7 recherche sur le mot-clé 'Resting-state functional connectivity'

Neural Correlates of Audiovisual Temporal Binding Window in Individuals With Schizotypal and Autistic Traits: Evidence From Resting-State Functional Connectivity / Han-Yu ZHOU in Autism Research, 14-4 (April 2021)  

Public ISBD [article]  inAutism Research > 14-4 (April 2021) . - p.668-680 Titre : Neural Correlates of Audiovisual Temporal Binding Window in Individuals With Schizotypal and Autistic Traits: Evidence From Resting-State Functional Connectivity Type de document : texte imprimé Auteurs : Han-Yu ZHOU, Auteur ; Yong-Ming WANG, Auteur ; Rui-Ting ZHANG, Auteur ; Eric F.C. CHEUNG, Auteur ; Christos PANTELIS, Auteur ; Raymond C.K. CHAN, Auteur Article en page(s) : p.668-680 Langues : Anglais (eng) Mots-clés : audiovisual  autistic traits  resting-state functional connectivity  schizotypal traits  temporal binding window Index. décimale : PER Périodiques Résumé : Temporal proximity is an important clue for multisensory integration. Previous evidence indicates that individuals with autism and schizophrenia are more likely to integrate multisensory inputs over a longer temporal binding window (TBW). However, whether such deficits in audiovisual temporal integration extend to subclinical populations with high schizotypal and autistic traits are unclear. Using audiovisual simultaneity judgment (SJ) tasks for nonspeech and speech stimuli, our results suggested that the width of the audiovisual TBW was not significantly correlated with self-reported schizotypal and autistic traits in a group of young adults. Functional magnetic resonance imaging (fMRI) resting-state activity was also acquired to explore the neural correlates underlying inter-individual variability of TBW width. Across the entire sample, stronger resting-state functional connectivity (rsFC) between the left superior temporal cortex and the left precuneus, and weaker rsFC between the left cerebellum and the right dorsal lateral prefrontal cortex were correlated with a narrower TBW for speech stimuli. Meanwhile, stronger rsFC between the left anterior superior temporal gyrus and the right inferior temporal gyrus was correlated with a wider audiovisual TBW for non-speech stimuli. The TBW-related rsFC was not affected by levels of subclinical traits. In conclusion, this study indicates that audiovisual temporal processing may not be affected by autistic and schizotypal traits and rsFC between brain regions responding to multisensory information and timing may account for the inter-individual difference in TBW width. LAY SUMMARY: Individuals with ASD and schizophrenia are more likely to perceive asynchronous auditory and visual events as occurring simultaneously even if they are well separated in time. We investigated whether similar difficulties in audiovisual temporal processing were present in subclinical populations with high autistic and schizotypal traits. We found that the ability to detect audiovisual asynchrony was not affected by different levels of autistic and schizotypal traits. We also found that connectivity of some brain regions engaging in multisensory and timing tasks might explain an individual's tendency to bind multisensory information within a wide or narrow time window. Autism Res 2021, 14: 668-680. © 2020 International Society for Autism Research and Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Neural Correlates of Audiovisual Temporal Binding Window in Individuals With Schizotypal and Autistic Traits: Evidence From Resting-State Functional Connectivity [texte imprimé] / Han-Yu ZHOU, Auteur ; Yong-Ming WANG, Auteur ; Rui-Ting ZHANG, Auteur ; Eric F.C. CHEUNG, Auteur ; Christos PANTELIS, Auteur ; Raymond C.K. CHAN, Auteur . - p.668-680. Langues : Anglais (eng) in Autism Research > 14-4 (April 2021) . - p.668-680 Mots-clés : audiovisual  autistic traits  resting-state functional connectivity  schizotypal traits  temporal binding window Index. décimale : PER Périodiques Résumé : Temporal proximity is an important clue for multisensory integration. Previous evidence indicates that individuals with autism and schizophrenia are more likely to integrate multisensory inputs over a longer temporal binding window (TBW). However, whether such deficits in audiovisual temporal integration extend to subclinical populations with high schizotypal and autistic traits are unclear. Using audiovisual simultaneity judgment (SJ) tasks for nonspeech and speech stimuli, our results suggested that the width of the audiovisual TBW was not significantly correlated with self-reported schizotypal and autistic traits in a group of young adults. Functional magnetic resonance imaging (fMRI) resting-state activity was also acquired to explore the neural correlates underlying inter-individual variability of TBW width. Across the entire sample, stronger resting-state functional connectivity (rsFC) between the left superior temporal cortex and the left precuneus, and weaker rsFC between the left cerebellum and the right dorsal lateral prefrontal cortex were correlated with a narrower TBW for speech stimuli. Meanwhile, stronger rsFC between the left anterior superior temporal gyrus and the right inferior temporal gyrus was correlated with a wider audiovisual TBW for non-speech stimuli. The TBW-related rsFC was not affected by levels of subclinical traits. In conclusion, this study indicates that audiovisual temporal processing may not be affected by autistic and schizotypal traits and rsFC between brain regions responding to multisensory information and timing may account for the inter-individual difference in TBW width. LAY SUMMARY: Individuals with ASD and schizophrenia are more likely to perceive asynchronous auditory and visual events as occurring simultaneously even if they are well separated in time. We investigated whether similar difficulties in audiovisual temporal processing were present in subclinical populations with high autistic and schizotypal traits. We found that the ability to detect audiovisual asynchrony was not affected by different levels of autistic and schizotypal traits. We also found that connectivity of some brain regions engaging in multisensory and timing tasks might explain an individual's tendency to bind multisensory information within a wide or narrow time window. Autism Res 2021, 14: 668-680. © 2020 International Society for Autism Research and Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

Brain structure and functional connectivity linking childhood cumulative trauma to COVID-19 vicarious traumatization / Xiqin LIU in Journal of Child Psychology and Psychiatry, 65-11 (November 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-11 (November 2024) . - p.1407-1418 Titre : Brain structure and functional connectivity linking childhood cumulative trauma to COVID-19 vicarious traumatization Type de document : texte imprimé Auteurs : Xiqin LIU, Auteur ; Yajun ZHAO, Auteur ; Jingguang LI, Auteur ; Xueling SUO, Auteur ; Qiyong GONG, Auteur ; Song WANG, Auteur Article en page(s) : p.1407-1418 Langues : Anglais (eng) Mots-clés : Childhood cumulative trauma  vicarious traumatization  COVID-19  gray matter volume  resting-state functional connectivity Index. décimale : PER Périodiques Résumé : Background The COVID-19 pandemic has caused some individuals to experience vicarious traumatization (VT), an adverse psychological reaction to those who are primarily traumatized, which may negatively impact one's mental health and well-being and has been demonstrated to vary with personal trauma history. The neural mechanism of VT and how past trauma history affects current VT remain largely unknown. This study aimed to identify neurobiological markers that track individual differences in VT and reveal the neural link between childhood cumulative trauma (CCT) and VT. Methods We used structural and resting-state functional magnetic resonance imaging before the pandemic to identify prospective brain markers for COVID-related VT by correlating individuals' VT levels during the pandemic with the gray matter volume (GMV) and seed-based resting-state functional connectivity (RSFC) and examined how these brain markers linked CCT to VT in a sample of general young adults (N 115/100). Results Whole-brain GMV?behavior correlation analysis showed that VT was positively associated with GMV in the right dorsolateral prefrontal gyrus (DLPFC). Using the cluster derived from the GMV?behavior correlation analysis as the seed region, we further revealed that the RSFC between the right DLPFC and right precuneus was negatively associated with VT. Importantly, the right DLPFC volume and DLPFC-precuneus RSFC mediated the effect of CCT on VT. These findings remained unaffected by factors such as family socioeconomic status, other stressful life events, and general mental health. Conclusions Overall, our study presents structural and functional brain markers for VT and highlights these brain-based markers as a potential neural mechanism linking CCT to COVID-related VT, which has implications for treating and preventing the development of trauma-related mental disorders. En ligne : https://doi.org/10.1111/jcpp.13989 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 [article] Brain structure and functional connectivity linking childhood cumulative trauma to COVID-19 vicarious traumatization [texte imprimé] / Xiqin LIU, Auteur ; Yajun ZHAO, Auteur ; Jingguang LI, Auteur ; Xueling SUO, Auteur ; Qiyong GONG, Auteur ; Song WANG, Auteur . - p.1407-1418. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-11 (November 2024) . - p.1407-1418 Mots-clés : Childhood cumulative trauma  vicarious traumatization  COVID-19  gray matter volume  resting-state functional connectivity Index. décimale : PER Périodiques Résumé : Background The COVID-19 pandemic has caused some individuals to experience vicarious traumatization (VT), an adverse psychological reaction to those who are primarily traumatized, which may negatively impact one's mental health and well-being and has been demonstrated to vary with personal trauma history. The neural mechanism of VT and how past trauma history affects current VT remain largely unknown. This study aimed to identify neurobiological markers that track individual differences in VT and reveal the neural link between childhood cumulative trauma (CCT) and VT. Methods We used structural and resting-state functional magnetic resonance imaging before the pandemic to identify prospective brain markers for COVID-related VT by correlating individuals' VT levels during the pandemic with the gray matter volume (GMV) and seed-based resting-state functional connectivity (RSFC) and examined how these brain markers linked CCT to VT in a sample of general young adults (N 115/100). Results Whole-brain GMV?behavior correlation analysis showed that VT was positively associated with GMV in the right dorsolateral prefrontal gyrus (DLPFC). Using the cluster derived from the GMV?behavior correlation analysis as the seed region, we further revealed that the RSFC between the right DLPFC and right precuneus was negatively associated with VT. Importantly, the right DLPFC volume and DLPFC-precuneus RSFC mediated the effect of CCT on VT. These findings remained unaffected by factors such as family socioeconomic status, other stressful life events, and general mental health. Conclusions Overall, our study presents structural and functional brain markers for VT and highlights these brain-based markers as a potential neural mechanism linking CCT to COVID-related VT, which has implications for treating and preventing the development of trauma-related mental disorders. En ligne : https://doi.org/10.1111/jcpp.13989 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537

Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder / Toshiki IWABUCHI in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2451-2462 Titre : Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Toshiki IWABUCHI, Auteur ; Takaharu HIRAI, Auteur ; Naoko UMEDA, Auteur ; Hideto YOGO, Auteur ; Yuuta NISHIMIYA, Auteur ; Yuuki NISHIGAKI, Auteur ; Masaru WATANABE, Auteur ; Hidenori YAMASUE, Auteur ; Masatsugu TSUJII, Auteur ; Kenji J. TSUCHIYA, Auteur ; Hideo MATSUZAKI, Auteur Article en page(s) : p.2451-2462 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  glutathione  magnetic resonance spectroscopy  myelin map  resting-state functional connectivity Index. décimale : PER Périodiques Résumé : ABSTRACT Recent studies have implicated oxidative stress in the pathophysiology of autism spectrum disorder (ASD). Postmortem brain studies have revealed decreased levels of the reduced form of glutathione (GSH), an important antioxidant, in some brain regions in individuals with ASD; however, in vivo evidence is lacking. Using proton magnetic resonance spectroscopy, T1-weighted/T2-weighted ratio-derived myelin maps, resting-state functional magnetic resonance imaging (MRI), and cognitive tasks, we examined whether brain GSH levels are lower in individuals with ASD than in those with typical development (TD) and explored ASD-specific association patterns between brain GSH levels, myelination, functional connectivity, and behavioral characteristics. Data from 30 adults with ASD and 27 adults with TD were analyzed. Contrary to our hypothesis, GSH levels in the left temporoparietal junction (TPJ) were higher in the ASD group than in the TD group. Using individual myelin maps, we found a significant group difference in the correlation between left middle frontal gyrus (MFG) myelination and left TPJ GSH levels. Multivariate pattern analysis of resting-state functional MRI revealed that whole-brain functional connectivity patterns from the left MFG differed between the groups in their association with left MFG myelination. Finally, we found a significant group difference in the correlation between emotion recognition ability and the functional connectivity of the left MFG with the bilateral occipitoparietal junction. In conclusion, our findings demonstrate an ASD-specific pattern of associations between left TPJ GSH levels, left MFG myelination, whole-brain functional connectivity patterns of the left MFG, and cognitive phenotype, which suggests compensatory neural mechanisms in ASD. En ligne : https://doi.org/10.1002/aur.70134 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder [texte imprimé] / Toshiki IWABUCHI, Auteur ; Takaharu HIRAI, Auteur ; Naoko UMEDA, Auteur ; Hideto YOGO, Auteur ; Yuuta NISHIMIYA, Auteur ; Yuuki NISHIGAKI, Auteur ; Masaru WATANABE, Auteur ; Hidenori YAMASUE, Auteur ; Masatsugu TSUJII, Auteur ; Kenji J. TSUCHIYA, Auteur ; Hideo MATSUZAKI, Auteur . - p.2451-2462. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2451-2462 Mots-clés : autism spectrum disorder  glutathione  magnetic resonance spectroscopy  myelin map  resting-state functional connectivity Index. décimale : PER Périodiques Résumé : ABSTRACT Recent studies have implicated oxidative stress in the pathophysiology of autism spectrum disorder (ASD). Postmortem brain studies have revealed decreased levels of the reduced form of glutathione (GSH), an important antioxidant, in some brain regions in individuals with ASD; however, in vivo evidence is lacking. Using proton magnetic resonance spectroscopy, T1-weighted/T2-weighted ratio-derived myelin maps, resting-state functional magnetic resonance imaging (MRI), and cognitive tasks, we examined whether brain GSH levels are lower in individuals with ASD than in those with typical development (TD) and explored ASD-specific association patterns between brain GSH levels, myelination, functional connectivity, and behavioral characteristics. Data from 30 adults with ASD and 27 adults with TD were analyzed. Contrary to our hypothesis, GSH levels in the left temporoparietal junction (TPJ) were higher in the ASD group than in the TD group. Using individual myelin maps, we found a significant group difference in the correlation between left middle frontal gyrus (MFG) myelination and left TPJ GSH levels. Multivariate pattern analysis of resting-state functional MRI revealed that whole-brain functional connectivity patterns from the left MFG differed between the groups in their association with left MFG myelination. Finally, we found a significant group difference in the correlation between emotion recognition ability and the functional connectivity of the left MFG with the bilateral occipitoparietal junction. In conclusion, our findings demonstrate an ASD-specific pattern of associations between left TPJ GSH levels, left MFG myelination, whole-brain functional connectivity patterns of the left MFG, and cognitive phenotype, which suggests compensatory neural mechanisms in ASD. En ligne : https://doi.org/10.1002/aur.70134 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

Altered topological properties of functional brain network is associated with social communication difficulties in autistic children with motor coordination difficulties / Tingfeng GU in Research in Autism, 128 (October 2025)  

Public ISBD [article]  inResearch in Autism > 128 (October 2025) . - p.202722 Titre : Altered topological properties of functional brain network is associated with social communication difficulties in autistic children with motor coordination difficulties Type de document : texte imprimé Auteurs : Tingfeng GU, Auteur ; Xiuhong LI, Auteur ; Jin JING, Auteur ; Muqing CAO, Auteur Article en page(s) : p.202722 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Motor coordination  Social communication difficulties  Developmental coordination disorder  Motor skills disorder  Resting-state functional connectivity  Graph theory Index. décimale : PER Périodiques Résumé : Background The association between social communication function and motor coordination function in neuropsycological level among autistic children is not fully understood. Our study investigates this relationship in a neuroimage context, shedding light on the underlying mechanisms. Methods Participants with autism spectrum disorder (ASD), aged 3–6 years (n = 81), were recruited from rehabilitation facilities with confirmed diagnosis of autism. We utilized the Developmental Coordination Disorder Questionnaire (DCDQ) to evaluate the motor coordination function and classify children with or without motor coordination difficulties (DCD, if the score ≤48). Social Responsiveness Scale (SRS) was used for assessing social communication function of participants. Using resting-state functional magnetic resonance imaging (rs-fMRI) and network-based statistics, we compared functional connectivity (FC) and network topological properties (eg. small-worldness, degree centrality, and nodal efficiency) between ASD children with (n = 36) or without DCD (n = 39), graph theory-based analysis was also employed. Multiple covariates were included in the analysis to minimize potential bias. Results Autistic children with motor coordination difficulties (ASD-DCD, n = 36) exhibited diminished small-worldness and increased FCs in regions including visual-motor network, insula, and cerebellum. Notably, the right pallidum in ASD-DCD demonstrated reduced degree centrality and nodal efficiency. Furthermore, ASD-only (n = 39) revealed a correlation between degree centrality of right pallidum and social communication, as well as nodal efficiency. Conclusions Altered FCs and topological properties in the visual-motor network underlie visual-motor integration difficulties in the ASD-DCD subgroup. The right pallidum may persist as a common neural foundation for both motor coordination and social communication in autism. Difficulties in motor coordination could, however, attenuate the connection between the right pallidum and social communication in the ASD-DCD group. Overall, this study contributes new insights into the relationship between motor and social skills in autistic children, and offers a potential biomarker to support screening, diagnosis, and rehabilitation. En ligne : https://doi.org/10.1016/j.reia.2025.202722 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] Altered topological properties of functional brain network is associated with social communication difficulties in autistic children with motor coordination difficulties [texte imprimé] / Tingfeng GU, Auteur ; Xiuhong LI, Auteur ; Jin JING, Auteur ; Muqing CAO, Auteur . - p.202722. Langues : Anglais (eng) in Research in Autism > 128 (October 2025) . - p.202722 Mots-clés : Autism spectrum disorder  Motor coordination  Social communication difficulties  Developmental coordination disorder  Motor skills disorder  Resting-state functional connectivity  Graph theory Index. décimale : PER Périodiques Résumé : Background The association between social communication function and motor coordination function in neuropsycological level among autistic children is not fully understood. Our study investigates this relationship in a neuroimage context, shedding light on the underlying mechanisms. Methods Participants with autism spectrum disorder (ASD), aged 3–6 years (n = 81), were recruited from rehabilitation facilities with confirmed diagnosis of autism. We utilized the Developmental Coordination Disorder Questionnaire (DCDQ) to evaluate the motor coordination function and classify children with or without motor coordination difficulties (DCD, if the score ≤48). Social Responsiveness Scale (SRS) was used for assessing social communication function of participants. Using resting-state functional magnetic resonance imaging (rs-fMRI) and network-based statistics, we compared functional connectivity (FC) and network topological properties (eg. small-worldness, degree centrality, and nodal efficiency) between ASD children with (n = 36) or without DCD (n = 39), graph theory-based analysis was also employed. Multiple covariates were included in the analysis to minimize potential bias. Results Autistic children with motor coordination difficulties (ASD-DCD, n = 36) exhibited diminished small-worldness and increased FCs in regions including visual-motor network, insula, and cerebellum. Notably, the right pallidum in ASD-DCD demonstrated reduced degree centrality and nodal efficiency. Furthermore, ASD-only (n = 39) revealed a correlation between degree centrality of right pallidum and social communication, as well as nodal efficiency. Conclusions Altered FCs and topological properties in the visual-motor network underlie visual-motor integration difficulties in the ASD-DCD subgroup. The right pallidum may persist as a common neural foundation for both motor coordination and social communication in autism. Difficulties in motor coordination could, however, attenuate the connection between the right pallidum and social communication in the ASD-DCD group. Overall, this study contributes new insights into the relationship between motor and social skills in autistic children, and offers a potential biomarker to support screening, diagnosis, and rehabilitation. En ligne : https://doi.org/10.1016/j.reia.2025.202722 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

Specific Functional Connectivity Patterns of Middle Temporal Gyrus Subregions in Children and Adults with Autism Spectrum Disorder / Jinping XU in Autism Research, 13-3 (March 2020)  

Public ISBD [article]  inAutism Research > 13-3 (March 2020) . - p.410-422 Titre : Specific Functional Connectivity Patterns of Middle Temporal Gyrus Subregions in Children and Adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Jinping XU, Auteur ; Chao WANG, Auteur ; Ziyun XU, Auteur ; Tian LI, Auteur ; Fangfang CHEN, Auteur ; Kai CHEN, Auteur ; Jingjing GAO, Auteur ; Jiaojian WANG, Auteur ; Qingmao HU, Auteur Article en page(s) : p.410-422 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  coactivation-based parcellation  functional characterization  middle temporal gyrus  resting-state functional connectivity Index. décimale : PER Périodiques Résumé : As one of the key regions in the "social brain" network, the middle temporal gyrus (MTG) has been widely reported to be associated with autism spectrum disorder (ASD), but there have been contradictory results in terms of whether it shows hyperconnectivity or hypoconnectivity. Delineating roles of MTG at the subregional level may eliminate the observed inconsistencies and provide a new avenue to reveal the neurophysiologic mechanism of ASD. Thus, we first performed connectivity-based parcellation using the BrainMap database to identify fine-grained functional topography of the MTG. Then, the MTG subregions were used to investigate differences in the functional connectivity in children and adults with ASD using two data sets from Autism Brain Imaging Data Exchange database. Four distinct subregions in the human left and right MTG were identified, including the anterior MTG (aMTG), middle-anterior MTG (maMTG), middle-posterior MTG, and posterior MTG (pMTG). The bilateral pMTG was more vulnerable in both children and adults with ASD than in the typically developing (TD) group, mainly showing hypoconnectivity with different brain regions. In addition, the bilateral aMTG and right maMTG also showed altered functional connectivity in adults with ASD compared to the TD group. Moreover, all these altered MTG subregions were mainly associated with social cognition and language, as revealed by functional characterization. Further correlation analyses also showed trends of association between altered connectivity of the left aMTG and the Autism Diagnostic Observation Schedule scores in adults with ASD. Together, these results suggest a potential objective way to explore sub-regional differences associated with such disorders. Autism Res 2020, 13: 410-422. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Four distinct subregions in the human left and right middle temporal gyrus (MTG) were identified, including the anterior MTG (aMTG), middle-anterior MTG (maMTG), middle-posterior MTG, and posterior MTG (pMTG). The bilateral pMTG was more vulnerable in both children and adults with autism spectrum disorder (ASD) than in the typically developing (TD) group, mainly showing hypoconnectivity with different brain regions. In addition, the bilateral aMTG and right maMTG also showed altered functional connectivity in adults with ASD compared to the TD group. Moreover, all these altered MTG subregions were mainly associated with social cognition and language, as revealed by functional characterization. Further correlation analyses also showed trends of association between altered connectivity of the left aMTG and the Autism Diagnostic Observation Schedule scores in adults with ASD. En ligne : http://dx.doi.org/10.1002/aur.2239 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] Specific Functional Connectivity Patterns of Middle Temporal Gyrus Subregions in Children and Adults with Autism Spectrum Disorder [texte imprimé] / Jinping XU, Auteur ; Chao WANG, Auteur ; Ziyun XU, Auteur ; Tian LI, Auteur ; Fangfang CHEN, Auteur ; Kai CHEN, Auteur ; Jingjing GAO, Auteur ; Jiaojian WANG, Auteur ; Qingmao HU, Auteur . - p.410-422. Langues : Anglais (eng) in Autism Research > 13-3 (March 2020) . - p.410-422 Mots-clés : autism spectrum disorders  coactivation-based parcellation  functional characterization  middle temporal gyrus  resting-state functional connectivity Index. décimale : PER Périodiques Résumé : As one of the key regions in the "social brain" network, the middle temporal gyrus (MTG) has been widely reported to be associated with autism spectrum disorder (ASD), but there have been contradictory results in terms of whether it shows hyperconnectivity or hypoconnectivity. Delineating roles of MTG at the subregional level may eliminate the observed inconsistencies and provide a new avenue to reveal the neurophysiologic mechanism of ASD. Thus, we first performed connectivity-based parcellation using the BrainMap database to identify fine-grained functional topography of the MTG. Then, the MTG subregions were used to investigate differences in the functional connectivity in children and adults with ASD using two data sets from Autism Brain Imaging Data Exchange database. Four distinct subregions in the human left and right MTG were identified, including the anterior MTG (aMTG), middle-anterior MTG (maMTG), middle-posterior MTG, and posterior MTG (pMTG). The bilateral pMTG was more vulnerable in both children and adults with ASD than in the typically developing (TD) group, mainly showing hypoconnectivity with different brain regions. In addition, the bilateral aMTG and right maMTG also showed altered functional connectivity in adults with ASD compared to the TD group. Moreover, all these altered MTG subregions were mainly associated with social cognition and language, as revealed by functional characterization. Further correlation analyses also showed trends of association between altered connectivity of the left aMTG and the Autism Diagnostic Observation Schedule scores in adults with ASD. Together, these results suggest a potential objective way to explore sub-regional differences associated with such disorders. Autism Res 2020, 13: 410-422. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Four distinct subregions in the human left and right middle temporal gyrus (MTG) were identified, including the anterior MTG (aMTG), middle-anterior MTG (maMTG), middle-posterior MTG, and posterior MTG (pMTG). The bilateral pMTG was more vulnerable in both children and adults with autism spectrum disorder (ASD) than in the typically developing (TD) group, mainly showing hypoconnectivity with different brain regions. In addition, the bilateral aMTG and right maMTG also showed altered functional connectivity in adults with ASD compared to the TD group. Moreover, all these altered MTG subregions were mainly associated with social cognition and language, as revealed by functional characterization. Further correlation analyses also showed trends of association between altered connectivity of the left aMTG and the Autism Diagnostic Observation Schedule scores in adults with ASD. En ligne : http://dx.doi.org/10.1002/aur.2239 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Preserved Self-other Distinction During Empathy in Autism is Linked to Network Integrity of Right Supramarginal Gyrus / Ferdinand HOFFMANN in Journal of Autism and Developmental Disorders, 46-2 (February 2016)  

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Towards robust and replicable sex differences in the intrinsic brain function of autism / Dorothea L. FLORIS in Molecular Autism, 12 (2021)  

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