Family income and polygenic scores are independently but not interactively associated with cognitive performance among youth genetically similar to European reference populations / N.M. ELSAYED ; S.M.C. COLBERT ; Ryan BOGDAN ; Alexander S. HATOUM ; Deanna M. BARCH in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.2011-2025 Titre : Family income and polygenic scores are independently but not interactively associated with cognitive performance among youth genetically similar to European reference populations Type de document : texte imprimé Auteurs : N.M. ELSAYED, Auteur ; S.M.C. COLBERT, Auteur ; Ryan BOGDAN, Auteur ; Alexander S. HATOUM, Auteur ; Deanna M. BARCH, Auteur Article en page(s) : p.2011-2025 Langues : Anglais (eng) Mots-clés : cognitive ability  familial income  gene-environment interaction  neighborhood advantage  polygenic risk scores Index. décimale : PER Périodiques Résumé : Cognitive abilities are heritable and influenced by socioeconomic status (SES). It is critical to understand the association between SES and cognition beyond genetic propensity to inform potential benefits of SES-based interventions and to determine if such associations vary across (i) cognitive domains, (ii) facets of SES, and/or (iii) genetic propensity for different aspects of cognition. We examined the contributions of neighborhood socioeconomic advantage, family income, and polygenic scores (PGS) for domains of cognition (i.e., general cognitive ability, executive function, learning and memory, fluid reasoning) in a sample of children (ages 9-10; n = 5549) most genetically similar to reference populations from Europe. With some variability across cognitive outcomes, family income and PGS were independently significantly associated with cognitive performance. Within-sibling analyses revealed that cognitive PGS associations were predominantly driven by between-family effects suggestive of non-direct genetic mechanisms. These findings provide evidence that SES and genetic propensity to cognition have unique associations with cognitive performance in middle childhood. These results underscore the importance of environmental factors and genetic influences in the development of cognitive abilities and caution against overinterpreting associations with PGS of cognitive and educational outcomes as predominantly direct genetic effects. En ligne : https://dx.doi.org/10.1017/S0954579424001573 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Family income and polygenic scores are independently but not interactively associated with cognitive performance among youth genetically similar to European reference populations [texte imprimé] / N.M. ELSAYED, Auteur ; S.M.C. COLBERT, Auteur ; Ryan BOGDAN, Auteur ; Alexander S. HATOUM, Auteur ; Deanna M. BARCH, Auteur . - p.2011-2025. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.2011-2025 Mots-clés : cognitive ability  familial income  gene-environment interaction  neighborhood advantage  polygenic risk scores Index. décimale : PER Périodiques Résumé : Cognitive abilities are heritable and influenced by socioeconomic status (SES). It is critical to understand the association between SES and cognition beyond genetic propensity to inform potential benefits of SES-based interventions and to determine if such associations vary across (i) cognitive domains, (ii) facets of SES, and/or (iii) genetic propensity for different aspects of cognition. We examined the contributions of neighborhood socioeconomic advantage, family income, and polygenic scores (PGS) for domains of cognition (i.e., general cognitive ability, executive function, learning and memory, fluid reasoning) in a sample of children (ages 9-10; n = 5549) most genetically similar to reference populations from Europe. With some variability across cognitive outcomes, family income and PGS were independently significantly associated with cognitive performance. Within-sibling analyses revealed that cognitive PGS associations were predominantly driven by between-family effects suggestive of non-direct genetic mechanisms. These findings provide evidence that SES and genetic propensity to cognition have unique associations with cognitive performance in middle childhood. These results underscore the importance of environmental factors and genetic influences in the development of cognitive abilities and caution against overinterpreting associations with PGS of cognitive and educational outcomes as predominantly direct genetic effects. En ligne : https://dx.doi.org/10.1017/S0954579424001573 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype and stressful life events interact to predict preschool-onset depression: a replication and developmental extension / Ryan BOGDAN in Journal of Child Psychology and Psychiatry, 55-5 (May 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-5 (May 2014) . - p.448-457 Titre : Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype and stressful life events interact to predict preschool-onset depression: a replication and developmental extension Type de document : texte imprimé Auteurs : Ryan BOGDAN, Auteur ; Arpana AGRAWAL, Auteur ; Michael S. GAFFREY, Auteur ; Rebecca TILLMAN, Auteur ; Joan L. LUBY, Auteur Article en page(s) : p.448-457 Mots-clés : Depression  stress  5-HTTLPR  serotonin  gene*  interaction  plasticity  childhood  development  gene × environment Index. décimale : PER Périodiques Résumé : Background Scientific enthusiasm about gene × environment interactions, spurred by the 5-HTTLPR (serotonin transporter-linked polymorphic region) × SLEs (stressful life events) interaction predicting depression, have recently been tempered by sober realizations of small effects and meta-analyses reaching opposing conclusions. These mixed findings highlight the need for further research. Converging evidence suggests that the effects of 5-HTTLPR genotype may be neurodevelopmental in origin, but we are not aware of empirical studies that have investigated whether the 5-HTTLPR genotype × SLE interaction predicts preschool-onset depression (PO-MDD), the earliest validated form of depression. Methods Children (n = 234) aged 3–5 were recruited for a longitudinal study designed to examine PO-MDD. In a comprehensive baseline assessment, the child's primary caregivers completed questionnaires and were interviewed about their child's behaviors, psychiatric symptoms, and exposure to SLEs. Results A 5-HTTLPR × SLEs interaction emerged, such that children homozygous for the short allele were more susceptible to depression in the context of elevated SLE than long allele carriers. In contrast, at low SLE exposure, short allele homozygotes had fewer depressive symptoms. The data were best fit by a plasticity model with a substantial reduction in fit by diathesis-stress models. Conclusions Extending studies in adult and adolescent populations, these data suggest that 5-HTTLPR genotype may provide plasticity to environmental influence, for better or worse. Specifically, children homozygous for the short allele were more susceptible to the depressogenic effects of SLEs but benefitted, in the form of reduced depressive symptoms, in the context of relatively benign environmental conditions (i.e. relatively low SLE exposure). These data highlight the importance of examining gene × environment interactions across development, environment, and outcome but should be interpreted cautiously given the small sample size. En ligne : http://dx.doi.org/10.1111/jcpp.12142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=231 [article] Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype and stressful life events interact to predict preschool-onset depression: a replication and developmental extension [texte imprimé] / Ryan BOGDAN, Auteur ; Arpana AGRAWAL, Auteur ; Michael S. GAFFREY, Auteur ; Rebecca TILLMAN, Auteur ; Joan L. LUBY, Auteur . - p.448-457. in Journal of Child Psychology and Psychiatry > 55-5 (May 2014) . - p.448-457 Mots-clés : Depression  stress  5-HTTLPR  serotonin  gene*  interaction  plasticity  childhood  development  gene × environment Index. décimale : PER Périodiques Résumé : Background Scientific enthusiasm about gene × environment interactions, spurred by the 5-HTTLPR (serotonin transporter-linked polymorphic region) × SLEs (stressful life events) interaction predicting depression, have recently been tempered by sober realizations of small effects and meta-analyses reaching opposing conclusions. These mixed findings highlight the need for further research. Converging evidence suggests that the effects of 5-HTTLPR genotype may be neurodevelopmental in origin, but we are not aware of empirical studies that have investigated whether the 5-HTTLPR genotype × SLE interaction predicts preschool-onset depression (PO-MDD), the earliest validated form of depression. Methods Children (n = 234) aged 3–5 were recruited for a longitudinal study designed to examine PO-MDD. In a comprehensive baseline assessment, the child's primary caregivers completed questionnaires and were interviewed about their child's behaviors, psychiatric symptoms, and exposure to SLEs. Results A 5-HTTLPR × SLEs interaction emerged, such that children homozygous for the short allele were more susceptible to depression in the context of elevated SLE than long allele carriers. In contrast, at low SLE exposure, short allele homozygotes had fewer depressive symptoms. The data were best fit by a plasticity model with a substantial reduction in fit by diathesis-stress models. Conclusions Extending studies in adult and adolescent populations, these data suggest that 5-HTTLPR genotype may provide plasticity to environmental influence, for better or worse. Specifically, children homozygous for the short allele were more susceptible to the depressogenic effects of SLEs but benefitted, in the form of reduced depressive symptoms, in the context of relatively benign environmental conditions (i.e. relatively low SLE exposure). These data highlight the importance of examining gene × environment interactions across development, environment, and outcome but should be interpreted cautiously given the small sample size. En ligne : http://dx.doi.org/10.1111/jcpp.12142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=231

The intergenerational transmission of childhood maltreatment: Nonspecificity of maltreatment type and associations with borderline personality pathology / Sarah E. PAUL in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.1157-1171 Titre : The intergenerational transmission of childhood maltreatment: Nonspecificity of maltreatment type and associations with borderline personality pathology Type de document : texte imprimé Auteurs : Sarah E. PAUL, Auteur ; Michael J. BOUDREAUX, Auteur ; Erin BONDY, Auteur ; Jennifer L. TACKETT, Auteur ; Thomas F. OLTMANNS, Auteur ; Ryan BOGDAN, Auteur Article en page(s) : p.1157-1171 Langues : Anglais (eng) Mots-clés : abuse  borderline personality  childhood maltreatment  intergenerational transmission  neglect  stress Index. décimale : PER Périodiques Résumé : One generation's experience of childhood maltreatment is associated with that of the next. However, whether this intergenerational transmission is specific to distinct forms of maltreatment and what factors may contribute to its continuity remains unclear. Borderline personality pathology is predicted by childhood maltreatment and characterized by features (e.g., dysregulated emotion, relationship instability, impulsivity, and inconsistent appraisals of others) that may contribute to its propagation. Among 364 older adults and 573 of their adult children (total n = 937), self-reported exposure to distinct forms of childhood maltreatment (i.e., emotional, physical, and sexual abuse, and emotional and physical neglect as assessed by the Childhood Trauma Questionnaire) showed homotypic and heterotypic associations across generations with little evidence that latent factors unique to specific forms of maltreatment show generational continuity. General nonspecific indices of childhood maltreatment showed evidence of intergenerational transmission after accounting for demographic factors and parent socioeconomic status (b = 0.126, p = 9.21 × 10−4). This continuity was partially mediated by parental borderline personality pathology (assessed longitudinally through a variety of measures and sources, indirect effect: b = 0.031, 95% confidence interval [0.003, 0.060]). The intergenerational continuity of childhood maltreatment may largely represent general risk for nonspecific maltreatment that may, in part, be propagated by borderline personality pathology and/or shared risk factors. En ligne : http://dx.doi.org/10.1017/S095457941900066X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] The intergenerational transmission of childhood maltreatment: Nonspecificity of maltreatment type and associations with borderline personality pathology [texte imprimé] / Sarah E. PAUL, Auteur ; Michael J. BOUDREAUX, Auteur ; Erin BONDY, Auteur ; Jennifer L. TACKETT, Auteur ; Thomas F. OLTMANNS, Auteur ; Ryan BOGDAN, Auteur . - p.1157-1171. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.1157-1171 Mots-clés : abuse  borderline personality  childhood maltreatment  intergenerational transmission  neglect  stress Index. décimale : PER Périodiques Résumé : One generation's experience of childhood maltreatment is associated with that of the next. However, whether this intergenerational transmission is specific to distinct forms of maltreatment and what factors may contribute to its continuity remains unclear. Borderline personality pathology is predicted by childhood maltreatment and characterized by features (e.g., dysregulated emotion, relationship instability, impulsivity, and inconsistent appraisals of others) that may contribute to its propagation. Among 364 older adults and 573 of their adult children (total n = 937), self-reported exposure to distinct forms of childhood maltreatment (i.e., emotional, physical, and sexual abuse, and emotional and physical neglect as assessed by the Childhood Trauma Questionnaire) showed homotypic and heterotypic associations across generations with little evidence that latent factors unique to specific forms of maltreatment show generational continuity. General nonspecific indices of childhood maltreatment showed evidence of intergenerational transmission after accounting for demographic factors and parent socioeconomic status (b = 0.126, p = 9.21 × 10−4). This continuity was partially mediated by parental borderline personality pathology (assessed longitudinally through a variety of measures and sources, indirect effect: b = 0.031, 95% confidence interval [0.003, 0.060]). The intergenerational continuity of childhood maltreatment may largely represent general risk for nonspecific maltreatment that may, in part, be propagated by borderline personality pathology and/or shared risk factors. En ligne : http://dx.doi.org/10.1017/S095457941900066X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

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