10 recherche sur le mot-clé 'plasticity'

Plasticity of temporal binding in children with autism spectrum disorder: A single case experimental design perceptual training study / Jacob I. FELDMAN in Research in Autism Spectrum Disorders, 74 (June 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 74 (June 2020) . - p.101555 Titre : Plasticity of temporal binding in children with autism spectrum disorder: A single case experimental design perceptual training study Type de document : Texte imprimé et/ou numérique Auteurs : Jacob I. FELDMAN, Auteur ; Kacie DUNHAM, Auteur ; Julie G. CONRAD, Auteur ; David M. SIMON, Auteur ; Margaret CASSIDY, Auteur ; Yupeng LIU, Auteur ; Alexander TU, Auteur ; Neill A. BRODERICK, Auteur ; Mark T. WALLACE, Auteur ; Tiffany G. WOYNAROSKI, Auteur Article en page(s) : p.101555 Langues : Anglais (eng) Mots-clés : Autism  Multisensory integration  Perceptual training  Audiovisual  Plasticity Index. décimale : PER Périodiques Résumé : Background Many children with autism spectrum disorder (ASD) demonstrate atypical responses to multisensory stimuli. These disruptions, which are frequently seen in response to audiovisual speech, may produce cascading effects on the broader development of children with ASD. Perceptual training has been shown to enhance multisensory speech perception in typically developed adults. This study was the first to examine the effects of perceptual training on audiovisual speech perception in children with ASD. Method A multiple baseline across participants design was utilized with four 7- to 13-year-old children with ASD. The dependent variable, which was probed outside the training task each day using a simultaneity judgment task in baseline, intervention, and maintenance conditions, was audiovisual temporal binding window (TBW), an index of multisensory temporal acuity. During perceptual training, participants completed the same simultaneity judgment task with feedback on their accuracy after each trial in easy-, medium-, and hard-difficulty blocks. Results A functional relation between the multisensory perceptual training program and TBW size was not observed. Of the three participants who were entered into training, one participant demonstrated a strong effect, characterized by a fairly immediate change in TBW trend. The two remaining participants demonstrated a less clear response (i.e., longer latency to effect, lack of functional independence). The first participant to enter the training condition demonstrated some maintenance of a narrower TBW post-training. Conclusions Results indicate TBWs in children with ASD may be malleable, but additional research is needed and may entail further adaptation to the multisensory perceptual training paradigm. En ligne : https://doi.org/10.1016/j.rasd.2020.101555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Plasticity of temporal binding in children with autism spectrum disorder: A single case experimental design perceptual training study [Texte imprimé et/ou numérique] / Jacob I. FELDMAN, Auteur ; Kacie DUNHAM, Auteur ; Julie G. CONRAD, Auteur ; David M. SIMON, Auteur ; Margaret CASSIDY, Auteur ; Yupeng LIU, Auteur ; Alexander TU, Auteur ; Neill A. BRODERICK, Auteur ; Mark T. WALLACE, Auteur ; Tiffany G. WOYNAROSKI, Auteur . - p.101555. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 74 (June 2020) . - p.101555 Mots-clés : Autism  Multisensory integration  Perceptual training  Audiovisual  Plasticity Index. décimale : PER Périodiques Résumé : Background Many children with autism spectrum disorder (ASD) demonstrate atypical responses to multisensory stimuli. These disruptions, which are frequently seen in response to audiovisual speech, may produce cascading effects on the broader development of children with ASD. Perceptual training has been shown to enhance multisensory speech perception in typically developed adults. This study was the first to examine the effects of perceptual training on audiovisual speech perception in children with ASD. Method A multiple baseline across participants design was utilized with four 7- to 13-year-old children with ASD. The dependent variable, which was probed outside the training task each day using a simultaneity judgment task in baseline, intervention, and maintenance conditions, was audiovisual temporal binding window (TBW), an index of multisensory temporal acuity. During perceptual training, participants completed the same simultaneity judgment task with feedback on their accuracy after each trial in easy-, medium-, and hard-difficulty blocks. Results A functional relation between the multisensory perceptual training program and TBW size was not observed. Of the three participants who were entered into training, one participant demonstrated a strong effect, characterized by a fairly immediate change in TBW trend. The two remaining participants demonstrated a less clear response (i.e., longer latency to effect, lack of functional independence). The first participant to enter the training condition demonstrated some maintenance of a narrower TBW post-training. Conclusions Results indicate TBWs in children with ASD may be malleable, but additional research is needed and may entail further adaptation to the multisensory perceptual training paradigm. En ligne : https://doi.org/10.1016/j.rasd.2020.101555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Cumulative-genetic plasticity, parenting and adolescent self-regulation / Jay BELSKY in Journal of Child Psychology and Psychiatry, 52-5 (May 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-5 (May 2011) . - p.619-626 Titre : Cumulative-genetic plasticity, parenting and adolescent self-regulation Type de document : Texte imprimé et/ou numérique Auteurs : Jay BELSKY, Auteur ; Kevin M. BEAVER, Auteur Année de publication : 2011 Article en page(s) : p.619-626 Langues : Anglais (eng) Mots-clés : Self-control  self-regulation  plasticity  G×E  parenting Index. décimale : PER Périodiques Résumé : Background:  The capacity to control or regulate one’s emotions, cognitions and behavior is central to competent functioning, with limitations in these abilities associated with developmental problems. Parenting appears to influence such self-regulation. Here the differential-susceptibility hypothesis is tested that the more putative ‘plasticity alleles’ adolescents carry, the more positively and negatively influenced they will be by, respectively, supportive and unsupportive parenting. Methods:  One thousand, five hundred and eighty-six (1586) adolescents (n = 754 males; n = 832 females) enrolled in the American Add Health project were scored in terms of how many of 5 putative ‘plasticity alleles’ they carried – the 10R allele of DAT1, the A1 allele of DRD2, the 7R allele of DRD4, the short allele of 5HTTLPR, and the 2R/3R alleles of MAOA. Then the effect of the resultant index (ranging from 0 to 5) of cumulative-genetic plasticity in moderating effects of parenting on adolescent self-regulation was evaluated. Results:  Consistent with differential susceptibility, the more plasticity alleles males (but not females) carried, the more and less self-regulation they manifested under, respectively, supportive and unsupportive parenting conditions. Conclusion:  Adolescent males appear to vary for genetic reasons in their susceptibility to parenting vis-à-vis self-regulation, perhaps due to epistatic and/or epigenetic processes. G×E research may benefit from compositing candidate genes. To afford comparative evaluation of differential-susceptibility vs. diathesis-stress models of environmental action, future G×E work should focus on positive as well as negative environmental conditions and developmental outcomes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02327.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 [article] Cumulative-genetic plasticity, parenting and adolescent self-regulation [Texte imprimé et/ou numérique] / Jay BELSKY, Auteur ; Kevin M. BEAVER, Auteur . - 2011 . - p.619-626. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-5 (May 2011) . - p.619-626 Mots-clés : Self-control  self-regulation  plasticity  G×E  parenting Index. décimale : PER Périodiques Résumé : Background:  The capacity to control or regulate one’s emotions, cognitions and behavior is central to competent functioning, with limitations in these abilities associated with developmental problems. Parenting appears to influence such self-regulation. Here the differential-susceptibility hypothesis is tested that the more putative ‘plasticity alleles’ adolescents carry, the more positively and negatively influenced they will be by, respectively, supportive and unsupportive parenting. Methods:  One thousand, five hundred and eighty-six (1586) adolescents (n = 754 males; n = 832 females) enrolled in the American Add Health project were scored in terms of how many of 5 putative ‘plasticity alleles’ they carried – the 10R allele of DAT1, the A1 allele of DRD2, the 7R allele of DRD4, the short allele of 5HTTLPR, and the 2R/3R alleles of MAOA. Then the effect of the resultant index (ranging from 0 to 5) of cumulative-genetic plasticity in moderating effects of parenting on adolescent self-regulation was evaluated. Results:  Consistent with differential susceptibility, the more plasticity alleles males (but not females) carried, the more and less self-regulation they manifested under, respectively, supportive and unsupportive parenting conditions. Conclusion:  Adolescent males appear to vary for genetic reasons in their susceptibility to parenting vis-à-vis self-regulation, perhaps due to epistatic and/or epigenetic processes. G×E research may benefit from compositing candidate genes. To afford comparative evaluation of differential-susceptibility vs. diathesis-stress models of environmental action, future G×E work should focus on positive as well as negative environmental conditions and developmental outcomes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02327.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121

Evidence of hyper-plasticity in adults with Autism Spectrum Disorder / J. F. WILSON in Research in Autism Spectrum Disorders, 43-44 (November 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 43-44 (November 2017) . - p.40-52 Titre : Evidence of hyper-plasticity in adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. F. WILSON, Auteur ; V. LODHIA, Auteur ; D. P. COURTNEY, Auteur ; I. J. KIRK, Auteur ; J. P. HAMM, Auteur Article en page(s) : p.40-52 Langues : Anglais (eng) Mots-clés : Long-term potentiation  Autism spectrum disorder  Plasticity  Visual evoked potentials  EEG Index. décimale : PER Périodiques Résumé : AbstractBackground Long-term potentiation (LTP) is a form of synaptic plasticity involved in learning and memory. Abnormal levels of LTP have been suggested to contribute to symptoms in a number of disorders, and here we examined the extent to which LTP may be affected in autism spectrum disorders (ASD). While animal models of ASD have suggested LTP may be atypical, the results have been inconsistent in terms of the direction of abnormality. Method In the present study a paradigm for non-invasively eliciting LTP in humans was utilized to test a group of adults with ASD and matched controls. This paradigm uses high-frequency visual stimulation as the LTP-inducing stimulus, and the effect of LTP is reflected by an increase in amplitude of the visually-elicited N1b component of the visual evoked potential (VEP). Result Main effects for Hemisphere and Tetanus were found. While Group interactions were not found, a Group by Tetanus interaction was approaching significance and was determined to be weak evidence against the null ((pH0|D = 0.44) therefore, LTP effects were explored within groups for the N1 component. It was found that the ASD group had a greater N1 amplitude compared to controls. Conclusion Our results showed that the ASD group had greater N1 amplitude post-tetanus over the right hemisphere compared to controls and demonstrate elevated LTP. These results support the notion of enhanced perceptual functioning, as elevated LTP may be related to superior visual processing due to overspecialised neural networks in ASD. En ligne : https://doi.org/10.1016/j.rasd.2017.09.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327 [article] Evidence of hyper-plasticity in adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / J. F. WILSON, Auteur ; V. LODHIA, Auteur ; D. P. COURTNEY, Auteur ; I. J. KIRK, Auteur ; J. P. HAMM, Auteur . - p.40-52. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 43-44 (November 2017) . - p.40-52 Mots-clés : Long-term potentiation  Autism spectrum disorder  Plasticity  Visual evoked potentials  EEG Index. décimale : PER Périodiques Résumé : AbstractBackground Long-term potentiation (LTP) is a form of synaptic plasticity involved in learning and memory. Abnormal levels of LTP have been suggested to contribute to symptoms in a number of disorders, and here we examined the extent to which LTP may be affected in autism spectrum disorders (ASD). While animal models of ASD have suggested LTP may be atypical, the results have been inconsistent in terms of the direction of abnormality. Method In the present study a paradigm for non-invasively eliciting LTP in humans was utilized to test a group of adults with ASD and matched controls. This paradigm uses high-frequency visual stimulation as the LTP-inducing stimulus, and the effect of LTP is reflected by an increase in amplitude of the visually-elicited N1b component of the visual evoked potential (VEP). Result Main effects for Hemisphere and Tetanus were found. While Group interactions were not found, a Group by Tetanus interaction was approaching significance and was determined to be weak evidence against the null ((pH0|D = 0.44) therefore, LTP effects were explored within groups for the N1 component. It was found that the ASD group had a greater N1 amplitude compared to controls. Conclusion Our results showed that the ASD group had greater N1 amplitude post-tetanus over the right hemisphere compared to controls and demonstrate elevated LTP. These results support the notion of enhanced perceptual functioning, as elevated LTP may be related to superior visual processing due to overspecialised neural networks in ASD. En ligne : https://doi.org/10.1016/j.rasd.2017.09.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327

Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1354-1362 Titre : Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism Type de document : Texte imprimé et/ou numérique Auteurs : Andrew PICKLES, Auteur ; Deborah K. ANDERSON, Auteur ; Catherine LORD, Auteur Article en page(s) : p.1354-1362 Langues : Anglais (eng) Mots-clés : Early intervention  heterogeneity  language impairment  plasticity Index. décimale : PER Périodiques Résumé : Background Delayed, abnormal language is a common feature of autism and language therapy often a significant component of recommended treatment. However, as with other disorders with a language component, we know surprisingly little about the language trajectories and how varied these might be across different children. Thus, we know little about how and when language problems might resolve, whether there are periods of relative stability or lack of change and what periods might offer more favourable circumstances for intervention. Methods Expressive and receptive language was measured on six occasions between age 2 and 19 on a cohort of 192 children initially referred for autism. Latent class growth models were fitted to characterize the patterns of heterogeneous development. Results Latent class growth analysis identified seven classes. Between age 6 and 19, all classes tracked in parallel. Between ages 2 and 6, development was more heterogeneous with considerable variation in relative progress. In all groups, receptive and expressive language developed very largely in tandem. Conclusions The results confirmed previous analysis of children with specific language impairment where progress beyond age 6 was remarkably uniform. Greater variation was evident before this age with some groups making clearly better or worse progress compared to others. While this developmental heterogeneity may simply be a reflection of variation in preexisting and unchanging biological disposition, it may also reflect, at least in part, greater sensitivity in the early years to environments that are more or less supportive of language development. These findings contribute to the case for the importance of early intervention. En ligne : http://dx.doi.org/10.1111/jcpp.12269 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism [Texte imprimé et/ou numérique] / Andrew PICKLES, Auteur ; Deborah K. ANDERSON, Auteur ; Catherine LORD, Auteur . - p.1354-1362. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1354-1362 Mots-clés : Early intervention  heterogeneity  language impairment  plasticity Index. décimale : PER Périodiques Résumé : Background Delayed, abnormal language is a common feature of autism and language therapy often a significant component of recommended treatment. However, as with other disorders with a language component, we know surprisingly little about the language trajectories and how varied these might be across different children. Thus, we know little about how and when language problems might resolve, whether there are periods of relative stability or lack of change and what periods might offer more favourable circumstances for intervention. Methods Expressive and receptive language was measured on six occasions between age 2 and 19 on a cohort of 192 children initially referred for autism. Latent class growth models were fitted to characterize the patterns of heterogeneous development. Results Latent class growth analysis identified seven classes. Between age 6 and 19, all classes tracked in parallel. Between ages 2 and 6, development was more heterogeneous with considerable variation in relative progress. In all groups, receptive and expressive language developed very largely in tandem. Conclusions The results confirmed previous analysis of children with specific language impairment where progress beyond age 6 was remarkably uniform. Greater variation was evident before this age with some groups making clearly better or worse progress compared to others. While this developmental heterogeneity may simply be a reflection of variation in preexisting and unchanging biological disposition, it may also reflect, at least in part, greater sensitivity in the early years to environments that are more or less supportive of language development. These findings contribute to the case for the importance of early intervention. En ligne : http://dx.doi.org/10.1111/jcpp.12269 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Measuring the Plasticity of Social Approach: A Randomized Controlled Trial of the Effects of the PEERS Intervention on EEG Asymmetry in Adolescents with Autism Spectrum Disorders / Amy Vaughan VAN HECKE in Journal of Autism and Developmental Disorders, 45-2 (February 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.316-335 Titre : Measuring the Plasticity of Social Approach: A Randomized Controlled Trial of the Effects of the PEERS Intervention on EEG Asymmetry in Adolescents with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Amy Vaughan VAN HECKE, Auteur ; Sheryl STEVENS, Auteur ; Audrey M. CARSON, Auteur ; Jeffrey S. KARST, Auteur ; Bridget DOLAN, Auteur ; Kirsten SCHOHL, Auteur ; Ryan J. MCKINDLES, Auteur ; Rheanna REMMEL, Auteur ; Scott BROCKMAN, Auteur Article en page(s) : p.316-335 Langues : Anglais (eng) Mots-clés : Autism  Adolescence  EEG  Asymmetry  PEERS  Intervention  Brain  Plasticity Index. décimale : PER Périodiques Résumé : This study examined whether the Program for the Education and Enrichment of Relational Skills (PEERS: Social skills for teenagers with developmental and autism spectrum disorders: The PEERS treatment manual, Routledge, New York, 2010a) affected neural function, via EEG asymmetry, in a randomized controlled trial of adolescents with Autism spectrum disorders (ASD) and a group of typically developing adolescents. Adolescents with ASD in PEERS shifted from right-hemisphere gamma-band EEG asymmetry before PEERS to left-hemisphere EEG asymmetry after PEERS, versus a waitlist ASD group. Left-hemisphere EEG asymmetry was associated with more social contacts and knowledge, and fewer symptoms of autism. Adolescents with ASD in PEERS no longer differed from typically developing adolescents in left-dominant EEG asymmetry at post-test. These findings are discussed via the Modifier Model of Autism (Mundy et al. in Res Pract Persons Severe Disabl 32(2):124, 2007), with emphasis on remediating isolation/withdrawal in ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1883-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Measuring the Plasticity of Social Approach: A Randomized Controlled Trial of the Effects of the PEERS Intervention on EEG Asymmetry in Adolescents with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Amy Vaughan VAN HECKE, Auteur ; Sheryl STEVENS, Auteur ; Audrey M. CARSON, Auteur ; Jeffrey S. KARST, Auteur ; Bridget DOLAN, Auteur ; Kirsten SCHOHL, Auteur ; Ryan J. MCKINDLES, Auteur ; Rheanna REMMEL, Auteur ; Scott BROCKMAN, Auteur . - p.316-335. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.316-335 Mots-clés : Autism  Adolescence  EEG  Asymmetry  PEERS  Intervention  Brain  Plasticity Index. décimale : PER Périodiques Résumé : This study examined whether the Program for the Education and Enrichment of Relational Skills (PEERS: Social skills for teenagers with developmental and autism spectrum disorders: The PEERS treatment manual, Routledge, New York, 2010a) affected neural function, via EEG asymmetry, in a randomized controlled trial of adolescents with Autism spectrum disorders (ASD) and a group of typically developing adolescents. Adolescents with ASD in PEERS shifted from right-hemisphere gamma-band EEG asymmetry before PEERS to left-hemisphere EEG asymmetry after PEERS, versus a waitlist ASD group. Left-hemisphere EEG asymmetry was associated with more social contacts and knowledge, and fewer symptoms of autism. Adolescents with ASD in PEERS no longer differed from typically developing adolescents in left-dominant EEG asymmetry at post-test. These findings are discussed via the Modifier Model of Autism (Mundy et al. in Res Pract Persons Severe Disabl 32(2):124, 2007), with emphasis on remediating isolation/withdrawal in ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1883-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Oxytocin-induced increase in N,N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms / Y. KATO in Molecular Autism, 12 (2021)  

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Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype and stressful life events interact to predict preschool-onset depression: a replication and developmental extension / Ryan BOGDAN in Journal of Child Psychology and Psychiatry, 55-5 (May 2014)  

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Atypical rapid audio-visual temporal recalibration in autism spectrum disorders / Jean-Paul NOEL in Autism Research, 10-1 (January 2017)  

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Vagus nerve stimulation as a potential adjuvant to behavioral therapy for autism and other neurodevelopmental disorders / C. T. ENGINEER in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

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Wnt signaling networks in autism spectrum disorder and intellectual disability / V. KWAN in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

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