Development, behaviour and autism in individuals with SMC1A variants / Paul A. MULDER in Journal of Child Psychology and Psychiatry, 60-3 (March 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-3 (March 2019) . - p.305-313 Titre : Development, behaviour and autism in individuals with SMC1A variants Type de document : texte imprimé Auteurs : Paul A. MULDER, Auteur ; Sylvia HUISMAN, Auteur ; Annemiek M. LANDLUST, Auteur ; Jo MOSS, Auteur ; Sigrid PIENING, Auteur ; Raoul C. HENNEKAM, Auteur ; Ingrid D.C. VAN BALKOM, Auteur Article en page(s) : p.305-313 Langues : Anglais (eng) Mots-clés : Behavioural phenotype  autism  cognition  cornelia de lange syndrome  rett syndrome  self-injurious behaviour Index. décimale : PER Périodiques Résumé : INTRODUCTION: Development and behaviour in Cornelia de Lange Syndrome (CdLS), including autism characteristics, have been described infrequently stratified to genetic cause and only a few studies have considered behavioural characteristics in relation to developmental level. Here, we describe the behavioural phenotype in individuals with CdLS with SMC1A variants. METHODS: We performed an international, interdisciplinary study on 51 individuals with SMC1A variants. Results of questionnaire studies are compared to those in individuals with Down Syndrome and with Autism Spectrum Disorder. Results on cognition and self-injurious behaviour (SIB) are compared to those in individuals with CdLS caused by NIPBL variants. For Dutch participants with SMC1A variants we performed direct in-person assessments of cognition, autism, and added an interview and questionnaire on adaptive behaviour and sensory processing. RESULTS: Individuals with SMC1A variants show a higher cognitive level and less SIB than individuals with NIPBL variants. Individuals with SMC1A variants without classic CdLS phenotype but with a Rett-like phenotype show more severe intellectual disability and more SIB compared to those with a CdLS phenotype. Autism is less present if outcomes in direct in-person assessments are evaluated taking developmental level into account compared to results based on a questionnaire. CONCLUSIONS: Behaviour in individuals with CdLS should be evaluated taking genetic cause into account. Detailed interdisciplinary approaches are of clinical importance to inform tailored care and may eventually improve quality of life of patients and families. En ligne : https://dx.doi.org/10.1111/jcpp.12979 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=385 [article] Development, behaviour and autism in individuals with SMC1A variants [texte imprimé] / Paul A. MULDER, Auteur ; Sylvia HUISMAN, Auteur ; Annemiek M. LANDLUST, Auteur ; Jo MOSS, Auteur ; Sigrid PIENING, Auteur ; Raoul C. HENNEKAM, Auteur ; Ingrid D.C. VAN BALKOM, Auteur . - p.305-313. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-3 (March 2019) . - p.305-313 Mots-clés : Behavioural phenotype  autism  cognition  cornelia de lange syndrome  rett syndrome  self-injurious behaviour Index. décimale : PER Périodiques Résumé : INTRODUCTION: Development and behaviour in Cornelia de Lange Syndrome (CdLS), including autism characteristics, have been described infrequently stratified to genetic cause and only a few studies have considered behavioural characteristics in relation to developmental level. Here, we describe the behavioural phenotype in individuals with CdLS with SMC1A variants. METHODS: We performed an international, interdisciplinary study on 51 individuals with SMC1A variants. Results of questionnaire studies are compared to those in individuals with Down Syndrome and with Autism Spectrum Disorder. Results on cognition and self-injurious behaviour (SIB) are compared to those in individuals with CdLS caused by NIPBL variants. For Dutch participants with SMC1A variants we performed direct in-person assessments of cognition, autism, and added an interview and questionnaire on adaptive behaviour and sensory processing. RESULTS: Individuals with SMC1A variants show a higher cognitive level and less SIB than individuals with NIPBL variants. Individuals with SMC1A variants without classic CdLS phenotype but with a Rett-like phenotype show more severe intellectual disability and more SIB compared to those with a CdLS phenotype. Autism is less present if outcomes in direct in-person assessments are evaluated taking developmental level into account compared to results based on a questionnaire. CONCLUSIONS: Behaviour in individuals with CdLS should be evaluated taking genetic cause into account. Detailed interdisciplinary approaches are of clinical importance to inform tailored care and may eventually improve quality of life of patients and families. En ligne : https://dx.doi.org/10.1111/jcpp.12979 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=385

Dynamic Interactive Social Cognition Training in Virtual Reality (DiSCoVR) for adults with Autism Spectrum Disorder: A feasibility study / B.J. VAN PELT in Research in Autism Spectrum Disorders, 96 (August 2022)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 96 (August 2022) . - 102003 Titre : Dynamic Interactive Social Cognition Training in Virtual Reality (DiSCoVR) for adults with Autism Spectrum Disorder: A feasibility study Type de document : texte imprimé Auteurs : B.J. VAN PELT, Auteur ; S.A. NIJMAN, Auteur ; N.E.M. VAN HAREN, Auteur ; W. VELING, Auteur ; G.H.M. PIJNENBORG, Auteur ; Ingrid D.C. VAN BALKOM, Auteur ; Annemiek M. LANDLUST, Auteur ; Kirstin GREAVES-LORD, Auteur Article en page(s) : 102003 Langues : Anglais (eng) Mots-clés : Social cognition training  Virtual reality  Autism spectrum disorder  Emotion perception  Theory of mind  Social functioning Index. décimale : PER Périodiques Résumé : Background Social cognitive difficulties in Autism Spectrum Disorder (ASD) can affect the daily lives of people with ASD profoundly, impacting the development and maintenance of meaningful social relations. Social cognition training (SCT) is commonly used for improving social functioning, but lacks ecological validity and the ability to effectively mimic social situations. Development of virtual reality (VR) interventions, focusing on enhancing social cognition, could add to the effectiveness of SCT within ASD care, by offering a safe, interactive and practical training setting, where generalization of knowledge and skills to the real-world are promoted. In this paper, our primary aim is to evaluate the feasibility and acceptance by participants and therapists of the Dynamic Interactive Social Cognition Method Training in Virtual Reality (DiSCoVR) protocol as developed for adults with schizophrenic spectrum disorder (SSD), adapted for ASD (DiSCoVR-A). 26 participants, aged 18 63, took part in a pilot study. 22 participants completed baseline and post-assessment, including primary outcome evaluation assessment through a semi-structured interview. Secondary measures focused on social cognition, emotion recognition, mental flexibility, social anxiety, empathy and social responsiveness and were assessed at baseline (T0), post-treatment (T1), and at follow-up (T2) sixteen weeks after completion of the intervention. Results Our results show that the majority of participant and therapists found the VR intervention acceptable and feasible, as reported in evaluation questionnaires and interviews. Conclusion These preliminary findings are promising; however, controlled research is needed to further investigate the effectiveness of VR within social cognition training for adults with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.102003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=480 [article] Dynamic Interactive Social Cognition Training in Virtual Reality (DiSCoVR) for adults with Autism Spectrum Disorder: A feasibility study [texte imprimé] / B.J. VAN PELT, Auteur ; S.A. NIJMAN, Auteur ; N.E.M. VAN HAREN, Auteur ; W. VELING, Auteur ; G.H.M. PIJNENBORG, Auteur ; Ingrid D.C. VAN BALKOM, Auteur ; Annemiek M. LANDLUST, Auteur ; Kirstin GREAVES-LORD, Auteur . - 102003. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 96 (August 2022) . - 102003 Mots-clés : Social cognition training  Virtual reality  Autism spectrum disorder  Emotion perception  Theory of mind  Social functioning Index. décimale : PER Périodiques Résumé : Background Social cognitive difficulties in Autism Spectrum Disorder (ASD) can affect the daily lives of people with ASD profoundly, impacting the development and maintenance of meaningful social relations. Social cognition training (SCT) is commonly used for improving social functioning, but lacks ecological validity and the ability to effectively mimic social situations. Development of virtual reality (VR) interventions, focusing on enhancing social cognition, could add to the effectiveness of SCT within ASD care, by offering a safe, interactive and practical training setting, where generalization of knowledge and skills to the real-world are promoted. In this paper, our primary aim is to evaluate the feasibility and acceptance by participants and therapists of the Dynamic Interactive Social Cognition Method Training in Virtual Reality (DiSCoVR) protocol as developed for adults with schizophrenic spectrum disorder (SSD), adapted for ASD (DiSCoVR-A). 26 participants, aged 18 63, took part in a pilot study. 22 participants completed baseline and post-assessment, including primary outcome evaluation assessment through a semi-structured interview. Secondary measures focused on social cognition, emotion recognition, mental flexibility, social anxiety, empathy and social responsiveness and were assessed at baseline (T0), post-treatment (T1), and at follow-up (T2) sixteen weeks after completion of the intervention. Results Our results show that the majority of participant and therapists found the VR intervention acceptable and feasible, as reported in evaluation questionnaires and interviews. Conclusion These preliminary findings are promising; however, controlled research is needed to further investigate the effectiveness of VR within social cognition training for adults with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.102003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=480

Executive Functions in Older Adults With Autism Spectrum Disorder: Objective Performance and Subjective Complaints / Roeliena C.D. DAVIDS in Journal of Autism and Developmental Disorders, 46-9 (September 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.2859-2873 Titre : Executive Functions in Older Adults With Autism Spectrum Disorder: Objective Performance and Subjective Complaints Type de document : texte imprimé Auteurs : Roeliena C.D. DAVIDS, Auteur ; Yvonne GROEN, Auteur ; Ina J. BERG, Auteur ; Oliver TUCHA, Auteur ; Ingrid D.C. VAN BALKOM, Auteur Article en page(s) : p.2859-2873 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Neuropsychological assessment  Cognition  Executive function  Processing speed  Aging Index. décimale : PER Périodiques Résumé : Although deficits in Executive Functioning (EF) are reported frequently in young individuals with Autism Spectrum Disorders (ASD), they remain relatively unexplored later in life (>50 years). We studied objective performance on EF measures (Tower of London, Zoo map, phonetic/semantic fluency) as well as subjective complaints (self- and proxy reported BRIEF) in 36 ASD and 36 typically developed individuals (n = 72). High functioning older adults with ASD reported EF-impairments in metacognition, but did not deviate in EF task performance, except for a longer execution time of the Tower of London. The need for additional time to complete daily tasks may contribute to impairments in daily life and may be correlated to a higher level of experienced EF-difficulties in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2831-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 [article] Executive Functions in Older Adults With Autism Spectrum Disorder: Objective Performance and Subjective Complaints [texte imprimé] / Roeliena C.D. DAVIDS, Auteur ; Yvonne GROEN, Auteur ; Ina J. BERG, Auteur ; Oliver TUCHA, Auteur ; Ingrid D.C. VAN BALKOM, Auteur . - p.2859-2873. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.2859-2873 Mots-clés : Autism spectrum disorder  Neuropsychological assessment  Cognition  Executive function  Processing speed  Aging Index. décimale : PER Périodiques Résumé : Although deficits in Executive Functioning (EF) are reported frequently in young individuals with Autism Spectrum Disorders (ASD), they remain relatively unexplored later in life (>50 years). We studied objective performance on EF measures (Tower of London, Zoo map, phonetic/semantic fluency) as well as subjective complaints (self- and proxy reported BRIEF) in 36 ASD and 36 typically developed individuals (n = 72). High functioning older adults with ASD reported EF-impairments in metacognition, but did not deviate in EF task performance, except for a longer execution time of the Tower of London. The need for additional time to complete daily tasks may contribute to impairments in daily life and may be correlated to a higher level of experienced EF-difficulties in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2831-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292

Local-global processing approaches in older autistic adults: A matched control study using RCFT and WAIS-IV / Roeliena C.D. DAVIDS in Research in Autism Spectrum Disorders, 78 (October 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 78 (October 2020) . - 101655 Titre : Local-global processing approaches in older autistic adults: A matched control study using RCFT and WAIS-IV Type de document : texte imprimé Auteurs : Roeliena C.D. DAVIDS, Auteur ; Yvonne GROEN, Auteur ; Ina J. BERG, Auteur ; Oliver TUCHA, Auteur ; Ingrid D.C. VAN BALKOM, Auteur Article en page(s) : 101655 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Adult  Neuropsychological assessment  Local processing  Global processing  Qualitative scoring Index. décimale : PER Périodiques Résumé : Background Research on information processing of older adults with autism spectrum disorder (ASD) is scarce, which is a caveat because findings in children may not apply to (older) autistic adults. This study examines visual local-global processing approaches in older autistic adults. Method The Rey-Osterrieth Complex Figure Test (RCFT) is a popular measure of visual-constructional ability, organisational strategy and memory. In this matched-control study, we explore if the qualitative and quantitative performance on the RCFT can be used as an operationalisation of central coherence in autistic older adults (n = 36; ages 50−84 years), and whether RCFT performance associates with autism-symptoms. WAIS-IV scores were also obtained to test for local-global differences in performance. Results No evidence was found for deviating processing approaches on the RCFT (both quantitative and qualitative) in the ASD group, although copying the RCFT was significantly slower. The WAIS-IV showed no differences between participant-groups, except for a significantly better performance on Visual Puzzles by autistic participants. Conclusions Using visual local-global processing tests common to clinical practice, this study provides no evidence for a weak central coherence but some support for enhanced perceptual functioning in late-diagnosed high functioning older autistic adults. There was no evidence for altered strategic approaches during the completion of a complex visual information processing task (RCFT). Combining a quantitative and a qualitative scoring system of visual information processing tasks (such as RCFT) can elucidate the preferred visual information processing style in autistic individuals. En ligne : https://doi.org/10.1016/j.rasd.2020.101655 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Local-global processing approaches in older autistic adults: A matched control study using RCFT and WAIS-IV [texte imprimé] / Roeliena C.D. DAVIDS, Auteur ; Yvonne GROEN, Auteur ; Ina J. BERG, Auteur ; Oliver TUCHA, Auteur ; Ingrid D.C. VAN BALKOM, Auteur . - 101655. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 78 (October 2020) . - 101655 Mots-clés : Autism spectrum disorder  Adult  Neuropsychological assessment  Local processing  Global processing  Qualitative scoring Index. décimale : PER Périodiques Résumé : Background Research on information processing of older adults with autism spectrum disorder (ASD) is scarce, which is a caveat because findings in children may not apply to (older) autistic adults. This study examines visual local-global processing approaches in older autistic adults. Method The Rey-Osterrieth Complex Figure Test (RCFT) is a popular measure of visual-constructional ability, organisational strategy and memory. In this matched-control study, we explore if the qualitative and quantitative performance on the RCFT can be used as an operationalisation of central coherence in autistic older adults (n = 36; ages 50−84 years), and whether RCFT performance associates with autism-symptoms. WAIS-IV scores were also obtained to test for local-global differences in performance. Results No evidence was found for deviating processing approaches on the RCFT (both quantitative and qualitative) in the ASD group, although copying the RCFT was significantly slower. The WAIS-IV showed no differences between participant-groups, except for a significantly better performance on Visual Puzzles by autistic participants. Conclusions Using visual local-global processing tests common to clinical practice, this study provides no evidence for a weak central coherence but some support for enhanced perceptual functioning in late-diagnosed high functioning older autistic adults. There was no evidence for altered strategic approaches during the completion of a complex visual information processing task (RCFT). Combining a quantitative and a qualitative scoring system of visual information processing tasks (such as RCFT) can elucidate the preferred visual information processing style in autistic individuals. En ligne : https://doi.org/10.1016/j.rasd.2020.101655 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Prevalence of treated autism spectrum disorders in Aruba / Ingrid D.C. VAN BALKOM in Journal of Neurodevelopmental Disorders, 1-3 (September 2009)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 1-3 (September 2009) . - p.197-204 Titre : Prevalence of treated autism spectrum disorders in Aruba Type de document : texte imprimé Auteurs : Ingrid D.C. VAN BALKOM, Auteur ; Michaeline BRESNAHAN, Auteur ; M.F. VOGTLANDER, Auteur ; Daphne VAN HOEKEN, Auteur ; Ruud B. MINDERAA, Auteur ; Ezra SUSSER, Auteur ; Hans W. HOEK, Auteur Article en page(s) : p.197-204 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : To study autism outside of a narrow range of settings previously studied, and in a particularly distinctive setting in the Caribbean. The aim of the Aruba Autism Project was to determine the prevalence of autism spectrum disorders (ASDs) in birth years 1990-1999 in Aruba. A record review study was conducted; cases were ascertained from children treated at the Child & Adolescent Psychiatry Clinic of Aruba, the first and only child psychiatry service on the island. In these 10 birth years we found a prevalence for autistic disorder (AD) of 1.9 per 1,000 (95% CI 1.2-2.8) and for autism spectrum disorders of 5.3 per 1,000 (95% CI 4.1-6.7). Comparison analysis with a cumulative incidence report from the UK, showed a similar cumulative incidence to age five in Aruba. Prevalence of ASDs in birth years 1990-1999 and cumulative incidence to age five in Aruba are similar to recent reports from the United Kingdom and the United States. En ligne : http://dx.doi.org/10.1007/s11689-009-9011-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341 [article] Prevalence of treated autism spectrum disorders in Aruba [texte imprimé] / Ingrid D.C. VAN BALKOM, Auteur ; Michaeline BRESNAHAN, Auteur ; M.F. VOGTLANDER, Auteur ; Daphne VAN HOEKEN, Auteur ; Ruud B. MINDERAA, Auteur ; Ezra SUSSER, Auteur ; Hans W. HOEK, Auteur . - p.197-204. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 1-3 (September 2009) . - p.197-204 Index. décimale : PER Périodiques Résumé : To study autism outside of a narrow range of settings previously studied, and in a particularly distinctive setting in the Caribbean. The aim of the Aruba Autism Project was to determine the prevalence of autism spectrum disorders (ASDs) in birth years 1990-1999 in Aruba. A record review study was conducted; cases were ascertained from children treated at the Child & Adolescent Psychiatry Clinic of Aruba, the first and only child psychiatry service on the island. In these 10 birth years we found a prevalence for autistic disorder (AD) of 1.9 per 1,000 (95% CI 1.2-2.8) and for autism spectrum disorders of 5.3 per 1,000 (95% CI 4.1-6.7). Comparison analysis with a cumulative incidence report from the UK, showed a similar cumulative incidence to age five in Aruba. Prevalence of ASDs in birth years 1990-1999 and cumulative incidence to age five in Aruba are similar to recent reports from the United Kingdom and the United States. En ligne : http://dx.doi.org/10.1007/s11689-009-9011-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341

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