Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study / Charlotte A. M. CECIL in Development and Psychopathology, 30-2 (May 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-2 (May 2018) . - p.383-397 Titre : Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study Type de document : Texte imprimé et/ou numérique Auteurs : Charlotte A. M. CECIL, Auteur ; Esther WALTON, Auteur ; Sara R. JAFFEE, Auteur ; Tom O'CONNOR, Auteur ; Barbara MAUGHAN, Auteur ; Caroline L. RELTON, Auteur ; Rebecca G. SMITH, Auteur ; Wendy MCARDLE, Auteur ; Tom R. GAUNT, Auteur ; Isabelle OUELLET-MORIN, Auteur ; Edward D. BARKER, Auteur Article en page(s) : p.383-397 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early-onset conduct problems (CP) are a key predictor of adult criminality and poor mental health. While previous studies suggest that both genetic and environmental risks play an important role in the development of early-onset CP, little is known about potential biological processes underlying these associations. In this study, we examined prospective associations between DNA methylation (cord blood at birth) and trajectories of CP (4–13 years), using data drawn from the Avon Longitudinal Study of Parents and Children. Methylomic variation at seven loci across the genome (false discovery rate < 0.05) differentiated children who go on to develop early-onset (n = 174) versus low (n = 86) CP, including sites in the vicinity of the monoglyceride lipase (MGLL) gene (involved in endocannabinoid signaling and pain perception). Subthreshold associations in the vicinity of three candidate genes for CP (monoamine oxidase A [MAOA], brain-derived neurotrophic factor [BDNF], and FK506 binding protein 5 [FKBP5]) were also identified. Within the early-onset CP group, methylation levels of the identified sites did not distinguish children who will go on to persist versus desist in CP behavior over time. Overall, we found that several of the identified sites correlated with prenatal exposures, and none were linked to known genetic methylation quantitative trait loci. Findings contribute to a better understanding of epigenetic patterns associated with early-onset CP. En ligne : http://dx.doi.org/10.1017/S095457941700092X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358 [article] Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study [Texte imprimé et/ou numérique] / Charlotte A. M. CECIL, Auteur ; Esther WALTON, Auteur ; Sara R. JAFFEE, Auteur ; Tom O'CONNOR, Auteur ; Barbara MAUGHAN, Auteur ; Caroline L. RELTON, Auteur ; Rebecca G. SMITH, Auteur ; Wendy MCARDLE, Auteur ; Tom R. GAUNT, Auteur ; Isabelle OUELLET-MORIN, Auteur ; Edward D. BARKER, Auteur . - p.383-397. Langues : Anglais (eng) in Development and Psychopathology > 30-2 (May 2018) . - p.383-397 Index. décimale : PER Périodiques Résumé : Early-onset conduct problems (CP) are a key predictor of adult criminality and poor mental health. While previous studies suggest that both genetic and environmental risks play an important role in the development of early-onset CP, little is known about potential biological processes underlying these associations. In this study, we examined prospective associations between DNA methylation (cord blood at birth) and trajectories of CP (4–13 years), using data drawn from the Avon Longitudinal Study of Parents and Children. Methylomic variation at seven loci across the genome (false discovery rate < 0.05) differentiated children who go on to develop early-onset (n = 174) versus low (n = 86) CP, including sites in the vicinity of the monoglyceride lipase (MGLL) gene (involved in endocannabinoid signaling and pain perception). Subthreshold associations in the vicinity of three candidate genes for CP (monoamine oxidase A [MAOA], brain-derived neurotrophic factor [BDNF], and FK506 binding protein 5 [FKBP5]) were also identified. Within the early-onset CP group, methylation levels of the identified sites did not distinguish children who will go on to persist versus desist in CP behavior over time. Overall, we found that several of the identified sites correlated with prenatal exposures, and none were linked to known genetic methylation quantitative trait loci. Findings contribute to a better understanding of epigenetic patterns associated with early-onset CP. En ligne : http://dx.doi.org/10.1017/S095457941700092X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358

Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems / Jolien RIJLAARSDAM in Journal of Child Psychology and Psychiatry, 58-1 (January 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.19-27 Titre : Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems Type de document : Texte imprimé et/ou numérique Auteurs : Jolien RIJLAARSDAM, Auteur ; Charlotte A. M. CECIL, Auteur ; Esther WALTON, Auteur ; Maurissa S. C. MESIROW, Auteur ; Caroline L. RELTON, Auteur ; Tom R. GAUNT, Auteur ; Wendy MCARDLE, Auteur ; Edward D. BARKER, Auteur Article en page(s) : p.19-27 Langues : Anglais (eng) Mots-clés : DNA methylation  Avon Longitudinal Study of Parents and Children  diet  conduct problems  attention deficit hyperactivity disorder  IGF2 Index. décimale : PER Périodiques Résumé : Background Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to ‘unhealthy diet’. Early-life diet also associates with DNA methylation of the insulin-like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high-fat and -sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early-onset persistent (EOP) versus low CP youth. Methods Participants were 164 youth with EOP (n = 83) versus low (n = 81) CP drawn from the Avon Longitudinal Study of Parents and Children. We assessed if the interrelationships between high-fat and -sugar diet (prenatal, postnatal), IGF2 methylation (birth and age 7, collected from blood), and ADHD symptoms (age 7–13) differed for EOP versus low CP youth. Results Prenatal ‘unhealthy diet’ was positively associated with IGF2 methylation at birth for both the EOP and low CP youth. For EOP only: (a) higher IGF2 methylation predicted ADHD symptoms; and (b) prenatal ‘unhealthy diet’ was associated with higher ADHD symptoms indirectly via higher IGF2 methylation. Conclusions Preventing ‘unhealthy diet’ in pregnancy might reduce the risk of ADHD symptoms in EOP youth via lower offspring IGF2 methylation. En ligne : http://dx.doi.org/10.1111/jcpp.12589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems [Texte imprimé et/ou numérique] / Jolien RIJLAARSDAM, Auteur ; Charlotte A. M. CECIL, Auteur ; Esther WALTON, Auteur ; Maurissa S. C. MESIROW, Auteur ; Caroline L. RELTON, Auteur ; Tom R. GAUNT, Auteur ; Wendy MCARDLE, Auteur ; Edward D. BARKER, Auteur . - p.19-27. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.19-27 Mots-clés : DNA methylation  Avon Longitudinal Study of Parents and Children  diet  conduct problems  attention deficit hyperactivity disorder  IGF2 Index. décimale : PER Périodiques Résumé : Background Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to ‘unhealthy diet’. Early-life diet also associates with DNA methylation of the insulin-like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high-fat and -sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early-onset persistent (EOP) versus low CP youth. Methods Participants were 164 youth with EOP (n = 83) versus low (n = 81) CP drawn from the Avon Longitudinal Study of Parents and Children. We assessed if the interrelationships between high-fat and -sugar diet (prenatal, postnatal), IGF2 methylation (birth and age 7, collected from blood), and ADHD symptoms (age 7–13) differed for EOP versus low CP youth. Results Prenatal ‘unhealthy diet’ was positively associated with IGF2 methylation at birth for both the EOP and low CP youth. For EOP only: (a) higher IGF2 methylation predicted ADHD symptoms; and (b) prenatal ‘unhealthy diet’ was associated with higher ADHD symptoms indirectly via higher IGF2 methylation. Conclusions Preventing ‘unhealthy diet’ in pregnancy might reduce the risk of ADHD symptoms in EOP youth via lower offspring IGF2 methylation. En ligne : http://dx.doi.org/10.1111/jcpp.12589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress / Izabela MILANIAK in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1663-1674 Titre : Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress Type de document : Texte imprimé et/ou numérique Auteurs : Izabela MILANIAK, Auteur ; Charlotte A. M. CECIL, Auteur ; Edward D. BARKER, Auteur ; Caroline L. RELTON, Auteur ; Tom R. GAUNT, Auteur ; Wendy MCARDLE, Auteur ; Sara R. JAFFEE, Auteur Article en page(s) : p.1663-1674 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Emerging research in epigenetics has shown that there is variability in how environmental exposures “get under the skin” through mechanisms like DNA methylation to influence gene expression that may lead to differential adaptations to stress. This is the first study to examine prospectively the relationship between DNA methylation at birth and resilience to prenatal environmental stressors in several domains (conduct, hyperactivity, emotional problems, and global symptomatology) in middle childhood. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously associated with impairments in social–cognitive processes that may underlie a wide range of childhood psychopathology. Participants were 91 youth exposed to pre- and postnatal adversity with established conduct problem trajectories drawn from the Avon Longitudinal Study of Parents and Children. Consistent with our hypothesis, OXTR DNA methylation was predictive of resilience in the conduct problems domain in middle childhood. DNA methylation profiles did not predict resilience in domains of emotional, hyperactivity, and global symptomatology, suggesting a potential role for OXTR in the development of conduct problems in particular. However, individuals who were resilient to conduct problems were also broadly resilient across multiple domains. Therefore, future research should elucidate the biological pathways between OXTR DNA methylation and gene expression and its relation to impairments in social behavior. En ligne : http://dx.doi.org/10.1017/S0954579417001316 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress [Texte imprimé et/ou numérique] / Izabela MILANIAK, Auteur ; Charlotte A. M. CECIL, Auteur ; Edward D. BARKER, Auteur ; Caroline L. RELTON, Auteur ; Tom R. GAUNT, Auteur ; Wendy MCARDLE, Auteur ; Sara R. JAFFEE, Auteur . - p.1663-1674. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1663-1674 Index. décimale : PER Périodiques Résumé : Emerging research in epigenetics has shown that there is variability in how environmental exposures “get under the skin” through mechanisms like DNA methylation to influence gene expression that may lead to differential adaptations to stress. This is the first study to examine prospectively the relationship between DNA methylation at birth and resilience to prenatal environmental stressors in several domains (conduct, hyperactivity, emotional problems, and global symptomatology) in middle childhood. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously associated with impairments in social–cognitive processes that may underlie a wide range of childhood psychopathology. Participants were 91 youth exposed to pre- and postnatal adversity with established conduct problem trajectories drawn from the Avon Longitudinal Study of Parents and Children. Consistent with our hypothesis, OXTR DNA methylation was predictive of resilience in the conduct problems domain in middle childhood. DNA methylation profiles did not predict resilience in domains of emotional, hyperactivity, and global symptomatology, suggesting a potential role for OXTR in the development of conduct problems in particular. However, individuals who were resilient to conduct problems were also broadly resilient across multiple domains. Therefore, future research should elucidate the biological pathways between OXTR DNA methylation and gene expression and its relation to impairments in social behavior. En ligne : http://dx.doi.org/10.1017/S0954579417001316 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

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