Alterations in the inferior longitudinal fasciculus in autism and associations with visual processing: a diffusion-weighted MRI study / Bart BOETS in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 10p. Titre : Alterations in the inferior longitudinal fasciculus in autism and associations with visual processing: a diffusion-weighted MRI study Type de document : Texte imprimé et/ou numérique Auteurs : Bart BOETS, Auteur ; L. VAN EYLEN, Auteur ; K. SITEK, Auteur ; P. MOORS, Auteur ; I. NOENS, Auteur ; J. STEYAERT, Auteur ; S. SUNAERT, Auteur ; J. WAGEMANS, Auteur Article en page(s) : 10p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Diffusion-weighted imaging  Inferior longitudinal fasciculus  Structural connectivity  Visual processing Index. décimale : PER Périodiques Résumé : Background: One of the most reported neural features of autism spectrum disorder (ASD) is the alteration of multiple long-range white matter fiber tracts, as assessed by diffusion-weighted imaging and indexed by reduced fractional anisotropy (FA). Recent methodological advances, however, have shown that this same pattern of reduced FA may be an artifact resulting from excessive head motion and poorer data quality and that aberrant structural connectivity in children with ASD is confined to the right inferior longitudinal fasciculus (ILF). This study aimed at replicating the observation of reduced FA along the right ILF in ASD, while controlling for group differences in head motion and data quality. In addition, we explored associations between reduced FA in the right ILF and quantitative ASD characteristics, and the involvement of the right ILF in visual processing, which is known to be altered in ASD. Method: Global probabilistic tractography was performed on diffusion-weighted imaging data of 17 adolescent boys with ASD and 17 typically developing boys, matched for age, performance IQ, handedness, and data quality. Four tasks were administered to measure various aspects of visual information processing, together with questionnaires assessing ASD characteristics. Group differences were examined and the neural data were integrated with previously published findings using Bayesian statistics to quantify evidence for replication and to pool data and thus increase statistical power. (Partial) correlations were calculated to investigate associations between measures. Results: The ASD group showed consistently reduced FA only in the right ILF and slower performance on the visual search task. Bayesian statistics pooling data across studies confirmed that group differences in FA were confined to the right ILF only, with the evidence for altered FA in the left ILF being indecisive. Lower FA in the right ILF tended to covary with slower visual search and a more fragmented part-oriented processing style. Individual differences in FA of the right ILF were not reliably associated with the severity of ASD traits after controlling for clinical status. Conclusion: Our findings support the growing evidence for reduced FA along a specific fiber tract in ASD, the right ILF. En ligne : http://dx.doi.org/10.1186/s13229-018-0188-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 [article] Alterations in the inferior longitudinal fasciculus in autism and associations with visual processing: a diffusion-weighted MRI study [Texte imprimé et/ou numérique] / Bart BOETS, Auteur ; L. VAN EYLEN, Auteur ; K. SITEK, Auteur ; P. MOORS, Auteur ; I. NOENS, Auteur ; J. STEYAERT, Auteur ; S. SUNAERT, Auteur ; J. WAGEMANS, Auteur . - 10p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 10p. Mots-clés : Autism spectrum disorder  Diffusion-weighted imaging  Inferior longitudinal fasciculus  Structural connectivity  Visual processing Index. décimale : PER Périodiques Résumé : Background: One of the most reported neural features of autism spectrum disorder (ASD) is the alteration of multiple long-range white matter fiber tracts, as assessed by diffusion-weighted imaging and indexed by reduced fractional anisotropy (FA). Recent methodological advances, however, have shown that this same pattern of reduced FA may be an artifact resulting from excessive head motion and poorer data quality and that aberrant structural connectivity in children with ASD is confined to the right inferior longitudinal fasciculus (ILF). This study aimed at replicating the observation of reduced FA along the right ILF in ASD, while controlling for group differences in head motion and data quality. In addition, we explored associations between reduced FA in the right ILF and quantitative ASD characteristics, and the involvement of the right ILF in visual processing, which is known to be altered in ASD. Method: Global probabilistic tractography was performed on diffusion-weighted imaging data of 17 adolescent boys with ASD and 17 typically developing boys, matched for age, performance IQ, handedness, and data quality. Four tasks were administered to measure various aspects of visual information processing, together with questionnaires assessing ASD characteristics. Group differences were examined and the neural data were integrated with previously published findings using Bayesian statistics to quantify evidence for replication and to pool data and thus increase statistical power. (Partial) correlations were calculated to investigate associations between measures. Results: The ASD group showed consistently reduced FA only in the right ILF and slower performance on the visual search task. Bayesian statistics pooling data across studies confirmed that group differences in FA were confined to the right ILF only, with the evidence for altered FA in the left ILF being indecisive. Lower FA in the right ILF tended to covary with slower visual search and a more fragmented part-oriented processing style. Individual differences in FA of the right ILF were not reliably associated with the severity of ASD traits after controlling for clinical status. Conclusion: Our findings support the growing evidence for reduced FA along a specific fiber tract in ASD, the right ILF. En ligne : http://dx.doi.org/10.1186/s13229-018-0188-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354

Change detection of meaningful objects in real-world scenes in adolescents with and without autism spectrum disorder / S. VANMARCKE in Autism, 22-6 (August 2018)  

Public ISBD [article]  inAutism > 22-6 (August 2018) . - p.728-739 Titre : Change detection of meaningful objects in real-world scenes in adolescents with and without autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. VANMARCKE, Auteur ; I. NOENS, Auteur ; J. STEYAERT, Auteur ; J. WAGEMANS, Auteur Article en page(s) : p.728-739 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  change blindness  local-global processing  vision research Index. décimale : PER Périodiques Résumé : Previous research suggested that adolescents with autism spectrum disorder are better than typically developing children in detecting local, non-social details within complex visual scenes. To better understand these differences, we used the image database by Sareen et al., containing the size and on-screen location information of all changes in the images, in a change blindness paradigm. In this task, an original and a modified real-world scene, separated by a gray blank, alternate repeatedly until observers detect the change. Our results indicated that participants with and without autism spectrum disorder performed similarly when scenes were presented upright, but that only the performance of the typically developing adolescents became worse in the inverted scene condition. In this condition, the correlation between performance and both image difficulty and change predictability was significantly weaker in autism spectrum disorder than in typically developing participants. We suggest that these findings result from a more locally biased search strategy in people with autism spectrum disorder, compared to typically developing participants, in tasks in which the rapid processing of global information does not help to improve change detection performance. Finally, although we found change location, change size, and age to influence participant performance, none of these was directly linked to the observed group-level differences. En ligne : http://dx.doi.org/10.1177/1362361317702559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] Change detection of meaningful objects in real-world scenes in adolescents with and without autism spectrum disorder [Texte imprimé et/ou numérique] / S. VANMARCKE, Auteur ; I. NOENS, Auteur ; J. STEYAERT, Auteur ; J. WAGEMANS, Auteur . - p.728-739. Langues : Anglais (eng) in Autism > 22-6 (August 2018) . - p.728-739 Mots-clés : autism spectrum disorders  change blindness  local-global processing  vision research Index. décimale : PER Périodiques Résumé : Previous research suggested that adolescents with autism spectrum disorder are better than typically developing children in detecting local, non-social details within complex visual scenes. To better understand these differences, we used the image database by Sareen et al., containing the size and on-screen location information of all changes in the images, in a change blindness paradigm. In this task, an original and a modified real-world scene, separated by a gray blank, alternate repeatedly until observers detect the change. Our results indicated that participants with and without autism spectrum disorder performed similarly when scenes were presented upright, but that only the performance of the typically developing adolescents became worse in the inverted scene condition. In this condition, the correlation between performance and both image difficulty and change predictability was significantly weaker in autism spectrum disorder than in typically developing participants. We suggest that these findings result from a more locally biased search strategy in people with autism spectrum disorder, compared to typically developing participants, in tasks in which the rapid processing of global information does not help to improve change detection performance. Finally, although we found change location, change size, and age to influence participant performance, none of these was directly linked to the observed group-level differences. En ligne : http://dx.doi.org/10.1177/1362361317702559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Global Motion Perception in Autism Spectrum Disorder: A Meta-Analysis / R. VAN DER HALLEN in Journal of Autism and Developmental Disorders, 49-12 (December 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.4901-4918 Titre : Global Motion Perception in Autism Spectrum Disorder: A Meta-Analysis Type de document : Texte imprimé et/ou numérique Auteurs : R. VAN DER HALLEN, Auteur ; C. MANNING, Auteur ; K. EVERS, Auteur ; J. WAGEMANS, Auteur Article en page(s) : p.4901-4918 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Biological motion  Coherent motion  Meta-analysis  Motion perception Index. décimale : PER Périodiques Résumé : Visual perception in individuals with autism spectrum disorder (ASD) is often debated in terms of enhanced local and impaired global perception. Deficits in global motion perception seem to support this characterization, although the evidence is inconsistent. We conducted a large meta-analysis on global motion, combining 48 articles on biological and coherent motion. Results provide evidence for a small global motion processing deficit in individuals with ASD compared to controls in both biological and coherent motion. This deficit appears to be present independent of the paradigm, task, dependent variable, age or IQ of the groups. Results indicate that individuals with ASD are less sensitive to these types of global motion, although the difference in neural mechanisms underlying this behavioral difference remains unclear. En ligne : http://dx.doi.org/10.1007/s10803-019-04194-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411 [article] Global Motion Perception in Autism Spectrum Disorder: A Meta-Analysis [Texte imprimé et/ou numérique] / R. VAN DER HALLEN, Auteur ; C. MANNING, Auteur ; K. EVERS, Auteur ; J. WAGEMANS, Auteur . - p.4901-4918. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.4901-4918 Mots-clés : Autism spectrum disorder (ASD)  Biological motion  Coherent motion  Meta-analysis  Motion perception Index. décimale : PER Périodiques Résumé : Visual perception in individuals with autism spectrum disorder (ASD) is often debated in terms of enhanced local and impaired global perception. Deficits in global motion perception seem to support this characterization, although the evidence is inconsistent. We conducted a large meta-analysis on global motion, combining 48 articles on biological and coherent motion. Results provide evidence for a small global motion processing deficit in individuals with ASD compared to controls in both biological and coherent motion. This deficit appears to be present independent of the paradigm, task, dependent variable, age or IQ of the groups. Results indicate that individuals with ASD are less sensitive to these types of global motion, although the difference in neural mechanisms underlying this behavioral difference remains unclear. En ligne : http://dx.doi.org/10.1007/s10803-019-04194-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411

Local and Global Visual Processing in Autism Spectrum Disorders: Influence of Task and Sample Characteristics and Relation to Symptom Severity / L. VAN EYLEN in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1359-1381 Titre : Local and Global Visual Processing in Autism Spectrum Disorders: Influence of Task and Sample Characteristics and Relation to Symptom Severity Type de document : Texte imprimé et/ou numérique Auteurs : L. VAN EYLEN, Auteur ; Bart BOETS, Auteur ; J. STEYAERT, Auteur ; J. WAGEMANS, Auteur ; I. NOENS, Auteur Article en page(s) : p.1359-1381 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Global processing  Local processing  Sample characteristics  Symptom severity  Visual processing Index. décimale : PER Périodiques Résumé : Local and global visual processing abilities and processing style were investigated in individuals with autism spectrum disorder (ASD) versus typically developing individuals, children versus adolescents and boys versus girls. Individuals with ASD displayed more attention to detail in daily life, while laboratory tasks showed slightly reduced global processing abilities, intact local processing abilities, and a more locally oriented processing style. However, the presence of these group differences depended on particular task and sample (i.e., age and gender) characteristics. Most measures of local and global processing did not correlate with each other and were not associated with processing style. Significant associations between local-global processing and ASD symptom severity were observed, but the causality of these associations remains unclear. En ligne : http://dx.doi.org/10.1007/s10803-015-2526-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352 [article] Local and Global Visual Processing in Autism Spectrum Disorders: Influence of Task and Sample Characteristics and Relation to Symptom Severity [Texte imprimé et/ou numérique] / L. VAN EYLEN, Auteur ; Bart BOETS, Auteur ; J. STEYAERT, Auteur ; J. WAGEMANS, Auteur ; I. NOENS, Auteur . - p.1359-1381. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1359-1381 Mots-clés : Autism spectrum disorders  Global processing  Local processing  Sample characteristics  Symptom severity  Visual processing Index. décimale : PER Périodiques Résumé : Local and global visual processing abilities and processing style were investigated in individuals with autism spectrum disorder (ASD) versus typically developing individuals, children versus adolescents and boys versus girls. Individuals with ASD displayed more attention to detail in daily life, while laboratory tasks showed slightly reduced global processing abilities, intact local processing abilities, and a more locally oriented processing style. However, the presence of these group differences depended on particular task and sample (i.e., age and gender) characteristics. Most measures of local and global processing did not correlate with each other and were not associated with processing style. Significant associations between local-global processing and ASD symptom severity were observed, but the causality of these associations remains unclear. En ligne : http://dx.doi.org/10.1007/s10803-015-2526-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352

Multiple Object Tracking Reveals Object-Based Grouping Interference in Children with ASD / R. VAN DER HALLEN in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1341-1349 Titre : Multiple Object Tracking Reveals Object-Based Grouping Interference in Children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : R. VAN DER HALLEN, Auteur ; K. EVERS, Auteur ; L. DE-WIT, Auteur ; J. STEYAERT, Auteur ; I. NOENS, Auteur ; J. WAGEMANS, Auteur Article en page(s) : p.1341-1349 Langues : Anglais (eng) Mots-clés : Attention  Autism spectrum disorder (ASD)  Grouping  Interference  Multiple object tracking (MOT)  Vision research Index. décimale : PER Périodiques Résumé : The multiple object tracking (MOT) paradigm has proven its value in targeting a number of aspects of visual cognition. This study used MOT to investigate the effect of object-based grouping, both in children with and without autism spectrum disorder (ASD). A modified MOT task was administered to both groups, who had to track and distinguish four targets that moved randomly amongst four distracters, irrespective of the grouping condition. No group difference was revealed between children with and without ASD: both showed adequate MOT abilities and a similar amount of grouping interference. Implications of the current result are considered for previous MOT studies, the developmental trajectory of perceptual grouping, and the idea of heightened sensitivity to task characteristics in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2463-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352 [article] Multiple Object Tracking Reveals Object-Based Grouping Interference in Children with ASD [Texte imprimé et/ou numérique] / R. VAN DER HALLEN, Auteur ; K. EVERS, Auteur ; L. DE-WIT, Auteur ; J. STEYAERT, Auteur ; I. NOENS, Auteur ; J. WAGEMANS, Auteur . - p.1341-1349. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1341-1349 Mots-clés : Attention  Autism spectrum disorder (ASD)  Grouping  Interference  Multiple object tracking (MOT)  Vision research Index. décimale : PER Périodiques Résumé : The multiple object tracking (MOT) paradigm has proven its value in targeting a number of aspects of visual cognition. This study used MOT to investigate the effect of object-based grouping, both in children with and without autism spectrum disorder (ASD). A modified MOT task was administered to both groups, who had to track and distinguish four targets that moved randomly amongst four distracters, irrespective of the grouping condition. No group difference was revealed between children with and without ASD: both showed adequate MOT abilities and a similar amount of grouping interference. Implications of the current result are considered for previous MOT studies, the developmental trajectory of perceptual grouping, and the idea of heightened sensitivity to task characteristics in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2463-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352

Prediction learning in adults with autism and its molecular correlates / L. A. SAPEY-TRIOMPHE in Molecular Autism, 12 (2021)  

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Priors Bias Perceptual Decisions in Autism, But Are Less Flexibly Adjusted to the Context / L. A. SAPEY-TRIOMPHE in Autism Research, 14-6 (June 2021)  

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Structural and contextual priors affect visual search in children with and without autism / S. VAN DE CRUYS in Autism Research, 14-7 (July 2021)  

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Superior Disembedding in Children with ASD: New Tests Using Abstract, Meaningful, and 3D Contexts / R. VAN DER HALLEN in Journal of Autism and Developmental Disorders, 48-7 (July 2018)  

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