Anxiety disorders in children with williams syndrome, their mothers, and their siblings: implications for the etiology of anxiety disorders / Ovsanna LEYFER in Journal of Neurodevelopmental Disorders, 1-1 (March 2009)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 1-1 (March 2009) . - p.4-14 Titre : Anxiety disorders in children with williams syndrome, their mothers, and their siblings: implications for the etiology of anxiety disorders Type de document : texte imprimé Auteurs : Ovsanna LEYFER, Auteur ; Janet WOODRUFF-BORDEN, Auteur ; Carolyn B. MERVIS, Auteur Article en page(s) : p.4-14 Langues : Anglais (eng) Mots-clés : Anxiety  Family  Genetics  Intellectual disability  Mental retardation  Williams syndrome Index. décimale : PER Périodiques Résumé : PURPOSE: To determine the prevalence of anxiety disorders in children with Williams syndrome (WS), their sibling closest in age, and their mothers and to examine the predictors of anxiety in these groups. METHODS: The prevalence of anxiety disorders was assessed and compared to that in the general population. RESULTS: Children with WS had a significantly higher prevalence of specific phobia, generalized anxiety disorder (GAD), and separation anxiety in comparison to children in the general population. While mothers had a higher prevalence of GAD than population controls, the excess was accounted for by mothers who had onset after the birth of their WS child. The siblings had rates similar to the general population. CONCLUSIONS: This pattern of findings suggests the presence of a gene in the WS region whose deletion predisposes to anxiety disorders. It is also worthwhile to investigate relations between genes deleted in WS and genes previously implicated in anxiety disorders. En ligne : http://dx.doi.org/10.1007/s11689-009-9003-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341 [article] Anxiety disorders in children with williams syndrome, their mothers, and their siblings: implications for the etiology of anxiety disorders [texte imprimé] / Ovsanna LEYFER, Auteur ; Janet WOODRUFF-BORDEN, Auteur ; Carolyn B. MERVIS, Auteur . - p.4-14. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 1-1 (March 2009) . - p.4-14 Mots-clés : Anxiety  Family  Genetics  Intellectual disability  Mental retardation  Williams syndrome Index. décimale : PER Périodiques Résumé : PURPOSE: To determine the prevalence of anxiety disorders in children with Williams syndrome (WS), their sibling closest in age, and their mothers and to examine the predictors of anxiety in these groups. METHODS: The prevalence of anxiety disorders was assessed and compared to that in the general population. RESULTS: Children with WS had a significantly higher prevalence of specific phobia, generalized anxiety disorder (GAD), and separation anxiety in comparison to children in the general population. While mothers had a higher prevalence of GAD than population controls, the excess was accounted for by mothers who had onset after the birth of their WS child. The siblings had rates similar to the general population. CONCLUSIONS: This pattern of findings suggests the presence of a gene in the WS region whose deletion predisposes to anxiety disorders. It is also worthwhile to investigate relations between genes deleted in WS and genes previously implicated in anxiety disorders. En ligne : http://dx.doi.org/10.1007/s11689-009-9003-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341

Factor Structure of the Children’s Behavior Questionnaire in Children with Williams Syndrome / Ovsanna T. LEYFER in Journal of Autism and Developmental Disorders, 42-11 (November 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2346-2353 Titre : Factor Structure of the Children’s Behavior Questionnaire in Children with Williams Syndrome Type de document : texte imprimé Auteurs : Ovsanna T. LEYFER, Auteur ; Angela JOHN, Auteur ; Janet WOODRUFF-BORDEN, Auteur ; Carolyn B. MERVIS, Auteur Article en page(s) : p.2346-2353 Langues : Anglais (eng) Mots-clés : Temperament  Williams syndrome  Developmental disorders  Psychopathology  Intellectual disability Index. décimale : PER Périodiques Résumé : To examine the factor structure of temperament in 5–10-year-olds with Williams syndrome, an exploratory factor analysis was conducted on the responses of parents of 192 children on the children’s behavior questionnaire. Four factors were identified. Two corresponded to factors reported for typically developing children: effortful control and extraversion/surgency and two corresponded to the temperament constructs of withdrawal/inhibition and irritability/frustration and activity, observed in typically developing infants. Parents of 109 of the 192 participants also completed the anxiety disorders interview schedule, parent version. Children with an anxiety disorder other than specific phobia differed significantly from children without an anxiety disorder on all factors except extraversion/surgency. Children with attention deficit hyperactivity disorder (ADHD) differed significantly from children without ADHD on effortful control and extraversion/surgency. En ligne : http://dx.doi.org/10.1007/s10803-012-1482-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183 [article] Factor Structure of the Children’s Behavior Questionnaire in Children with Williams Syndrome [texte imprimé] / Ovsanna T. LEYFER, Auteur ; Angela JOHN, Auteur ; Janet WOODRUFF-BORDEN, Auteur ; Carolyn B. MERVIS, Auteur . - p.2346-2353. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2346-2353 Mots-clés : Temperament  Williams syndrome  Developmental disorders  Psychopathology  Intellectual disability Index. décimale : PER Périodiques Résumé : To examine the factor structure of temperament in 5–10-year-olds with Williams syndrome, an exploratory factor analysis was conducted on the responses of parents of 192 children on the children’s behavior questionnaire. Four factors were identified. Two corresponded to factors reported for typically developing children: effortful control and extraversion/surgency and two corresponded to the temperament constructs of withdrawal/inhibition and irritability/frustration and activity, observed in typically developing infants. Parents of 109 of the 192 participants also completed the anxiety disorders interview schedule, parent version. Children with an anxiety disorder other than specific phobia differed significantly from children without an anxiety disorder on all factors except extraversion/surgency. Children with attention deficit hyperactivity disorder (ADHD) differed significantly from children without ADHD on effortful control and extraversion/surgency. En ligne : http://dx.doi.org/10.1007/s10803-012-1482-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183

Overlap between autism and specific language impairment: comparison of Autism Diagnostic Interview and Autism Diagnostic Observation Schedule scores / Ovsanna T. LEYFER in Autism Research, 1-5 (October 2008)  

Public ISBD [article]  inAutism Research > 1-5 (October 2008) . - p.284-296 Titre : Overlap between autism and specific language impairment: comparison of Autism Diagnostic Interview and Autism Diagnostic Observation Schedule scores Type de document : texte imprimé Auteurs : Ovsanna T. LEYFER, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Michael DOWD, Auteur ; J. Bruce TOMBLIN, Auteur ; S.E. FOLSTEIN, Auteur Année de publication : 2008 Article en page(s) : p.284-296 Langues : Anglais (eng) Mots-clés : autism specific-language-impairment developmental-disorders etiology Autism-Diagnostic-Interview-Revised Autism-Diagnostic-Observation-Schedule Index. décimale : PER Périodiques Résumé : Autism and specific language impairment (SLI) are developmental disorders that, although distinct by definition, have in common some features of both language and social behavior. The goal of this study was to further explore the extent to which specific clinical features of autism are seen in SLI. The children with the two disorders, matched for non-verbal IQ, were compared on the Autism Diagnostic Interview - Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS). In the SLI group, 41% met autism or autism spectrum cut-offs for social or communication domains either on the ADI or ADOS or both. No relationship was found between the language deficits exhibited by the children with SLI and their scores on the ADI and ADOS. These findings contribute to evidence that there is some overlap in social and communicative deficits between autism and SLI, supporting the view that autism and SLI share etiologic factors. This continuum of pathology between SLI and autism appears to range from structural language abnormalities as seen in individuals with SLI to individuals with SLI with both structural and social abnormalities to individuals with autism with pragmatic impairment and language abnormalities. En ligne : http://dx.doi.org/10.1002/aur.43 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933 [article] Overlap between autism and specific language impairment: comparison of Autism Diagnostic Interview and Autism Diagnostic Observation Schedule scores [texte imprimé] / Ovsanna T. LEYFER, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Michael DOWD, Auteur ; J. Bruce TOMBLIN, Auteur ; S.E. FOLSTEIN, Auteur . - 2008 . - p.284-296. Langues : Anglais (eng) in Autism Research > 1-5 (October 2008) . - p.284-296 Mots-clés : autism specific-language-impairment developmental-disorders etiology Autism-Diagnostic-Interview-Revised Autism-Diagnostic-Observation-Schedule Index. décimale : PER Périodiques Résumé : Autism and specific language impairment (SLI) are developmental disorders that, although distinct by definition, have in common some features of both language and social behavior. The goal of this study was to further explore the extent to which specific clinical features of autism are seen in SLI. The children with the two disorders, matched for non-verbal IQ, were compared on the Autism Diagnostic Interview - Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS). In the SLI group, 41% met autism or autism spectrum cut-offs for social or communication domains either on the ADI or ADOS or both. No relationship was found between the language deficits exhibited by the children with SLI and their scores on the ADI and ADOS. These findings contribute to evidence that there is some overlap in social and communicative deficits between autism and SLI, supporting the view that autism and SLI share etiologic factors. This continuum of pathology between SLI and autism appears to range from structural language abnormalities as seen in individuals with SLI to individuals with SLI with both structural and social abnormalities to individuals with autism with pragmatic impairment and language abnormalities. En ligne : http://dx.doi.org/10.1002/aur.43 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933

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