Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 / Maja GREGERSEN in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1046-1056 Titre : Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 Type de document : texte imprimé Auteurs : Maja GREGERSEN, Auteur ; Anne SØNDERGAARD, Auteur ; Julie Marie BRANDT, Auteur ; Ditte ELLERSGAARD, Auteur ; Sinnika Birkehøj ROHD, Auteur ; Carsten HJORTHØJ, Auteur ; Jessica OHLAND, Auteur ; Mette Falkenberg KRANTZ, Auteur ; Martin WILMS, Auteur ; Anna Krogh ANDREASSEN, Auteur ; Christina Bruun KNUDSEN, Auteur ; Lotte VEDDUM, Auteur ; Aja GREVE, Auteur ; Vibeke BLIKSTED, Auteur ; Ole MORS, Auteur ; Lars CLEMMENSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Merete NORDENTOFT, Auteur ; Nicoline HEMAGER, Auteur ; Anne Amalie Elgaard THORUP, Auteur Article en page(s) : p.1046-1056 Langues : Anglais (eng) Mots-clés : Bipolar Disorder/epidemiology  Child  Child, Preschool  Denmark/epidemiology  Follow-Up Studies  Humans  Longitudinal Studies  Schizophrenia/epidemiology  Child and adolescent psychiatry  bipolar disorder  familial high-risk  psychopathology  schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Children at familial high-risk of schizophrenia and bipolar disorder have an elevated prevalence of mental disorders but studies of children within a narrow age range are lacking and there are few conjoint studies of these two groups. Knowledge on their mental health is important for prevention and early intervention. METHODS: The authors examined mental disorders and global functioning in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) compared with population-based controls. In a longitudinal cohort study, 450 children (FHR-SZ, n=171; FHR-BP, n=104; controls, n=175), were assessed for Axis I disorders at baseline and four-year follow-up (mean age 11.9, SD 0.2) with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children and for global functioning with Children's Global Assessment Scale. RESULTS: Cumulative incidence of Any Axis I disorder was elevated by age 11 in children at FHR-SZ (54.4%, OR 3.0, 95% CI 1.9-4.7, p<.001) and children at FHR-BP (52.9%, OR 2.8, 95% CI 1.7-4.7, p<.001) compared with controls (28.6%). Children at FHR-SZ and FHR-BP had higher rates of affective disorders (OR 4.4, 95% CI 1.4-13.5, p=.009; OR 5.1, 95% CI 1.6-16.4, p=.007), anxiety disorders (OR 2.1, 95% CI 1.1-4.0, p=.02; OR 3.0, 95% CI 1.5-6.1, p=.002), and stress and adjustment disorders (OR 3.3, 95% CI 1.4-7.5, p=.006; OR 5.3, 95% CI 2.2-12.4, p<.001). Disruptive behavior disorders (OR 2.8, 95% CI 1.0-7.3, p=.04) and ADHD (OR 2.9, 95% CI 1.6-5.3, p<.001) were elevated in children at FHR-SZ. Both FHR groups had lower global functioning than controls. Cumulative incidence of disorders increased equally across the three groups from early childhood to preadolescence and level of functioning did not change differentially. CONCLUSIONS: Children at FHR-SZ and FHR-BP have an elevated prevalence of mental disorders and poorer functioning than controls. Vulnerability in children at FHR manifests early and remains stable throughout childhood. Early attention toward their mental health and identification of those in need of intervention is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.13548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 [texte imprimé] / Maja GREGERSEN, Auteur ; Anne SØNDERGAARD, Auteur ; Julie Marie BRANDT, Auteur ; Ditte ELLERSGAARD, Auteur ; Sinnika Birkehøj ROHD, Auteur ; Carsten HJORTHØJ, Auteur ; Jessica OHLAND, Auteur ; Mette Falkenberg KRANTZ, Auteur ; Martin WILMS, Auteur ; Anna Krogh ANDREASSEN, Auteur ; Christina Bruun KNUDSEN, Auteur ; Lotte VEDDUM, Auteur ; Aja GREVE, Auteur ; Vibeke BLIKSTED, Auteur ; Ole MORS, Auteur ; Lars CLEMMENSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Merete NORDENTOFT, Auteur ; Nicoline HEMAGER, Auteur ; Anne Amalie Elgaard THORUP, Auteur . - p.1046-1056. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1046-1056 Mots-clés : Bipolar Disorder/epidemiology  Child  Child, Preschool  Denmark/epidemiology  Follow-Up Studies  Humans  Longitudinal Studies  Schizophrenia/epidemiology  Child and adolescent psychiatry  bipolar disorder  familial high-risk  psychopathology  schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Children at familial high-risk of schizophrenia and bipolar disorder have an elevated prevalence of mental disorders but studies of children within a narrow age range are lacking and there are few conjoint studies of these two groups. Knowledge on their mental health is important for prevention and early intervention. METHODS: The authors examined mental disorders and global functioning in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) compared with population-based controls. In a longitudinal cohort study, 450 children (FHR-SZ, n=171; FHR-BP, n=104; controls, n=175), were assessed for Axis I disorders at baseline and four-year follow-up (mean age 11.9, SD 0.2) with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children and for global functioning with Children's Global Assessment Scale. RESULTS: Cumulative incidence of Any Axis I disorder was elevated by age 11 in children at FHR-SZ (54.4%, OR 3.0, 95% CI 1.9-4.7, p<.001) and children at FHR-BP (52.9%, OR 2.8, 95% CI 1.7-4.7, p<.001) compared with controls (28.6%). Children at FHR-SZ and FHR-BP had higher rates of affective disorders (OR 4.4, 95% CI 1.4-13.5, p=.009; OR 5.1, 95% CI 1.6-16.4, p=.007), anxiety disorders (OR 2.1, 95% CI 1.1-4.0, p=.02; OR 3.0, 95% CI 1.5-6.1, p=.002), and stress and adjustment disorders (OR 3.3, 95% CI 1.4-7.5, p=.006; OR 5.3, 95% CI 2.2-12.4, p<.001). Disruptive behavior disorders (OR 2.8, 95% CI 1.0-7.3, p=.04) and ADHD (OR 2.9, 95% CI 1.6-5.3, p<.001) were elevated in children at FHR-SZ. Both FHR groups had lower global functioning than controls. Cumulative incidence of disorders increased equally across the three groups from early childhood to preadolescence and level of functioning did not change differentially. CONCLUSIONS: Children at FHR-SZ and FHR-BP have an elevated prevalence of mental disorders and poorer functioning than controls. Vulnerability in children at FHR manifests early and remains stable throughout childhood. Early attention toward their mental health and identification of those in need of intervention is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.13548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Psychotic experiences are associated with health anxiety and functional somatic symptoms in preadolescence / Martin K. RIMVALL in Journal of Child Psychology and Psychiatry, 60-5 (May 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-5 (May 2019) . - p.524-532 Titre : Psychotic experiences are associated with health anxiety and functional somatic symptoms in preadolescence Type de document : texte imprimé Auteurs : Martin K. RIMVALL, Auteur ; Cecilia Pihl JESPERSEN, Auteur ; Lars CLEMMENSEN, Auteur ; Anja MUNKHOLM, Auteur ; Anne M. SKOVGAARD, Auteur ; Frank VERHULST, Auteur ; Jim VAN OS, Auteur ; Charlotte U. RASK, Auteur ; Pia JEPPESEN, Auteur Article en page(s) : p.524-532 Langues : Anglais (eng) Mots-clés : Psychosis  anxiety  epidemiology  somatization Index. décimale : PER Périodiques Résumé : BACKGROUND: Health anxiety (HA) is an increasing public health problem related to increased health service costs, and associated with functional somatic symptoms (FSS) and considerable personal suffering. Abnormal bodily experiences which may resemble HA and FSS are common in psychotic disorders, but a potential link between HA and psychosis vulnerability in childhood is largely unexplored. The current study estimates the association between subclinical psychotic experiences (PE) and HA and FSS in a general population cohort of preadolescents. METHODS: The study population consisted of 1,572 11-12-year-old children from the Copenhagen Child Cohort 2000. PE were comprehensibly assessed as either present or not present using the Kiddie Schedule of Affective Disorders and Schizophrenia psychosis section. HA and FSS were assessed by self-report on validated questionnaires. Additional variables on general psychopathology, puberty, and chronic somatic illness were also obtained. RESULTS: Psychotic experiences were associated with the top 10% high scores of HA (Odds Ratio (OR) 3.2; 95% CI: 2.1-4.8) and FSS (OR 4.6; 95% CI: 3.1-6.9) in univariate analyses. After mutual adjustment, the association was reduced to (HA: OR 2.3; 95% CI: 1.5-3.5; FSS: OR 3.7; 95% CI: 2.4-4.7), suggesting interdependence. Further adjustment for potential confounders and general psychopathology only reduced the associations slightly: HA OR 2.2 (95% CI: 1.4-3.4); FSS OR 3.3 (95% CI: 2.1-5.2). Secondary analyses of subdimensions of HA showed that PE were associated with fears (OR 3.0; 95% CI: 2.0-4.6) and daily impact of HA symptoms (OR 5.0; 95% CI: 3.4-7.5), but not help seeking (OR 1.2; 95% CI: 0.7-2.1). CONCLUSIONS: This is the first study to investigate the associations between PE and HA and FSS, respectively. PE were significantly associated with HA and FSS over and above general psychopathology in preadolescence. Individuals with PE expressed high levels of health-related fears and daily impact, but no corresponding help-seeking behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12986 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392 [article] Psychotic experiences are associated with health anxiety and functional somatic symptoms in preadolescence [texte imprimé] / Martin K. RIMVALL, Auteur ; Cecilia Pihl JESPERSEN, Auteur ; Lars CLEMMENSEN, Auteur ; Anja MUNKHOLM, Auteur ; Anne M. SKOVGAARD, Auteur ; Frank VERHULST, Auteur ; Jim VAN OS, Auteur ; Charlotte U. RASK, Auteur ; Pia JEPPESEN, Auteur . - p.524-532. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-5 (May 2019) . - p.524-532 Mots-clés : Psychosis  anxiety  epidemiology  somatization Index. décimale : PER Périodiques Résumé : BACKGROUND: Health anxiety (HA) is an increasing public health problem related to increased health service costs, and associated with functional somatic symptoms (FSS) and considerable personal suffering. Abnormal bodily experiences which may resemble HA and FSS are common in psychotic disorders, but a potential link between HA and psychosis vulnerability in childhood is largely unexplored. The current study estimates the association between subclinical psychotic experiences (PE) and HA and FSS in a general population cohort of preadolescents. METHODS: The study population consisted of 1,572 11-12-year-old children from the Copenhagen Child Cohort 2000. PE were comprehensibly assessed as either present or not present using the Kiddie Schedule of Affective Disorders and Schizophrenia psychosis section. HA and FSS were assessed by self-report on validated questionnaires. Additional variables on general psychopathology, puberty, and chronic somatic illness were also obtained. RESULTS: Psychotic experiences were associated with the top 10% high scores of HA (Odds Ratio (OR) 3.2; 95% CI: 2.1-4.8) and FSS (OR 4.6; 95% CI: 3.1-6.9) in univariate analyses. After mutual adjustment, the association was reduced to (HA: OR 2.3; 95% CI: 1.5-3.5; FSS: OR 3.7; 95% CI: 2.4-4.7), suggesting interdependence. Further adjustment for potential confounders and general psychopathology only reduced the associations slightly: HA OR 2.2 (95% CI: 1.4-3.4); FSS OR 3.3 (95% CI: 2.1-5.2). Secondary analyses of subdimensions of HA showed that PE were associated with fears (OR 3.0; 95% CI: 2.0-4.6) and daily impact of HA symptoms (OR 5.0; 95% CI: 3.4-7.5), but not help seeking (OR 1.2; 95% CI: 0.7-2.1). CONCLUSIONS: This is the first study to investigate the associations between PE and HA and FSS, respectively. PE were significantly associated with HA and FSS over and above general psychopathology in preadolescence. Individuals with PE expressed high levels of health-related fears and daily impact, but no corresponding help-seeking behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12986 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392

Psychotic experiences co-occur with sleep problems, negative affect and mental disorders in preadolescence / Pia JEPPESEN in Journal of Child Psychology and Psychiatry, 56-5 (May 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-5 (May 2015) . - p.558-565 Titre : Psychotic experiences co-occur with sleep problems, negative affect and mental disorders in preadolescence Type de document : texte imprimé Auteurs : Pia JEPPESEN, Auteur ; Lars CLEMMENSEN, Auteur ; Anja MUNKHOLM, Auteur ; Martin K. RIMVALL, Auteur ; Charlotte U. RASK, Auteur ; Torben JØRGENSEN, Auteur ; Janne T. LARSEN, Auteur ; Liselotte PETERSEN, Auteur ; Jim VAN OS, Auteur ; Anne M. SKOVGAARD, Auteur Article en page(s) : p.558-565 Langues : Anglais (eng) Mots-clés : Preadolescence  psychosis  emotional disorders  sleep  puberty  developmental psychopathology Index. décimale : PER Périodiques Résumé : Background Knowledge on the significance of childhood psychotic symptoms and experiences (PE) is still limited. This study aimed to investigate the prevalence and clinical significance of PE in preadolescent children from the general population by use of in-depth psychopathological interviews and comprehensive diagnostic assessments. Methods We investigated 1,632 children from the general population-based Copenhagen Child Cohort 2000. PE were measured by semistructured interviews using the K-SADS-PL-items on psychotic and affective symptoms, each symptom scored as not present versus likely or definitely present. The Development and Well-Being Assessment (DAWBA) was used independently to diagnose DSM-IV-mental disorders. Puberty development and sleep disturbance were self-reported. The associations between PE (any lifetime hallucination and/or delusion) and various mental problems and disorders were examined by multivariable binomial regression analyses, adjusting for gender and onset of puberty. Results The weighted life time prevalence of PE at age 11–12 years was 10.9% (CI 9.1–12.7). The majority of children with PE (n = 172) either had a diagnosable DSM-IV-mental disorder (31.4%) or self-reported mental health difficulties in absence of a diagnosis (31.4%). The risk of delusions increased with onset of puberty. The risk of PE increased with emotional and neurodevelopmental disorders, subthreshold depressive symptoms, sleep problems and lack of sleep, regardless of whether PE were expressed as hallucinations and/or delusions. The highest correlations were seen for emotional and multiple disorders. Conclusions Psychotic experiences are particularly prevalent in the context of affective dysregulation and sleep disturbance, increase with onset of puberty and represent a trans-diagnostic marker of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Psychotic experiences co-occur with sleep problems, negative affect and mental disorders in preadolescence [texte imprimé] / Pia JEPPESEN, Auteur ; Lars CLEMMENSEN, Auteur ; Anja MUNKHOLM, Auteur ; Martin K. RIMVALL, Auteur ; Charlotte U. RASK, Auteur ; Torben JØRGENSEN, Auteur ; Janne T. LARSEN, Auteur ; Liselotte PETERSEN, Auteur ; Jim VAN OS, Auteur ; Anne M. SKOVGAARD, Auteur . - p.558-565. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-5 (May 2015) . - p.558-565 Mots-clés : Preadolescence  psychosis  emotional disorders  sleep  puberty  developmental psychopathology Index. décimale : PER Périodiques Résumé : Background Knowledge on the significance of childhood psychotic symptoms and experiences (PE) is still limited. This study aimed to investigate the prevalence and clinical significance of PE in preadolescent children from the general population by use of in-depth psychopathological interviews and comprehensive diagnostic assessments. Methods We investigated 1,632 children from the general population-based Copenhagen Child Cohort 2000. PE were measured by semistructured interviews using the K-SADS-PL-items on psychotic and affective symptoms, each symptom scored as not present versus likely or definitely present. The Development and Well-Being Assessment (DAWBA) was used independently to diagnose DSM-IV-mental disorders. Puberty development and sleep disturbance were self-reported. The associations between PE (any lifetime hallucination and/or delusion) and various mental problems and disorders were examined by multivariable binomial regression analyses, adjusting for gender and onset of puberty. Results The weighted life time prevalence of PE at age 11–12 years was 10.9% (CI 9.1–12.7). The majority of children with PE (n = 172) either had a diagnosable DSM-IV-mental disorder (31.4%) or self-reported mental health difficulties in absence of a diagnosis (31.4%). The risk of delusions increased with onset of puberty. The risk of PE increased with emotional and neurodevelopmental disorders, subthreshold depressive symptoms, sleep problems and lack of sleep, regardless of whether PE were expressed as hallucinations and/or delusions. The highest correlations were seen for emotional and multiple disorders. Conclusions Psychotic experiences are particularly prevalent in the context of affective dysregulation and sleep disturbance, increase with onset of puberty and represent a trans-diagnostic marker of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

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