Assessment of autonomic symptom scales in patients with neurodevelopmental diagnoses using electronic health record data / Antoinette Sabatino DICRISCIO in Research in Autism Spectrum Disorders, 108 (October 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 108 (October 2023) . - p.102234 Titre : Assessment of autonomic symptom scales in patients with neurodevelopmental diagnoses using electronic health record data Type de document : texte imprimé Auteurs : Antoinette Sabatino DICRISCIO, Auteur ; D. BEILER, Auteur ; Jodie SMITH, Auteur ; P. ASDELL, Auteur ; S. DICKEY, Auteur ; M. DISTEFANO, Auteur ; Vanessa TROIANI, Auteur Article en page(s) : p.102234 Mots-clés : Autonomic function  Chart review  Autism spectrum disorder  Developmental brain dysfunction  Individual differences Index. décimale : PER Périodiques Résumé : Background Sleep disturbances, gastrointestinal problems, and atypical heart rate are commonly observed in patients with autism spectrum disorder (ASD) and may relate to underlying function of the autonomic nervous system (ANS). The overall objective of the current study was to quantitatively characterize features of ANS function using symptom scales and available electronic health record (EHR) data in a clinically and genetically characterized pediatric cohort. Methods We assessed features of ANS function via chart review of patient records adapted from items drawn from a clinical research questionnaire of autonomic symptoms. This procedure coded for the presence and/or absence of targeted symptoms and was completed in 3 groups of patients, including patients with a clinical neurodevelopmental diagnosis and identified genetic etiology (NPD, n = 244), those with an ASD diagnosis with no known genetic cause (ASD, n = 159), and age and sex matched controls (MC, n = 213). Symptoms were assessed across four main categories: (1) Mood, Behavior, and Emotion; (2) Secretomotor, Sensory Integration; (3) Urinary, Gastrointestinal, and Digestion; and (4) Circulation, Thermoregulation, Circadian function, and Sleep/Wake cycles. Results Chart review scores indicate an increased rate of autonomic symptoms across all four sections in our NPD group as compared to scores with ASD and/or MC. Additionally, we note several significant relationships between individual differences in autonomic symptoms and quantitative ASD traits. Conclusion These results highlight EHR review as a potentially useful method for quantifying variance in symptoms adapted from a questionnaire or survey. Further, using this method indicates that autonomic features are more prevalent in children with genetic disorders conferring risk for ASD and other neurodevelopmental diagnoses. En ligne : https://doi.org/10.1016/j.rasd.2023.102234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514 [article] Assessment of autonomic symptom scales in patients with neurodevelopmental diagnoses using electronic health record data [texte imprimé] / Antoinette Sabatino DICRISCIO, Auteur ; D. BEILER, Auteur ; Jodie SMITH, Auteur ; P. ASDELL, Auteur ; S. DICKEY, Auteur ; M. DISTEFANO, Auteur ; Vanessa TROIANI, Auteur . - p.102234. in Research in Autism Spectrum Disorders > 108 (October 2023) . - p.102234 Mots-clés : Autonomic function  Chart review  Autism spectrum disorder  Developmental brain dysfunction  Individual differences Index. décimale : PER Périodiques Résumé : Background Sleep disturbances, gastrointestinal problems, and atypical heart rate are commonly observed in patients with autism spectrum disorder (ASD) and may relate to underlying function of the autonomic nervous system (ANS). The overall objective of the current study was to quantitatively characterize features of ANS function using symptom scales and available electronic health record (EHR) data in a clinically and genetically characterized pediatric cohort. Methods We assessed features of ANS function via chart review of patient records adapted from items drawn from a clinical research questionnaire of autonomic symptoms. This procedure coded for the presence and/or absence of targeted symptoms and was completed in 3 groups of patients, including patients with a clinical neurodevelopmental diagnosis and identified genetic etiology (NPD, n = 244), those with an ASD diagnosis with no known genetic cause (ASD, n = 159), and age and sex matched controls (MC, n = 213). Symptoms were assessed across four main categories: (1) Mood, Behavior, and Emotion; (2) Secretomotor, Sensory Integration; (3) Urinary, Gastrointestinal, and Digestion; and (4) Circulation, Thermoregulation, Circadian function, and Sleep/Wake cycles. Results Chart review scores indicate an increased rate of autonomic symptoms across all four sections in our NPD group as compared to scores with ASD and/or MC. Additionally, we note several significant relationships between individual differences in autonomic symptoms and quantitative ASD traits. Conclusion These results highlight EHR review as a potentially useful method for quantifying variance in symptoms adapted from a questionnaire or survey. Further, using this method indicates that autonomic features are more prevalent in children with genetic disorders conferring risk for ASD and other neurodevelopmental diagnoses. En ligne : https://doi.org/10.1016/j.rasd.2023.102234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514

Brief Report: Autism-like Traits are Associated With Enhanced Ability to Disembed Visual Forms / Antoinette SABATINO-DICRISCIO in Journal of Autism and Developmental Disorders, 47-5 (May 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1568-1576 Titre : Brief Report: Autism-like Traits are Associated With Enhanced Ability to Disembed Visual Forms Type de document : texte imprimé Auteurs : Antoinette SABATINO-DICRISCIO, Auteur ; Vanessa TROIANI, Auteur Article en page(s) : p.1568-1576 Langues : Anglais (eng) Mots-clés : Broader autism phenotype  Visual attention  Perception Individual differences  Gender differences  Figure-ground discrimination Index. décimale : PER Périodiques Résumé : Atypical visual perceptual skills are thought to underlie unusual visual attention in autism spectrum disorders. We assessed whether individual differences in visual processing skills scaled with quantitative traits associated with the broader autism phenotype (BAP). Visual perception was assessed using the Figure-ground subtest of the Test of visual perceptual skills-3rd Edition (TVPS). In a large adult cohort (n = 209), TVPS-Figure Ground scores were positively correlated with autistic-like social features as assessed by the Broader autism phenotype questionnaire. This relationship was gender-specific, with males showing a correspondence between visual perceptual skills and autistic-like traits. This work supports the link between atypical visual perception and autism and highlights the importance in characterizing meaningful individual differences in clinically relevant behavioral phenotypes. En ligne : http://dx.doi.org/10.1007/s10803-017-3053-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=306 [article] Brief Report: Autism-like Traits are Associated With Enhanced Ability to Disembed Visual Forms [texte imprimé] / Antoinette SABATINO-DICRISCIO, Auteur ; Vanessa TROIANI, Auteur . - p.1568-1576. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1568-1576 Mots-clés : Broader autism phenotype  Visual attention  Perception Individual differences  Gender differences  Figure-ground discrimination Index. décimale : PER Périodiques Résumé : Atypical visual perceptual skills are thought to underlie unusual visual attention in autism spectrum disorders. We assessed whether individual differences in visual processing skills scaled with quantitative traits associated with the broader autism phenotype (BAP). Visual perception was assessed using the Figure-ground subtest of the Test of visual perceptual skills-3rd Edition (TVPS). In a large adult cohort (n = 209), TVPS-Figure Ground scores were positively correlated with autistic-like social features as assessed by the Broader autism phenotype questionnaire. This relationship was gender-specific, with males showing a correspondence between visual perceptual skills and autistic-like traits. This work supports the link between atypical visual perception and autism and highlights the importance in characterizing meaningful individual differences in clinically relevant behavioral phenotypes. En ligne : http://dx.doi.org/10.1007/s10803-017-3053-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=306

Brief Report: Cognitive Control of Social and Nonsocial Visual Attention in Autism / Antoinette SABATINO-DICRISCIO in Journal of Autism and Developmental Disorders, 46-8 (August 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2797-2805 Titre : Brief Report: Cognitive Control of Social and Nonsocial Visual Attention in Autism Type de document : texte imprimé Auteurs : Antoinette SABATINO-DICRISCIO, Auteur ; Stephanie MILLER, Auteur ; Eleanor K. HANNA, Auteur ; Megan KOVAC, Auteur ; Lauren M. TURNER-BROWN, Auteur ; Noah J. SASSON, Auteur ; Jeffrey SAPYTA, Auteur ; Vanessa TROIANI, Auteur ; Gabriel S. DICHTER, Auteur Article en page(s) : p.2797-2805 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Visual attention  Cognitive control  Eyetracking Index. décimale : PER Périodiques Résumé : Prosaccade and antisaccade errors in the context of social and nonsocial stimuli were investigated in youth with autism spectrum disorder (ASD; n = 19) a matched control sample (n = 19), and a small sample of youth with obsessive compulsive disorder (n = 9). Groups did not differ in error rates in the prosaccade condition for any stimulus category. In the antisaccade condition, the ASD group demonstrated more errors than the control group for nonsocial stimuli related to circumscribed interests, but not for other nonsocial stimuli or for social stimuli. Additionally, antisaccade error rates were predictive of core ASD symptom severity. Results indicate that the cognitive control of visual attention in ASD is impaired specifically in the context of nonsocial stimuli related to circumscribed interests. En ligne : http://dx.doi.org/10.1007/s10803-016-2804-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Brief Report: Cognitive Control of Social and Nonsocial Visual Attention in Autism [texte imprimé] / Antoinette SABATINO-DICRISCIO, Auteur ; Stephanie MILLER, Auteur ; Eleanor K. HANNA, Auteur ; Megan KOVAC, Auteur ; Lauren M. TURNER-BROWN, Auteur ; Noah J. SASSON, Auteur ; Jeffrey SAPYTA, Auteur ; Vanessa TROIANI, Auteur ; Gabriel S. DICHTER, Auteur . - p.2797-2805. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2797-2805 Mots-clés : Autism spectrum disorder  Visual attention  Cognitive control  Eyetracking Index. décimale : PER Périodiques Résumé : Prosaccade and antisaccade errors in the context of social and nonsocial stimuli were investigated in youth with autism spectrum disorder (ASD; n = 19) a matched control sample (n = 19), and a small sample of youth with obsessive compulsive disorder (n = 9). Groups did not differ in error rates in the prosaccade condition for any stimulus category. In the antisaccade condition, the ASD group demonstrated more errors than the control group for nonsocial stimuli related to circumscribed interests, but not for other nonsocial stimuli or for social stimuli. Additionally, antisaccade error rates were predictive of core ASD symptom severity. Results indicate that the cognitive control of visual attention in ASD is impaired specifically in the context of nonsocial stimuli related to circumscribed interests. En ligne : http://dx.doi.org/10.1007/s10803-016-2804-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

Brief Report: Pupillometry, Visual Perception, and ASD Features in a Task-Switching Paradigm / Antoinette Sabatino DICRISCIO in Journal of Autism and Developmental Disorders, 49-12 (December 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.5086-5099 Titre : Brief Report: Pupillometry, Visual Perception, and ASD Features in a Task-Switching Paradigm Type de document : texte imprimé Auteurs : Antoinette Sabatino DICRISCIO, Auteur ; Yirui HU, Auteur ; Vanessa TROIANI, Auteur Année de publication : 2019 Article en page(s) : p.5086-5099 Langues : Anglais (eng) Mots-clés : Attention  Autism  Eye tracking  Pupillometry  Visual perception Index. décimale : PER Périodiques Résumé : We assessed the association between dynamic changes in pupil response in the context of visual perception and quantitative measures of the autism phenotype in healthy adults. Using Navon stimuli in a task-switching paradigm, participants were instructed to identify global or local information based on a cue. Multiple pupil response trajectories across conditions were identified. We combined trajectory patterns for global and local conditions and used data-driven methods to identify three distinct pupil trajectory sub-groups. We report higher scores on quantitative measures of autism features in individuals who demonstrated an increased change in pupil diameter across both conditions. Results demonstrate the use of individualized pupil response trajectories in order to quantitatively characterize visual perception associated with the broader autism phenotype (BAP). En ligne : http://dx.doi.org/10.1007/s10803-019-04213-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411 [article] Brief Report: Pupillometry, Visual Perception, and ASD Features in a Task-Switching Paradigm [texte imprimé] / Antoinette Sabatino DICRISCIO, Auteur ; Yirui HU, Auteur ; Vanessa TROIANI, Auteur . - 2019 . - p.5086-5099. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.5086-5099 Mots-clés : Attention  Autism  Eye tracking  Pupillometry  Visual perception Index. décimale : PER Périodiques Résumé : We assessed the association between dynamic changes in pupil response in the context of visual perception and quantitative measures of the autism phenotype in healthy adults. Using Navon stimuli in a task-switching paradigm, participants were instructed to identify global or local information based on a cue. Multiple pupil response trajectories across conditions were identified. We combined trajectory patterns for global and local conditions and used data-driven methods to identify three distinct pupil trajectory sub-groups. We report higher scores on quantitative measures of autism features in individuals who demonstrated an increased change in pupil diameter across both conditions. Results demonstrate the use of individualized pupil response trajectories in order to quantitatively characterize visual perception associated with the broader autism phenotype (BAP). En ligne : http://dx.doi.org/10.1007/s10803-019-04213-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411

Brief Report: Visual Perception, Task-Induced Pupil Response Trajectories and ASD Features in Children / Antoinette Sabatino DICRISCIO in Journal of Autism and Developmental Disorders, 49-7 (July 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.3016-3030 Titre : Brief Report: Visual Perception, Task-Induced Pupil Response Trajectories and ASD Features in Children Type de document : texte imprimé Auteurs : Antoinette Sabatino DICRISCIO, Auteur ; Yirui HU, Auteur ; Vanessa TROIANI, Auteur Année de publication : 2019 Article en page(s) : p.3016-3030 Langues : Anglais (eng) Mots-clés : Autism  Eye tracking  Global-local processing  Perception  Pupillometry Index. décimale : PER Périodiques Résumé : We applied a trajectory-based analysis to eye tracking data in order to quantify individualized patterns of pupil response in the context of global-local processing that may be associated with autism spectrum disorder (ASD) features. Multiple pupil response trajectories across both global and local conditions were identified. Using the combined trajectory patterns for global and local conditions for each individual, we were able to identify three groups based on trajectory group membership that were thought to reflect perceptual strategy. Results indicated that the proportion of children with ASD was significantly greater in the group demonstrating a local-focus response. This research presents a novel analytic approach to the objective characterization of individualized pupil response patterns that are associated with ASD features. En ligne : http://dx.doi.org/10.1007/s10803-019-04028-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Brief Report: Visual Perception, Task-Induced Pupil Response Trajectories and ASD Features in Children [texte imprimé] / Antoinette Sabatino DICRISCIO, Auteur ; Yirui HU, Auteur ; Vanessa TROIANI, Auteur . - 2019 . - p.3016-3030. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.3016-3030 Mots-clés : Autism  Eye tracking  Global-local processing  Perception  Pupillometry Index. décimale : PER Périodiques Résumé : We applied a trajectory-based analysis to eye tracking data in order to quantify individualized patterns of pupil response in the context of global-local processing that may be associated with autism spectrum disorder (ASD) features. Multiple pupil response trajectories across both global and local conditions were identified. Using the combined trajectory patterns for global and local conditions for each individual, we were able to identify three groups based on trajectory group membership that were thought to reflect perceptual strategy. Results indicated that the proportion of children with ASD was significantly greater in the group demonstrating a local-focus response. This research presents a novel analytic approach to the objective characterization of individualized pupil response patterns that are associated with ASD features. En ligne : http://dx.doi.org/10.1007/s10803-019-04028-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

Resting and Functional Pupil Response Metrics Indicate Features of Reward Sensitivity and ASD in Children / Antoinette Sabatino DICRISCIO in Journal of Autism and Developmental Disorders, 51-7 (July 2021)  

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Social-Emotional Inhibition of Return in Children with Autism Spectrum Disorder Versus Typical Development / Ligia ANTEZANA in Journal of Autism and Developmental Disorders, 46-4 (April 2016)  

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Social 'wanting' dysfunction in autism: neurobiological underpinnings and treatment implications / Gregor KOHLS in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

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The Broader Autism Phenotype and Visual Perception in Children / Antoinette SABATINO-DICRISCIO in Journal of Autism and Developmental Disorders, 48-8 (August 2018)  

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