Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort / Novika Purnama SARI in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 26 p. Titre : Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort Type de document : Texte imprimé et/ou numérique Auteurs : Novika Purnama SARI, Auteur ; Pauline W. JANSEN, Auteur ; Laura M. E. BLANKEN, Auteur ; Amber N. V. RUIGROK, Auteur ; Peter PRINZIE, Auteur ; Henning TIEMEIER, Auteur ; Simon BARON-COHEN, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Tonya WHITE, Auteur Article en page(s) : 26 p. Langues : Anglais (eng) Mots-clés : Autistic Disorder/epidemiology  Child  Female  Humans  Male  Maternal Age  Mentalization  Mothers  Netherlands/epidemiology  Pregnancy  Autistic-like traits  Children   Mentalizing Index. décimale : PER Périodiques Résumé : BACKGROUND: Many empirical studies suggest that higher maternal age increases the likelihood of having an autistic child. However, little is known about factors that may explain this relationship or if higher maternal age is related to the number of autistic-like traits in offspring. One possibility is that mothers who have a higher number of autistic-like traits, including greater challenges performing mentalizing skills, are delayed in finding a partner. The goal of our study is to assess the relationship between maternal age, mentalizing skills and autistic-like traits as independent predictors of the number of autistic-like traits in offspring. METHODS: In a population-based study in the Netherlands, information on maternal age was collected during pre- and perinatal enrolment. Maternal mentalizing skills and autistic-like traits were assessed using the Reading the Mind in the Eyes Test and the Autism Spectrum Quotient, respectively. Autistic-like traits in children were assessed with the Social Responsiveness Scale. A total of 5718 mother/child dyads had complete data (M(agechild)=13.5 years; 50.2% girls). RESULTS: The relationship between maternal age and autistic-like traits in offspring best fits a U-shaped curve. Furthermore, higher levels of autistic features in mothers are linked to higher levels of autistic-like traits in their children. Lower mentalizing performance in mothers is linked to higher levels of autistic-like traits in their children. LIMITATIONS: We were able to collect data on both autistic-like traits and the mentalizing skills test in a large population of mothers, but we did not collect these data in a large number of the fathers. CONCLUSIONS: The relationships between older and younger mothers may have comparable underlying mechanisms, but it is also possible that the tails of the U-shaped curve are influenced by disparate mechanisms. En ligne : http://dx.doi.org/10.1186/s13229-022-00507-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort [Texte imprimé et/ou numérique] / Novika Purnama SARI, Auteur ; Pauline W. JANSEN, Auteur ; Laura M. E. BLANKEN, Auteur ; Amber N. V. RUIGROK, Auteur ; Peter PRINZIE, Auteur ; Henning TIEMEIER, Auteur ; Simon BARON-COHEN, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Tonya WHITE, Auteur . - 26 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 26 p. Mots-clés : Autistic Disorder/epidemiology  Child  Female  Humans  Male  Maternal Age  Mentalization  Mothers  Netherlands/epidemiology  Pregnancy  Autistic-like traits  Children   Mentalizing Index. décimale : PER Périodiques Résumé : BACKGROUND: Many empirical studies suggest that higher maternal age increases the likelihood of having an autistic child. However, little is known about factors that may explain this relationship or if higher maternal age is related to the number of autistic-like traits in offspring. One possibility is that mothers who have a higher number of autistic-like traits, including greater challenges performing mentalizing skills, are delayed in finding a partner. The goal of our study is to assess the relationship between maternal age, mentalizing skills and autistic-like traits as independent predictors of the number of autistic-like traits in offspring. METHODS: In a population-based study in the Netherlands, information on maternal age was collected during pre- and perinatal enrolment. Maternal mentalizing skills and autistic-like traits were assessed using the Reading the Mind in the Eyes Test and the Autism Spectrum Quotient, respectively. Autistic-like traits in children were assessed with the Social Responsiveness Scale. A total of 5718 mother/child dyads had complete data (M(agechild)=13.5 years; 50.2% girls). RESULTS: The relationship between maternal age and autistic-like traits in offspring best fits a U-shaped curve. Furthermore, higher levels of autistic features in mothers are linked to higher levels of autistic-like traits in their children. Lower mentalizing performance in mothers is linked to higher levels of autistic-like traits in their children. LIMITATIONS: We were able to collect data on both autistic-like traits and the mentalizing skills test in a large population of mothers, but we did not collect these data in a large number of the fathers. CONCLUSIONS: The relationships between older and younger mothers may have comparable underlying mechanisms, but it is also possible that the tails of the U-shaped curve are influenced by disparate mechanisms. En ligne : http://dx.doi.org/10.1186/s13229-022-00507-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Quantifying and exploring camouflaging in men and women with autism / Meng-Chuan LAI in Autism, 21-6 (August 2017)  

Public ISBD [article]  inAutism > 21-6 (August 2017) . - p.690-702 Titre : Quantifying and exploring camouflaging in men and women with autism Type de document : Texte imprimé et/ou numérique Auteurs : Meng-Chuan LAI, Auteur ; Michael V. LOMBARDO, Auteur ; Amber N. V. RUIGROK, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Bonnie AUYEUNG, Auteur ; Peter SZATMARI, Auteur ; Francesca HAPPE, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : p.690-702 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autobiographical descriptions and clinician observations suggest that some individuals with autism, particularly females, ?camouflage? their social communication difficulties, which may require considerable cognitive effort and lead to increased stress, anxiety and depression. Using data from 60 age- and IQ-matched men and women with autism (without intellectual disability), we operationalized camouflaging in adults with autism for the first time as the quantitative discrepancy between the person?s ?external? behavioural presentation in social?interpersonal contexts (measured by the Autism Diagnostic Observation Schedule) and the person?s ?internal? status (dispositional traits measured by the Autism Spectrum Quotient and social cognitive capability measured by the ?Reading the Mind in the Eyes? Test). We found that the operationalized camouflaging measure was not significantly correlated with age or IQ. On average, women with autism had higher camouflaging scores than men with autism (Cohen?s d=0.98), with substantial variability in both groups. Greater camouflaging was associated with more depressive symptoms in men and better signal-detection sensitivity in women with autism. The neuroanatomical association with camouflaging score was largely sex/gender-dependent and significant only in women: from reverse inference, the most correlated cognitive terms were about emotion and memory. The underlying constructs, measurement, mechanisms, consequences and heterogeneity of camouflaging in autism warrant further investigation. En ligne : http://dx.doi.org/10.1177/1362361316671012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311 [article] Quantifying and exploring camouflaging in men and women with autism [Texte imprimé et/ou numérique] / Meng-Chuan LAI, Auteur ; Michael V. LOMBARDO, Auteur ; Amber N. V. RUIGROK, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Bonnie AUYEUNG, Auteur ; Peter SZATMARI, Auteur ; Francesca HAPPE, Auteur ; Simon BARON-COHEN, Auteur . - p.690-702. Langues : Anglais (eng) in Autism > 21-6 (August 2017) . - p.690-702 Index. décimale : PER Périodiques Résumé : Autobiographical descriptions and clinician observations suggest that some individuals with autism, particularly females, ?camouflage? their social communication difficulties, which may require considerable cognitive effort and lead to increased stress, anxiety and depression. Using data from 60 age- and IQ-matched men and women with autism (without intellectual disability), we operationalized camouflaging in adults with autism for the first time as the quantitative discrepancy between the person?s ?external? behavioural presentation in social?interpersonal contexts (measured by the Autism Diagnostic Observation Schedule) and the person?s ?internal? status (dispositional traits measured by the Autism Spectrum Quotient and social cognitive capability measured by the ?Reading the Mind in the Eyes? Test). We found that the operationalized camouflaging measure was not significantly correlated with age or IQ. On average, women with autism had higher camouflaging scores than men with autism (Cohen?s d=0.98), with substantial variability in both groups. Greater camouflaging was associated with more depressive symptoms in men and better signal-detection sensitivity in women with autism. The neuroanatomical association with camouflaging score was largely sex/gender-dependent and significant only in women: from reverse inference, the most correlated cognitive terms were about emotion and memory. The underlying constructs, measurement, mechanisms, consequences and heterogeneity of camouflaging in autism warrant further investigation. En ligne : http://dx.doi.org/10.1177/1362361316671012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311

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