Exploring the Event-Related Potentials' Time Course of Associative Recognition in Autism / Pierre DESAUNAY in Autism Research, 13-11 (November 2020)  

Public ISBD [article]  inAutism Research > 13-11 (November 2020) . - p.1998-2016 Titre : Exploring the Event-Related Potentials' Time Course of Associative Recognition in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Pierre DESAUNAY, Auteur ; Patrice CLOCHON, Auteur ; Franck DOIDY, Auteur ; Anna LAMBRECHTS, Auteur ; Prany WANTZEN, Auteur ; Fabrice WALLOIS, Auteur ; Mahdi MAHMOUDZADEH, Auteur ; Jean-Marc GUILE, Auteur ; Fabian GUENOLE, Auteur ; Jean-Marc BALEYTE, Auteur ; Francis EUSTACHE, Auteur ; Dermot M. BOWLER, Auteur ; Bérengère GUILLERY-GIRARD, Auteur Article en page(s) : p.1998-2016 Langues : Anglais (eng) Mots-clés : Eeg  associative memory  autism  episodic memory  event-related potentials  late positive component  recollection Index. décimale : PER Périodiques Résumé : Behavioral data on episodic recollection in autism spectrum disorders (ASD) point limited relational memory functioning. However, the involvement of successive memory processes in the profile of episodic memory in ASD needs more study. Here, we used event-related potentials (ERP) to investigate the time course of episodic recollection with an associative recognition paradigm with picture pairs. Twenty-two participants with ASD and 32 with typical development (TD), all right-handed, were included. Behavioral results confirmed difficulties in correctly recognizing identical pairs in the ASD relative to TD group. We found an unexpected amplitude decrement on the P2 (220-270?msec) and FN400 (350-470?msec) potentials, suggesting diminished priming and familiarity effects in the ASD relative to TD group. However, ERP data revealed that the recognition of associative information relies on the same electrophysiological process (old/new effect in the 600-700-msec late positive component) in ASD participants as in TD ones, with a parietal extension in the ASD group. These results suggest that the electrophysiological processes of associative recognition are qualitatively similar in individuals with and without ASD but may differ quantitatively. This difference may be driven by the reduced early processing of picture pairs that may in turn lead to their diminished integration into the semantic memory system, being partially compensated by a greater involvement of associative memory during the recollection process. Other studies would be useful to go further in identifying these cognitive processes involved in atypical recognition in ASD and their neural substrates. Autism Res 2020, 13: 1998-2016. © 2020 International Society for Autism Research and Wiley Periodicals LLC LAY SUMMARY: We identified diminished performance on the associative recognition of picture pairs in adolescents and young adults with autism when compared to typical development. Electrophysiological data revealed qualitative similarities but quantitative differences between-group, with diminished priming and familiarity processes partially compensated by an enhanced parietal recollection process. En ligne : http://dx.doi.org/10.1002/aur.2384 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Exploring the Event-Related Potentials' Time Course of Associative Recognition in Autism [Texte imprimé et/ou numérique] / Pierre DESAUNAY, Auteur ; Patrice CLOCHON, Auteur ; Franck DOIDY, Auteur ; Anna LAMBRECHTS, Auteur ; Prany WANTZEN, Auteur ; Fabrice WALLOIS, Auteur ; Mahdi MAHMOUDZADEH, Auteur ; Jean-Marc GUILE, Auteur ; Fabian GUENOLE, Auteur ; Jean-Marc BALEYTE, Auteur ; Francis EUSTACHE, Auteur ; Dermot M. BOWLER, Auteur ; Bérengère GUILLERY-GIRARD, Auteur . - p.1998-2016. Langues : Anglais (eng) in Autism Research > 13-11 (November 2020) . - p.1998-2016 Mots-clés : Eeg  associative memory  autism  episodic memory  event-related potentials  late positive component  recollection Index. décimale : PER Périodiques Résumé : Behavioral data on episodic recollection in autism spectrum disorders (ASD) point limited relational memory functioning. However, the involvement of successive memory processes in the profile of episodic memory in ASD needs more study. Here, we used event-related potentials (ERP) to investigate the time course of episodic recollection with an associative recognition paradigm with picture pairs. Twenty-two participants with ASD and 32 with typical development (TD), all right-handed, were included. Behavioral results confirmed difficulties in correctly recognizing identical pairs in the ASD relative to TD group. We found an unexpected amplitude decrement on the P2 (220-270?msec) and FN400 (350-470?msec) potentials, suggesting diminished priming and familiarity effects in the ASD relative to TD group. However, ERP data revealed that the recognition of associative information relies on the same electrophysiological process (old/new effect in the 600-700-msec late positive component) in ASD participants as in TD ones, with a parietal extension in the ASD group. These results suggest that the electrophysiological processes of associative recognition are qualitatively similar in individuals with and without ASD but may differ quantitatively. This difference may be driven by the reduced early processing of picture pairs that may in turn lead to their diminished integration into the semantic memory system, being partially compensated by a greater involvement of associative memory during the recollection process. Other studies would be useful to go further in identifying these cognitive processes involved in atypical recognition in ASD and their neural substrates. Autism Res 2020, 13: 1998-2016. © 2020 International Society for Autism Research and Wiley Periodicals LLC LAY SUMMARY: We identified diminished performance on the associative recognition of picture pairs in adolescents and young adults with autism when compared to typical development. Electrophysiological data revealed qualitative similarities but quantitative differences between-group, with diminished priming and familiarity processes partially compensated by an enhanced parietal recollection process. En ligne : http://dx.doi.org/10.1002/aur.2384 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Intact memory storage but impaired retrieval in visual memory in autism: New insights from an electrophysiological study / Patrice CLOCHON ; Franck DOIDY ; Thomas HINAULT ; Anna LAMBRECHTS ; Prany WANTZEN ; Fabrice WALLOIS ; Mahdi MAHMOUDZADEH ; Jean-Marc GUILE ; Fabian GUENOLE ; Jean-Marc BALEYTE ; Francis EUSTACHE ; Dermot M. BOWLER ; Bérengère GUILLERY-GIRARD in Autism Research, 16-1 (January 2023)  

Public ISBD [article]  inAutism Research > 16-1 (January 2023) . - p.99-105 Titre : Intact memory storage but impaired retrieval in visual memory in autism: New insights from an electrophysiological study Type de document : Texte imprimé et/ou numérique Auteurs : Patrice CLOCHON, Auteur ; Franck DOIDY, Auteur ; Thomas HINAULT, Auteur ; Anna LAMBRECHTS, Auteur ; Prany WANTZEN, Auteur ; Fabrice WALLOIS, Auteur ; Mahdi MAHMOUDZADEH, Auteur ; Jean-Marc GUILE, Auteur ; Fabian GUENOLE, Auteur ; Jean-Marc BALEYTE, Auteur ; Francis EUSTACHE, Auteur ; Dermot M. BOWLER, Auteur ; Bérengère GUILLERY-GIRARD, Auteur Article en page(s) : p.99-105 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract In a recent study on visual episodic memory (Desaunay, Clochon, et al., 2020), we have shown event-related potentials (ERPs) differences associated with priming (150-300 msec), familiarity (350-470 msec), and recollection (600-700 msec), in young people with autism spectrum disorders (ASD) compared with typical development (TD). To go further into the study of the processes of storage and retrieval of the memory trace, we re-analyzed Desaunay, Clochon, et al's data using time-frequency analysis, that is, event-related synchronization and desynchronization (ERS/ERD). This allows a decomposition of the spectral power within frequency bands associated with these ERPs. We focused both on the same time windows and the same regions of interest as previously published. We mainly identified, in ASD compared with TD, reduced ERS in low-frequencies (delta, theta) in early time-windows, and non-significant differences in ERD in higher frequencies (alpha, beta1) in all time-windows. Reduced ERS during recognition confirmed previously reported diminution of priming effects and difficulties in manipulation and retrieval of both semantic and episodic information. Conversely, preserved ERD corroborates a preservation of memory storage processes. These observations are consistent with a cognitive model of memory in ASD, that suggests difficulties in cognitive operations or executive demand at retrieval, subsequent to successful long-term storage of information. Lay Summary We assessed the EEG synchronization and desynchronization, during visual episodic recognition. We observed, in youth with Autism, reduced synchronization in low-frequencies (delta, theta), suggesting reduced access to and manipulation of long-term stored information. By contrast, non-significant differences in desynchronization at higher frequencies (alpha, beta frequency bands), that support long-term stored semantic and episodic information, suggested preserved memory traces. En ligne : https://doi.org/10.1002/aur.2838 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Intact memory storage but impaired retrieval in visual memory in autism: New insights from an electrophysiological study [Texte imprimé et/ou numérique] / Patrice CLOCHON, Auteur ; Franck DOIDY, Auteur ; Thomas HINAULT, Auteur ; Anna LAMBRECHTS, Auteur ; Prany WANTZEN, Auteur ; Fabrice WALLOIS, Auteur ; Mahdi MAHMOUDZADEH, Auteur ; Jean-Marc GUILE, Auteur ; Fabian GUENOLE, Auteur ; Jean-Marc BALEYTE, Auteur ; Francis EUSTACHE, Auteur ; Dermot M. BOWLER, Auteur ; Bérengère GUILLERY-GIRARD, Auteur . - p.99-105. Langues : Anglais (eng) in Autism Research > 16-1 (January 2023) . - p.99-105 Index. décimale : PER Périodiques Résumé : Abstract In a recent study on visual episodic memory (Desaunay, Clochon, et al., 2020), we have shown event-related potentials (ERPs) differences associated with priming (150-300 msec), familiarity (350-470 msec), and recollection (600-700 msec), in young people with autism spectrum disorders (ASD) compared with typical development (TD). To go further into the study of the processes of storage and retrieval of the memory trace, we re-analyzed Desaunay, Clochon, et al's data using time-frequency analysis, that is, event-related synchronization and desynchronization (ERS/ERD). This allows a decomposition of the spectral power within frequency bands associated with these ERPs. We focused both on the same time windows and the same regions of interest as previously published. We mainly identified, in ASD compared with TD, reduced ERS in low-frequencies (delta, theta) in early time-windows, and non-significant differences in ERD in higher frequencies (alpha, beta1) in all time-windows. Reduced ERS during recognition confirmed previously reported diminution of priming effects and difficulties in manipulation and retrieval of both semantic and episodic information. Conversely, preserved ERD corroborates a preservation of memory storage processes. These observations are consistent with a cognitive model of memory in ASD, that suggests difficulties in cognitive operations or executive demand at retrieval, subsequent to successful long-term storage of information. Lay Summary We assessed the EEG synchronization and desynchronization, during visual episodic recognition. We observed, in youth with Autism, reduced synchronization in low-frequencies (delta, theta), suggesting reduced access to and manipulation of long-term stored information. By contrast, non-significant differences in desynchronization at higher frequencies (alpha, beta frequency bands), that support long-term stored semantic and episodic information, suggested preserved memory traces. En ligne : https://doi.org/10.1002/aur.2838 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

“Is voice a marker for Autism spectrum disorder? A systematic review and meta-analysis” / Riccardo FUSAROLI in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.384-407 Titre : “Is voice a marker for Autism spectrum disorder? A systematic review and meta-analysis” Type de document : Texte imprimé et/ou numérique Auteurs : Riccardo FUSAROLI, Auteur ; Anna LAMBRECHTS, Auteur ; Dan BANG, Auteur ; Dermot M. BOWLER, Auteur ; Sebastian B. GAIGG, Auteur Article en page(s) : p.384-407 Langues : Anglais (eng) Mots-clés : voice  speech  acoustic properties  machine learning  biomarker Index. décimale : PER Périodiques Résumé : Individuals with Autism Spectrum Disorder (ASD) tend to show distinctive, atypical acoustic patterns of speech. These behaviors affect social interactions and social development and could represent a non-invasive marker for ASD. We systematically reviewed the literature quantifying acoustic patterns in ASD. Search terms were: (prosody OR intonation OR inflection OR intensity OR pitch OR fundamental frequency OR speech rate OR voice quality OR acoustic) AND (autis* OR Asperger). Results were filtered to include only: empirical studies quantifying acoustic features of vocal production in ASD, with a sample size >2, and the inclusion of a neurotypical comparison group and/or correlations between acoustic measures and severity of clinical features. We identified 34 articles, including 30 univariate studies and 15 multivariate machine-learning studies. We performed meta-analyses of the univariate studies, identifying significant differences in mean pitch and pitch range between individuals with ASD and comparison participants (Cohen's d of 0.4–0.5 and discriminatory accuracy of about 61–64%). The multivariate studies reported higher accuracies than the univariate studies (63–96%). However, the methods used and the acoustic features investigated were too diverse for performing meta-analysis. We conclude that multivariate studies of acoustic patterns are a promising but yet unsystematic avenue for establishing ASD markers. We outline three recommendations for future studies: open data, open methods, and theory-driven research. En ligne : http://dx.doi.org/10.1002/aur.1678 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] “Is voice a marker for Autism spectrum disorder? A systematic review and meta-analysis” [Texte imprimé et/ou numérique] / Riccardo FUSAROLI, Auteur ; Anna LAMBRECHTS, Auteur ; Dan BANG, Auteur ; Dermot M. BOWLER, Auteur ; Sebastian B. GAIGG, Auteur . - p.384-407. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.384-407 Mots-clés : voice  speech  acoustic properties  machine learning  biomarker Index. décimale : PER Périodiques Résumé : Individuals with Autism Spectrum Disorder (ASD) tend to show distinctive, atypical acoustic patterns of speech. These behaviors affect social interactions and social development and could represent a non-invasive marker for ASD. We systematically reviewed the literature quantifying acoustic patterns in ASD. Search terms were: (prosody OR intonation OR inflection OR intensity OR pitch OR fundamental frequency OR speech rate OR voice quality OR acoustic) AND (autis* OR Asperger). Results were filtered to include only: empirical studies quantifying acoustic features of vocal production in ASD, with a sample size >2, and the inclusion of a neurotypical comparison group and/or correlations between acoustic measures and severity of clinical features. We identified 34 articles, including 30 univariate studies and 15 multivariate machine-learning studies. We performed meta-analyses of the univariate studies, identifying significant differences in mean pitch and pitch range between individuals with ASD and comparison participants (Cohen's d of 0.4–0.5 and discriminatory accuracy of about 61–64%). The multivariate studies reported higher accuracies than the univariate studies (63–96%). However, the methods used and the acoustic features investigated were too diverse for performing meta-analysis. We conclude that multivariate studies of acoustic patterns are a promising but yet unsystematic avenue for establishing ASD markers. We outline three recommendations for future studies: open data, open methods, and theory-driven research. En ligne : http://dx.doi.org/10.1002/aur.1678 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Recall of a live and personally experienced eyewitness event by adults with autism spectrum disorder / Katie L. MARAS in Journal of Autism and Developmental Disorders, 43-8 (August 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1798-1810 Titre : Recall of a live and personally experienced eyewitness event by adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Katie L. MARAS, Auteur ; Amina MEMON, Auteur ; Anna LAMBRECHTS, Auteur ; Dermot M. BOWLER, Auteur Article en page(s) : p.1798-1810 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Eyewitness  Self-enactment effect  Source monitoring  Memory Index. décimale : PER Périodiques Résumé : The aim of the present study was to (a) extend previous eyewitness research in autism spectrum disorder (ASD) using a live and personally experienced event; (b) examine whether witnesses with ASD demonstrate a facilitative effect in memory for self- over other-performed actions; (c) explore source monitoring abilities by witnesses with ASD in discriminating who performed which actions within the event. Eighteen high-functioning adults with ASD and 18 age- and IQ-matched typical counterparts participated in a live first aid scenario in which they and the experimenter each performed a number of actions. Participants were subsequently interviewed for their memory of the event using a standard interview procedure with free recall followed by questioning. The ASD group recalled just as many correct details as the comparison group from the event overall, however they made more errors. This was the case across both free recall and questioning phases. Both groups showed a self-enactment effect across both interview phases, recalling more actions that they had performed themselves than actions that the experimenter had performed. However, the ASD group were more likely than their typical comparisons to confuse the source of self-performed actions in free recall, but not in questioning, which may indicate executive functioning difficulties with unsupported test procedures. Findings are discussed in terms of their theoretical and practical implications. En ligne : http://dx.doi.org/10.1007/s10803-012-1729-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205 [article] Recall of a live and personally experienced eyewitness event by adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Katie L. MARAS, Auteur ; Amina MEMON, Auteur ; Anna LAMBRECHTS, Auteur ; Dermot M. BOWLER, Auteur . - p.1798-1810. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1798-1810 Mots-clés : Autism spectrum disorder  Eyewitness  Self-enactment effect  Source monitoring  Memory Index. décimale : PER Périodiques Résumé : The aim of the present study was to (a) extend previous eyewitness research in autism spectrum disorder (ASD) using a live and personally experienced event; (b) examine whether witnesses with ASD demonstrate a facilitative effect in memory for self- over other-performed actions; (c) explore source monitoring abilities by witnesses with ASD in discriminating who performed which actions within the event. Eighteen high-functioning adults with ASD and 18 age- and IQ-matched typical counterparts participated in a live first aid scenario in which they and the experimenter each performed a number of actions. Participants were subsequently interviewed for their memory of the event using a standard interview procedure with free recall followed by questioning. The ASD group recalled just as many correct details as the comparison group from the event overall, however they made more errors. This was the case across both free recall and questioning phases. Both groups showed a self-enactment effect across both interview phases, recalling more actions that they had performed themselves than actions that the experimenter had performed. However, the ASD group were more likely than their typical comparisons to confuse the source of self-performed actions in free recall, but not in questioning, which may indicate executive functioning difficulties with unsupported test procedures. Findings are discussed in terms of their theoretical and practical implications. En ligne : http://dx.doi.org/10.1007/s10803-012-1729-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205

Reward Devaluation in Autistic Children and Adolescents with Complex Needs: A Feasibility Study / Anna LAMBRECHTS in Autism Research, 13-11 (November 2020)  

Public ISBD [article]  inAutism Research > 13-11 (November 2020) . - p.1915-1928 Titre : Reward Devaluation in Autistic Children and Adolescents with Complex Needs: A Feasibility Study Type de document : Texte imprimé et/ou numérique Auteurs : Anna LAMBRECHTS, Auteur ; Jennifer L. COOK, Auteur ; Elliot A. LUDVIG, Auteur ; Eduardo ALONSO, Auteur ; Sophie ANNS, Auteur ; Maddison TAYLOR, Auteur ; Sebastian B GAIGG, Auteur Article en page(s) : p.1915-1928 Langues : Anglais (eng) Mots-clés : autism  complex needs  devaluation  intellectual disability  reward processing Index. décimale : PER Périodiques Résumé : Rewards act as a motivator for positive behavior and learning. Although compounding evidence indicates that reward processing operates differently in autistic individuals who do not have co-occurring learning disabilities, little is known about individuals who have such difficulties or other complex needs. This study aimed first to assess the feasibility of using an adapted reward devaluation paradigm to examine basic reward processes in this underrepresented population, and second to investigate whether autistic children and adolescents with complex needs would show dynamic behavioral changes in response to changes in the motivational value of a reward. Twenty-seven autistic children and adolescents with complex needs and 20 typically developing 5-year-old children took part in the study. Participants were presented with two visual cues on a touchscreen laptop, which triggered the delivery of a video, music, or physical reward. One of the rewards was then presented in abundance to decrease its motivational value. Participants showed decreased interest in the video and music rewards after devaluation. The experimental setup was found to be suitable to test individuals with complex needs, although recommendations are made for the use of physical rewards. The results suggest that autistic participants with complex needs demonstrate goal-directed behavior and that it is feasible to develop experimental paradigms that can shed important light on learning processes that are fundamental to many education and intervention strategies for this population. Autism Res 2020, 13: 1915-1928. © 2020 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals LLC. LAY SUMMARY: We adapted an experimental task to conduct research with autistic children and adolescents with complex needs, who remain grossly underrepresented in autism research. We found that once a reward was presented in great quantity, participants were less motivated to obtain it, showing that they adapted their behavior to changes in the value of that reward. This is an important finding to help promote learning and design better interventions for this population. En ligne : http://dx.doi.org/10.1002/aur.2388 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Reward Devaluation in Autistic Children and Adolescents with Complex Needs: A Feasibility Study [Texte imprimé et/ou numérique] / Anna LAMBRECHTS, Auteur ; Jennifer L. COOK, Auteur ; Elliot A. LUDVIG, Auteur ; Eduardo ALONSO, Auteur ; Sophie ANNS, Auteur ; Maddison TAYLOR, Auteur ; Sebastian B GAIGG, Auteur . - p.1915-1928. Langues : Anglais (eng) in Autism Research > 13-11 (November 2020) . - p.1915-1928 Mots-clés : autism  complex needs  devaluation  intellectual disability  reward processing Index. décimale : PER Périodiques Résumé : Rewards act as a motivator for positive behavior and learning. Although compounding evidence indicates that reward processing operates differently in autistic individuals who do not have co-occurring learning disabilities, little is known about individuals who have such difficulties or other complex needs. This study aimed first to assess the feasibility of using an adapted reward devaluation paradigm to examine basic reward processes in this underrepresented population, and second to investigate whether autistic children and adolescents with complex needs would show dynamic behavioral changes in response to changes in the motivational value of a reward. Twenty-seven autistic children and adolescents with complex needs and 20 typically developing 5-year-old children took part in the study. Participants were presented with two visual cues on a touchscreen laptop, which triggered the delivery of a video, music, or physical reward. One of the rewards was then presented in abundance to decrease its motivational value. Participants showed decreased interest in the video and music rewards after devaluation. The experimental setup was found to be suitable to test individuals with complex needs, although recommendations are made for the use of physical rewards. The results suggest that autistic participants with complex needs demonstrate goal-directed behavior and that it is feasible to develop experimental paradigms that can shed important light on learning processes that are fundamental to many education and intervention strategies for this population. Autism Res 2020, 13: 1915-1928. © 2020 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals LLC. LAY SUMMARY: We adapted an experimental task to conduct research with autistic children and adolescents with complex needs, who remain grossly underrepresented in autism research. We found that once a reward was presented in great quantity, participants were less motivated to obtain it, showing that they adapted their behavior to changes in the value of that reward. This is an important finding to help promote learning and design better interventions for this population. En ligne : http://dx.doi.org/10.1002/aur.2388 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

The Witness-Aimed First Account (WAFA): A new technique for interviewing autistic witnesses and victims / Katie MARAS in Autism, 24-6 (August 2020)  

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Using Time Perception to Explore Implicit Sensitivity to Emotional Stimuli in Autism Spectrum Disorder / Catherine R. G. JONES in Journal of Autism and Developmental Disorders, 47-7 (July 2017)  

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