Basic oculomotor function is similar in young children with ASD and typically developing controls / Inbar AVNI in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2580-2591 Titre : Basic oculomotor function is similar in young children with ASD and typically developing controls Type de document : Texte imprimé et/ou numérique Auteurs : Inbar AVNI, Auteur ; G. MEIRI, Auteur ; A. MICHAELOVSKI, Auteur ; I. MENASHE, Auteur ; L. SHMUELOF, Auteur ; I. DINSTEIN, Auteur Article en page(s) : p.2580-2591 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder  Child  Child, Preschool  Eye Movements  Humans  Infant  Saccades  eye position  eye tracking  gaze  kinematic characteristics  movies  oculomotor control  saccade Index. décimale : PER Périodiques Résumé : A variety of eye tracking studies have demonstrated that young children with ASD gaze at images and movies of social interactions differently than typically developing children. These findings have supported the hypothesis that gaze behavior differences are generated by a weaker preference for social stimuli in ASD children. The hypothesis assumes that gaze differences are not caused by abnormalities in oculomotor function including saccade frequency and kinematics. Previous studies of oculomotor function have mostly been performed with school-age children, adolescents, and adults using visual search, anti-saccade, and gap saccade tasks that are less suitable for young pre-school children. Here, we examined oculomotor function in 144 children (90 with ASD and 54 controls), 1-10-years-old, as they watched two animated movies interleaved with the presentation of multiple salient stimuli that elicited saccades-to-targets. The results revealed that the number of fixations, fixation duration, number of saccades, saccade duration, saccade accuracy, and saccade latency did not differ significantly across groups. Minor initial differences in saccade peak velocity were not supported by analysis with a linear mixed model. These findings suggest that most children with ASD exhibit similar oculomotor function to that of controls, when performing saccades-to-targets or freely viewing child-friendly movies. This suggests that previously reported gaze abnormalities in children with ASD are not due to underlying oculomotor deficiencies. LAY SUMMARY: This study demonstrates that children with ASD perform similar eye movements to those of controls when freely observing movies or making eye movements to targets. Similar results were apparent across groups in the number of eye movements, their accuracy, duration, and other measures that assess eye movement control. These findings are important for interpreting previously reported differences in gaze behavior of children with ASD, which are likely due to atypical social preferences rather than impaired control of eye movements. En ligne : http://dx.doi.org/10.1002/aur.2592 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Basic oculomotor function is similar in young children with ASD and typically developing controls [Texte imprimé et/ou numérique] / Inbar AVNI, Auteur ; G. MEIRI, Auteur ; A. MICHAELOVSKI, Auteur ; I. MENASHE, Auteur ; L. SHMUELOF, Auteur ; I. DINSTEIN, Auteur . - p.2580-2591. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2580-2591 Mots-clés : Adolescent  Adult  Autism Spectrum Disorder  Child  Child, Preschool  Eye Movements  Humans  Infant  Saccades  eye position  eye tracking  gaze  kinematic characteristics  movies  oculomotor control  saccade Index. décimale : PER Périodiques Résumé : A variety of eye tracking studies have demonstrated that young children with ASD gaze at images and movies of social interactions differently than typically developing children. These findings have supported the hypothesis that gaze behavior differences are generated by a weaker preference for social stimuli in ASD children. The hypothesis assumes that gaze differences are not caused by abnormalities in oculomotor function including saccade frequency and kinematics. Previous studies of oculomotor function have mostly been performed with school-age children, adolescents, and adults using visual search, anti-saccade, and gap saccade tasks that are less suitable for young pre-school children. Here, we examined oculomotor function in 144 children (90 with ASD and 54 controls), 1-10-years-old, as they watched two animated movies interleaved with the presentation of multiple salient stimuli that elicited saccades-to-targets. The results revealed that the number of fixations, fixation duration, number of saccades, saccade duration, saccade accuracy, and saccade latency did not differ significantly across groups. Minor initial differences in saccade peak velocity were not supported by analysis with a linear mixed model. These findings suggest that most children with ASD exhibit similar oculomotor function to that of controls, when performing saccades-to-targets or freely viewing child-friendly movies. This suggests that previously reported gaze abnormalities in children with ASD are not due to underlying oculomotor deficiencies. LAY SUMMARY: This study demonstrates that children with ASD perform similar eye movements to those of controls when freely observing movies or making eye movements to targets. Similar results were apparent across groups in the number of eye movements, their accuracy, duration, and other measures that assess eye movement control. These findings are important for interpreting previously reported differences in gaze behavior of children with ASD, which are likely due to atypical social preferences rather than impaired control of eye movements. En ligne : http://dx.doi.org/10.1002/aur.2592 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Exposure to General Anesthesia May Contribute to the Association between Cesarean Delivery and Autism Spectrum Disorder / M. HUBERMAN SAMUEL in Journal of Autism and Developmental Disorders, 49-8 (August 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-8 (August 2019) . - p.3127-3135 Titre : Exposure to General Anesthesia May Contribute to the Association between Cesarean Delivery and Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : M. HUBERMAN SAMUEL, Auteur ; G. MEIRI, Auteur ; I. DINSTEIN, Auteur ; H. FLUSSER, Auteur ; A. MICHAELOVSKI, Auteur ; Asher BASHIRI, Auteur ; I. MENASHE, Auteur Article en page(s) : p.3127-3135 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Cesarean section  General anesthesia Index. décimale : PER Périodiques Résumé : Cesarean section (CS) has been consistently associated with susceptibility to autism spectrum disorder (ASD), however, the underlying mechanism for this association remains vague. Here, we studied various pre-peri-and-neonatal factors among 347 children with ASD, 117 children with other developmental delays (DD), and 2226 age, sex and ethnicity matched controls. We found that CS is significantly associated with an increased risk of ASD but not DD (p = 0.019 and p = 0.540 respectively). Furthermore, we show that only CS performed with general anesthesia (GA) elevated the risk of ASD with no significant difference between indicated and non-indicated surgeries (aOR = 1.537; 95% CI 1.026-2.302, and aOR = 1.692; 95% CI 1.057-2.709, pdiff = 0.865). We therefore suggest that exposure to GA during CS may explain the association between CS and ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04034-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Exposure to General Anesthesia May Contribute to the Association between Cesarean Delivery and Autism Spectrum Disorder [Texte imprimé et/ou numérique] / M. HUBERMAN SAMUEL, Auteur ; G. MEIRI, Auteur ; I. DINSTEIN, Auteur ; H. FLUSSER, Auteur ; A. MICHAELOVSKI, Auteur ; Asher BASHIRI, Auteur ; I. MENASHE, Auteur . - p.3127-3135. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-8 (August 2019) . - p.3127-3135 Mots-clés : Autism spectrum disorder  Cesarean section  General anesthesia Index. décimale : PER Périodiques Résumé : Cesarean section (CS) has been consistently associated with susceptibility to autism spectrum disorder (ASD), however, the underlying mechanism for this association remains vague. Here, we studied various pre-peri-and-neonatal factors among 347 children with ASD, 117 children with other developmental delays (DD), and 2226 age, sex and ethnicity matched controls. We found that CS is significantly associated with an increased risk of ASD but not DD (p = 0.019 and p = 0.540 respectively). Furthermore, we show that only CS performed with general anesthesia (GA) elevated the risk of ASD with no significant difference between indicated and non-indicated surgeries (aOR = 1.537; 95% CI 1.026-2.302, and aOR = 1.692; 95% CI 1.057-2.709, pdiff = 0.865). We therefore suggest that exposure to GA during CS may explain the association between CS and ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04034-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

Sleep Disturbances and Sensory Sensitivities Co-Vary in a Longitudinal Manner in Pre-School Children with Autism Spectrum Disorders / L. MANELIS-BARAM in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.923-937 Titre : Sleep Disturbances and Sensory Sensitivities Co-Vary in a Longitudinal Manner in Pre-School Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : L. MANELIS-BARAM, Auteur ; G. MEIRI, Auteur ; M. ILAN, Auteur ; M. FAROY, Auteur ; A. MICHAELOVSKI, Auteur ; H. FLUSSER, Auteur ; I. MENASHE, Auteur ; I. DINSTEIN, Auteur Article en page(s) : p.923-937 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Child  Child, Preschool  Cross-Sectional Studies  Humans  Sensation  Sleep  Sleep Wake Disorders/diagnosis/epidemiology  Autism Spectrum disorder  Sensory processing  Sensory sensitivities  Sleep disturbances Index. décimale : PER Périodiques Résumé : Previous research has demonstrated that sleep disturbances are positively correlated with sensory sensitivities in children with ASD. Most of these studies, however, were based on cross-sectional analyses, where the relationship across symptom domains was examined at a single time-point. Here, we examined the development of 103 pre-school children with ASD over a 1-3-year period. The results revealed that spontaneous longitudinal changes in sleep disturbances were specifically correlated with changes in sensory sensitivities and not with changes in other sensory processing domains nor with changes in core ASD symptoms. These finding demonstrate a consistent longitudinal relationship between sleep disturbances and sensory sensitivities, which suggests that these symptoms may be generated by common or interacting underlying physiological mechanisms. En ligne : http://dx.doi.org/10.1007/s10803-021-04973-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Sleep Disturbances and Sensory Sensitivities Co-Vary in a Longitudinal Manner in Pre-School Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / L. MANELIS-BARAM, Auteur ; G. MEIRI, Auteur ; M. ILAN, Auteur ; M. FAROY, Auteur ; A. MICHAELOVSKI, Auteur ; H. FLUSSER, Auteur ; I. MENASHE, Auteur ; I. DINSTEIN, Auteur . - p.923-937. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.923-937 Mots-clés : Autism Spectrum Disorder/diagnosis  Child  Child, Preschool  Cross-Sectional Studies  Humans  Sensation  Sleep  Sleep Wake Disorders/diagnosis/epidemiology  Autism Spectrum disorder  Sensory processing  Sensory sensitivities  Sleep disturbances Index. décimale : PER Périodiques Résumé : Previous research has demonstrated that sleep disturbances are positively correlated with sensory sensitivities in children with ASD. Most of these studies, however, were based on cross-sectional analyses, where the relationship across symptom domains was examined at a single time-point. Here, we examined the development of 103 pre-school children with ASD over a 1-3-year period. The results revealed that spontaneous longitudinal changes in sleep disturbances were specifically correlated with changes in sensory sensitivities and not with changes in other sensory processing domains nor with changes in core ASD symptoms. These finding demonstrate a consistent longitudinal relationship between sleep disturbances and sensory sensitivities, which suggests that these symptoms may be generated by common or interacting underlying physiological mechanisms. En ligne : http://dx.doi.org/10.1007/s10803-021-04973-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Sleep disturbances are associated with specific sensory sensitivities in children with autism / O. TZISCHINSKY in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 22p. Titre : Sleep disturbances are associated with specific sensory sensitivities in children with autism Type de document : Texte imprimé et/ou numérique Auteurs : O. TZISCHINSKY, Auteur ; G. MEIRI, Auteur ; L. MANELIS, Auteur ; A. BAR-SINAI, Auteur ; H. FLUSSER, Auteur ; A. MICHAELOVSKI, Auteur ; O. ZIVAN, Auteur ; M. ILAN, Auteur ; M. FAROY, Auteur ; I. MENASHE, Auteur ; I. DINSTEIN, Auteur Article en page(s) : 22p. Langues : Anglais (eng) Mots-clés : Autism  Children  Hypersensitivity towards touch  Sensory abnormalities  Sleep disturbances Index. décimale : PER Périodiques Résumé : Background: Sensory abnormalities and sleep disturbances are highly prevalent in children with autism, but the potential relationship between these two domains has rarely been explored. Understanding such relationships is important for identifying children with autism who exhibit more homogeneous symptoms. Methods: Here, we examined this relationship using the Caregiver Sensory Profile and the Children's Sleep Habits Questionnaire, which were completed by parents of 69 children with autism and 62 age-matched controls. Results: In line with previous studies, children with autism exhibited more severe sensory abnormalities and sleep disturbances than age-matched controls. The sleep disturbance scores were moderately associated with touch and oral sensitivities in the autism group and with touch and vestibular sensitivities in the control group. Hypersensitivity towards touch, in particular, exhibited the strongest relationship with sleep disturbances in the autism group and single-handedly explained 24% of the variance in total sleep disturbance scores. In contrast, sensitivity in other sensory domains such as vision and audition was not associated with sleep quality in either group. Conclusions: While it is often assumed that sensitivities in all sensory domains are similarly associated with sleep problems, our results suggest that hypersensitivity towards touch exhibits the strongest relationship with sleep disturbances when examining children autism. We speculate that hypersensitivity towards touch interferes with sleep onset and maintenance in a considerable number of children with autism who exhibit severe sleep disturbances. This may indicate the existence of a specific sleep disturbance mechanism that is associated with sensitivity to touch, which may be important to consider in future scientific and clinical studies. En ligne : http://dx.doi.org/10.1186/s13229-018-0206-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 [article] Sleep disturbances are associated with specific sensory sensitivities in children with autism [Texte imprimé et/ou numérique] / O. TZISCHINSKY, Auteur ; G. MEIRI, Auteur ; L. MANELIS, Auteur ; A. BAR-SINAI, Auteur ; H. FLUSSER, Auteur ; A. MICHAELOVSKI, Auteur ; O. ZIVAN, Auteur ; M. ILAN, Auteur ; M. FAROY, Auteur ; I. MENASHE, Auteur ; I. DINSTEIN, Auteur . - 22p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 22p. Mots-clés : Autism  Children  Hypersensitivity towards touch  Sensory abnormalities  Sleep disturbances Index. décimale : PER Périodiques Résumé : Background: Sensory abnormalities and sleep disturbances are highly prevalent in children with autism, but the potential relationship between these two domains has rarely been explored. Understanding such relationships is important for identifying children with autism who exhibit more homogeneous symptoms. Methods: Here, we examined this relationship using the Caregiver Sensory Profile and the Children's Sleep Habits Questionnaire, which were completed by parents of 69 children with autism and 62 age-matched controls. Results: In line with previous studies, children with autism exhibited more severe sensory abnormalities and sleep disturbances than age-matched controls. The sleep disturbance scores were moderately associated with touch and oral sensitivities in the autism group and with touch and vestibular sensitivities in the control group. Hypersensitivity towards touch, in particular, exhibited the strongest relationship with sleep disturbances in the autism group and single-handedly explained 24% of the variance in total sleep disturbance scores. In contrast, sensitivity in other sensory domains such as vision and audition was not associated with sleep quality in either group. Conclusions: While it is often assumed that sensitivities in all sensory domains are similarly associated with sleep problems, our results suggest that hypersensitivity towards touch exhibits the strongest relationship with sleep disturbances when examining children autism. We speculate that hypersensitivity towards touch interferes with sleep onset and maintenance in a considerable number of children with autism who exhibit severe sleep disturbances. This may indicate the existence of a specific sleep disturbance mechanism that is associated with sensitivity to touch, which may be important to consider in future scientific and clinical studies. En ligne : http://dx.doi.org/10.1186/s13229-018-0206-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354

A systematic variant annotation approach for ranking genes associated with autism spectrum disorders / E. LARSEN in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 44p. Titre : A systematic variant annotation approach for ranking genes associated with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : E. LARSEN, Auteur ; I. MENASHE, Auteur ; M. N. ZIATS, Auteur ; W. PEREANU, Auteur ; A. PACKER, Auteur ; Sharmila BANERJEE-BASU, Auteur Article en page(s) : 44p. Langues : Anglais (eng) Mots-clés : Algorithms  Autism Spectrum Disorder/genetics/physiopathology  DNA-Binding Proteins/genetics  Databases, Genetic  Datasets as Topic  Gene Expression  Genetic Predisposition to Disease  Genetic Variation  Homeodomain Proteins/genetics  Humans  Molecular Sequence Annotation  Nerve Tissue Proteins/genetics  Research Design  Transcription Factors/genetics  Autistic disorder  Autosomal recessive  Common variants  Genetic variation  Rare variants Index. décimale : PER Périodiques Résumé : BACKGROUND: The search for genetic factors underlying autism spectrum disorders (ASD) has led to the identification of hundreds of genes containing thousands of variants that differ in mode of inheritance, effect size, frequency, and function. A major challenge involves assessing the collective evidence in an unbiased, systematic manner for their functional relevance. METHODS: Here, we describe a scoring algorithm for prioritization of candidate genes based on the cumulative strength of evidence for each ASD-associated variant cataloged in AutDB (also known as SFARI Gene). We retrieved data from 889 publications to generate a dataset of 2187 rare and 711 common variants distributed across 461 genes implicated in ASD. Each individual variant was manually annotated with multiple attributes extracted from the original report, followed by score assignment using a set of standardized parameters yielding a single score for each gene. RESULTS: There was a wide variation in scores; SHANK3, CHD8, and ADNP had distinctly higher scores than all other genes in the dataset. Our gene scores were significantly correlated with other recently published rankings of ASD genes (RSpearman = 0.40-0.63; p< 0.0001), providing support for our scoring algorithm. CONCLUSIONS: This new resource, which is freely available, for the first time aggregates on one-platform variants identified from various study types (simplex, multiplex, multigenerational, and consanguineous families), from both common and rare variants, and also incorporates their putative functional consequences to arrive at a genetically and biologically driven ranking scheme. This work represents a major step in moving from simply cataloging autism variants to using data-driven approaches to gain insight into their significance. En ligne : http://dx.doi.org/10.1186/s13229-016-0103-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] A systematic variant annotation approach for ranking genes associated with autism spectrum disorders [Texte imprimé et/ou numérique] / E. LARSEN, Auteur ; I. MENASHE, Auteur ; M. N. ZIATS, Auteur ; W. PEREANU, Auteur ; A. PACKER, Auteur ; Sharmila BANERJEE-BASU, Auteur . - 44p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 44p. Mots-clés : Algorithms  Autism Spectrum Disorder/genetics/physiopathology  DNA-Binding Proteins/genetics  Databases, Genetic  Datasets as Topic  Gene Expression  Genetic Predisposition to Disease  Genetic Variation  Homeodomain Proteins/genetics  Humans  Molecular Sequence Annotation  Nerve Tissue Proteins/genetics  Research Design  Transcription Factors/genetics  Autistic disorder  Autosomal recessive  Common variants  Genetic variation  Rare variants Index. décimale : PER Périodiques Résumé : BACKGROUND: The search for genetic factors underlying autism spectrum disorders (ASD) has led to the identification of hundreds of genes containing thousands of variants that differ in mode of inheritance, effect size, frequency, and function. A major challenge involves assessing the collective evidence in an unbiased, systematic manner for their functional relevance. METHODS: Here, we describe a scoring algorithm for prioritization of candidate genes based on the cumulative strength of evidence for each ASD-associated variant cataloged in AutDB (also known as SFARI Gene). We retrieved data from 889 publications to generate a dataset of 2187 rare and 711 common variants distributed across 461 genes implicated in ASD. Each individual variant was manually annotated with multiple attributes extracted from the original report, followed by score assignment using a set of standardized parameters yielding a single score for each gene. RESULTS: There was a wide variation in scores; SHANK3, CHD8, and ADNP had distinctly higher scores than all other genes in the dataset. Our gene scores were significantly correlated with other recently published rankings of ASD genes (RSpearman = 0.40-0.63; p< 0.0001), providing support for our scoring algorithm. CONCLUSIONS: This new resource, which is freely available, for the first time aggregates on one-platform variants identified from various study types (simplex, multiplex, multigenerational, and consanguineous families), from both common and rare variants, and also incorporates their putative functional consequences to arrive at a genetically and biologically driven ranking scheme. This work represents a major step in moving from simply cataloging autism variants to using data-driven approaches to gain insight into their significance. En ligne : http://dx.doi.org/10.1186/s13229-016-0103-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

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