Continuity of trajectories of autism symptom severity from infancy to childhood / Martina FRANCHINI in Journal of Child Psychology and Psychiatry, 64-6 (June 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.895-906 Titre : Continuity of trajectories of autism symptom severity from infancy to childhood Type de document : texte imprimé Auteurs : Martina FRANCHINI, Auteur ; Isabel M. SMITH, Auteur ; Lori-Ann R. SACREY, Auteur ; Eric DUKU, Auteur ; Jessica BRIAN, Auteur ; Susan E. BRYSON, Auteur ; Tracy VAILLANCOURT, Auteur ; Vickie ARMSTRONG, Auteur ; Peter SZATMARI, Auteur ; Wendy ROBERTS, Auteur ; Caroline RONCADIN, Auteur ; Lonnie ZWAIGENBAUM, Auteur Article en page(s) : p.895-906 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Behavioral symptom trajectories are informative of the development of young children at increased likelihood for autism spectrum disorder (ASD). Methods Developmental trajectories of early signs were examined in a cohort of siblings of children diagnosed with ASD (n = 502) from 6 to 18 months using the Autism Observation Scale for Infants (AOSI), and from 18 months to 5-7 years using the Autism Diagnostic Observation Schedule (ADOS). Diagnostic outcomes for ASD at age 3 confirmed diagnosis for 137 children. We further analyzed the conditional probability of a switch from a trajectory measured with the AOSI to a trajectory measured with the ADOS as well as predictors from age 6 months. Results We derived three early trajectories of behavioral signs (''Low,'' ''Intermediate,'' and ''Increasing'') from 6 to 18 months using the AOSI. We then derived three similar, distinct trajectories for the evolution of symptom severity between 18 and 60-84 months of age (Low, Intermediate, Increasing) using the ADOS. Globally, the Low trajectory included children showing fewer ASD signs or symptoms and the Increasing trajectory included children showing more severe symptoms. We also found that most children in the Low AOSI trajectory stayed in the corresponding ADOS trajectory, whereas children in an Increasing AOSI trajectory tended to transition to an Intermediate or Increasing ADOS trajectory. Developmental measures taken at 6 months (early signs of ASD, Fine Motor, and Visual Reception skills) were predictive of trajectory membership. Conclusions Results confirm substantial heterogeneity in the early emergence of ASD signs in children at increased likelihood for ASD. Moreover, we showed that the way those early behavioral signs emerge in infants is predictive of later symptomatology. Results yield clear clinical implications, supporting the need to repeatedly assess infants at increased likelihood for ASD as this can be highly indicative of their later development and behavior. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13744 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Continuity of trajectories of autism symptom severity from infancy to childhood [texte imprimé] / Martina FRANCHINI, Auteur ; Isabel M. SMITH, Auteur ; Lori-Ann R. SACREY, Auteur ; Eric DUKU, Auteur ; Jessica BRIAN, Auteur ; Susan E. BRYSON, Auteur ; Tracy VAILLANCOURT, Auteur ; Vickie ARMSTRONG, Auteur ; Peter SZATMARI, Auteur ; Wendy ROBERTS, Auteur ; Caroline RONCADIN, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - p.895-906. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.895-906 Index. décimale : PER Périodiques Résumé : Background Behavioral symptom trajectories are informative of the development of young children at increased likelihood for autism spectrum disorder (ASD). Methods Developmental trajectories of early signs were examined in a cohort of siblings of children diagnosed with ASD (n = 502) from 6 to 18 months using the Autism Observation Scale for Infants (AOSI), and from 18 months to 5-7 years using the Autism Diagnostic Observation Schedule (ADOS). Diagnostic outcomes for ASD at age 3 confirmed diagnosis for 137 children. We further analyzed the conditional probability of a switch from a trajectory measured with the AOSI to a trajectory measured with the ADOS as well as predictors from age 6 months. Results We derived three early trajectories of behavioral signs (''Low,'' ''Intermediate,'' and ''Increasing'') from 6 to 18 months using the AOSI. We then derived three similar, distinct trajectories for the evolution of symptom severity between 18 and 60-84 months of age (Low, Intermediate, Increasing) using the ADOS. Globally, the Low trajectory included children showing fewer ASD signs or symptoms and the Increasing trajectory included children showing more severe symptoms. We also found that most children in the Low AOSI trajectory stayed in the corresponding ADOS trajectory, whereas children in an Increasing AOSI trajectory tended to transition to an Intermediate or Increasing ADOS trajectory. Developmental measures taken at 6 months (early signs of ASD, Fine Motor, and Visual Reception skills) were predictive of trajectory membership. Conclusions Results confirm substantial heterogeneity in the early emergence of ASD signs in children at increased likelihood for ASD. Moreover, we showed that the way those early behavioral signs emerge in infants is predictive of later symptomatology. Results yield clear clinical implications, supporting the need to repeatedly assess infants at increased likelihood for ASD as this can be highly indicative of their later development and behavior. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13744 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

Early trajectories and moderators of autistic language profiles: A longitudinal study in preschoolers / Michel GODEL ; Martina FRANCHINI ; Fiona JOURNAL ; Nada KOJOVIC ; Marie SCHAER in Autism, 28-12 (December 2024)  

Public ISBD [article]  inAutism > 28-12 (December 2024) . - p.3043-3062 Titre : Early trajectories and moderators of autistic language profiles: A longitudinal study in preschoolers Type de document : texte imprimé Auteurs : Michel GODEL, Auteur ; Martina FRANCHINI, Auteur ; Fiona JOURNAL, Auteur ; Nada KOJOVIC, Auteur ; Marie SCHAER, Auteur Article en page(s) : p.3043-3062 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  cluster analysis  early intervention  Early Start Denver Model  moderators  precision medicine  prognosis Index. décimale : PER Périodiques Résumé : Both expressive and receptive language difficulties in autism emerge early and significantly have an impact on social functioning and quality of life. Despite their wide heterogeneity, autistic language abilities can be stratified into three distinct profiles. Language unimpaired exhibit near-typical verbal performance, language impaired show significant alterations in language structure, and minimally verbal display limited verbal abilities. However, little is known about the early trajectories and moderators specific to each profile. Here, we used a longitudinal sample of 286 preschoolers with autism and 85 typically developing (aged 1.5-5.7 years old), yielding 1164 visits. Our cluster analysis replicated the three well-established autistic language profiles (language unimpaired, n = 86; language impaired, n = 85; minimally verbal, n = 44) and revealed their specific early trajectories in expressive vocabulary, syntax, and pragmatics. At age 2.4, non-verbal cognition moderated the participants' attribution to each language profile. Moreover, early stereotyped language specifically moderated the later verbal performance of language unimpaired participants, while the language outcome of language impaired participants was moderated by early intensive behavioral intervention. In conclusion, we provided a fine-grained description of language acquisition trajectories and moderators of autistic language profiles in a longitudinal sample exposed to French language, paving the way toward personalized medicine to autistic language difficulties. Lay Abstract Language development can greatly vary among autistic children. Children who struggle with language acquisition often face many challenges and experience lower quality of life. However, little is known about the early language trajectories of autistic preschoolers and their moderators. Autistic language can be stratified into three profiles. Language unimpaired experience little to no language difficulties; language impaired show significant difficulties in language; minimally verbal never develop functional language. In this study, we used a longitudinal sample of preschoolers with autism and with typical development (aged 1.5-5.7 years). We replicated the three language profiles through a data-driven approach. We also found that different factors modulated the language outcome within each group. For instance, non-verbal cognition at age 2.4 moderated the participants' attribution to each language profile. Moreover, early intervention moderated verbal outcome in the language impaired profile. In conclusion, we provided a detailed description of how autistic preschoolers acquire language, and what factors might influence their trajectories. Our findings could inspire more personalized intervention for early autistic language difficulties. En ligne : https://dx.doi.org/10.1177/13623613241253015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=543 [article] Early trajectories and moderators of autistic language profiles: A longitudinal study in preschoolers [texte imprimé] / Michel GODEL, Auteur ; Martina FRANCHINI, Auteur ; Fiona JOURNAL, Auteur ; Nada KOJOVIC, Auteur ; Marie SCHAER, Auteur . - p.3043-3062. Langues : Anglais (eng) in Autism > 28-12 (December 2024) . - p.3043-3062 Mots-clés : autism spectrum disorders  cluster analysis  early intervention  Early Start Denver Model  moderators  precision medicine  prognosis Index. décimale : PER Périodiques Résumé : Both expressive and receptive language difficulties in autism emerge early and significantly have an impact on social functioning and quality of life. Despite their wide heterogeneity, autistic language abilities can be stratified into three distinct profiles. Language unimpaired exhibit near-typical verbal performance, language impaired show significant alterations in language structure, and minimally verbal display limited verbal abilities. However, little is known about the early trajectories and moderators specific to each profile. Here, we used a longitudinal sample of 286 preschoolers with autism and 85 typically developing (aged 1.5-5.7 years old), yielding 1164 visits. Our cluster analysis replicated the three well-established autistic language profiles (language unimpaired, n = 86; language impaired, n = 85; minimally verbal, n = 44) and revealed their specific early trajectories in expressive vocabulary, syntax, and pragmatics. At age 2.4, non-verbal cognition moderated the participants' attribution to each language profile. Moreover, early stereotyped language specifically moderated the later verbal performance of language unimpaired participants, while the language outcome of language impaired participants was moderated by early intensive behavioral intervention. In conclusion, we provided a fine-grained description of language acquisition trajectories and moderators of autistic language profiles in a longitudinal sample exposed to French language, paving the way toward personalized medicine to autistic language difficulties. Lay Abstract Language development can greatly vary among autistic children. Children who struggle with language acquisition often face many challenges and experience lower quality of life. However, little is known about the early language trajectories of autistic preschoolers and their moderators. Autistic language can be stratified into three profiles. Language unimpaired experience little to no language difficulties; language impaired show significant difficulties in language; minimally verbal never develop functional language. In this study, we used a longitudinal sample of preschoolers with autism and with typical development (aged 1.5-5.7 years). We replicated the three language profiles through a data-driven approach. We also found that different factors modulated the language outcome within each group. For instance, non-verbal cognition at age 2.4 moderated the participants' attribution to each language profile. Moreover, early intervention moderated verbal outcome in the language impaired profile. In conclusion, we provided a detailed description of how autistic preschoolers acquire language, and what factors might influence their trajectories. Our findings could inspire more personalized intervention for early autistic language difficulties. En ligne : https://dx.doi.org/10.1177/13623613241253015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=543

Early trajectories of motor skills in infant siblings of children with autism spectrum disorder / James W. PATTERSON in Autism Research, 15-3 (March 2022)  

Public ISBD [article]  inAutism Research > 15-3 (March 2022) . - p.481-492 Titre : Early trajectories of motor skills in infant siblings of children with autism spectrum disorder Type de document : texte imprimé Auteurs : James W. PATTERSON, Auteur ; Vickie ARMSTRONG, Auteur ; Eric DUKU, Auteur ; Annie E. RICHARD, Auteur ; Martina FRANCHINI, Auteur ; Jessica BRIAN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Lori-Ann R. SACREY, Auteur ; Caroline RONCADIN, Auteur ; Isabel M. SMITH, Auteur Article en page(s) : p.481-492 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Delays in motor development are not considered a core feature of autism spectrum disorder (ASD). Yet, recent studies of infant siblings of children with ASD suggest that early delays in motor skills may be associated with later delays in developmental areas considered to be core features of an ASD diagnosis. While these studies demonstrate the longitudinal association between core features and motor delays observed at single time points, there is considerable interest in studying the trajectories of motor development over the first 3 years of life. To accomplish this, we investigated early trajectories of motor development in a cohort of 499 infant siblings of children with ASD and 176 children with no family history of ASD. Data for the current study were drawn from the prospective, multi-site, Canadian Infant Sibling Study. We evaluated trajectories of fine and gross motor development over the first 3 years using group-based trajectory modeling. Our results show that membership for both fine and gross motor trajectory groups was related to expressive language skills, receptive language skills, ASD symptom severity scores, and diagnostic classification at age 3. These results provide evidence that the trajectory of a child's early motor development may have important prognostic implications in ASD. En ligne : https://doi.org/10.1002/aur.2641 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Early trajectories of motor skills in infant siblings of children with autism spectrum disorder [texte imprimé] / James W. PATTERSON, Auteur ; Vickie ARMSTRONG, Auteur ; Eric DUKU, Auteur ; Annie E. RICHARD, Auteur ; Martina FRANCHINI, Auteur ; Jessica BRIAN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Lori-Ann R. SACREY, Auteur ; Caroline RONCADIN, Auteur ; Isabel M. SMITH, Auteur . - p.481-492. Langues : Anglais (eng) in Autism Research > 15-3 (March 2022) . - p.481-492 Index. décimale : PER Périodiques Résumé : Abstract Delays in motor development are not considered a core feature of autism spectrum disorder (ASD). Yet, recent studies of infant siblings of children with ASD suggest that early delays in motor skills may be associated with later delays in developmental areas considered to be core features of an ASD diagnosis. While these studies demonstrate the longitudinal association between core features and motor delays observed at single time points, there is considerable interest in studying the trajectories of motor development over the first 3 years of life. To accomplish this, we investigated early trajectories of motor development in a cohort of 499 infant siblings of children with ASD and 176 children with no family history of ASD. Data for the current study were drawn from the prospective, multi-site, Canadian Infant Sibling Study. We evaluated trajectories of fine and gross motor development over the first 3 years using group-based trajectory modeling. Our results show that membership for both fine and gross motor trajectory groups was related to expressive language skills, receptive language skills, ASD symptom severity scores, and diagnostic classification at age 3. These results provide evidence that the trajectory of a child's early motor development may have important prognostic implications in ASD. En ligne : https://doi.org/10.1002/aur.2641 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

Face processing in 22q11.2 deletion syndrome: atypical development and visual scanning alterations / Alexandra ZAHARIA in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 26 p. Titre : Face processing in 22q11.2 deletion syndrome: atypical development and visual scanning alterations Type de document : texte imprimé Auteurs : Alexandra ZAHARIA, Auteur ; Maude SCHNEIDER, Auteur ; Bronwyn GLASER, Auteur ; Martina FRANCHINI, Auteur ; Sarah MENGHETTI, Auteur ; Marie SCHAER, Auteur ; Martin DEBBANE, Auteur ; Stephan ELIEZ, Auteur Année de publication : 2018 Article en page(s) : 26 p. Langues : Anglais (eng) Mots-clés : Configural face processing  Eye-tracking  Featural face processing  Neurodevelopmental disorders  Social difficulties Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research links social difficulties to atypical face exploration in 22q11.2 deletion syndrome (22q11.2DS). Two types of face processing are distinguished: configural (CFP) and featural (FFP). CFP develops later in life and plays an important role in face and emotion recognition abilities. Recent studies reported atypical development of CFP in several neurodevelopmental disorders. Taking previous reports of atypical face exploration one step further, our study aims at characterizing face processing in children and adolescents with 22q11.2DS. First, we sought to identify biases in the first two fixation positions on faces and to detect differences between CFP and FFP in 22q11.2DS using eye-tracking technology. Second, we investigated the developmental trajectories of CFP and FFP using accuracy data from follow-up evaluation. METHODS: Seventy-five individuals with 22q11.2DS and 84 typically developed (TD) individuals (aged 6-21 years) completed a discrimination task ("Jane task") inducing CFP and FFP in an eye-tracking setting. Thirty-six individuals with 22q11DS and 30 TD from our sample completed a longitudinal follow-up evaluation. RESULTS: Findings revealed that individuals with 22q11.2DS demonstrate an early bias toward the mouth region during the initial fixations on the faces and reduced flexibility exploration of the faces, with a reduced number of transitions between faces and longer fixations compared to the TD group. Further, scanpaths did not differ between CFP and FFP in the 22q11.2DS group. Longitudinal analysis of accuracy data provided evidence for atypical development of CFP in 22q11.2DS. CONCLUSIONS: The current study brings new evidence of altered face exploration in 22q11.2DS and identifies developmental mechanisms that may contribute to difficulties impacting social interactions in the syndrome. En ligne : http://dx.doi.org/10.1186/s11689-018-9245-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Face processing in 22q11.2 deletion syndrome: atypical development and visual scanning alterations [texte imprimé] / Alexandra ZAHARIA, Auteur ; Maude SCHNEIDER, Auteur ; Bronwyn GLASER, Auteur ; Martina FRANCHINI, Auteur ; Sarah MENGHETTI, Auteur ; Marie SCHAER, Auteur ; Martin DEBBANE, Auteur ; Stephan ELIEZ, Auteur . - 2018 . - 26 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 26 p. Mots-clés : Configural face processing  Eye-tracking  Featural face processing  Neurodevelopmental disorders  Social difficulties Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research links social difficulties to atypical face exploration in 22q11.2 deletion syndrome (22q11.2DS). Two types of face processing are distinguished: configural (CFP) and featural (FFP). CFP develops later in life and plays an important role in face and emotion recognition abilities. Recent studies reported atypical development of CFP in several neurodevelopmental disorders. Taking previous reports of atypical face exploration one step further, our study aims at characterizing face processing in children and adolescents with 22q11.2DS. First, we sought to identify biases in the first two fixation positions on faces and to detect differences between CFP and FFP in 22q11.2DS using eye-tracking technology. Second, we investigated the developmental trajectories of CFP and FFP using accuracy data from follow-up evaluation. METHODS: Seventy-five individuals with 22q11.2DS and 84 typically developed (TD) individuals (aged 6-21 years) completed a discrimination task ("Jane task") inducing CFP and FFP in an eye-tracking setting. Thirty-six individuals with 22q11DS and 30 TD from our sample completed a longitudinal follow-up evaluation. RESULTS: Findings revealed that individuals with 22q11.2DS demonstrate an early bias toward the mouth region during the initial fixations on the faces and reduced flexibility exploration of the faces, with a reduced number of transitions between faces and longer fixations compared to the TD group. Further, scanpaths did not differ between CFP and FFP in the 22q11.2DS group. Longitudinal analysis of accuracy data provided evidence for atypical development of CFP in 22q11.2DS. CONCLUSIONS: The current study brings new evidence of altered face exploration in 22q11.2DS and identifies developmental mechanisms that may contribute to difficulties impacting social interactions in the syndrome. En ligne : http://dx.doi.org/10.1186/s11689-018-9245-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

L’orientation sociale chez les jeunes enfants avec un trouble du spectre de l’autisme : apports des techniques d’oculométrie / Martina FRANCHINI in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E., 142 (Juillet 2016)

Public ISBD [article]  inApproche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E. > 142 (Juillet 2016) . - p.327-332 Titre : L’orientation sociale chez les jeunes enfants avec un trouble du spectre de l’autisme : apports des techniques d’oculométrie Type de document : texte imprimé Auteurs : Martina FRANCHINI, Auteur ; Edouard GENTAZ, Auteur ; Marie SCHAER, Auteur Article en page(s) : p.327-332 Langues : Français (fre) Mots-clés : Troubles du spectre autistique  Orientation sociale  Oculométrie  Développement socio-communicatif Index. décimale : PER Périodiques Résumé : Selon la théorie de la motivation sociale en autisme, une réduction de l’orientation vers des stimuli socialement saillants serait à l’origine d’une cascade développementale d’effets successifs qui expliquerait l’apparition des symptômes observables chez les personnes avec un trouble du spectre autistique. Cette réduction entraverait le développement sociocognitif des personnes avec autisme. Cette réduction peut être quantifiée de manière précise et fiable avec les techniques d’oculométrie chez des jeunes enfants avec autisme. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] L’orientation sociale chez les jeunes enfants avec un trouble du spectre de l’autisme : apports des techniques d’oculométrie [texte imprimé] / Martina FRANCHINI, Auteur ; Edouard GENTAZ, Auteur ; Marie SCHAER, Auteur . - p.327-332. Langues : Français (fre) in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E. > 142 (Juillet 2016) . - p.327-332 Mots-clés : Troubles du spectre autistique  Orientation sociale  Oculométrie  Développement socio-communicatif Index. décimale : PER Périodiques Résumé : Selon la théorie de la motivation sociale en autisme, une réduction de l’orientation vers des stimuli socialement saillants serait à l’origine d’une cascade développementale d’effets successifs qui expliquerait l’apparition des symptômes observables chez les personnes avec un trouble du spectre autistique. Cette réduction entraverait le développement sociocognitif des personnes avec autisme. Cette réduction peut être quantifiée de manière précise et fiable avec les techniques d’oculométrie chez des jeunes enfants avec autisme. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

Phenotyping variability in early socio-communicative skills in young children with autism and its influence on later development / Fiona JOURNAL in Autism Research, 17-10 (October 2024)  

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Predictors of Treatment Outcome in Preschoolers with Autism Spectrum Disorder: An Observational Study in the Greater Geneva Area, Switzerland / François ROBAIN in Journal of Autism and Developmental Disorders, 50-11 (November 2020)  

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Symptom trajectories in the first 18 months and autism risk in a prospective high-risk cohort / Lonnie ZWAIGENBAUM in Journal of Child Psychology and Psychiatry, 62-12 (December 2021)  

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The effect of emotional intensity on responses to joint attention in preschoolers with an autism spectrum disorder / Martina FRANCHINI in Research in Autism Spectrum Disorders, 35 (March 2017)  

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Trajectories of imitation skills in preschoolers with autism spectrum disorders / Irène PITTET in Journal of Neurodevelopmental Disorders, 14 (2022)  

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Variability in Verbal and Nonverbal Communication in Infants at Risk for Autism Spectrum Disorder: Predictors and Outcomes / Martina FRANCHINI in Journal of Autism and Developmental Disorders, 48-10 (October 2018)  

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