Assessment of Autistic Traits in Children Aged 2 to 4½ Years With the Preschool Version of the Social Responsiveness Scale (SRS-P): Findings from Japan / Andrew STICKLEY in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.852-865 Titre : Assessment of Autistic Traits in Children Aged 2 to 4½ Years With the Preschool Version of the Social Responsiveness Scale (SRS-P): Findings from Japan Type de document : Texte imprimé et/ou numérique Auteurs : Andrew STICKLEY, Auteur ; Yoshiyuki TACHIBANA, Auteur ; Keiji HASHIMOTO, Auteur ; Hideyuki HARAGUCHI, Auteur ; Atsuko MIYAKE, Auteur ; Seiichi MOROKUMA, Auteur ; Hiroshi NITTA, Auteur ; Masako ODA, Auteur ; Yukihiro OHYA, Auteur ; Ayako SENJU, Auteur ; Hidetoshi TAKAHASHI, Auteur ; Takanori YAMAGATA, Auteur ; Yoko KAMIO, Auteur Article en page(s) : p.852-865 Langues : Anglais (eng) Mots-clés : ASD  autistic traits  quantitative measure  reliability  validity  preschool children  questionnaire Index. décimale : PER Périodiques Résumé : The recent development and use of autism measures for the general population has led to a growing body of evidence which suggests that autistic traits are distributed along a continuum. However, as most existing autism measures were designed for use in children older than age 4, to date, little is known about the autistic continuum in children younger than age 4. As autistic symptoms are evident in the first few years, to address this research gap, the current study tested the preschool version of the Social Responsiveness Scale (SRS-P) in children aged 2 to 4½ years in clinical (N?=?74, average age 40 months, 26–51 months) and community settings (N?=?357, average age 39 months, 25–50 months) in Japan. Using information obtained from different raters (mothers, other caregivers, and teachers) it was found that the scale demonstrated a good degree of internal consistency, inter-rater reliability and test-retest reliability, and a satisfactory degree of convergent validity for the clinical sample when compared with scores from diagnostic “gold standard” autism measures. Receiver operating characteristic analyses and the group comparisons also showed that the SRS-P total score discriminated well between children with autism spectrum disorder (ASD) and those without ASD. Importantly, this scale could identify autistic symptoms or traits distributed continually across the child population at this age irrespective of the presence of an ASD diagnosis. These findings suggest that the SRS-P might be a sensitive instrument for case identification including subthreshold ASD, as well as a potentially useful research tool for exploring ASD endophenotypes. En ligne : http://dx.doi.org/10.1002/aur.1742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Assessment of Autistic Traits in Children Aged 2 to 4½ Years With the Preschool Version of the Social Responsiveness Scale (SRS-P): Findings from Japan [Texte imprimé et/ou numérique] / Andrew STICKLEY, Auteur ; Yoshiyuki TACHIBANA, Auteur ; Keiji HASHIMOTO, Auteur ; Hideyuki HARAGUCHI, Auteur ; Atsuko MIYAKE, Auteur ; Seiichi MOROKUMA, Auteur ; Hiroshi NITTA, Auteur ; Masako ODA, Auteur ; Yukihiro OHYA, Auteur ; Ayako SENJU, Auteur ; Hidetoshi TAKAHASHI, Auteur ; Takanori YAMAGATA, Auteur ; Yoko KAMIO, Auteur . - p.852-865. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.852-865 Mots-clés : ASD  autistic traits  quantitative measure  reliability  validity  preschool children  questionnaire Index. décimale : PER Périodiques Résumé : The recent development and use of autism measures for the general population has led to a growing body of evidence which suggests that autistic traits are distributed along a continuum. However, as most existing autism measures were designed for use in children older than age 4, to date, little is known about the autistic continuum in children younger than age 4. As autistic symptoms are evident in the first few years, to address this research gap, the current study tested the preschool version of the Social Responsiveness Scale (SRS-P) in children aged 2 to 4½ years in clinical (N?=?74, average age 40 months, 26–51 months) and community settings (N?=?357, average age 39 months, 25–50 months) in Japan. Using information obtained from different raters (mothers, other caregivers, and teachers) it was found that the scale demonstrated a good degree of internal consistency, inter-rater reliability and test-retest reliability, and a satisfactory degree of convergent validity for the clinical sample when compared with scores from diagnostic “gold standard” autism measures. Receiver operating characteristic analyses and the group comparisons also showed that the SRS-P total score discriminated well between children with autism spectrum disorder (ASD) and those without ASD. Importantly, this scale could identify autistic symptoms or traits distributed continually across the child population at this age irrespective of the presence of an ASD diagnosis. These findings suggest that the SRS-P might be a sensitive instrument for case identification including subthreshold ASD, as well as a potentially useful research tool for exploring ASD endophenotypes. En ligne : http://dx.doi.org/10.1002/aur.1742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Brief Report: Best Discriminators for Identifying Children with Autism Spectrum Disorder at an 18-Month Health Check-Up in Japan / Yoko KAMIO in Journal of Autism and Developmental Disorders, 45-12 (December 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4147-4153 Titre : Brief Report: Best Discriminators for Identifying Children with Autism Spectrum Disorder at an 18-Month Health Check-Up in Japan Type de document : Texte imprimé et/ou numérique Auteurs : Yoko KAMIO, Auteur ; Hideyuki HARAGUCHI, Auteur ; Andrew STICKLEY, Auteur ; Kazuo OGINO, Auteur ; Makoto ISHITOBI, Auteur ; Hidetoshi TAKAHASHI, Auteur Article en page(s) : p.4147-4153 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Screening  Short form  Modified checklist for autism in toddlers (M-CHAT)  Primary care settings Index. décimale : PER Périodiques Résumé : To determine the best discriminative items for identifying young children with autism spectrum disorders (ASD), we conducted a secondary analysis using longitudinal cohort data that included the Japanese version of the 23-item modified checklist for autism in toddlers (M-CHAT-JV). M-CHAT-JV data at 18 months of age and diagnostic information evaluated at age 3 or later from 1851 Japanese children was used to isolate six highly discriminative items. Using data from two different community samples (n = 1851, n = 665) these items were shown to have comparable psychometric values with those of the full version. Our results suggest that these items might work as a short form screener for early identification of ASD in primary care settings where there are time constraints on screening. En ligne : http://dx.doi.org/10.1007/s10803-015-2527-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274 [article] Brief Report: Best Discriminators for Identifying Children with Autism Spectrum Disorder at an 18-Month Health Check-Up in Japan [Texte imprimé et/ou numérique] / Yoko KAMIO, Auteur ; Hideyuki HARAGUCHI, Auteur ; Andrew STICKLEY, Auteur ; Kazuo OGINO, Auteur ; Makoto ISHITOBI, Auteur ; Hidetoshi TAKAHASHI, Auteur . - p.4147-4153. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4147-4153 Mots-clés : Autism spectrum disorder  Screening  Short form  Modified checklist for autism in toddlers (M-CHAT)  Primary care settings Index. décimale : PER Périodiques Résumé : To determine the best discriminative items for identifying young children with autism spectrum disorders (ASD), we conducted a secondary analysis using longitudinal cohort data that included the Japanese version of the 23-item modified checklist for autism in toddlers (M-CHAT-JV). M-CHAT-JV data at 18 months of age and diagnostic information evaluated at age 3 or later from 1851 Japanese children was used to isolate six highly discriminative items. Using data from two different community samples (n = 1851, n = 665) these items were shown to have comparable psychometric values with those of the full version. Our results suggest that these items might work as a short form screener for early identification of ASD in primary care settings where there are time constraints on screening. En ligne : http://dx.doi.org/10.1007/s10803-015-2527-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274

Hyperreactivity to weak acoustic stimuli and prolonged acoustic startle latency in children with autism spectrum disorders / Hidetoshi TAKAHASHI in Molecular Autism, (March 2014)  

Public ISBD [article]  inMolecular Autism > (March 2014) . - p.1-8 Titre : Hyperreactivity to weak acoustic stimuli and prolonged acoustic startle latency in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Hidetoshi TAKAHASHI, Auteur ; Takayuki NAKAHACHI, Auteur ; Sahoko KOMATSU, Auteur ; Kazuo OGINO, Auteur ; Yukako IIDA, Auteur ; Yoko KAMIO, Auteur Article en page(s) : p.1-8 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : People with autism spectrum disorders (ASD) are known to have enhanced auditory perception, however, acoustic startle response to weak stimuli has not been well documented in this population. The objectives of this study are to evaluate the basic profile of acoustic startle response, including peak startle latency and startle magnitude to weaker stimuli, in children with ASD and typical development (TD), and to evaluate their relationship to ASD characteristics. En ligne : http://dx.doi.org/10.1186/2040-2392-5-23 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] Hyperreactivity to weak acoustic stimuli and prolonged acoustic startle latency in children with autism spectrum disorders [Texte imprimé et/ou numérique] / Hidetoshi TAKAHASHI, Auteur ; Takayuki NAKAHACHI, Auteur ; Sahoko KOMATSU, Auteur ; Kazuo OGINO, Auteur ; Yukako IIDA, Auteur ; Yoko KAMIO, Auteur . - p.1-8. Langues : Anglais (eng) in Molecular Autism > (March 2014) . - p.1-8 Index. décimale : PER Périodiques Résumé : People with autism spectrum disorders (ASD) are known to have enhanced auditory perception, however, acoustic startle response to weak stimuli has not been well documented in this population. The objectives of this study are to evaluate the basic profile of acoustic startle response, including peak startle latency and startle magnitude to weaker stimuli, in children with ASD and typical development (TD), and to evaluate their relationship to ASD characteristics. En ligne : http://dx.doi.org/10.1186/2040-2392-5-23 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

Relationship of the Acoustic Startle Response and Its Modulation to Emotional and Behavioral Problems in Typical Development Children and Those with Autism Spectrum Disorders / Hidetoshi TAKAHASHI in Journal of Autism and Developmental Disorders, 46-2 (February 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.534-543 Titre : Relationship of the Acoustic Startle Response and Its Modulation to Emotional and Behavioral Problems in Typical Development Children and Those with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Hidetoshi TAKAHASHI, Auteur ; Sahoko KOMATSU, Auteur ; Takayuki NAKAHACHI, Auteur ; Kazuo OGINO, Auteur ; Yoko KAMIO, Auteur Année de publication : 2016 Article en page(s) : p.534-543 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Acoustic startle response  Prepulse inhibition  Sensory-motor gating  Habituation  Startle latency Index. décimale : PER Périodiques Résumé : Auditory hyper-reactivity is a common sensory-perceptual abnormality in autism spectrum disorders (ASD), which interrupts behavioral adaptation. We investigated acoustic startle response (ASR) modulations in 17 children with ASD and 27 with typical development (TD). Compared to TD, children with ASD had larger ASR magnitude to weak stimuli and more prolonged peak startle-latency. We could not find significant difference of prepulse inhibition (PPI) or habituation in ASD children compared to TD. However, habituation and PPI at 70-dB prepulses were negatively related to several subscales of Social Responsiveness Scale and the Strengths and Difficulties Questionnaire, when considering all children. Comprehensive investigation of ASR and its modulation might increase understanding of the neurophysiological impairments underlying ASD and other mental health problems in children. En ligne : http://dx.doi.org/10.1007/s10803-015-2593-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 [article] Relationship of the Acoustic Startle Response and Its Modulation to Emotional and Behavioral Problems in Typical Development Children and Those with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Hidetoshi TAKAHASHI, Auteur ; Sahoko KOMATSU, Auteur ; Takayuki NAKAHACHI, Auteur ; Kazuo OGINO, Auteur ; Yoko KAMIO, Auteur . - 2016 . - p.534-543. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.534-543 Mots-clés : Autism spectrum disorders  Acoustic startle response  Prepulse inhibition  Sensory-motor gating  Habituation  Startle latency Index. décimale : PER Périodiques Résumé : Auditory hyper-reactivity is a common sensory-perceptual abnormality in autism spectrum disorders (ASD), which interrupts behavioral adaptation. We investigated acoustic startle response (ASR) modulations in 17 children with ASD and 27 with typical development (TD). Compared to TD, children with ASD had larger ASR magnitude to weak stimuli and more prolonged peak startle-latency. We could not find significant difference of prepulse inhibition (PPI) or habituation in ASD children compared to TD. However, habituation and PPI at 70-dB prepulses were negatively related to several subscales of Social Responsiveness Scale and the Strengths and Difficulties Questionnaire, when considering all children. Comprehensive investigation of ASR and its modulation might increase understanding of the neurophysiological impairments underlying ASD and other mental health problems in children. En ligne : http://dx.doi.org/10.1007/s10803-015-2593-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280

Stability of the acoustic startle response and its modulation in children with typical development and those with autism spectrum disorders: A one-year follow-up / Hidetoshi TAKAHASHI in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.673-679 Titre : Stability of the acoustic startle response and its modulation in children with typical development and those with autism spectrum disorders: A one-year follow-up Type de document : Texte imprimé et/ou numérique Auteurs : Hidetoshi TAKAHASHI, Auteur ; Takayuki NAKAHACHI, Auteur ; Andrew STICKLEY, Auteur ; Makoto ISHITOBI, Auteur ; Yoko KAMIO, Auteur Article en page(s) : p.673-679 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  acoustic startle response  prepulse inhibition  sensory-motor gating  habituation  startle latency  long-term stability  test–retest reliability Index. décimale : PER Périodiques Résumé : Auditory hyper-reactivity is a common sensory–perceptual abnormality that interrupts behavioral adaptations in autism spectrum disorders (ASD). Recently, prolonged acoustic startle response (ASR) latency and hyper-reactivity to weak acoustic stimuli were reported in children with ASD. Indexes of ASR and its modulation are known to be stable biological markers for translational research in the adult population. However, little is known about the stability of these indexes in children. Thus, the objective of our study was to investigate the stability of neurophysiological ASR indexes in children with ASD and typical development (TD). Participants included 12 children with ASD and 24 with TD. Mean startle magnitudes to acoustic stimuli presented at 65–105 dB in increments of 10 dB were analyzed. Average peak startle latency (PSL), ASR modulation of habituation, and prepulse inhibition were also analyzed. These startle measures were examined after a follow-up period of 15.7?±?5.1 months from baseline. At both baseline and in the follow-up period, children with ASD had significantly greater startle magnitudes to weak stimuli of 65–85 dB and more prolonged PSL compared with controls. Intraclass correlation coefficients for these ASR measures between both periods were 0.499–0.705. None of the ASR measures differed significantly between the two periods. Our results suggest that prolonged PSL and greater startle magnitudes to weak stimuli in children with ASD might serve as moderately stable neurophysiological indexes of ASD. En ligne : http://dx.doi.org/10.1002/aur.1710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Stability of the acoustic startle response and its modulation in children with typical development and those with autism spectrum disorders: A one-year follow-up [Texte imprimé et/ou numérique] / Hidetoshi TAKAHASHI, Auteur ; Takayuki NAKAHACHI, Auteur ; Andrew STICKLEY, Auteur ; Makoto ISHITOBI, Auteur ; Yoko KAMIO, Auteur . - p.673-679. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.673-679 Mots-clés : autism spectrum disorders  acoustic startle response  prepulse inhibition  sensory-motor gating  habituation  startle latency  long-term stability  test–retest reliability Index. décimale : PER Périodiques Résumé : Auditory hyper-reactivity is a common sensory–perceptual abnormality that interrupts behavioral adaptations in autism spectrum disorders (ASD). Recently, prolonged acoustic startle response (ASR) latency and hyper-reactivity to weak acoustic stimuli were reported in children with ASD. Indexes of ASR and its modulation are known to be stable biological markers for translational research in the adult population. However, little is known about the stability of these indexes in children. Thus, the objective of our study was to investigate the stability of neurophysiological ASR indexes in children with ASD and typical development (TD). Participants included 12 children with ASD and 24 with TD. Mean startle magnitudes to acoustic stimuli presented at 65–105 dB in increments of 10 dB were analyzed. Average peak startle latency (PSL), ASR modulation of habituation, and prepulse inhibition were also analyzed. These startle measures were examined after a follow-up period of 15.7?±?5.1 months from baseline. At both baseline and in the follow-up period, children with ASD had significantly greater startle magnitudes to weak stimuli of 65–85 dB and more prolonged PSL compared with controls. Intraclass correlation coefficients for these ASR measures between both periods were 0.499–0.705. None of the ASR measures differed significantly between the two periods. Our results suggest that prolonged PSL and greater startle magnitudes to weak stimuli in children with ASD might serve as moderately stable neurophysiological indexes of ASD. En ligne : http://dx.doi.org/10.1002/aur.1710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

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