An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder / Alan S. LEWIS in Journal of Autism and Developmental Disorders, 48-8 (August 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757 Titre : An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Alan S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; Mayra Ortiz LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; Marina R. PICCIOTTO, Auteur ; Denis G. SUKHODOLSKY, Auteur Article en page(s) : p.2748-2757 Langues : Anglais (eng) Mots-clés : Adult  Aggression  Autism spectrum disorder  Irritability  Nicotine  Nicotinic acetylcholine receptor  Sleep Index. décimale : PER Périodiques Résumé : Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3536-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder [texte imprimé] / Alan S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; Mayra Ortiz LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; Marina R. PICCIOTTO, Auteur ; Denis G. SUKHODOLSKY, Auteur . - p.2748-2757. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757 Mots-clés : Adult  Aggression  Autism spectrum disorder  Irritability  Nicotine  Nicotinic acetylcholine receptor  Sleep Index. décimale : PER Périodiques Résumé : Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3536-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder / Gerrit I. VAN SCHALKWYK in Journal of Autism and Developmental Disorders, 45-9 (September 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3061-3066 Titre : Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Gerrit I. VAN SCHALKWYK, Auteur ; Alan S. LEWIS, Auteur ; Zheala QAYYUM, Auteur ; Kourtney KOSLOSKY, Auteur ; Marina R. PICCIOTTO, Auteur ; Fred R. VOLKMAR, Auteur Article en page(s) : p.3061-3066 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Developmental disorder  Aggression  Irritability  Nicotine  Nicotine patch  Nicotinic acetylcholine receptor Index. décimale : PER Périodiques Résumé : Aggression remains a major cause of morbidity in patients with autism spectrum disorder (ASD). Current pharmacotherapy for aggression is not always effective and is often associated with morbidity. Nicotinic acetylcholinergic neurotransmission may play a prominent role in ASD pathophysiology based on human and animal studies, and preclinical studies show nicotine administration can reduce aggression-related behaviors. Transdermal nicotine has been used to treat agitation in neuropsychiatric conditions with cholinergic dysfunction. Here we report the use of transdermal nicotine as an adjunctive medication to treat aggression in a hospitalized adolescent with ASD. Nicotine patch was recurrently well tolerated, and reduced the need for emergency medication and restraint. These findings suggest further study of transdermal nicotine for aggression comorbid with ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-015-2471-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder [texte imprimé] / Gerrit I. VAN SCHALKWYK, Auteur ; Alan S. LEWIS, Auteur ; Zheala QAYYUM, Auteur ; Kourtney KOSLOSKY, Auteur ; Marina R. PICCIOTTO, Auteur ; Fred R. VOLKMAR, Auteur . - p.3061-3066. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3061-3066 Mots-clés : Autism spectrum disorder  Developmental disorder  Aggression  Irritability  Nicotine  Nicotine patch  Nicotinic acetylcholine receptor Index. décimale : PER Périodiques Résumé : Aggression remains a major cause of morbidity in patients with autism spectrum disorder (ASD). Current pharmacotherapy for aggression is not always effective and is often associated with morbidity. Nicotinic acetylcholinergic neurotransmission may play a prominent role in ASD pathophysiology based on human and animal studies, and preclinical studies show nicotine administration can reduce aggression-related behaviors. Transdermal nicotine has been used to treat agitation in neuropsychiatric conditions with cholinergic dysfunction. Here we report the use of transdermal nicotine as an adjunctive medication to treat aggression in a hospitalized adolescent with ASD. Nicotine patch was recurrently well tolerated, and reduced the need for emergency medication and restraint. These findings suggest further study of transdermal nicotine for aggression comorbid with ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-015-2471-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

Systematic Review: Distribution of Age and Intervention Modalities in Therapeutic Clinical Trials for Autism Spectrum Disorder / Alan S. LEWIS in Journal of Autism and Developmental Disorders, 50-6 (June 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2208-2216 Titre : Systematic Review: Distribution of Age and Intervention Modalities in Therapeutic Clinical Trials for Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Alan S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur Article en page(s) : p.2208-2216 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism  Clinical trial  Disparity  Systematic review Index. décimale : PER Périodiques Résumé : The prevalence of ASD remains relatively stable across the lifespan, necessitating a quantitative understanding of how intervention clinical research is applied across age groups. Here we report a systematic review of treatment studies between 2013 and 2017, enrolling 11,213 subjects with ASD in 218 studies. Individuals under 18 years old constituted the majority of studies (84%) and subjects (92%). Subjects under 18 years old were more likely to be enrolled in behavioral studies (OR (CI) = 1.34 (1.17-1.54)), and less likely to be enrolled in pharmacological (OR = 0.60 (0.52-0.69)) studies than subjects ≥ 18 years old. Identified disparities in both intervention modalities and outcome measures should serve to guide future research priorities. En ligne : http://dx.doi.org/10.1007/s10803-019-03942-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 [article] Systematic Review: Distribution of Age and Intervention Modalities in Therapeutic Clinical Trials for Autism Spectrum Disorder [texte imprimé] / Alan S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur . - p.2208-2216. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2208-2216 Mots-clés : Adolescent  Adult  Autism  Clinical trial  Disparity  Systematic review Index. décimale : PER Périodiques Résumé : The prevalence of ASD remains relatively stable across the lifespan, necessitating a quantitative understanding of how intervention clinical research is applied across age groups. Here we report a systematic review of treatment studies between 2013 and 2017, enrolling 11,213 subjects with ASD in 218 studies. Individuals under 18 years old constituted the majority of studies (84%) and subjects (92%). Subjects under 18 years old were more likely to be enrolled in behavioral studies (OR (CI) = 1.34 (1.17-1.54)), and less likely to be enrolled in pharmacological (OR = 0.60 (0.52-0.69)) studies than subjects ≥ 18 years old. Identified disparities in both intervention modalities and outcome measures should serve to guide future research priorities. En ligne : http://dx.doi.org/10.1007/s10803-019-03942-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425

---

1 (1 - 3 / 3) Par page : 25 50 100 200