographic characteristics, comorbid physical health, and mental health conditions. Results indicated that youth with an ASD had greater health care use in many categories, but were less likely to receive important preventive services including flu shots and other vaccinations. An improved understanding of the overall patterns of health care use among this population could enable health systems to facilitate the receipt of appropriate and effective health care. En ligne : http://dx.doi.org/10.1007/s10803-015-2634-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281 [article] Health Services Utilization Among Children With and Without Autism Spectrum Disorders [texte imprimé] / Janet R. CUMMINGS, Auteur ; Frances L. LYNCH, Auteur ; Kristal C. RUST, Auteur ; Karen J. COLEMAN, Auteur ; Jeanne M. MADDEN, Auteur ; Ashli A. OWEN-SMITH, Auteur ; Vincent M. YAU, Auteur ; Yinge QIAN, Auteur ; Kathryn A. PEARSON, Auteur ; Phillip M. CRAWFORD, Auteur ; Maria L. MASSOLO, Auteur ; Virginia P. QUINN, Auteur ; Lisa A. CROEN, Auteur . - p.910-920. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.910-920 Mots-clés : Autism spectrum disorders  Health care utilization  Preventive services  Children  Adolescents Index. décimale : PER Périodiques Résumé : Using data from multiple health systems (2009–2010) and the largest sample to date, this study compares health services use among youth with and without an autism spectrum disorder (ASD)—including preventive services not previously studied. To examine these differences, we estimated logistic and count data models, controlling for demographic characteristics, comorbid physical health, and mental health conditions. Results indicated that youth with an ASD had greater health care use in many categories, but were less likely to receive important preventive services including flu shots and other vaccinations. An improved understanding of the overall patterns of health care use among this population could enable health systems to facilitate the receipt of appropriate and effective health care. En ligne : http://dx.doi.org/10.1007/s10803-015-2634-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281

Healthcare service utilization and cost among transition-age youth with autism spectrum disorder and other special healthcare needs / Jennifer L. AMES in Autism, 25-3 (April 2021)  

Public ISBD [article]  inAutism > 25-3 (April 2021) . - p.705-718 Titre : Healthcare service utilization and cost among transition-age youth with autism spectrum disorder and other special healthcare needs Type de document : texte imprimé Auteurs : Jennifer L. AMES, Auteur ; Maria L. MASSOLO, Auteur ; Meghan N. DAVIGNON, Auteur ; Yinge QIAN, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.705-718 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  health services  transition Index. décimale : PER Périodiques Résumé : Youth with autism spectrum disorder often have complex medical needs. Disruptions of healthcare during the transition from pediatric to adult healthcare may put youth with autism spectrum disorder at higher risk of medical emergencies and high medical costs. To understand healthcare utilization during the transition years, we conducted a study among transition-age youth (14-25 years old) receiving healthcare at Kaiser Permanente Northern California during 2014-2015. We examined differences in healthcare utilization and costs among youth with autism spectrum disorder (n = 4123), attention deficit and hyperactivity disorder (n = 20,6015), diabetes mellitus (n = 2156), and general population controls (n = 20,615). Analyses were also stratified by age and sex. Youth with autism spectrum disorder had the highest utilization of outpatient primary care, mental health, and psychotropic medications and the lowest utilization of obstetrics/gynecology and urgent care. Costs for youth with autism spectrum disorder were higher than those for attention deficit and hyperactivity disorder and general population peers and lower than for diabetes mellitus. Healthcare utilization patterns varied by age. Transition-age youth with autism spectrum disorder generally used healthcare at higher rates relative to attention deficit and hyperactivity disorder and general population peers but at similar or lower rates than diabetes mellitus peers, indicating this group's complex combination of psychiatric and medical healthcare needs. The relatively high utilization of psychiatric services and low utilization of women's health services in transition-age youth with autism spectrum disorder may have implications for long-term health and warrants additional research. En ligne : http://dx.doi.org/10.1177/1362361320931268 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444 [article] Healthcare service utilization and cost among transition-age youth with autism spectrum disorder and other special healthcare needs [texte imprimé] / Jennifer L. AMES, Auteur ; Maria L. MASSOLO, Auteur ; Meghan N. DAVIGNON, Auteur ; Yinge QIAN, Auteur ; Lisa A. CROEN, Auteur . - p.705-718. Langues : Anglais (eng) in Autism > 25-3 (April 2021) . - p.705-718 Mots-clés : autism spectrum disorders  health services  transition Index. décimale : PER Périodiques Résumé : Youth with autism spectrum disorder often have complex medical needs. Disruptions of healthcare during the transition from pediatric to adult healthcare may put youth with autism spectrum disorder at higher risk of medical emergencies and high medical costs. To understand healthcare utilization during the transition years, we conducted a study among transition-age youth (14-25 years old) receiving healthcare at Kaiser Permanente Northern California during 2014-2015. We examined differences in healthcare utilization and costs among youth with autism spectrum disorder (n = 4123), attention deficit and hyperactivity disorder (n = 20,6015), diabetes mellitus (n = 2156), and general population controls (n = 20,615). Analyses were also stratified by age and sex. Youth with autism spectrum disorder had the highest utilization of outpatient primary care, mental health, and psychotropic medications and the lowest utilization of obstetrics/gynecology and urgent care. Costs for youth with autism spectrum disorder were higher than those for attention deficit and hyperactivity disorder and general population peers and lower than for diabetes mellitus. Healthcare utilization patterns varied by age. Transition-age youth with autism spectrum disorder generally used healthcare at higher rates relative to attention deficit and hyperactivity disorder and general population peers but at similar or lower rates than diabetes mellitus peers, indicating this group's complex combination of psychiatric and medical healthcare needs. The relatively high utilization of psychiatric services and low utilization of women's health services in transition-age youth with autism spectrum disorder may have implications for long-term health and warrants additional research. En ligne : http://dx.doi.org/10.1177/1362361320931268 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444

Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development / Lisa A. CROEN in Autism Research, 12-10 (October 2019)  

Public ISBD [article]  inAutism Research > 12-10 (October 2019) . - p.1551-1561 Titre : Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development Type de document : texte imprimé Auteurs : Lisa A. CROEN, Auteur ; Yinge QIAN, Auteur ; Paul ASHWOOD, Auteur ; Ousseny ZERBO, Auteur ; Diana SCHENDEL, Auteur ; Jennifer A. PINTO-MARTIN, Auteur ; M. Daniele FALLIN, Auteur ; Sebastien LEVY, Auteur ; Laura A. SCHIEVE, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Katherine R. SABOURIN, Auteur ; Jennifer L. AMES, Auteur Article en page(s) : p.1551-1561 Langues : Anglais (eng) Mots-clés : autism  developmental disorder  immune function  infection  neurodevelopment  prenatal Index. décimale : PER Périodiques Résumé : Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case-control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3-5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14-4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551-1561. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multisite study in the United States-the Study to Explore Early Development-we found that women who had an infection during the second trimester of pregnancy accompanied by a fever are more likely to have children with ASD. These findings suggest the possibility that only more severe infections accompanied by a robust inflammatory response increase the risk of ASD. En ligne : http://dx.doi.org/10.1002/aur.2175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development [texte imprimé] / Lisa A. CROEN, Auteur ; Yinge QIAN, Auteur ; Paul ASHWOOD, Auteur ; Ousseny ZERBO, Auteur ; Diana SCHENDEL, Auteur ; Jennifer A. PINTO-MARTIN, Auteur ; M. Daniele FALLIN, Auteur ; Sebastien LEVY, Auteur ; Laura A. SCHIEVE, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Katherine R. SABOURIN, Auteur ; Jennifer L. AMES, Auteur . - p.1551-1561. Langues : Anglais (eng) in Autism Research > 12-10 (October 2019) . - p.1551-1561 Mots-clés : autism  developmental disorder  immune function  infection  neurodevelopment  prenatal Index. décimale : PER Périodiques Résumé : Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case-control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3-5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14-4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551-1561. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multisite study in the United States-the Study to Explore Early Development-we found that women who had an infection during the second trimester of pregnancy accompanied by a fever are more likely to have children with ASD. These findings suggest the possibility that only more severe infections accompanied by a robust inflammatory response increase the risk of ASD. En ligne : http://dx.doi.org/10.1002/aur.2175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Is Infertility Associated with Childhood Autism? / Judith K. GRETHER in Journal of Autism and Developmental Disorders, 43-3 (March 2013)  

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Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development / Alison B. SINGER in Journal of Autism and Developmental Disorders, 46-11 (November 2016)  

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Maternal Infection During Pregnancy and Autism Spectrum Disorders / Ousseny ZERBO in Journal of Autism and Developmental Disorders, 45-12 (December 2015)  

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Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children / Stacey E. ALEXEEFF in Journal of Autism and Developmental Disorders, 47-7 (July 2017)  

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Prenatal exposure to beta2-adrenergic receptor agonists and risk of autism spectrum disorders / Lisa A. CROEN in Journal of Neurodevelopmental Disorders, 3-4 (December 2011)  

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Psychotropic Medication Use among Insured Children with Autism Spectrum Disorder / Jeanne M. MADDEN in Journal of Autism and Developmental Disorders, 47-1 (January 2017)  

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A Study of Physician Knowledge and Experience with Autism in Adults in a Large Integrated Healthcare System / Ousseny ZERBO in Journal of Autism and Developmental Disorders, 45-12 (December 2015)  

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The health status of adults on the autism spectrum / Lisa A. CROEN in Autism, 19-7 (October 2015)  

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Transitioning youth with autism spectrum disorders and other special health care needs into adult primary care: A provider survey / Jennifer L. AMES in Autism, 25-3 (April 2021)  

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Validation of Autism Spectrum Disorder Diagnoses in Large Healthcare Systems with Electronic Medical Records / Karen J. COLEMAN in Journal of Autism and Developmental Disorders, 45-7 (July 2015)  

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