Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes / Li CHEN in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.137-150 Titre : Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes Type de document : texte imprimé Auteurs : Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur Article en page(s) : p.137-150 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes [texte imprimé] / Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur . - p.137-150. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.137-150 Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Early language ability and depressive symptoms in preadolescence: Sex-specific mediating effects of self-concept domains / Sharon TING in Development and Psychopathology, 38-3 (August 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-3 (August 2026) . - p.1468-1483 Titre : Early language ability and depressive symptoms in preadolescence: Sex-specific mediating effects of self-concept domains Type de document : texte imprimé Auteurs : Sharon TING, Auteur ; Germaine Y. Q. TNG, Auteur ; Pei HUANG, Auteur ; Jordan LEGASPI, Auteur ; Helen CHEN, Auteur ; Johan Gunnar ERIKSSON, Auteur ; Yap Seng CHONG, Auteur ; Henning TIEMEIER, Auteur ; Peipei SETOH, Auteur Article en page(s) : p.1468-1483 Langues : Anglais (eng) Mots-clés : depressive symptoms  language ability  longitudinal research  mediation  self-concept Index. décimale : PER Périodiques Résumé : Poorer language ability is a known risk factor for elevated depressive symptoms. However, the cognitive mechanisms underlying this association remain underexplored. Utilizing data from a comprehensive pre-birth cohort in Singapore (N = 473; 49.9% boys; 57.3% Chinese, 27.9% Malay, 14.8% Indian), the present study examined whether (i) self-concept domains mediate the association between early language ability and depressive symptoms during preadolescence, and (ii) these indirect pathways differ by child sex. Children’s early language ability was assessed at ages 2 and 4 using standardized assessments of vocabulary and phonological processing. Self-concept and depressive symptoms were measured at ages 8.5 and 10, respectively. Results indicated that the domain of behavioral adjustment mediated the relationship between early language ability and subsequent depressive symptoms for girls (β = −0.07, 95% CI [−0.15, −0.01]), whereas happiness and satisfaction served as a key mediator for boys (β = −0.12, 95% CI [−0.24, −0.03]). After accounting for these mediators, there was no direct association between early language ability and depressive symptoms. These findings highlight potential sex-specific mechanisms through which early language ability is prospectively associated with depressive symptoms. Future research is necessary to determine whether enhancing self-concept can mitigate depressive symptoms in children with early language difficulties. En ligne : https://dx.doi.org/10.1017/S0954579426101308 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] Early language ability and depressive symptoms in preadolescence: Sex-specific mediating effects of self-concept domains [texte imprimé] / Sharon TING, Auteur ; Germaine Y. Q. TNG, Auteur ; Pei HUANG, Auteur ; Jordan LEGASPI, Auteur ; Helen CHEN, Auteur ; Johan Gunnar ERIKSSON, Auteur ; Yap Seng CHONG, Auteur ; Henning TIEMEIER, Auteur ; Peipei SETOH, Auteur . - p.1468-1483. Langues : Anglais (eng) in Development and Psychopathology > 38-3 (August 2026) . - p.1468-1483 Mots-clés : depressive symptoms  language ability  longitudinal research  mediation  self-concept Index. décimale : PER Périodiques Résumé : Poorer language ability is a known risk factor for elevated depressive symptoms. However, the cognitive mechanisms underlying this association remain underexplored. Utilizing data from a comprehensive pre-birth cohort in Singapore (N = 473; 49.9% boys; 57.3% Chinese, 27.9% Malay, 14.8% Indian), the present study examined whether (i) self-concept domains mediate the association between early language ability and depressive symptoms during preadolescence, and (ii) these indirect pathways differ by child sex. Children’s early language ability was assessed at ages 2 and 4 using standardized assessments of vocabulary and phonological processing. Self-concept and depressive symptoms were measured at ages 8.5 and 10, respectively. Results indicated that the domain of behavioral adjustment mediated the relationship between early language ability and subsequent depressive symptoms for girls (β = −0.07, 95% CI [−0.15, −0.01]), whereas happiness and satisfaction served as a key mediator for boys (β = −0.12, 95% CI [−0.24, −0.03]). After accounting for these mediators, there was no direct association between early language ability and depressive symptoms. These findings highlight potential sex-specific mechanisms through which early language ability is prospectively associated with depressive symptoms. Future research is necessary to determine whether enhancing self-concept can mitigate depressive symptoms in children with early language difficulties. En ligne : https://dx.doi.org/10.1017/S0954579426101308 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways / Jessica P. UY in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.426-436 Titre : Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways Type de document : texte imprimé Auteurs : Jessica P. UY, Auteur ; Ai Peng TAN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Peter D. GLUCKMAN, Auteur ; Yap Seng CHONG, Auteur ; Helen CHEN, Auteur ; Marielle V. FORTIER, Auteur ; Michael J. MEANEY, Auteur ; Bridget L. CALLAGHAN, Auteur Article en page(s) : p.426-436 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. Methods The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418). Results Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes. Conclusions Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences. En ligne : https://doi.org/10.1111/jcpp.13721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways [texte imprimé] / Jessica P. UY, Auteur ; Ai Peng TAN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Peter D. GLUCKMAN, Auteur ; Yap Seng CHONG, Auteur ; Helen CHEN, Auteur ; Marielle V. FORTIER, Auteur ; Michael J. MEANEY, Auteur ; Bridget L. CALLAGHAN, Auteur . - p.426-436. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.426-436 Index. décimale : PER Périodiques Résumé : Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. Methods The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418). Results Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes. Conclusions Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences. En ligne : https://doi.org/10.1111/jcpp.13721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Maternal mood entropy and children’s hippocampal development: Enduring versus transient effects / Katherine E. JENNINGS in Development and Psychopathology, 38-3 (August 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-3 (August 2026) . - p.1454-1467 Titre : Maternal mood entropy and children’s hippocampal development: Enduring versus transient effects Type de document : texte imprimé Auteurs : Katherine E. JENNINGS, Auteur ; Daniela G. JUAREZ, Auteur ; Jessica P. UY, Auteur ; Jessica L. BUTHMANN, Auteur ; Yap Seng CHONG, Auteur ; Peter D. GLUCKMAN, Auteur ; Johan G. ERIKSSON, Auteur ; Marielle V. FORTIER, Auteur ; Helen CHEN, Auteur ; Michael J. MEANEY, Auteur ; Ai Peng TAN, Auteur ; Ian H. GOTLIB, Auteur ; Jonas G. MILLER, Auteur Article en page(s) : p.1454-1467 Langues : Anglais (eng) Mots-clés : biological embedding  enduring effects  hippocampus  maternal mood  revisionist effects Index. décimale : PER Périodiques Résumé : Recent research suggests that maternal mood entropy, a novel measure of mood dysfunction, is associated with child outcomes. However, the link between maternal mood entropy and children’s structural brain development, and how this association may change across childhood, remains unclear. In a longitudinal study with neuroimaging data collected at ages 4.5, 6, 7.5, and 10.5 years (n = 1,498; n = 674 with neuroimaging), we examined whether maternal mood entropy is associated with children’s hippocampal and amygdala volumes over time. Mothers reported on negative mood symptoms at several assessments between ages 3 months and 4.5 years. We calculated maternal mood levels as the sum of mood symptoms and computed maternal mood entropy by applying Shannon’s entropy to the distributions of mood questionnaire responses. Maternal mood measures were not associated with amygdala volumes; however, mood entropy was directly associated with smaller hippocampal volumes at age 4.5 years and indirectly associated with smaller hippocampal volumes at 10.5 years through rank-order stability over time. These effects were present beyond the effects of socioeconomic status and intracranial volume and were specific to mood entropy, not mood levels. Our findings indicate that patterns of maternal mood are embedded in early childhood brain structure, setting the stage for subsequent neurodevelopment. En ligne : https://dx.doi.org/10.1017/S0954579426101291 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] Maternal mood entropy and children’s hippocampal development: Enduring versus transient effects [texte imprimé] / Katherine E. JENNINGS, Auteur ; Daniela G. JUAREZ, Auteur ; Jessica P. UY, Auteur ; Jessica L. BUTHMANN, Auteur ; Yap Seng CHONG, Auteur ; Peter D. GLUCKMAN, Auteur ; Johan G. ERIKSSON, Auteur ; Marielle V. FORTIER, Auteur ; Helen CHEN, Auteur ; Michael J. MEANEY, Auteur ; Ai Peng TAN, Auteur ; Ian H. GOTLIB, Auteur ; Jonas G. MILLER, Auteur . - p.1454-1467. Langues : Anglais (eng) in Development and Psychopathology > 38-3 (August 2026) . - p.1454-1467 Mots-clés : biological embedding  enduring effects  hippocampus  maternal mood  revisionist effects Index. décimale : PER Périodiques Résumé : Recent research suggests that maternal mood entropy, a novel measure of mood dysfunction, is associated with child outcomes. However, the link between maternal mood entropy and children’s structural brain development, and how this association may change across childhood, remains unclear. In a longitudinal study with neuroimaging data collected at ages 4.5, 6, 7.5, and 10.5 years (n = 1,498; n = 674 with neuroimaging), we examined whether maternal mood entropy is associated with children’s hippocampal and amygdala volumes over time. Mothers reported on negative mood symptoms at several assessments between ages 3 months and 4.5 years. We calculated maternal mood levels as the sum of mood symptoms and computed maternal mood entropy by applying Shannon’s entropy to the distributions of mood questionnaire responses. Maternal mood measures were not associated with amygdala volumes; however, mood entropy was directly associated with smaller hippocampal volumes at age 4.5 years and indirectly associated with smaller hippocampal volumes at 10.5 years through rank-order stability over time. These effects were present beyond the effects of socioeconomic status and intracranial volume and were specific to mood entropy, not mood levels. Our findings indicate that patterns of maternal mood are embedded in early childhood brain structure, setting the stage for subsequent neurodevelopment. En ligne : https://dx.doi.org/10.1017/S0954579426101291 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study / Desiree Y. PHUA in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1573-1587 Titre : Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study Type de document : texte imprimé Auteurs : Desiree Y. PHUA, Auteur ; Michelle K.Z.L. KEE, Auteur ; Dawn X.P. KOH, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Mary DANIELS, Auteur ; Helen CHEN, Auteur ; Yap Seng CHONG, Auteur ; Birit F.P. BROEKMAN, Auteur ; Iliana MAGIATI, Auteur ; Neerja KARNANI, Auteur ; Michael PLUESS, Auteur ; Michael J. MEANEY, Auteur Article en page(s) : p.1573-1587 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The quality of prenatal maternal mental health, from psychological stress and depressive symptoms to anxiety and other nonpsychotic mental disorders, profoundly affects fetal neurodevelopment. Despite the evidence for the influence of positive mental well-being on health, there is, to our knowledge, no research examining the possible effects of positive antenatal mental health on the development of the offspring. Using exploratory bifactor analysis, this prospective study (n = 1,066) demonstrated the feasibility of using common psychiatric screening tools to examine the effect of positive maternal mental health. Antenatal mental health was assessed during 26th week of pregnancy. The effects on offspring were assessed when the child was 12, 18, and 24 months old. Results showed that positive antenatal mental health was uniquely associated with the offspring's cognitive, language and parentally rated competences. This study shows that the effects of positive maternal mental health are likely to be specific and distinct from the sheer absence of symptoms of depression or anxiety. En ligne : http://dx.doi.org/10.1017/S0954579417001249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study [texte imprimé] / Desiree Y. PHUA, Auteur ; Michelle K.Z.L. KEE, Auteur ; Dawn X.P. KOH, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Mary DANIELS, Auteur ; Helen CHEN, Auteur ; Yap Seng CHONG, Auteur ; Birit F.P. BROEKMAN, Auteur ; Iliana MAGIATI, Auteur ; Neerja KARNANI, Auteur ; Michael PLUESS, Auteur ; Michael J. MEANEY, Auteur . - p.1573-1587. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1573-1587 Index. décimale : PER Périodiques Résumé : The quality of prenatal maternal mental health, from psychological stress and depressive symptoms to anxiety and other nonpsychotic mental disorders, profoundly affects fetal neurodevelopment. Despite the evidence for the influence of positive mental well-being on health, there is, to our knowledge, no research examining the possible effects of positive antenatal mental health on the development of the offspring. Using exploratory bifactor analysis, this prospective study (n = 1,066) demonstrated the feasibility of using common psychiatric screening tools to examine the effect of positive maternal mental health. Antenatal mental health was assessed during 26th week of pregnancy. The effects on offspring were assessed when the child was 12, 18, and 24 months old. Results showed that positive antenatal mental health was uniquely associated with the offspring's cognitive, language and parentally rated competences. This study shows that the effects of positive maternal mental health are likely to be specific and distinct from the sheer absence of symptoms of depression or anxiety. En ligne : http://dx.doi.org/10.1017/S0954579417001249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study—CORRIGENDUM / Desiree Y. PHUA in Development and Psychopathology, 30-4 (October 2018)  

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Preschoolers' emotion reactivity and regulation: Links with maternal psychological distress and child behavior problems / Stella TSOTSI in Development and Psychopathology, 35-3 (August 2023)  

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