Association between irritability and bias in attention orienting to threat in children and adolescents / Giovanni A. SALUM in Journal of Child Psychology and Psychiatry, 58-5 (May 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-5 (May 2017) . - p.595-602 Titre : Association between irritability and bias in attention orienting to threat in children and adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Giovanni A. SALUM, Auteur ; Karin MOGG, Auteur ; Brendan P. BRADLEY, Auteur ; Argyris STRINGARIS, Auteur ; Ary GADELHA, Auteur ; Pedro M. PAN, Auteur ; Luis A. ROHDE, Auteur ; Guilherme V. POLANCZYK, Auteur ; Gisele G. MANFRO, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur Article en page(s) : p.595-602 Langues : Anglais (eng) Mots-clés : Irritability  anger  attention  bias  cognition  emotion Index. décimale : PER Périodiques Résumé : Background Irritability, a frequent complaint in children with psychiatric disorders, reflects increased predisposition to anger. Preliminary work in pediatric clinical samples links irritability to attention bias to threat, and the current study examines this association in a large population-based sample. Methods We studied 1,872 children (ages 6–14) using the Development and Well-Being Assessment (DAWBA), Childhood Behavior Checklist (CBCL), and dot-probe tasks. Irritability was defined using CBCL items that assessed temper tantrums and hot temper. The dot-probe task assessed attention biases for threat-related (angry face) stimuli. Multiple regression analysis was used to assess specificity of associations to irritability when adjusting for demographic variables and co-occurring psychiatric traits. Propensity score matching analysis was used to increase causal inference when matching for demographic variables and co-occurring psychiatric traits. Results Irritability was associated with increased attention bias toward threat-related cues. Multiple regression analysis suggests associations between irritability and threat bias are independent from demographic variables, anxiety, and externalizing traits (attention-deficit/hyperactivity, conduct, and headstrong/hurtful), but not from broad internalizing symptoms. Propensity score matching analysis indicated that this association was found for irritable versus nonirritable groups matched on demographic and co-occurring traits including internalizing symptoms. Conclusions Irritability in children is associated with biased attention toward threatening information. This finding, if replicated, warrants further investigation to examine the extent to which it contributes to chronic irritability and to explore possible treatment implications. En ligne : http://dx.doi.org/10.1111/jcpp.12659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=306 [article] Association between irritability and bias in attention orienting to threat in children and adolescents [Texte imprimé et/ou numérique] / Giovanni A. SALUM, Auteur ; Karin MOGG, Auteur ; Brendan P. BRADLEY, Auteur ; Argyris STRINGARIS, Auteur ; Ary GADELHA, Auteur ; Pedro M. PAN, Auteur ; Luis A. ROHDE, Auteur ; Guilherme V. POLANCZYK, Auteur ; Gisele G. MANFRO, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur . - p.595-602. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-5 (May 2017) . - p.595-602 Mots-clés : Irritability  anger  attention  bias  cognition  emotion Index. décimale : PER Périodiques Résumé : Background Irritability, a frequent complaint in children with psychiatric disorders, reflects increased predisposition to anger. Preliminary work in pediatric clinical samples links irritability to attention bias to threat, and the current study examines this association in a large population-based sample. Methods We studied 1,872 children (ages 6–14) using the Development and Well-Being Assessment (DAWBA), Childhood Behavior Checklist (CBCL), and dot-probe tasks. Irritability was defined using CBCL items that assessed temper tantrums and hot temper. The dot-probe task assessed attention biases for threat-related (angry face) stimuli. Multiple regression analysis was used to assess specificity of associations to irritability when adjusting for demographic variables and co-occurring psychiatric traits. Propensity score matching analysis was used to increase causal inference when matching for demographic variables and co-occurring psychiatric traits. Results Irritability was associated with increased attention bias toward threat-related cues. Multiple regression analysis suggests associations between irritability and threat bias are independent from demographic variables, anxiety, and externalizing traits (attention-deficit/hyperactivity, conduct, and headstrong/hurtful), but not from broad internalizing symptoms. Propensity score matching analysis indicated that this association was found for irritable versus nonirritable groups matched on demographic and co-occurring traits including internalizing symptoms. Conclusions Irritability in children is associated with biased attention toward threatening information. This finding, if replicated, warrants further investigation to examine the extent to which it contributes to chronic irritability and to explore possible treatment implications. En ligne : http://dx.doi.org/10.1111/jcpp.12659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=306

Default mode network maturation and psychopathology in children and adolescents / João Ricardo SATO in Journal of Child Psychology and Psychiatry, 57-1 (January 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.55-64 Titre : Default mode network maturation and psychopathology in children and adolescents Type de document : Texte imprimé et/ou numérique Auteurs : João Ricardo SATO, Auteur ; Giovanni A. SALUM, Auteur ; Ary GADELHA, Auteur ; Nicolas CROSSLEY, Auteur ; Gilson VIEIRA, Auteur ; Gisele Gus MANFRO, Auteur ; André ZUGMAN, Auteur ; Felipe Almeida PICON, Auteur ; Pedro M. PAN, Auteur ; Marcelo Queiroz HOEXTER, Auteur ; Mauricio ANÉS, Auteur ; Luciana Monteiro MOURA, Auteur ; Marco Antonio Gomes DEL'AQUILLA, Auteur ; Edson Amaro JR, Auteur ; Philip MCGUIRE, Auteur ; Acioly Luiz Tavares LACERDA, Auteur ; Luis Augusto ROHDE, Auteur ; Euripedes Constantino MIGUEL, Auteur ; Andrea Parolin JACKOWSKI, Auteur ; Rodrigo Affonseca BRESSAN, Auteur Article en page(s) : p.55-64 Langues : Anglais (eng) Mots-clés : Neurodevelopment  default mode network  neuroimaging  psychopathology  MVPA Index. décimale : PER Périodiques Résumé : Background The human default mode (DMN) is involved in a wide array of mental disorders. Current knowledge suggests that mental health disorders may reflect deviant trajectories of brain maturation. Method We studied 654 children using functional magnetic resonance imaging (fMRI) scans under a resting-state protocol. A machine-learning method was used to obtain age predictions of children based on the average coefficient of fractional amplitude of low frequency fluctuations (fALFFs) of the DMN, a measure of spontaneous local activity. The chronological ages of the children and fALFF measures from regions of this network, the response and predictor variables were considered respectively in a Gaussian Process Regression. Subsequently, we computed a network maturation status index for each subject (actual age minus predicted). We then evaluated the association between this maturation index and psychopathology scores on the Child Behavior Checklist (CBCL). Results Our hypothesis was that the maturation status of the DMN would be negatively associated with psychopathology. Consistent with previous studies, fALFF significantly predicted the age of participants (p < .001). Furthermore, as expected, we found an association between the DMN maturation status (precocious vs. delayed) and general psychopathology scores (p = .011). Conclusions Our findings suggest that child psychopathology seems to be associated with delayed maturation of the DMN. This delay in the neurodevelopmental trajectory may offer interesting insights into the pathophysiology of mental health disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Default mode network maturation and psychopathology in children and adolescents [Texte imprimé et/ou numérique] / João Ricardo SATO, Auteur ; Giovanni A. SALUM, Auteur ; Ary GADELHA, Auteur ; Nicolas CROSSLEY, Auteur ; Gilson VIEIRA, Auteur ; Gisele Gus MANFRO, Auteur ; André ZUGMAN, Auteur ; Felipe Almeida PICON, Auteur ; Pedro M. PAN, Auteur ; Marcelo Queiroz HOEXTER, Auteur ; Mauricio ANÉS, Auteur ; Luciana Monteiro MOURA, Auteur ; Marco Antonio Gomes DEL'AQUILLA, Auteur ; Edson Amaro JR, Auteur ; Philip MCGUIRE, Auteur ; Acioly Luiz Tavares LACERDA, Auteur ; Luis Augusto ROHDE, Auteur ; Euripedes Constantino MIGUEL, Auteur ; Andrea Parolin JACKOWSKI, Auteur ; Rodrigo Affonseca BRESSAN, Auteur . - p.55-64. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.55-64 Mots-clés : Neurodevelopment  default mode network  neuroimaging  psychopathology  MVPA Index. décimale : PER Périodiques Résumé : Background The human default mode (DMN) is involved in a wide array of mental disorders. Current knowledge suggests that mental health disorders may reflect deviant trajectories of brain maturation. Method We studied 654 children using functional magnetic resonance imaging (fMRI) scans under a resting-state protocol. A machine-learning method was used to obtain age predictions of children based on the average coefficient of fractional amplitude of low frequency fluctuations (fALFFs) of the DMN, a measure of spontaneous local activity. The chronological ages of the children and fALFF measures from regions of this network, the response and predictor variables were considered respectively in a Gaussian Process Regression. Subsequently, we computed a network maturation status index for each subject (actual age minus predicted). We then evaluated the association between this maturation index and psychopathology scores on the Child Behavior Checklist (CBCL). Results Our hypothesis was that the maturation status of the DMN would be negatively associated with psychopathology. Consistent with previous studies, fALFF significantly predicted the age of participants (p < .001). Furthermore, as expected, we found an association between the DMN maturation status (precocious vs. delayed) and general psychopathology scores (p = .011). Conclusions Our findings suggest that child psychopathology seems to be associated with delayed maturation of the DMN. This delay in the neurodevelopmental trajectory may offer interesting insights into the pathophysiology of mental health disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways / Luiza K. AXELRUD in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.408-416 Titre : Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways Type de document : Texte imprimé et/ou numérique Auteurs : Luiza K. AXELRUD, Auteur ; Mauricio S. HOFFMANN, Auteur ; Daniel E. VOSBERG, Auteur ; Marcos SANTORO, Auteur ; Pedro M. PAN, Auteur ; Ary GADELHA, Auteur ; Sintia I. BELANGERO, Auteur ; Euripedes C. MIGUEL, Auteur ; Jean SHIN, Auteur ; Anita THAPAR, Auteur ; Jordan W. SMOLLER, Auteur ; Zdenka PAUSOVA, Auteur ; Luis A. ROHDE, Auteur ; Matthew C. KELLER, Auteur ; Tomas PAUS, Auteur ; Giovanni A. SALUM, Auteur Article en page(s) : p.408-416 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Specific pathways of intergenerational transmission of behavioral traits remain unclear. Here, we aim to investigate how parental genetics influence offspring cognition, educational attainment, and psychopathology in youth. Methods Participants for the discovery sample were 2,189 offspring (aged 6-14 years), 1898 mothers and 1,017 fathers who underwent genotyping, psychiatric, and cognitive assessments. We calculated polygenic scores (PGS) for cognition, educational attainment, attention-deficit hyperactivity disorder (ADHD), and schizophrenia for the trios. Phenotypes studied included educational and cognitive measures, ADHD and psychotic symptoms. We used a stepwise approach and multiple mediation models to analyze the effect of parental PGS on offspring traits via offspring PGS and parental phenotype. Significant results were replicated in a sample of 1,029 adolescents, 363 mothers, and 307 fathers. Results Maternal and paternal PGS for cognition influenced offspring general intelligence and executive function via offspring PGS (genetic pathway) and parental education (phenotypic pathway). Similar results were found for parental PGS for educational attainment and offspring reading and writing skills. These pathways fully explained associations between parental PGS and offspring phenotypes, without residual direct association. Associations with maternal, but not paternal, PGS were replicated. No associations were found between parental PGS for psychopathology and offspring specific symptoms. Conclusions Our findings indicate that parental genetics influences offspring cognition and educational attainment by genetic and phenotypic pathways, suggesting the expression of parental phenotypes partially explain the association between parental genetic risk and offspring outcomes. Multiple mediations might represent an effective approach to disentangle distinct pathways for intergenerational transmission of behavioral traits. En ligne : https://doi.org/10.1111/jcpp.13708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways [Texte imprimé et/ou numérique] / Luiza K. AXELRUD, Auteur ; Mauricio S. HOFFMANN, Auteur ; Daniel E. VOSBERG, Auteur ; Marcos SANTORO, Auteur ; Pedro M. PAN, Auteur ; Ary GADELHA, Auteur ; Sintia I. BELANGERO, Auteur ; Euripedes C. MIGUEL, Auteur ; Jean SHIN, Auteur ; Anita THAPAR, Auteur ; Jordan W. SMOLLER, Auteur ; Zdenka PAUSOVA, Auteur ; Luis A. ROHDE, Auteur ; Matthew C. KELLER, Auteur ; Tomas PAUS, Auteur ; Giovanni A. SALUM, Auteur . - p.408-416. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.408-416 Index. décimale : PER Périodiques Résumé : Background Specific pathways of intergenerational transmission of behavioral traits remain unclear. Here, we aim to investigate how parental genetics influence offspring cognition, educational attainment, and psychopathology in youth. Methods Participants for the discovery sample were 2,189 offspring (aged 6-14 years), 1898 mothers and 1,017 fathers who underwent genotyping, psychiatric, and cognitive assessments. We calculated polygenic scores (PGS) for cognition, educational attainment, attention-deficit hyperactivity disorder (ADHD), and schizophrenia for the trios. Phenotypes studied included educational and cognitive measures, ADHD and psychotic symptoms. We used a stepwise approach and multiple mediation models to analyze the effect of parental PGS on offspring traits via offspring PGS and parental phenotype. Significant results were replicated in a sample of 1,029 adolescents, 363 mothers, and 307 fathers. Results Maternal and paternal PGS for cognition influenced offspring general intelligence and executive function via offspring PGS (genetic pathway) and parental education (phenotypic pathway). Similar results were found for parental PGS for educational attainment and offspring reading and writing skills. These pathways fully explained associations between parental PGS and offspring phenotypes, without residual direct association. Associations with maternal, but not paternal, PGS were replicated. No associations were found between parental PGS for psychopathology and offspring specific symptoms. Conclusions Our findings indicate that parental genetics influences offspring cognition and educational attainment by genetic and phenotypic pathways, suggesting the expression of parental phenotypes partially explain the association between parental genetic risk and offspring outcomes. Multiple mediations might represent an effective approach to disentangle distinct pathways for intergenerational transmission of behavioral traits. En ligne : https://doi.org/10.1111/jcpp.13708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Replication of a predictive model for youth ADHD in an independent sample from a developing country / Cezar H. LORENZI in Journal of Child Psychology and Psychiatry, 64-1 (January 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.167-174 Titre : Replication of a predictive model for youth ADHD in an independent sample from a developing country Type de document : Texte imprimé et/ou numérique Auteurs : Cezar H. LORENZI, Auteur ; Douglas TEIXEIRA LEFFA, Auteur ; Rodrigo BRESSAN, Auteur ; Sintia I. BELANGERO, Auteur ; Ary GADELHA, Auteur ; Marcos L. SANTORO, Auteur ; Giovanni A. SALUM, Auteur ; Luis Augusto ROHDE, Auteur ; Arthur CAYE, Auteur Article en page(s) : p.167-174 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Very few predictive models in Psychiatry had their performance validated in independent external samples. A previously developed multivariable demographic model for attention-deficit/hyperactivity disorder (ADHD) accurately predicted young adulthood ADHD using clinical and demographical information collected in childhood in three samples from developed countries, but failed to replicate its performance in a sample from a developing country. Furthermore, consolidated risk factors for ADHD were not included among its predictors. Methods Participants were 1905 children and adolescents from a community-based sample and followed from ages 6 to 14 years at baseline to ages 14 to 23 years (mean age 18) at follow-up. We applied the intercept and weights of the original model to the data, calculating the predicted probability of each participant according to the set of predictors collected in childhood, and compared the estimates with the actual outcome (ADHD) collected during adolescence and young adulthood. We explored the performance of the original model, and of models including novel predictors (prematurity, family history of ADHD, and polygenic risk score for ADHD). Results The observed area under the curve of the original model was .76 (95% Confidence Interval .70 to .82). The multivariable demographical model outperformed single variable models using only prematurity, family history, or the ADHD PRS. Adding either of these variables, or all at once, did not improve the performance of the original demographical model. Conclusions Our findings suggest that the originally developed ADHD predictive model is suitable for use in different settings for clinical and research purposes. En ligne : https://doi.org/10.1111/jcpp.13682 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Replication of a predictive model for youth ADHD in an independent sample from a developing country [Texte imprimé et/ou numérique] / Cezar H. LORENZI, Auteur ; Douglas TEIXEIRA LEFFA, Auteur ; Rodrigo BRESSAN, Auteur ; Sintia I. BELANGERO, Auteur ; Ary GADELHA, Auteur ; Marcos L. SANTORO, Auteur ; Giovanni A. SALUM, Auteur ; Luis Augusto ROHDE, Auteur ; Arthur CAYE, Auteur . - p.167-174. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.167-174 Index. décimale : PER Périodiques Résumé : Background Very few predictive models in Psychiatry had their performance validated in independent external samples. A previously developed multivariable demographic model for attention-deficit/hyperactivity disorder (ADHD) accurately predicted young adulthood ADHD using clinical and demographical information collected in childhood in three samples from developed countries, but failed to replicate its performance in a sample from a developing country. Furthermore, consolidated risk factors for ADHD were not included among its predictors. Methods Participants were 1905 children and adolescents from a community-based sample and followed from ages 6 to 14 years at baseline to ages 14 to 23 years (mean age 18) at follow-up. We applied the intercept and weights of the original model to the data, calculating the predicted probability of each participant according to the set of predictors collected in childhood, and compared the estimates with the actual outcome (ADHD) collected during adolescence and young adulthood. We explored the performance of the original model, and of models including novel predictors (prematurity, family history of ADHD, and polygenic risk score for ADHD). Results The observed area under the curve of the original model was .76 (95% Confidence Interval .70 to .82). The multivariable demographical model outperformed single variable models using only prematurity, family history, or the ADHD PRS. Adding either of these variables, or all at once, did not improve the performance of the original demographical model. Conclusions Our findings suggest that the originally developed ADHD predictive model is suitable for use in different settings for clinical and research purposes. En ligne : https://doi.org/10.1111/jcpp.13682 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

The synergistic effect of genetic and environmental factors in the development of attention-deficit/hyperactivity disorder symptoms in children and adolescents / Douglas Teixeira LEFFA in Development and Psychopathology, 36-3 (August 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-3 (August 2024) . - p.1134-1144 Titre : The synergistic effect of genetic and environmental factors in the development of attention-deficit/hyperactivity disorder symptoms in children and adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Douglas Teixeira LEFFA, Auteur ; Arthur CAYE, Auteur ; Sintia I. BELANGERO, Auteur ; Ary GADELHA, Auteur ; Pedro Mario PAN, Auteur ; Giovanni Abrahão SALUM, Auteur ; Luis Augusto ROHDE, Auteur Article en page(s) : p.1134-1144 Langues : Anglais (eng) Mots-clés : ADHD  environment  epidemiology  genetics  risk factors Index. décimale : PER Périodiques Résumé : Gene-environment interactions (GxE) have been increasingly explored in psychiatry but with low replication rates. Attention-deficit/hyperactivity disorder (ADHD) is a suitable candidate for studying GxE due to its high heritability and well-defined environmental risk factors. Here, we explored GxE using polygenic risk score (PRS) to represent the genetic liability to ADHD (ADHD-PRS) and environmental risk score (ERS) to represent the combined effects of environmental risk factors. We analyzed longitudinal data of 2,046 individuals (6-14 years of age at baseline and 14-23 at the last follow-up) from the Brazilian High-Risk Cohort Study for Psychiatric Disorders. Psychiatric evaluation included the Child Behavior Checklist and the Strength and Difficulties Questionnaire. Statistical analyses were performed using mixed-effects models. We observed statistically significant interactions between ADHD-PRS and ERS, suggesting that environmental and genetic factors act synergistically in the development of ADHD symptoms. These effects were not present for depression or anxiety symptoms. No evidence of GxE correlation was detected. Mechanistically, our findings suggest that environmental stressors modulate the genetic risk for ADHD. Future studies should investigate whether the reduction of environmental risks can prevent the development of symptoms of ADHD, especially in children with a family history of the disorder. En ligne : https://dx.doi.org/10.1017/S0954579423000366 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] The synergistic effect of genetic and environmental factors in the development of attention-deficit/hyperactivity disorder symptoms in children and adolescents [Texte imprimé et/ou numérique] / Douglas Teixeira LEFFA, Auteur ; Arthur CAYE, Auteur ; Sintia I. BELANGERO, Auteur ; Ary GADELHA, Auteur ; Pedro Mario PAN, Auteur ; Giovanni Abrahão SALUM, Auteur ; Luis Augusto ROHDE, Auteur . - p.1134-1144. Langues : Anglais (eng) in Development and Psychopathology > 36-3 (August 2024) . - p.1134-1144 Mots-clés : ADHD  environment  epidemiology  genetics  risk factors Index. décimale : PER Périodiques Résumé : Gene-environment interactions (GxE) have been increasingly explored in psychiatry but with low replication rates. Attention-deficit/hyperactivity disorder (ADHD) is a suitable candidate for studying GxE due to its high heritability and well-defined environmental risk factors. Here, we explored GxE using polygenic risk score (PRS) to represent the genetic liability to ADHD (ADHD-PRS) and environmental risk score (ERS) to represent the combined effects of environmental risk factors. We analyzed longitudinal data of 2,046 individuals (6-14 years of age at baseline and 14-23 at the last follow-up) from the Brazilian High-Risk Cohort Study for Psychiatric Disorders. Psychiatric evaluation included the Child Behavior Checklist and the Strength and Difficulties Questionnaire. Statistical analyses were performed using mixed-effects models. We observed statistically significant interactions between ADHD-PRS and ERS, suggesting that environmental and genetic factors act synergistically in the development of ADHD symptoms. These effects were not present for depression or anxiety symptoms. No evidence of GxE correlation was detected. Mechanistically, our findings suggest that environmental stressors modulate the genetic risk for ADHD. Future studies should investigate whether the reduction of environmental risks can prevent the development of symptoms of ADHD, especially in children with a family history of the disorder. En ligne : https://dx.doi.org/10.1017/S0954579423000366 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

---

1 (1 - 5 / 5)