Brief Report: An Open-Label Study of the Neurosteroid Pregnenolone in Adults with Autism Spectrum Disorder / Lawrence K. FUNG in Journal of Autism and Developmental Disorders, 44-11 (November 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2971-2977 Titre : Brief Report: An Open-Label Study of the Neurosteroid Pregnenolone in Adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence K. FUNG, Auteur ; Robin A. LIBOVE, Auteur ; Jennifer PHILLIPS, Auteur ; Francois HADDAD, Auteur ; Antonio Y. HARDAN, Auteur Article en page(s) : p.2971-2977 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Pregnenolone  Neurosteroids  Irritability  Open-label trial Index. décimale : PER Périodiques Résumé : The objective of this study was to assess the tolerability and efficacy of pregnenolone in reducing irritability in adults with autism spectrum disorder (ASD). This was a pilot, open-label, 12-week trial that included twelve subjects with a mean age of 22.5 ± 5.8 years. Two participants dropped out of the study due to reasons unrelated to adverse effects. Pregnenolone yielded a statistically significant improvement in the primary measure, Aberrant Behavior Checklist (ABC)-Irritability [from 17.4 ± 7.4 at baseline to 11.2 ± 7.0 at 12 weeks (p = 0.028)]. Secondary measures were not statistically significant with the exception of ABC-lethargy (p = 0.046) and total Short Sensory Profile score (p = 0.009). No significant vital sign changes occurred during this study. Pregnenolone was not associated with any severe side effects. Single episodes of tiredness, diarrhea and depressive affect that could be related to pregnenolone were reported. Overall, pregnenolone was modestly effective and well-tolerated in individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2144-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Brief Report: An Open-Label Study of the Neurosteroid Pregnenolone in Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Lawrence K. FUNG, Auteur ; Robin A. LIBOVE, Auteur ; Jennifer PHILLIPS, Auteur ; Francois HADDAD, Auteur ; Antonio Y. HARDAN, Auteur . - p.2971-2977. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2971-2977 Mots-clés : Autism spectrum disorder  Pregnenolone  Neurosteroids  Irritability  Open-label trial Index. décimale : PER Périodiques Résumé : The objective of this study was to assess the tolerability and efficacy of pregnenolone in reducing irritability in adults with autism spectrum disorder (ASD). This was a pilot, open-label, 12-week trial that included twelve subjects with a mean age of 22.5 ± 5.8 years. Two participants dropped out of the study due to reasons unrelated to adverse effects. Pregnenolone yielded a statistically significant improvement in the primary measure, Aberrant Behavior Checklist (ABC)-Irritability [from 17.4 ± 7.4 at baseline to 11.2 ± 7.0 at 12 weeks (p = 0.028)]. Secondary measures were not statistically significant with the exception of ABC-lethargy (p = 0.046) and total Short Sensory Profile score (p = 0.009). No significant vital sign changes occurred during this study. Pregnenolone was not associated with any severe side effects. Single episodes of tiredness, diarrhea and depressive affect that could be related to pregnenolone were reported. Overall, pregnenolone was modestly effective and well-tolerated in individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2144-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Corpus callosum and autism / Lawrence K. FUNG

Public ISBD in Autism imaging and Devices / Manuel F. CASANOVA Titre : Corpus callosum and autism Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence K. FUNG, Auteur ; Antonio HARDAN, Auteur Importance : p.157-170 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382 in Autism imaging and Devices / Manuel F. CASANOVA Corpus callosum and autism [Texte imprimé et/ou numérique] / Lawrence K. FUNG, Auteur ; Antonio HARDAN, Auteur . - [s.d.] . - p.157-170. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382

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Fatal Shooting of an Autistic Adolescent: What Should We Do? / Kyle LANE-MCKINLEY in Journal of Autism and Developmental Disorders, 54-12 (December 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-12 (December 2024) . - p.4757-4760 Titre : Fatal Shooting of an Autistic Adolescent: What Should We Do? Type de document : Texte imprimé et/ou numérique Auteurs : Kyle LANE-MCKINLEY, Auteur ; Justin HOGG, Auteur ; Lawrence K. FUNG, Auteur Article en page(s) : p.4757-4760 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Ryan Gainer, a 15-year-old African-American youth on the Autism-spectrum, was shot and killed by police officers in March 2024. The authors reflect on the tragedy of this incident and the harms that such police actions inflict on people living with disabilities and/or mental illnesses, as well as on their families, loved ones, and communities. Drawing on past research and similar incidents in recent years, the authors offer a series of systematic changes which may be effective in reducing the frequency and severity of police use of force on people on the autism spectrum. En ligne : https://doi.org/10.1007/s10803-024-06558-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=540 [article] Fatal Shooting of an Autistic Adolescent: What Should We Do? [Texte imprimé et/ou numérique] / Kyle LANE-MCKINLEY, Auteur ; Justin HOGG, Auteur ; Lawrence K. FUNG, Auteur . - p.4757-4760. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-12 (December 2024) . - p.4757-4760 Index. décimale : PER Périodiques Résumé : Ryan Gainer, a 15-year-old African-American youth on the Autism-spectrum, was shot and killed by police officers in March 2024. The authors reflect on the tragedy of this incident and the harms that such police actions inflict on people living with disabilities and/or mental illnesses, as well as on their families, loved ones, and communities. Drawing on past research and similar incidents in recent years, the authors offer a series of systematic changes which may be effective in reducing the frequency and severity of police use of force on people on the autism spectrum. En ligne : https://doi.org/10.1007/s10803-024-06558-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=540

Region-specific associations between gamma-aminobutyric acid A receptor binding and cortical thickness in high-functioning autistic adults / David JAMES in Autism Research, 15-6 (June 2022)  

Public ISBD [article]  inAutism Research > 15-6 (June 2022) . - p.1068-1082 Titre : Region-specific associations between gamma-aminobutyric acid A receptor binding and cortical thickness in high-functioning autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : David JAMES, Auteur ; Vicky T. LAM, Auteur ; Booil JO, Auteur ; Lawrence K. FUNG, Auteur Article en page(s) : p.1068-1082 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder/diagnostic imaging/pathology  Brain/pathology  Brain Mapping/methods  Female  Humans  Magnetic Resonance Imaging/methods  Male  gamma-Aminobutyric Acid  GABAA receptor density  autism  cortical thickness  postcentral gyrus Index. décimale : PER Périodiques Résumé : The neurobiology of autism has been shown to involve alterations in cortical morphology and gamma-aminobutyric acid A (GABA(A) ) receptor density. We hypothesized that GABA(A) receptor binding potential (GABA(A) R BP(ND) ) would correlate with cortical thickness, but their correlations would differ between autistic adults and typically developing (TD) controls. We studied 50 adults (23 autism, 27 TD, mean age of 27?years) using magnetic resonance imaging to measure cortical thickness, and [(18) F]flumazenil positron emission tomography imaging to measure GABA(A) R BP(ND) . We determined the correlations between cortical thickness and GABA(A) R BP(ND) by cortical lobe, region-of-interest, and diagnosis of autism spectrum disorder (ASD). We also explored potential sex differences in the relationship between cortical thickness and autism characteristics, as measured by autism spectrum quotient (AQ) scores. Comparing autism and TD groups, no significant differences were found in cortical thickness or GABA(A) R BP(ND) . In both autism and TD groups, a negative relationship between cortical thickness and GABA(A) R BP(ND) was observed in the frontal and occipital cortices, but no relationship was found in the temporal or limbic cortices. A positive correlation was seen in the parietal cortex that was only significant for the autism group. Interestingly, in an exploratory analysis, we found sex differences in the relationships between cortical thickness and GABA(A) R BP(ND) , and cortical thickness and AQ scores in the left postcentral gyrus. LAY SUMMARY: The thickness of the brain cortex and the density of the receptors associated with inhibitory neurotransmitter GABA have been hypothesized to underlie the neurobiology of autism. In this study, we found that these biomarkers correlate positively in the parietal cortex, but negatively in the frontal and occipital cortical regions of the brain. Furthermore, we collected preliminary evidence that the correlations between cortical thickness and GABA receptor density are sexdependent in a brain region where sensory inputs are registered. En ligne : http://dx.doi.org/10.1002/aur.2703 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Region-specific associations between gamma-aminobutyric acid A receptor binding and cortical thickness in high-functioning autistic adults [Texte imprimé et/ou numérique] / David JAMES, Auteur ; Vicky T. LAM, Auteur ; Booil JO, Auteur ; Lawrence K. FUNG, Auteur . - p.1068-1082. Langues : Anglais (eng) in Autism Research > 15-6 (June 2022) . - p.1068-1082 Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder/diagnostic imaging/pathology  Brain/pathology  Brain Mapping/methods  Female  Humans  Magnetic Resonance Imaging/methods  Male  gamma-Aminobutyric Acid  GABAA receptor density  autism  cortical thickness  postcentral gyrus Index. décimale : PER Périodiques Résumé : The neurobiology of autism has been shown to involve alterations in cortical morphology and gamma-aminobutyric acid A (GABA(A) ) receptor density. We hypothesized that GABA(A) receptor binding potential (GABA(A) R BP(ND) ) would correlate with cortical thickness, but their correlations would differ between autistic adults and typically developing (TD) controls. We studied 50 adults (23 autism, 27 TD, mean age of 27?years) using magnetic resonance imaging to measure cortical thickness, and [(18) F]flumazenil positron emission tomography imaging to measure GABA(A) R BP(ND) . We determined the correlations between cortical thickness and GABA(A) R BP(ND) by cortical lobe, region-of-interest, and diagnosis of autism spectrum disorder (ASD). We also explored potential sex differences in the relationship between cortical thickness and autism characteristics, as measured by autism spectrum quotient (AQ) scores. Comparing autism and TD groups, no significant differences were found in cortical thickness or GABA(A) R BP(ND) . In both autism and TD groups, a negative relationship between cortical thickness and GABA(A) R BP(ND) was observed in the frontal and occipital cortices, but no relationship was found in the temporal or limbic cortices. A positive correlation was seen in the parietal cortex that was only significant for the autism group. Interestingly, in an exploratory analysis, we found sex differences in the relationships between cortical thickness and GABA(A) R BP(ND) , and cortical thickness and AQ scores in the left postcentral gyrus. LAY SUMMARY: The thickness of the brain cortex and the density of the receptors associated with inhibitory neurotransmitter GABA have been hypothesized to underlie the neurobiology of autism. In this study, we found that these biomarkers correlate positively in the parietal cortex, but negatively in the frontal and occipital cortical regions of the brain. Furthermore, we collected preliminary evidence that the correlations between cortical thickness and GABA receptor density are sexdependent in a brain region where sensory inputs are registered. En ligne : http://dx.doi.org/10.1002/aur.2703 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

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