From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition / A. M. YOUNG in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 9p. Titre : From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition Type de document : Texte imprimé et/ou numérique Auteurs : A. M. YOUNG, Auteur ; Bhismadev CHAKRABARTI, Auteur ; D. ROBERTS, Auteur ; Meng-Chuan LAI, Auteur ; J. SUCKLING, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 9p. Langues : Anglais (eng) Mots-clés : Amniotic Fluid/chemistry  Animals  Antigens, Surface/immunology  Autism Spectrum Disorder/genetics/immunology/pathology  Autoantibodies/analysis  Body Fluids/chemistry  Brain/embryology/immunology/pathology  Brain Chemistry  Chemokines/analysis  Cytokines/analysis  Female  Glutamic Acid/metabolism  HLA Antigens/immunology  Haplorhini  Humans  Immunity, Maternally-Acquired  Inflammation  Inflammation Mediators/analysis  Lipopolysaccharides/blood  Maternal-Fetal Exchange  Mice  Nerve Tissue Proteins/immunology  Neuroglia/physiology  Neuroimaging  Pregnancy  Pregnancy Complications, Infectious/blood  Prenatal Exposure Delayed Effects  Signal Transduction  Autism  Brain  NF-kappaB Index. décimale : PER Périodiques Résumé : Growing evidence points toward a critical role for early (prenatal) atypical neurodevelopmental processes in the aetiology of autism spectrum condition (ASC). One such process that could impact early neural development is inflammation. We review the evidence for atypical expression of molecular markers in the amniotic fluid, serum, cerebrospinal fluid (CSF), and the brain parenchyma that suggest a role for inflammation in the emergence of ASC. This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed. En ligne : http://dx.doi.org/10.1186/s13229-016-0068-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition [Texte imprimé et/ou numérique] / A. M. YOUNG, Auteur ; Bhismadev CHAKRABARTI, Auteur ; D. ROBERTS, Auteur ; Meng-Chuan LAI, Auteur ; J. SUCKLING, Auteur ; Simon BARON-COHEN, Auteur . - 9p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 9p. Mots-clés : Amniotic Fluid/chemistry  Animals  Antigens, Surface/immunology  Autism Spectrum Disorder/genetics/immunology/pathology  Autoantibodies/analysis  Body Fluids/chemistry  Brain/embryology/immunology/pathology  Brain Chemistry  Chemokines/analysis  Cytokines/analysis  Female  Glutamic Acid/metabolism  HLA Antigens/immunology  Haplorhini  Humans  Immunity, Maternally-Acquired  Inflammation  Inflammation Mediators/analysis  Lipopolysaccharides/blood  Maternal-Fetal Exchange  Mice  Nerve Tissue Proteins/immunology  Neuroglia/physiology  Neuroimaging  Pregnancy  Pregnancy Complications, Infectious/blood  Prenatal Exposure Delayed Effects  Signal Transduction  Autism  Brain  NF-kappaB Index. décimale : PER Périodiques Résumé : Growing evidence points toward a critical role for early (prenatal) atypical neurodevelopmental processes in the aetiology of autism spectrum condition (ASC). One such process that could impact early neural development is inflammation. We review the evidence for atypical expression of molecular markers in the amniotic fluid, serum, cerebrospinal fluid (CSF), and the brain parenchyma that suggest a role for inflammation in the emergence of ASC. This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed. En ligne : http://dx.doi.org/10.1186/s13229-016-0068-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

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