Corpus callosum area in children and adults with autism / Molly D.B. PRIGGE in Research in Autism Spectrum Disorders, 7-2 (February 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-2 (February 2013) . - p.221-234 Titre : Corpus callosum area in children and adults with autism Type de document : texte imprimé Auteurs : Molly D.B. PRIGGE, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Tricia L. MERKLEY, Auteur ; E. Shannon NEELEY, Auteur ; Tracy J. ABILDSKOV, Auteur ; Alyson L. FROEHLICH, Auteur ; Jared A. NIELSEN, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; Caitlin RAVICHANDRAN, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Année de publication : 2013 Article en page(s) : p.221-234 Langues : Anglais (eng) Mots-clés : Autism  Corpus callosum area  Development  MRI Index. décimale : PER Périodiques Résumé : Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum growth in the disorder have not yet been reported. In this study, we examined corpus callosum size from a developmental perspective across a 30-year age range in a large cross-sectional sample of individuals with autism compared to a typically developing sample. Midsagittal corpus callosum area and the 7 Witelson subregions were examined in 68 males with autism (mean age 14.1 years; range 3'36 years) and 47 males with typical development (mean age 15.3 years; range 4'29 years). Controlling for total brain volume, increased variability in total corpus callosum area was found in autism. In autism, increased midsagittal areas were associated with reduced severity of autism behaviors, higher intelligence, and faster speed of processing (p = 0.003, p = 0.011, p = 0.013, respectively). A trend toward group differences in isthmus development was found (p = 0.029, uncorrected). These results suggest that individuals with autism benefit functionally from increased corpus callosum area. Our cross-sectional examination also shows potential maturational abnormalities in autism, a finding that should be examined further with longitudinal datasets. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.09.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 [article] Corpus callosum area in children and adults with autism [texte imprimé] / Molly D.B. PRIGGE, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Tricia L. MERKLEY, Auteur ; E. Shannon NEELEY, Auteur ; Tracy J. ABILDSKOV, Auteur ; Alyson L. FROEHLICH, Auteur ; Jared A. NIELSEN, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; Caitlin RAVICHANDRAN, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - 2013 . - p.221-234. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-2 (February 2013) . - p.221-234 Mots-clés : Autism  Corpus callosum area  Development  MRI Index. décimale : PER Périodiques Résumé : Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum growth in the disorder have not yet been reported. In this study, we examined corpus callosum size from a developmental perspective across a 30-year age range in a large cross-sectional sample of individuals with autism compared to a typically developing sample. Midsagittal corpus callosum area and the 7 Witelson subregions were examined in 68 males with autism (mean age 14.1 years; range 3'36 years) and 47 males with typical development (mean age 15.3 years; range 4'29 years). Controlling for total brain volume, increased variability in total corpus callosum area was found in autism. In autism, increased midsagittal areas were associated with reduced severity of autism behaviors, higher intelligence, and faster speed of processing (p = 0.003, p = 0.011, p = 0.013, respectively). A trend toward group differences in isthmus development was found (p = 0.029, uncorrected). These results suggest that individuals with autism benefit functionally from increased corpus callosum area. Our cross-sectional examination also shows potential maturational abnormalities in autism, a finding that should be examined further with longitudinal datasets. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.09.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186

Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder / Rebecca A. LUNDWALL in Research in Autism Spectrum Disorders, 34 (February 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 34 (February 2017) . - p.44-51 Titre : Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder Type de document : texte imprimé Auteurs : Rebecca A. LUNDWALL, Auteur ; Kevin G. STEPHENSON, Auteur ; E. Shannon NEELEY-TASS, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur ; Erin D. BIGLER, Auteur ; Emily I. ANDERBERG, Auteur ; Molly D.B. PRIGGE, Auteur ; Blake D. HANSEN, Auteur ; Janet E. LAINHART, Auteur ; Ryan O. KELLEMS, Auteur ; Jo Ann PETRIE, Auteur ; Terisa P. GABRIELSEN, Auteur Article en page(s) : p.44-51 Langues : Anglais (eng) Mots-clés : Autism  Aggression  Imaging  Brainstem  Structural MRI Index. décimale : PER Périodiques Résumé : AbstractBackground Aggressive behaviors are common in individuals diagnosed with autism spectrum disorder (ASD) and may be phenotypic indicators of different subtypes within ASD. In current research literature for non-ASD samples, aggression has been linked to several brain structures associated with emotion and behavioral control. However, few if any studies exist investigating brain volume differences in individuals with ASD who have comorbid aggression as indicated by standardized diagnostic and behavioral measures. Method We examined neuroimaging data from individuals rigorously diagnosed with ASD versus typically developing (TD) controls. We began with data from brain volume regions of interest (ROI) taken from previous literature on aggression including the brainstem, amygdala, orbitofrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex. We defined aggression status using the Irritability subscale of the Aberrant Behavior Checklist and used lasso logistic regression to select among these predictor variables. Brainstem volume was the only variable shown to be a predictor of aggression status. Results We found that smaller brainstem volumes are associated with higher odds of being in the high aggression group. Conclusions Understanding brain differences in individuals with ASD who engage in aggressive behavior from those with ASD who do not can inform treatment approaches. Future research should investigate brainstem structure and function in ASD to identify possible mechanisms related to arousal and aggression. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.12.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder [texte imprimé] / Rebecca A. LUNDWALL, Auteur ; Kevin G. STEPHENSON, Auteur ; E. Shannon NEELEY-TASS, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur ; Erin D. BIGLER, Auteur ; Emily I. ANDERBERG, Auteur ; Molly D.B. PRIGGE, Auteur ; Blake D. HANSEN, Auteur ; Janet E. LAINHART, Auteur ; Ryan O. KELLEMS, Auteur ; Jo Ann PETRIE, Auteur ; Terisa P. GABRIELSEN, Auteur . - p.44-51. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 34 (February 2017) . - p.44-51 Mots-clés : Autism  Aggression  Imaging  Brainstem  Structural MRI Index. décimale : PER Périodiques Résumé : AbstractBackground Aggressive behaviors are common in individuals diagnosed with autism spectrum disorder (ASD) and may be phenotypic indicators of different subtypes within ASD. In current research literature for non-ASD samples, aggression has been linked to several brain structures associated with emotion and behavioral control. However, few if any studies exist investigating brain volume differences in individuals with ASD who have comorbid aggression as indicated by standardized diagnostic and behavioral measures. Method We examined neuroimaging data from individuals rigorously diagnosed with ASD versus typically developing (TD) controls. We began with data from brain volume regions of interest (ROI) taken from previous literature on aggression including the brainstem, amygdala, orbitofrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex. We defined aggression status using the Irritability subscale of the Aberrant Behavior Checklist and used lasso logistic regression to select among these predictor variables. Brainstem volume was the only variable shown to be a predictor of aggression status. Results We found that smaller brainstem volumes are associated with higher odds of being in the high aggression group. Conclusions Understanding brain differences in individuals with ASD who engage in aggressive behavior from those with ASD who do not can inform treatment approaches. Future research should investigate brainstem structure and function in ASD to identify possible mechanisms related to arousal and aggression. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.12.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Sticking with it: Psychotherapy outcomes for adults with autism spectrum disorder in a university counseling center setting / Emily I. ANDERBERG in Autism Research, 10-12 (December 2017)  

Public ISBD [article]  inAutism Research > 10-12 (December 2017) . - p.2048-2055 Titre : Sticking with it: Psychotherapy outcomes for adults with autism spectrum disorder in a university counseling center setting Type de document : texte imprimé Auteurs : Emily I. ANDERBERG, Auteur ; Jonathan C. COX, Auteur ; E. Shannon NEELEY-TASS, Auteur ; David M. EREKSON, Auteur ; Terisa P. GABRIELSEN, Auteur ; Jared S. WARREN, Auteur ; Jared CLINE, Auteur ; Devin PETERSEN, Auteur ; Mikle SOUTH, Auteur Article en page(s) : p.2048-2055 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  adults  psychotherapy counseling centers  treatment  outcomes Index. décimale : PER Périodiques Résumé : Young adults with autism spectrum disorders (ASD) experience high rates of comorbid mental health concerns in addition to distress arising from the core symptoms of autism. Many adults with ASD seek psychological treatment in outpatient facilities in their communities that are not specifically geared toward individuals with ASD. However, few studies have looked at the effectiveness of standard psychotherapeutic care in adults with ASD. This study aimed to discover how individuals with ASD fare in psychotherapy within a college counseling setting, compared to their neurotypical peers. Clients with ASD (n = 76) or possible ASD (n = 91) were retrospectively identified from counseling center case notes. Data from the Outcome Questionnaire-45 (OQ) were retrieved for each therapy session as a measure of client distress. Clients with ASD showed no difference in level of distress at intake compared to their neurotypical peers (n = 21,546), and improved about the same amount from pre- to post-treatment. However, students with ASD stayed in treatment for significantly more sessions than neurotypical clients, and took significantly longer to achieve maximum improvement on OQ reports. Results are discussed with implications for university and other community based treatment settings. Autism Res 2017, 10: 2048–2055. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This study aimed to discover how individuals with autism spectrum disorders (ASD) fare in psychotherapy within a university counseling setting, compared to their neurotypical peers. Clients with ASD showed no difference in level of distress at intake compared to their neurotypical peers, and improved about the same amount from pre- to post-treatment. However, students with ASD stayed in treatment for significantly more sessions than neurotypical clients, and took significantly longer to achieve maximum improvement on Outcome Questionnaire-45 reports. En ligne : http://dx.doi.org/10.1002/aur.1843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Sticking with it: Psychotherapy outcomes for adults with autism spectrum disorder in a university counseling center setting [texte imprimé] / Emily I. ANDERBERG, Auteur ; Jonathan C. COX, Auteur ; E. Shannon NEELEY-TASS, Auteur ; David M. EREKSON, Auteur ; Terisa P. GABRIELSEN, Auteur ; Jared S. WARREN, Auteur ; Jared CLINE, Auteur ; Devin PETERSEN, Auteur ; Mikle SOUTH, Auteur . - p.2048-2055. Langues : Anglais (eng) in Autism Research > 10-12 (December 2017) . - p.2048-2055 Mots-clés : autism spectrum disorder  adults  psychotherapy counseling centers  treatment  outcomes Index. décimale : PER Périodiques Résumé : Young adults with autism spectrum disorders (ASD) experience high rates of comorbid mental health concerns in addition to distress arising from the core symptoms of autism. Many adults with ASD seek psychological treatment in outpatient facilities in their communities that are not specifically geared toward individuals with ASD. However, few studies have looked at the effectiveness of standard psychotherapeutic care in adults with ASD. This study aimed to discover how individuals with ASD fare in psychotherapy within a college counseling setting, compared to their neurotypical peers. Clients with ASD (n = 76) or possible ASD (n = 91) were retrospectively identified from counseling center case notes. Data from the Outcome Questionnaire-45 (OQ) were retrieved for each therapy session as a measure of client distress. Clients with ASD showed no difference in level of distress at intake compared to their neurotypical peers (n = 21,546), and improved about the same amount from pre- to post-treatment. However, students with ASD stayed in treatment for significantly more sessions than neurotypical clients, and took significantly longer to achieve maximum improvement on OQ reports. Results are discussed with implications for university and other community based treatment settings. Autism Res 2017, 10: 2048–2055. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This study aimed to discover how individuals with autism spectrum disorders (ASD) fare in psychotherapy within a university counseling setting, compared to their neurotypical peers. Clients with ASD showed no difference in level of distress at intake compared to their neurotypical peers, and improved about the same amount from pre- to post-treatment. However, students with ASD stayed in treatment for significantly more sessions than neurotypical clients, and took significantly longer to achieve maximum improvement on Outcome Questionnaire-45 reports. En ligne : http://dx.doi.org/10.1002/aur.1843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

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