Neural Correlates of Set-Shifting in Children With Autism / Benjamin E. YERYS in Autism Research, 8-4 (August 2015)  

Public ISBD [article]  inAutism Research > 8-4 (August 2015) . - p.386-397 Titre : Neural Correlates of Set-Shifting in Children With Autism Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin E. YERYS, Auteur ; Ligia ANTEZANA, Auteur ; Rachel WEINBLATT, Auteur ; Kathryn F. JANKOWSKI, Auteur ; John STRANG, Auteur ; Chandan J. VAIDYA, Auteur ; Robert T. SCHULTZ, Auteur ; William D. GAILLARD, Auteur ; Lauren KENWORTHY, Auteur Article en page(s) : p.386-397 Langues : Anglais (eng) Mots-clés : autism  cognitive control  set-shifting  functional magnetic resonance imaging  cingulate  prefrontal cortex Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is often associated with high levels of inflexible thinking and rigid behavior. The neural correlates of these behaviors have been investigated in adults and older adolescents, but not children. Prior studies utilized set-shifting tasks that engaged multiple levels of shifting, and depended on learning abstract rules and establishing a strong prepotent bias. These additional demands complicate simple interpretations of the results. We used functional magnetic resonance imaging (fMRI) to investigate the neural correlates of set-shifting in 20 children (ages 7–14) with ASD and 19 typically developing, matched, control children. Participants completed a set-shifting task that minimized nonshifting task demands through the use of concrete instructions that provide spatial mapping of stimuli-responses. The shift/stay sets were given an equal number of trials to limit the prepotent bias. Both groups showed an equivalent “switch cost,” responding less accurately and slower to Switch stimuli than Stay stimuli, although the ASD group was less accurate overall. Both groups showed activation in prefrontal, striatal, parietal, and cerebellum regions known to govern effective set-shifts. Compared to controls, children with ASD demonstrated decreased activation of the right middle temporal gyrus across all trials, but increased activation in the mid-dorsal cingulate cortex/superior frontal gyrus, left middle frontal, and right inferior frontal gyri during the Switch vs. Stay contrast. The successful behavioral switching performance of children with ASD comes at the cost of requiring greater engagement of frontal regions, suggesting less efficiency at this lowest level of shifting. Autism Res 2015, 8: 386–397. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1454 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Neural Correlates of Set-Shifting in Children With Autism [Texte imprimé et/ou numérique] / Benjamin E. YERYS, Auteur ; Ligia ANTEZANA, Auteur ; Rachel WEINBLATT, Auteur ; Kathryn F. JANKOWSKI, Auteur ; John STRANG, Auteur ; Chandan J. VAIDYA, Auteur ; Robert T. SCHULTZ, Auteur ; William D. GAILLARD, Auteur ; Lauren KENWORTHY, Auteur . - p.386-397. Langues : Anglais (eng) in Autism Research > 8-4 (August 2015) . - p.386-397 Mots-clés : autism  cognitive control  set-shifting  functional magnetic resonance imaging  cingulate  prefrontal cortex Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is often associated with high levels of inflexible thinking and rigid behavior. The neural correlates of these behaviors have been investigated in adults and older adolescents, but not children. Prior studies utilized set-shifting tasks that engaged multiple levels of shifting, and depended on learning abstract rules and establishing a strong prepotent bias. These additional demands complicate simple interpretations of the results. We used functional magnetic resonance imaging (fMRI) to investigate the neural correlates of set-shifting in 20 children (ages 7–14) with ASD and 19 typically developing, matched, control children. Participants completed a set-shifting task that minimized nonshifting task demands through the use of concrete instructions that provide spatial mapping of stimuli-responses. The shift/stay sets were given an equal number of trials to limit the prepotent bias. Both groups showed an equivalent “switch cost,” responding less accurately and slower to Switch stimuli than Stay stimuli, although the ASD group was less accurate overall. Both groups showed activation in prefrontal, striatal, parietal, and cerebellum regions known to govern effective set-shifts. Compared to controls, children with ASD demonstrated decreased activation of the right middle temporal gyrus across all trials, but increased activation in the mid-dorsal cingulate cortex/superior frontal gyrus, left middle frontal, and right inferior frontal gyri during the Switch vs. Stay contrast. The successful behavioral switching performance of children with ASD comes at the cost of requiring greater engagement of frontal regions, suggesting less efficiency at this lowest level of shifting. Autism Res 2015, 8: 386–397. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1454 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

Randomized controlled effectiveness trial of executive function intervention for children on the autism spectrum / Lauren E. KENWORTHY in Journal of Child Psychology and Psychiatry, 55-4 (April 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-4 (April 2014) . - p.374-383 Titre : Randomized controlled effectiveness trial of executive function intervention for children on the autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Lauren E. KENWORTHY, Auteur ; Laura G. ANTHONY, Auteur ; Daniel Q. NAIMAN, Auteur ; Lynn R. CANNON, Auteur ; Meagan C. WILLS, Auteur ; Caroline LUONG-TRAN, Auteur ; Monica Adler WERNER, Auteur ; Katie C. ALEXANDER, Auteur ; John STRANG, Auteur ; Elgiz BAL, Auteur ; Jennifer L. SOKOLOFF, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.374-383 Mots-clés : Autism  executive function  RRBI  intervention  CBT Index. décimale : PER Périodiques Résumé : Background Unstuck and On Target (UOT) is an executive function (EF) intervention for children with autism spectrum disorders (ASD) targeting insistence on sameness, flexibility, goal-setting, and planning through a cognitive-behavioral program of self-regulatory scripts, guided/faded practice, and visual/verbal cueing. UOT is contextually-based because it is implemented in school and at home, the contexts in which a child uses EF skills. Methods To evaluate the effectiveness of UOT compared with a social skills intervention (SS), 3rd–5th graders with ASD (mean IQ = 108; UOT n = 47; SS n = 20) received interventions delivered by school staff in small group sessions. Students were matched for gender, age, race, IQ, ASD symptomotolgy, medication status, and parents' education. Interventions were matched for ‘dose’ of intervention and training. Measures of pre–post change included classroom observations, parent/teacher report, and direct child measures of problem-solving, EF, and social skills. Schools were randomized and evaluators, but not parents or teachers, were blinded to intervention type. Results Interventions were administered with high fidelity. Children in both groups improved with intervention, but mean change scores from pre- to postintervention indicated significantly greater improvements for UOT than SS groups in: problem-solving, flexibility, and planning/organizing. Also, classroom observations revealed that participants in UOT made greater improvements than SS participants in their ability to follow rules, make transitions, and be flexible. Children in both groups made equivalent improvements in social skills. Conclusions These data support the effectiveness of the first contextually-based EF intervention for children with ASD. UOT improved classroom behavior, flexibility, and problem-solving in children with ASD. Individuals with variable background/training in ASD successfully implemented UOT in mainstream educational settings. En ligne : http://dx.doi.org/10.1111/jcpp.12161 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230 [article] Randomized controlled effectiveness trial of executive function intervention for children on the autism spectrum [Texte imprimé et/ou numérique] / Lauren E. KENWORTHY, Auteur ; Laura G. ANTHONY, Auteur ; Daniel Q. NAIMAN, Auteur ; Lynn R. CANNON, Auteur ; Meagan C. WILLS, Auteur ; Caroline LUONG-TRAN, Auteur ; Monica Adler WERNER, Auteur ; Katie C. ALEXANDER, Auteur ; John STRANG, Auteur ; Elgiz BAL, Auteur ; Jennifer L. SOKOLOFF, Auteur ; Gregory L. WALLACE, Auteur . - p.374-383. in Journal of Child Psychology and Psychiatry > 55-4 (April 2014) . - p.374-383 Mots-clés : Autism  executive function  RRBI  intervention  CBT Index. décimale : PER Périodiques Résumé : Background Unstuck and On Target (UOT) is an executive function (EF) intervention for children with autism spectrum disorders (ASD) targeting insistence on sameness, flexibility, goal-setting, and planning through a cognitive-behavioral program of self-regulatory scripts, guided/faded practice, and visual/verbal cueing. UOT is contextually-based because it is implemented in school and at home, the contexts in which a child uses EF skills. Methods To evaluate the effectiveness of UOT compared with a social skills intervention (SS), 3rd–5th graders with ASD (mean IQ = 108; UOT n = 47; SS n = 20) received interventions delivered by school staff in small group sessions. Students were matched for gender, age, race, IQ, ASD symptomotolgy, medication status, and parents' education. Interventions were matched for ‘dose’ of intervention and training. Measures of pre–post change included classroom observations, parent/teacher report, and direct child measures of problem-solving, EF, and social skills. Schools were randomized and evaluators, but not parents or teachers, were blinded to intervention type. Results Interventions were administered with high fidelity. Children in both groups improved with intervention, but mean change scores from pre- to postintervention indicated significantly greater improvements for UOT than SS groups in: problem-solving, flexibility, and planning/organizing. Also, classroom observations revealed that participants in UOT made greater improvements than SS participants in their ability to follow rules, make transitions, and be flexible. Children in both groups made equivalent improvements in social skills. Conclusions These data support the effectiveness of the first contextually-based EF intervention for children with ASD. UOT improved classroom behavior, flexibility, and problem-solving in children with ASD. Individuals with variable background/training in ASD successfully implemented UOT in mainstream educational settings. En ligne : http://dx.doi.org/10.1111/jcpp.12161 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230

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