[article] 
inJournal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3319-3329

Titre :	Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder
Type de document :	texte imprimé
Auteurs :	M. B. D. PRIGGE, Auteur ; Erin D. BIGLER, Auteur ; B. G. TRAVERS, Auteur ; A. FROEHLICH, Auteur ; Tracy J. ABILDSKOV, Auteur ; Jeffrey S. ANDERSON, Auteur ; A. L. ALEXANDER, Auteur ; N. LANGE, Auteur ; J. E. LAINHART, Auteur ; B. A. ZIELINSKI, Auteur
Article en page(s) :	p.3319-3329
Langues :	Anglais (eng)
Mots-clés :	Autism severity  Autism spectrum disorder (ASD)  Brain development  Cortical thickness  Longitudinal  Social Responsiveness Scale (SRS)
Index. décimale :	PER Périodiques
Résumé :	The relationship between brain development and clinical heterogeneity in autism (ASD) is unknown. This study examines the Social Responsiveness Scale (SRS) in relation to the longitudinal development of cortical thickness. Participants (N = 91 ASD, N = 56 TDC; 3-39 years at first scan) were scanned up to three times over a 7-year period. Mixed-effects models examined cortical thickness in relation to SRS score. ASD participants with higher SRS scores showed regionally increased age-related cortical thinning. Regional thickness differences and reduced age-related cortical thinning were found in predominantly right lateralized regions in ASD with decreasing SRS scores over time. Our findings emphasize the importance of examining clinical phenotypes in brain-based studies of ASD.
En ligne :	http://dx.doi.org/10.1007/s10803-018-3566-1
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

[article] Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder [texte imprimé] / M. B. D. PRIGGE, Auteur ; Erin D. BIGLER, Auteur ; B. G. TRAVERS, Auteur ; A. FROEHLICH, Auteur ; Tracy J. ABILDSKOV, Auteur ; Jeffrey S. ANDERSON, Auteur ; A. L. ALEXANDER, Auteur ; N. LANGE, Auteur ; J. E. LAINHART, Auteur ; B. A. ZIELINSKI, Auteur . - p.3319-3329.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3319-3329

Mots-clés :	Autism severity  Autism spectrum disorder (ASD)  Brain development  Cortical thickness  Longitudinal  Social Responsiveness Scale (SRS)
Index. décimale :	PER Périodiques
Résumé :	The relationship between brain development and clinical heterogeneity in autism (ASD) is unknown. This study examines the Social Responsiveness Scale (SRS) in relation to the longitudinal development of cortical thickness. Participants (N = 91 ASD, N = 56 TDC; 3-39 years at first scan) were scanned up to three times over a 7-year period. Mixed-effects models examined cortical thickness in relation to SRS score. ASD participants with higher SRS scores showed regionally increased age-related cortical thinning. Regional thickness differences and reduced age-related cortical thinning were found in predominantly right lateralized regions in ASD with decreasing SRS scores over time. Our findings emphasize the importance of examining clinical phenotypes in brain-based studies of ASD.
En ligne :	http://dx.doi.org/10.1007/s10803-018-3566-1
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369