Interpersonal violence moderates sustained-transient threat co-activation in the vmPFC and amygdala in a community sample of youth / Jane E. JOSEPH ; Zachary W. ADAMS ; Kathleen I. CRUM ; Christopher T. SEGE ; Lisa M. MCTEAGUE ; Greg HAJCAK ; Colleen A. HALLIDAY ; Carla Kmett DANIELSON in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.2151-2160 Titre : Interpersonal violence moderates sustained-transient threat co-activation in the vmPFC and amygdala in a community sample of youth Type de document : texte imprimé Auteurs : Jane E. JOSEPH, Auteur ; Zachary W. ADAMS, Auteur ; Kathleen I. CRUM, Auteur ; Christopher T. SEGE, Auteur ; Lisa M. MCTEAGUE, Auteur ; Greg HAJCAK, Auteur ; Colleen A. HALLIDAY, Auteur ; Carla Kmett DANIELSON, Auteur Article en page(s) : p.2151-2160 Langues : Anglais (eng) Mots-clés : Childhood adversity  RdoC  threat processing Index. décimale : PER Périodiques Résumé : The increased risk for psychopathology associated with interpersonal violence exposure (IPV, e.g., physical abuse, sexual assault) is partially mediated by neurobiological alterations in threat-related processes. Evidence supports parsing neural circuitry related to transient and sustained threat, as they appear to be separable processes with distinct neurobiological underpinnings. Although childhood is a sensitive period for neurodevelopment, most prior work has been conducted in adult samples. Further, it is unknown how IPV exposure may impact transient-sustained threat neural interactions. The current study tested the moderating role of IPV exposure on sustained vmPFC-transient amygdala co-activation during an fMRI task during which threat and neutral cues were predictably or unpredictably presented. Analyses were conducted in a sample of 212 community-recruited youth (M/SDage = 11.77/2.44 years old; 51.9% male; 56.1% White/Caucasian). IPV-exposed youth evidenced a positive sustained vmPFC-transient amygdala co-activation, while youth with no IPV exposure did not show this association. Consistent with theoretical models, effects were specific to unpredictable, negative trials and to exposure to IPV (i.e., unrelated to non-IPV traumatic experiences). Although preliminary, these findings provide novel insight into how childhood IPV exposure may alter neural circuity involved in specific facets of threat processing. En ligne : https://dx.doi.org/10.1017/S0954579424001743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Interpersonal violence moderates sustained-transient threat co-activation in the vmPFC and amygdala in a community sample of youth [texte imprimé] / Jane E. JOSEPH, Auteur ; Zachary W. ADAMS, Auteur ; Kathleen I. CRUM, Auteur ; Christopher T. SEGE, Auteur ; Lisa M. MCTEAGUE, Auteur ; Greg HAJCAK, Auteur ; Colleen A. HALLIDAY, Auteur ; Carla Kmett DANIELSON, Auteur . - p.2151-2160. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.2151-2160 Mots-clés : Childhood adversity  RdoC  threat processing Index. décimale : PER Périodiques Résumé : The increased risk for psychopathology associated with interpersonal violence exposure (IPV, e.g., physical abuse, sexual assault) is partially mediated by neurobiological alterations in threat-related processes. Evidence supports parsing neural circuitry related to transient and sustained threat, as they appear to be separable processes with distinct neurobiological underpinnings. Although childhood is a sensitive period for neurodevelopment, most prior work has been conducted in adult samples. Further, it is unknown how IPV exposure may impact transient-sustained threat neural interactions. The current study tested the moderating role of IPV exposure on sustained vmPFC-transient amygdala co-activation during an fMRI task during which threat and neutral cues were predictably or unpredictably presented. Analyses were conducted in a sample of 212 community-recruited youth (M/SDage = 11.77/2.44 years old; 51.9% male; 56.1% White/Caucasian). IPV-exposed youth evidenced a positive sustained vmPFC-transient amygdala co-activation, while youth with no IPV exposure did not show this association. Consistent with theoretical models, effects were specific to unpredictable, negative trials and to exposure to IPV (i.e., unrelated to non-IPV traumatic experiences). Although preliminary, these findings provide novel insight into how childhood IPV exposure may alter neural circuity involved in specific facets of threat processing. En ligne : https://dx.doi.org/10.1017/S0954579424001743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

Treatment of Adults with Autism and Major Depressive Disorder Using Transcranial Magnetic Stimulation: An Open Label Pilot Study / McLeod Frampton GWYNETTE in Autism Research, 13-3 (March 2020)  

Public ISBD [article]  inAutism Research > 13-3 (March 2020) . - p.346-351 Titre : Treatment of Adults with Autism and Major Depressive Disorder Using Transcranial Magnetic Stimulation: An Open Label Pilot Study Type de document : texte imprimé Auteurs : McLeod Frampton GWYNETTE, Auteur ; Danielle W. LOWE, Auteur ; Erin A. HENNEBERRY, Auteur ; Gregory L. SAHLEM, Auteur ; Melanie Gail WILEY, Auteur ; Hussam ALSARRAF, Auteur ; Sarah Brice RUSSO, Auteur ; Jane E. JOSEPH, Auteur ; Philipp M. SUMMERS, Auteur ; Laura LOHNES, Auteur ; Mark S. GEORGE, Auteur Article en page(s) : p.346-351 Langues : Anglais (eng) Mots-clés : adults with autism spectrum disorder  autism spectrum disorder  major depressive disorder  mood  psychiatric comorbidity  transcranial stimulation  treatment research Index. décimale : PER Périodiques Résumé : Patients with autism spectrum disorder (ASD) are at high risk for comorbid major depressive disorder (MDD), which can severely impair functioning and quality of life. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique, which is Food and Drug Administration (FDA) cleared for the treatment of MDD in adults. Despite demonstrated efficacy in the treatment of depression, there are limited data on the use of rTMS in patients with ASD and comorbid MDD. We hypothesized that a standard rTMS protocol for MDD would reduce depressive symptoms for adults with ASD and MDD. Secondarily, we investigated whether this treatment would also reduce core ASD symptoms. Participants of 18-65 years old with ASD and MDD without any medication changes in the last month were eligible for this open-label trial. Participants underwent 25 sessions of rTMS (figure-of-eight coil, 100-120% resting motor threshold, 10 Hz, 3,000 pulses per session) applied to the left dorsolateral prefrontal cortex. Thirteen participants enrolled in the study, with two withdrawing due to tolerability, and one excluded from analysis. Overall, side effects were mild and rTMS was well tolerated. The Hamilton rating scale for depression (HAM-D17 ) improved 13.5 points (IQR 5-15), and 40% of participants achieved remission (HAM-D17 En ligne : http://dx.doi.org/10.1002/aur.2266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] Treatment of Adults with Autism and Major Depressive Disorder Using Transcranial Magnetic Stimulation: An Open Label Pilot Study [texte imprimé] / McLeod Frampton GWYNETTE, Auteur ; Danielle W. LOWE, Auteur ; Erin A. HENNEBERRY, Auteur ; Gregory L. SAHLEM, Auteur ; Melanie Gail WILEY, Auteur ; Hussam ALSARRAF, Auteur ; Sarah Brice RUSSO, Auteur ; Jane E. JOSEPH, Auteur ; Philipp M. SUMMERS, Auteur ; Laura LOHNES, Auteur ; Mark S. GEORGE, Auteur . - p.346-351. Langues : Anglais (eng) in Autism Research > 13-3 (March 2020) . - p.346-351 Mots-clés : adults with autism spectrum disorder  autism spectrum disorder  major depressive disorder  mood  psychiatric comorbidity  transcranial stimulation  treatment research Index. décimale : PER Périodiques Résumé : Patients with autism spectrum disorder (ASD) are at high risk for comorbid major depressive disorder (MDD), which can severely impair functioning and quality of life. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique, which is Food and Drug Administration (FDA) cleared for the treatment of MDD in adults. Despite demonstrated efficacy in the treatment of depression, there are limited data on the use of rTMS in patients with ASD and comorbid MDD. We hypothesized that a standard rTMS protocol for MDD would reduce depressive symptoms for adults with ASD and MDD. Secondarily, we investigated whether this treatment would also reduce core ASD symptoms. Participants of 18-65 years old with ASD and MDD without any medication changes in the last month were eligible for this open-label trial. Participants underwent 25 sessions of rTMS (figure-of-eight coil, 100-120% resting motor threshold, 10 Hz, 3,000 pulses per session) applied to the left dorsolateral prefrontal cortex. Thirteen participants enrolled in the study, with two withdrawing due to tolerability, and one excluded from analysis. Overall, side effects were mild and rTMS was well tolerated. The Hamilton rating scale for depression (HAM-D17 ) improved 13.5 points (IQR 5-15), and 40% of participants achieved remission (HAM-D17 En ligne : http://dx.doi.org/10.1002/aur.2266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Typical and Atypical Neurodevelopment for Face Specialization: An fMRI Study / Jane E. JOSEPH in Journal of Autism and Developmental Disorders, 45-6 (June 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1725-1741 Titre : Typical and Atypical Neurodevelopment for Face Specialization: An fMRI Study Type de document : texte imprimé Auteurs : Jane E. JOSEPH, Auteur ; Xun ZHU, Auteur ; Andrew GUNDRAN, Auteur ; Faraday DAVIES, Auteur ; Jonathan D. CLARK, Auteur ; Lisa A. RUBLE, Auteur ; Paul GLASER, Auteur ; Ramesh S. BHATT, Auteur Article en page(s) : p.1725-1741 Langues : Anglais (eng) Mots-clés : Face processing  Typical development  Autism spectrum disorder  Undiagnosed siblings  fMRI Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) and their relatives process faces differently from typically developed (TD) individuals. In an fMRI face-viewing task, TD and undiagnosed sibling (SIB) children (5–18 years) showed face specialization in the right amygdala and ventromedial prefrontal cortex, with left fusiform and right amygdala face specialization increasing with age in TD subjects. SIBs showed extensive antero-medial temporal lobe activation for faces that was not present in any other group, suggesting a potential compensatory mechanism. In ASD, face specialization was minimal but increased with age in the right fusiform and decreased with age in the left amygdala, suggesting atypical development of a frontal–amygdala–fusiform system which is strongly linked to detecting salience and processing facial information. En ligne : http://dx.doi.org/10.1007/s10803-014-2330-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Typical and Atypical Neurodevelopment for Face Specialization: An fMRI Study [texte imprimé] / Jane E. JOSEPH, Auteur ; Xun ZHU, Auteur ; Andrew GUNDRAN, Auteur ; Faraday DAVIES, Auteur ; Jonathan D. CLARK, Auteur ; Lisa A. RUBLE, Auteur ; Paul GLASER, Auteur ; Ramesh S. BHATT, Auteur . - p.1725-1741. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1725-1741 Mots-clés : Face processing  Typical development  Autism spectrum disorder  Undiagnosed siblings  fMRI Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) and their relatives process faces differently from typically developed (TD) individuals. In an fMRI face-viewing task, TD and undiagnosed sibling (SIB) children (5–18 years) showed face specialization in the right amygdala and ventromedial prefrontal cortex, with left fusiform and right amygdala face specialization increasing with age in TD subjects. SIBs showed extensive antero-medial temporal lobe activation for faces that was not present in any other group, suggesting a potential compensatory mechanism. In ASD, face specialization was minimal but increased with age in the right fusiform and decreased with age in the left amygdala, suggesting atypical development of a frontal–amygdala–fusiform system which is strongly linked to detecting salience and processing facial information. En ligne : http://dx.doi.org/10.1007/s10803-014-2330-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

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