Altered topological properties of functional brain network is associated with social communication difficulties in autistic children with motor coordination difficulties / Tingfeng GU in Research in Autism, 128 (October 2025)  

Public ISBD [article]  inResearch in Autism > 128 (October 2025) . - p.202722 Titre : Altered topological properties of functional brain network is associated with social communication difficulties in autistic children with motor coordination difficulties Type de document : texte imprimé Auteurs : Tingfeng GU, Auteur ; Xiuhong LI, Auteur ; Jin JING, Auteur ; Muqing CAO, Auteur Article en page(s) : p.202722 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Motor coordination  Social communication difficulties  Developmental coordination disorder  Motor skills disorder  Resting-state functional connectivity  Graph theory Index. décimale : PER Périodiques Résumé : Background The association between social communication function and motor coordination function in neuropsycological level among autistic children is not fully understood. Our study investigates this relationship in a neuroimage context, shedding light on the underlying mechanisms. Methods Participants with autism spectrum disorder (ASD), aged 3–6 years (n = 81), were recruited from rehabilitation facilities with confirmed diagnosis of autism. We utilized the Developmental Coordination Disorder Questionnaire (DCDQ) to evaluate the motor coordination function and classify children with or without motor coordination difficulties (DCD, if the score ≤48). Social Responsiveness Scale (SRS) was used for assessing social communication function of participants. Using resting-state functional magnetic resonance imaging (rs-fMRI) and network-based statistics, we compared functional connectivity (FC) and network topological properties (eg. small-worldness, degree centrality, and nodal efficiency) between ASD children with (n = 36) or without DCD (n = 39), graph theory-based analysis was also employed. Multiple covariates were included in the analysis to minimize potential bias. Results Autistic children with motor coordination difficulties (ASD-DCD, n = 36) exhibited diminished small-worldness and increased FCs in regions including visual-motor network, insula, and cerebellum. Notably, the right pallidum in ASD-DCD demonstrated reduced degree centrality and nodal efficiency. Furthermore, ASD-only (n = 39) revealed a correlation between degree centrality of right pallidum and social communication, as well as nodal efficiency. Conclusions Altered FCs and topological properties in the visual-motor network underlie visual-motor integration difficulties in the ASD-DCD subgroup. The right pallidum may persist as a common neural foundation for both motor coordination and social communication in autism. Difficulties in motor coordination could, however, attenuate the connection between the right pallidum and social communication in the ASD-DCD group. Overall, this study contributes new insights into the relationship between motor and social skills in autistic children, and offers a potential biomarker to support screening, diagnosis, and rehabilitation. En ligne : https://doi.org/10.1016/j.reia.2025.202722 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] Altered topological properties of functional brain network is associated with social communication difficulties in autistic children with motor coordination difficulties [texte imprimé] / Tingfeng GU, Auteur ; Xiuhong LI, Auteur ; Jin JING, Auteur ; Muqing CAO, Auteur . - p.202722. Langues : Anglais (eng) in Research in Autism > 128 (October 2025) . - p.202722 Mots-clés : Autism spectrum disorder  Motor coordination  Social communication difficulties  Developmental coordination disorder  Motor skills disorder  Resting-state functional connectivity  Graph theory Index. décimale : PER Périodiques Résumé : Background The association between social communication function and motor coordination function in neuropsycological level among autistic children is not fully understood. Our study investigates this relationship in a neuroimage context, shedding light on the underlying mechanisms. Methods Participants with autism spectrum disorder (ASD), aged 3–6 years (n = 81), were recruited from rehabilitation facilities with confirmed diagnosis of autism. We utilized the Developmental Coordination Disorder Questionnaire (DCDQ) to evaluate the motor coordination function and classify children with or without motor coordination difficulties (DCD, if the score ≤48). Social Responsiveness Scale (SRS) was used for assessing social communication function of participants. Using resting-state functional magnetic resonance imaging (rs-fMRI) and network-based statistics, we compared functional connectivity (FC) and network topological properties (eg. small-worldness, degree centrality, and nodal efficiency) between ASD children with (n = 36) or without DCD (n = 39), graph theory-based analysis was also employed. Multiple covariates were included in the analysis to minimize potential bias. Results Autistic children with motor coordination difficulties (ASD-DCD, n = 36) exhibited diminished small-worldness and increased FCs in regions including visual-motor network, insula, and cerebellum. Notably, the right pallidum in ASD-DCD demonstrated reduced degree centrality and nodal efficiency. Furthermore, ASD-only (n = 39) revealed a correlation between degree centrality of right pallidum and social communication, as well as nodal efficiency. Conclusions Altered FCs and topological properties in the visual-motor network underlie visual-motor integration difficulties in the ASD-DCD subgroup. The right pallidum may persist as a common neural foundation for both motor coordination and social communication in autism. Difficulties in motor coordination could, however, attenuate the connection between the right pallidum and social communication in the ASD-DCD group. Overall, this study contributes new insights into the relationship between motor and social skills in autistic children, and offers a potential biomarker to support screening, diagnosis, and rehabilitation. En ligne : https://doi.org/10.1016/j.reia.2025.202722 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

Parenting and cognitive and psychomotor delay due to small-for-gestational-age birth / Xiuhong LI in Journal of Child Psychology and Psychiatry, 58-2 (February 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-2 (February 2017) . - p.169-179 Titre : Parenting and cognitive and psychomotor delay due to small-for-gestational-age birth Type de document : texte imprimé Auteurs : Xiuhong LI, Auteur ; Rina D. EIDEN, Auteur ; Leonard H. EPSTEIN, Auteur ; Edmond D. SHENASSA, Auteur ; Chuanbo XIE, Auteur ; Xiaozhong WEN, Auteur Année de publication : 2017 Article en page(s) : p.169-179 Langues : Anglais (eng) Mots-clés : Small-for-gestational-age  appropriate-for-gestational-age  children  cognition  psychomotor  parenting Index. décimale : PER Périodiques Résumé : Background To examine whether different dimensions of parenting at different ages help small-for-gestational-age (SGA) children ‘catch-up’ the normal children in cognition and psychomotor. Methods We analyzed data of 800 children born SGA and 3,000 children born appropriate-for-gestational-age (AGA) from the Early Childhood Longitudinal Study-Birth cohort. The Two Bag Task was used to measure 2-year or 4-year parenting dimensions. Children's reading, math, gross motor, and fine motor scores were assessed at 5 years. Multivariable linear regression models were fitted to test the interactions between SGA and 2-year or 4-year parenting dimensions on 5-year cognitive and psychomotor outcomes (dependent variables). Results There were significant interactions between SGA and early parenting on 5-year reading, math, and fine motor scores. The gap between SGA and AGA children in 5-year fine motor score was attenuated to null [−0.25 (95% confidence interval, −0.41, −0.09) vs. 0.03 (−0.13, 0.20)] when 2-year parental sensitivity score increased from 1 standard deviation (SD) below mean (Mean − SD) to 1 SD above mean (Mean + SD). The gap between SGA and AGA children in 5-year fine motor [−0.28 (−0.44, −0.13) vs. 0.06 (−0.09, 0.22)] and math [−1.32 (−2.27, −0.37) vs. 0.20 (−0.77, 1.17)] scores was also attenuated to null when 4-year parental emotional support score increased from Mean − SD to Mean + SD. In contrast, the gap between SGA and AGA children in 5-year reading score increased from 0.49 (−0.90, 1.88) to −1.31 (−2.55, −0.07) when 4-year parental intrusiveness score increased from Mean − SD to Mean + SD. Similarly, the gap between SGA and AGA children in fine motor score increased with 4-year parental negative regard from 0.02 (−0.14, 0.18) to −0.23 (−0.38, −0.08). Conclusions Early high-quality parenting may buffer some adversity in long-term reading, math, and fine motor skills related to SGA birth, whereas low-quality parenting can amplify the adversity. En ligne : http://dx.doi.org/10.1111/jcpp.12644 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=299 [article] Parenting and cognitive and psychomotor delay due to small-for-gestational-age birth [texte imprimé] / Xiuhong LI, Auteur ; Rina D. EIDEN, Auteur ; Leonard H. EPSTEIN, Auteur ; Edmond D. SHENASSA, Auteur ; Chuanbo XIE, Auteur ; Xiaozhong WEN, Auteur . - 2017 . - p.169-179. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-2 (February 2017) . - p.169-179 Mots-clés : Small-for-gestational-age  appropriate-for-gestational-age  children  cognition  psychomotor  parenting Index. décimale : PER Périodiques Résumé : Background To examine whether different dimensions of parenting at different ages help small-for-gestational-age (SGA) children ‘catch-up’ the normal children in cognition and psychomotor. Methods We analyzed data of 800 children born SGA and 3,000 children born appropriate-for-gestational-age (AGA) from the Early Childhood Longitudinal Study-Birth cohort. The Two Bag Task was used to measure 2-year or 4-year parenting dimensions. Children's reading, math, gross motor, and fine motor scores were assessed at 5 years. Multivariable linear regression models were fitted to test the interactions between SGA and 2-year or 4-year parenting dimensions on 5-year cognitive and psychomotor outcomes (dependent variables). Results There were significant interactions between SGA and early parenting on 5-year reading, math, and fine motor scores. The gap between SGA and AGA children in 5-year fine motor score was attenuated to null [−0.25 (95% confidence interval, −0.41, −0.09) vs. 0.03 (−0.13, 0.20)] when 2-year parental sensitivity score increased from 1 standard deviation (SD) below mean (Mean − SD) to 1 SD above mean (Mean + SD). The gap between SGA and AGA children in 5-year fine motor [−0.28 (−0.44, −0.13) vs. 0.06 (−0.09, 0.22)] and math [−1.32 (−2.27, −0.37) vs. 0.20 (−0.77, 1.17)] scores was also attenuated to null when 4-year parental emotional support score increased from Mean − SD to Mean + SD. In contrast, the gap between SGA and AGA children in 5-year reading score increased from 0.49 (−0.90, 1.88) to −1.31 (−2.55, −0.07) when 4-year parental intrusiveness score increased from Mean − SD to Mean + SD. Similarly, the gap between SGA and AGA children in fine motor score increased with 4-year parental negative regard from 0.02 (−0.14, 0.18) to −0.23 (−0.38, −0.08). Conclusions Early high-quality parenting may buffer some adversity in long-term reading, math, and fine motor skills related to SGA birth, whereas low-quality parenting can amplify the adversity. En ligne : http://dx.doi.org/10.1111/jcpp.12644 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=299

Prevalence of Autism Spectrum Disorder in the United States is Stable in the COVID-19 Era / Xin WANG in Journal of Autism and Developmental Disorders, 53-8 (August 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.3309-3312 Titre : Prevalence of Autism Spectrum Disorder in the United States is Stable in the COVID-19 Era Type de document : texte imprimé Auteurs : Xin WANG, Auteur ; Xuchu WENG, Auteur ; Ning PAN, Auteur ; Xiuhong LI, Auteur ; Lizi LIN, Auteur ; Jin JING, Auteur Article en page(s) : p.3309-3312 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although the United States (US) have been monitoring the autism spectrum disorder (ASD) prevalence, whether the prevalence has continued to increase, decrease, fluctuate or reached a stable level remained unclear during the COVID-19 pandemic. We have requested the 2016-2021 National Survey of Children s Health (NSCH) data in the United States to estimate weighted ASD prevalence and assess linearity/nonlinearity in the time trend. We did not observe linear or nonlinear trends of the ASD prevalence during the 2016-2021 periods. The current ASD prevalence experienced a 0.3% drop from 2019 to 2020 but a 0.3% uptick in 2021, suggesting a stable trend during the COVID-19 pandemic. Our findings shed lights on the need for the modified strategy of monitor ASD prevalence during the COVID-19 era. En ligne : https://doi.org/10.1007/s10803-023-05915-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Prevalence of Autism Spectrum Disorder in the United States is Stable in the COVID-19 Era [texte imprimé] / Xin WANG, Auteur ; Xuchu WENG, Auteur ; Ning PAN, Auteur ; Xiuhong LI, Auteur ; Lizi LIN, Auteur ; Jin JING, Auteur . - p.3309-3312. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.3309-3312 Index. décimale : PER Périodiques Résumé : Although the United States (US) have been monitoring the autism spectrum disorder (ASD) prevalence, whether the prevalence has continued to increase, decrease, fluctuate or reached a stable level remained unclear during the COVID-19 pandemic. We have requested the 2016-2021 National Survey of Children s Health (NSCH) data in the United States to estimate weighted ASD prevalence and assess linearity/nonlinearity in the time trend. We did not observe linear or nonlinear trends of the ASD prevalence during the 2016-2021 periods. The current ASD prevalence experienced a 0.3% drop from 2019 to 2020 but a 0.3% uptick in 2021, suggesting a stable trend during the COVID-19 pandemic. Our findings shed lights on the need for the modified strategy of monitor ASD prevalence during the COVID-19 era. En ligne : https://doi.org/10.1007/s10803-023-05915-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

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