Early indicators of response to transdiagnostic treatment of pediatric anxiety and depression / Michelle ROZENMAN ; Araceli GONZALEZ ; David A. BRENT ; Giovanna PORTA ; Frances L. LYNCH ; John F. DICKERSON ; V. Robin WEERSING in Journal of Child Psychology and Psychiatry, 64-12 (December 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-12 (December 2023) . - p.1689-1698 Titre : Early indicators of response to transdiagnostic treatment of pediatric anxiety and depression Type de document : Texte imprimé et/ou numérique Auteurs : Michelle ROZENMAN, Auteur ; Araceli GONZALEZ, Auteur ; David A. BRENT, Auteur ; Giovanna PORTA, Auteur ; Frances L. LYNCH, Auteur ; John F. DICKERSON, Auteur ; V. Robin WEERSING, Auteur Article en page(s) : p.1689-1698 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Pediatric anxiety and depression are prevalent, impairing, and highly comorbid. Available evidence-based treatments have an average response rate of 60%. One path to increasing response may be to identify likely non-responders midway through treatment to adjust course prior to completing an episode of care. The aims of this study, thus, were to identify predictors of post-intervention response assessing (a) mid-treatment symptom severity, (b) session-by-session treatment process factors, and (c) a model optimizing the combination of these. Method Data were drawn from the treatment arm (N=95, ages 8-16) of a randomized transdiagnostic intervention trial (Msessions=11.2). Mid-point measures of youth- and parent-reported anxiety and depression were collected, and therapists rated homework completion, youth and parent engagement, and youth therapeutic alliance at each session. Logistic regression was used to predict response on the Clinical Global Impression Improvement Scale (CGI-I ?2) rated by independent evaluators masked to treatment condition. Results Mid-point symptom measures were significant predictors of treatment response, as were therapist-ratings of youth and parent engagement, therapeutic alliance, and homework completion. Therapist ratings were significant when tested as mean ratings summing across the first eight sessions of treatment (all ps<.004) and at individual session points (all ps?<0.05). A combined prediction model included youth-reported anxiety, parent-reported depression, youth engagement at Session 2, and parent engagement at Session 8. This model correctly classified 76.5% of youth as non-responders and 91.3% as responders at post-treatment (Nagelkerke R2=.59, ?2 (4, 80)=46.54, p<.001). Conclusion This study provides initial evidence that response to transdiagnostic intervention for pediatric anxiety and depression may be reliably predicted by mid-point. These data may serve as foundational evidence to develop adaptive treatment strategies to personalize intervention, correct treatment course, and optimize outcomes for youth with anxiety and depression. En ligne : https://doi.org/10.1111/jcpp.13881 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Early indicators of response to transdiagnostic treatment of pediatric anxiety and depression [Texte imprimé et/ou numérique] / Michelle ROZENMAN, Auteur ; Araceli GONZALEZ, Auteur ; David A. BRENT, Auteur ; Giovanna PORTA, Auteur ; Frances L. LYNCH, Auteur ; John F. DICKERSON, Auteur ; V. Robin WEERSING, Auteur . - p.1689-1698. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-12 (December 2023) . - p.1689-1698 Index. décimale : PER Périodiques Résumé : Background Pediatric anxiety and depression are prevalent, impairing, and highly comorbid. Available evidence-based treatments have an average response rate of 60%. One path to increasing response may be to identify likely non-responders midway through treatment to adjust course prior to completing an episode of care. The aims of this study, thus, were to identify predictors of post-intervention response assessing (a) mid-treatment symptom severity, (b) session-by-session treatment process factors, and (c) a model optimizing the combination of these. Method Data were drawn from the treatment arm (N=95, ages 8-16) of a randomized transdiagnostic intervention trial (Msessions=11.2). Mid-point measures of youth- and parent-reported anxiety and depression were collected, and therapists rated homework completion, youth and parent engagement, and youth therapeutic alliance at each session. Logistic regression was used to predict response on the Clinical Global Impression Improvement Scale (CGI-I ?2) rated by independent evaluators masked to treatment condition. Results Mid-point symptom measures were significant predictors of treatment response, as were therapist-ratings of youth and parent engagement, therapeutic alliance, and homework completion. Therapist ratings were significant when tested as mean ratings summing across the first eight sessions of treatment (all ps<.004) and at individual session points (all ps?<0.05). A combined prediction model included youth-reported anxiety, parent-reported depression, youth engagement at Session 2, and parent engagement at Session 8. This model correctly classified 76.5% of youth as non-responders and 91.3% as responders at post-treatment (Nagelkerke R2=.59, ?2 (4, 80)=46.54, p<.001). Conclusion This study provides initial evidence that response to transdiagnostic intervention for pediatric anxiety and depression may be reliably predicted by mid-point. These data may serve as foundational evidence to develop adaptive treatment strategies to personalize intervention, correct treatment course, and optimize outcomes for youth with anxiety and depression. En ligne : https://doi.org/10.1111/jcpp.13881 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Health Services Utilization Among Children With and Without Autism Spectrum Disorders / Janet R. CUMMINGS in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.910-920 Titre : Health Services Utilization Among Children With and Without Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Janet R. CUMMINGS, Auteur ; Frances L. LYNCH, Auteur ; Kristal C. RUST, Auteur ; Karen J. COLEMAN, Auteur ; Jeanne M. MADDEN, Auteur ; Ashli A. OWEN-SMITH, Auteur ; Vincent M. YAU, Auteur ; Yinge QIAN, Auteur ; Kathryn A. PEARSON, Auteur ; Phillip M. CRAWFORD, Auteur ; Maria L. MASSOLO, Auteur ; Virginia P. QUINN, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.910-920 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Health care utilization  Preventive services  Children  Adolescents Index. décimale : PER Périodiques Résumé : Using data from multiple health systems (2009–2010) and the largest sample to date, this study compares health services use among youth with and without an autism spectrum disorder (ASD)—including preventive services not previously studied. To examine these differences, we estimated logistic and count data models, controlling for demographic characteristics, comorbid physical health, and mental health conditions. Results indicated that youth with an ASD had greater health care use in many categories, but were less likely to receive important preventive services including flu shots and other vaccinations. An improved understanding of the overall patterns of health care use among this population could enable health systems to facilitate the receipt of appropriate and effective health care. En ligne : http://dx.doi.org/10.1007/s10803-015-2634-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281 [article] Health Services Utilization Among Children With and Without Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Janet R. CUMMINGS, Auteur ; Frances L. LYNCH, Auteur ; Kristal C. RUST, Auteur ; Karen J. COLEMAN, Auteur ; Jeanne M. MADDEN, Auteur ; Ashli A. OWEN-SMITH, Auteur ; Vincent M. YAU, Auteur ; Yinge QIAN, Auteur ; Kathryn A. PEARSON, Auteur ; Phillip M. CRAWFORD, Auteur ; Maria L. MASSOLO, Auteur ; Virginia P. QUINN, Auteur ; Lisa A. CROEN, Auteur . - p.910-920. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.910-920 Mots-clés : Autism spectrum disorders  Health care utilization  Preventive services  Children  Adolescents Index. décimale : PER Périodiques Résumé : Using data from multiple health systems (2009–2010) and the largest sample to date, this study compares health services use among youth with and without an autism spectrum disorder (ASD)—including preventive services not previously studied. To examine these differences, we estimated logistic and count data models, controlling for demographic characteristics, comorbid physical health, and mental health conditions. Results indicated that youth with an ASD had greater health care use in many categories, but were less likely to receive important preventive services including flu shots and other vaccinations. An improved understanding of the overall patterns of health care use among this population could enable health systems to facilitate the receipt of appropriate and effective health care. En ligne : http://dx.doi.org/10.1007/s10803-015-2634-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281

Parental First Concerns and Timing of Autism Spectrum Disorder Diagnosis / Tracy A. BECERRA-CULQUI in Journal of Autism and Developmental Disorders, 48-10 (October 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3367-3376 Titre : Parental First Concerns and Timing of Autism Spectrum Disorder Diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Tracy A. BECERRA-CULQUI, Auteur ; Frances L. LYNCH, Auteur ; Ashli A. OWEN-SMITH, Auteur ; Joseph SPITZER, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.3367-3376 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Parent Survey  Developmental concerns  Early diagnosis Index. décimale : PER Périodiques Résumé : Specific developmental concerns can distinguish between an early versus later diagnosis of autism spectrum disorder (ASD). Caregiver survey responses of children ??9 years-of-age (2012) with ASD were used to evaluate developmental concerns and associations with age of diagnosis [early ( En ligne : https://doi.org/10.1007/s10803-018-3598-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Parental First Concerns and Timing of Autism Spectrum Disorder Diagnosis [Texte imprimé et/ou numérique] / Tracy A. BECERRA-CULQUI, Auteur ; Frances L. LYNCH, Auteur ; Ashli A. OWEN-SMITH, Auteur ; Joseph SPITZER, Auteur ; Lisa A. CROEN, Auteur . - p.3367-3376. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3367-3376 Mots-clés : Autism spectrum disorder  Parent Survey  Developmental concerns  Early diagnosis Index. décimale : PER Périodiques Résumé : Specific developmental concerns can distinguish between an early versus later diagnosis of autism spectrum disorder (ASD). Caregiver survey responses of children ??9 years-of-age (2012) with ASD were used to evaluate developmental concerns and associations with age of diagnosis [early ( En ligne : https://doi.org/10.1007/s10803-018-3598-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Prevalence and predictors of complementary and alternative medicine use in a large insured sample of children with Autism Spectrum Disorders / Ashli A. OWEN-SMITH in Research in Autism Spectrum Disorders, 17 (September 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 17 (September 2015) . - p.40-51 Titre : Prevalence and predictors of complementary and alternative medicine use in a large insured sample of children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Ashli A. OWEN-SMITH, Auteur ; Stephen BENT, Auteur ; Frances L. LYNCH, Auteur ; Karen J. COLEMAN, Auteur ; Vincent M. YAU, Auteur ; Kathryn A. PEARSON, Auteur ; Maria L. MASSOLO, Auteur ; Virginia QUINN, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2015 Article en page(s) : p.40-51 Langues : Anglais (eng) Mots-clés : Complementary and alternative medicine  Autism spectrum disorders  Drug interactions Index. décimale : PER Périodiques Résumé : AbstractPurpose The purpose of the present study was to examine the prevalence and predictors of complementary and alternative medicine (CAM) use as well as parental perceptions of CAM efficacy in a large, geographically diverse sample of children with Autism Spectrum Disorders (ASD). Methodology Data were obtained from a web-based survey administered to parents of children with ASD at four sites participating in the Mental Health Research Network (MHRN). The web survey obtained information about services and treatments received by children with ASD as well as the caregivers’ experiences with having a child with ASD. Results Approximately 88% of the sample had either used CAM in the past or had recently used some type of CAM. The following characteristics were associated with CAM use: greater parental education, younger child age, a mix of regular and special classroom settings and prescription drug use in the past three months. Conclusions The use of CAM was very prevalent in this large, geographically diverse sample of children with ASD. It is critical that providers be prepared to discuss the advantages and potential side effects with families to help them make well-informed health care decisions and prevent possible CAM-drug interactions. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.05.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Prevalence and predictors of complementary and alternative medicine use in a large insured sample of children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Ashli A. OWEN-SMITH, Auteur ; Stephen BENT, Auteur ; Frances L. LYNCH, Auteur ; Karen J. COLEMAN, Auteur ; Vincent M. YAU, Auteur ; Kathryn A. PEARSON, Auteur ; Maria L. MASSOLO, Auteur ; Virginia QUINN, Auteur ; Lisa A. CROEN, Auteur . - 2015 . - p.40-51. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 17 (September 2015) . - p.40-51 Mots-clés : Complementary and alternative medicine  Autism spectrum disorders  Drug interactions Index. décimale : PER Périodiques Résumé : AbstractPurpose The purpose of the present study was to examine the prevalence and predictors of complementary and alternative medicine (CAM) use as well as parental perceptions of CAM efficacy in a large, geographically diverse sample of children with Autism Spectrum Disorders (ASD). Methodology Data were obtained from a web-based survey administered to parents of children with ASD at four sites participating in the Mental Health Research Network (MHRN). The web survey obtained information about services and treatments received by children with ASD as well as the caregivers’ experiences with having a child with ASD. Results Approximately 88% of the sample had either used CAM in the past or had recently used some type of CAM. The following characteristics were associated with CAM use: greater parental education, younger child age, a mix of regular and special classroom settings and prescription drug use in the past three months. Conclusions The use of CAM was very prevalent in this large, geographically diverse sample of children with ASD. It is critical that providers be prepared to discuss the advantages and potential side effects with families to help them make well-informed health care decisions and prevent possible CAM-drug interactions. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.05.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

Psychotropic Medication Use among Insured Children with Autism Spectrum Disorder / Jeanne M. MADDEN in Journal of Autism and Developmental Disorders, 47-1 (January 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-1 (January 2017) . - p.144-154 Titre : Psychotropic Medication Use among Insured Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jeanne M. MADDEN, Auteur ; Matthew D. LAKOMA, Auteur ; Frances L. LYNCH, Auteur ; Donna RUSINAK, Auteur ; Ashli A. OWEN-SMITH, Auteur ; Karen J. COLEMAN, Auteur ; Virginia P. QUINN, Auteur ; Vincent M. YAU, Auteur ; Yinge X. QIAN, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.144-154 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Medications  Antipsychotics  Comorbidities  Epidemiological studies Index. décimale : PER Périodiques Résumé : This study examined psychotropic medication use among 7901 children aged 1–17 with autism spectrum disorder (ASD) in five health systems, comparing to matched cohorts with no ASD. Nearly half (48.5?%) of children with ASD received psychotropics in the year observed; the most common classes were stimulants, alpha-agonists, or atomoxetine (30.2?%), antipsychotics (20.5?%), and antidepressants (17.8?%). Psychotropic treatment was far more prevalent among children with ASD, as compared to children with no ASD (7.7?% overall), even within strata defined by the presence or absence of other psychiatric diagnoses. The widespread use of psychotropics we observed, particularly given weak evidence supporting the effectiveness of these medications for most children with ASD, highlights challenges in ASD treatment and the need for greater investment in its evaluation. En ligne : http://dx.doi.org/10.1007/s10803-016-2946-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Psychotropic Medication Use among Insured Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Jeanne M. MADDEN, Auteur ; Matthew D. LAKOMA, Auteur ; Frances L. LYNCH, Auteur ; Donna RUSINAK, Auteur ; Ashli A. OWEN-SMITH, Auteur ; Karen J. COLEMAN, Auteur ; Virginia P. QUINN, Auteur ; Vincent M. YAU, Auteur ; Yinge X. QIAN, Auteur ; Lisa A. CROEN, Auteur . - p.144-154. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-1 (January 2017) . - p.144-154 Mots-clés : Autism spectrum disorder  Medications  Antipsychotics  Comorbidities  Epidemiological studies Index. décimale : PER Périodiques Résumé : This study examined psychotropic medication use among 7901 children aged 1–17 with autism spectrum disorder (ASD) in five health systems, comparing to matched cohorts with no ASD. Nearly half (48.5?%) of children with ASD received psychotropics in the year observed; the most common classes were stimulants, alpha-agonists, or atomoxetine (30.2?%), antipsychotics (20.5?%), and antidepressants (17.8?%). Psychotropic treatment was far more prevalent among children with ASD, as compared to children with no ASD (7.7?% overall), even within strata defined by the presence or absence of other psychiatric diagnoses. The widespread use of psychotropics we observed, particularly given weak evidence supporting the effectiveness of these medications for most children with ASD, highlights challenges in ASD treatment and the need for greater investment in its evaluation. En ligne : http://dx.doi.org/10.1007/s10803-016-2946-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

The impact of autism spectrum disorder on parent employment: Results from the r-Kids study / Frances L. LYNCH in Autism Research, 16-3 (March 2023)  

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Validation of Autism Spectrum Disorder Diagnoses in Large Healthcare Systems with Electronic Medical Records / Karen J. COLEMAN in Journal of Autism and Developmental Disorders, 45-7 (July 2015)  

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