Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18-month randomized clinical trial / S. M. EACK in Autism Research, 11-3 (March 2018)  

Public ISBD [article]  inAutism Research > 11-3 (March 2018) . - p.519-530 Titre : Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18-month randomized clinical trial Type de document : Texte imprimé et/ou numérique Auteurs : S. M. EACK, Auteur ; S. S. HOGARTY, Auteur ; D. P. GREENWALD, Auteur ; M. Y. LITSCHGE, Auteur ; S. A. PORTON, Auteur ; C. A. MAZEFSKY, Auteur ; N. J. MINSHEW, Auteur Article en page(s) : p.519-530 Langues : Anglais (eng) Mots-clés : adult autism  cognitive enhancement  cognitive remediation  neurocognition  social cognition Index. décimale : PER Périodiques Résumé : Cognitive remediation is a promising approach to treating core cognitive deficits in adults with autism, but rigorously controlled trials of comprehensive interventions that target both social and non-social cognition over a sufficient period of time to impact functioning are lacking. This study examined the efficacy of cognitive enhancement therapy (CET) for improving core cognitive and employment outcomes in adult autism. Verbal adult outpatients with autism spectrum disorder (N = 54) were randomized to an 18-month, single-blind trial of CET, a cognitive remediation approach that integrates computer-based neurocognitive training with group-based training in social cognition, or an active enriched supportive therapy (EST) comparison focused on psychoeducation and condition management. Primary outcomes were composite indexes of neurocognitive and social-cognitive change. Competitive employment was a secondary outcome. Intent-to-treat analyses indicated that CET produced significant differential increases in neurocognitive function relative to EST (d = .46, P = .013). Both CET and EST were associated with large social-cognitive improvements, with CET demonstrating an advantage at 9 (d = .58, P = 0.020), but not 18 months (d = .27, P = 0.298). Effects on employment indicated that participants treated with CET were significantly more likely to gain competitive employment than those in EST, OR = 6.21, P = 0.023, which was mediated by cognitive improvement. CET is a feasible and potentially effective treatment for core cognitive deficits in adult autism spectrum disorder. The treatment of cognitive impairments in this population can contribute to meaningful improvements in adult outcomes. Autism Res 2018, 11: 519-530. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Cognitive enhancement therapy (CET), an 18-month cognitive remediation intervention designed to improve thinking and social understanding, was found to be more effective than supportive therapy at improving mental quickness, attention, and employment in adults living with autism. Social understanding was equally improved in CET and supportive therapy. Cognitive remediation interventions are feasible and may confer significant functional benefits to adults with autism. En ligne : http://dx.doi.org/10.1002/aur.1913 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352 [article] Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18-month randomized clinical trial [Texte imprimé et/ou numérique] / S. M. EACK, Auteur ; S. S. HOGARTY, Auteur ; D. P. GREENWALD, Auteur ; M. Y. LITSCHGE, Auteur ; S. A. PORTON, Auteur ; C. A. MAZEFSKY, Auteur ; N. J. MINSHEW, Auteur . - p.519-530. Langues : Anglais (eng) in Autism Research > 11-3 (March 2018) . - p.519-530 Mots-clés : adult autism  cognitive enhancement  cognitive remediation  neurocognition  social cognition Index. décimale : PER Périodiques Résumé : Cognitive remediation is a promising approach to treating core cognitive deficits in adults with autism, but rigorously controlled trials of comprehensive interventions that target both social and non-social cognition over a sufficient period of time to impact functioning are lacking. This study examined the efficacy of cognitive enhancement therapy (CET) for improving core cognitive and employment outcomes in adult autism. Verbal adult outpatients with autism spectrum disorder (N = 54) were randomized to an 18-month, single-blind trial of CET, a cognitive remediation approach that integrates computer-based neurocognitive training with group-based training in social cognition, or an active enriched supportive therapy (EST) comparison focused on psychoeducation and condition management. Primary outcomes were composite indexes of neurocognitive and social-cognitive change. Competitive employment was a secondary outcome. Intent-to-treat analyses indicated that CET produced significant differential increases in neurocognitive function relative to EST (d = .46, P = .013). Both CET and EST were associated with large social-cognitive improvements, with CET demonstrating an advantage at 9 (d = .58, P = 0.020), but not 18 months (d = .27, P = 0.298). Effects on employment indicated that participants treated with CET were significantly more likely to gain competitive employment than those in EST, OR = 6.21, P = 0.023, which was mediated by cognitive improvement. CET is a feasible and potentially effective treatment for core cognitive deficits in adult autism spectrum disorder. The treatment of cognitive impairments in this population can contribute to meaningful improvements in adult outcomes. Autism Res 2018, 11: 519-530. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Cognitive enhancement therapy (CET), an 18-month cognitive remediation intervention designed to improve thinking and social understanding, was found to be more effective than supportive therapy at improving mental quickness, attention, and employment in adults living with autism. Social understanding was equally improved in CET and supportive therapy. Cognitive remediation interventions are feasible and may confer significant functional benefits to adults with autism. En ligne : http://dx.doi.org/10.1002/aur.1913 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352

Development of the Emotion Dysregulation Inventory: A PROMIS(R)ing Method for Creating Sensitive and Unbiased Questionnaires for Autism Spectrum Disorder / C. A. MAZEFSKY in Journal of Autism and Developmental Disorders, 48-11 (November 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3736-3746 Titre : Development of the Emotion Dysregulation Inventory: A PROMIS(R)ing Method for Creating Sensitive and Unbiased Questionnaires for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : C. A. MAZEFSKY, Auteur ; T. N. DAY, Auteur ; M. SIEGEL, Auteur ; Susan W. WHITE, Auteur ; L. YU, Auteur ; P. A. PILKONIS, Auteur Article en page(s) : p.3736-3746 Langues : Anglais (eng) Mots-clés : Autism Inpatient Collection  Autism spectrum disorder (ASD)  Emotion regulation  Patient-Reported Outcomes Measurement Information System (PROMIS(R))  Psychiatric inpatients  Questionnaire development Index. décimale : PER Périodiques Résumé : The lack of sensitive measures suitable for use across the range of functioning in autism spectrum disorder (ASD) is a barrier to treatment development and monitoring. The Emotion Dysregulation Inventory (EDI) is a caregiver-report questionnaire designed to capture emotional distress and problems with emotion regulation in both minimally verbal and verbal individuals. The first two phases of the EDI's development are described, including: (1) utilizing methods from the Patient-Reported Outcomes Measurement Information System (PROMIS(R)) project to develop the item pool and response options; and (2) assessment of the EDI in psychiatric inpatients with ASD. The results suggest that the EDI captures a wide range of emotion dysregulation, is sensitive to change, and is not biased by verbal or intellectual ability. En ligne : http://dx.doi.org/10.1007/s10803-016-2907-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Development of the Emotion Dysregulation Inventory: A PROMIS(R)ing Method for Creating Sensitive and Unbiased Questionnaires for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / C. A. MAZEFSKY, Auteur ; T. N. DAY, Auteur ; M. SIEGEL, Auteur ; Susan W. WHITE, Auteur ; L. YU, Auteur ; P. A. PILKONIS, Auteur . - p.3736-3746. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3736-3746 Mots-clés : Autism Inpatient Collection  Autism spectrum disorder (ASD)  Emotion regulation  Patient-Reported Outcomes Measurement Information System (PROMIS(R))  Psychiatric inpatients  Questionnaire development Index. décimale : PER Périodiques Résumé : The lack of sensitive measures suitable for use across the range of functioning in autism spectrum disorder (ASD) is a barrier to treatment development and monitoring. The Emotion Dysregulation Inventory (EDI) is a caregiver-report questionnaire designed to capture emotional distress and problems with emotion regulation in both minimally verbal and verbal individuals. The first two phases of the EDI's development are described, including: (1) utilizing methods from the Patient-Reported Outcomes Measurement Information System (PROMIS(R)) project to develop the item pool and response options; and (2) assessment of the EDI in psychiatric inpatients with ASD. The results suggest that the EDI captures a wide range of emotion dysregulation, is sensitive to change, and is not biased by verbal or intellectual ability. En ligne : http://dx.doi.org/10.1007/s10803-016-2907-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Improving emotion regulation ability in autism: The Emotional Awareness and Skills Enhancement (EASE) program / C. M. CONNER in Autism, 23-5 (July 2019)  

Public ISBD [article]  inAutism > 23-5 (July 2019) . - p.1273-1287 Titre : Improving emotion regulation ability in autism: The Emotional Awareness and Skills Enhancement (EASE) program Type de document : Texte imprimé et/ou numérique Auteurs : C. M. CONNER, Auteur ; Susan W. WHITE, Auteur ; K. B. BECK, Auteur ; J. GOLT, Auteur ; I. C. SMITH, Auteur ; C. A. MAZEFSKY, Auteur Article en page(s) : p.1273-1287 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  emotion regulation  irritability  mindfulness  transdiagnostic Index. décimale : PER Périodiques Résumé : Emotion regulation impairments are common among individuals with autism spectrum disorder and are believed to often underlie commonly seen problems with aggression, depression, and anxiety. The Emotional Awareness and Skills Enhancement program was developed to reduce emotion regulation impairment and thereby improve behavioral disturbance, via mindfulness. Emotional Awareness and Skills Enhancement consists of a 16-week individual therapy treatment targeting emotion regulation impairments among individuals with autism spectrum disorder. We describe the conceptual framework and development of the program and present data on feasibility and preliminary efficacy from a pilot trial. The Emotional Awareness and Skills Enhancement manual was developed using a participatory action framework, based on emotion regulation research specific to autism spectrum disorder and input from individuals with autism spectrum disorder, therapists, and parents of children with autism spectrum disorder. Emotional Awareness and Skills Enhancement was piloted in a two-site open trial with 20 participants with autism spectrum disorder (12-17 years old, confirmed autism spectrum disorder diagnosis, IQ > 80).Outcome data support program feasibility and acceptability to participants, as well as significant improvement in emotion regulation impairments and related concerns.Findings offer preliminary support for both the feasibility and clinical effectiveness of the Emotional Awareness and Skills Enhancement program. En ligne : http://dx.doi.org/10.1177/1362361318810709 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 [article] Improving emotion regulation ability in autism: The Emotional Awareness and Skills Enhancement (EASE) program [Texte imprimé et/ou numérique] / C. M. CONNER, Auteur ; Susan W. WHITE, Auteur ; K. B. BECK, Auteur ; J. GOLT, Auteur ; I. C. SMITH, Auteur ; C. A. MAZEFSKY, Auteur . - p.1273-1287. Langues : Anglais (eng) in Autism > 23-5 (July 2019) . - p.1273-1287 Mots-clés : autism spectrum disorder  emotion regulation  irritability  mindfulness  transdiagnostic Index. décimale : PER Périodiques Résumé : Emotion regulation impairments are common among individuals with autism spectrum disorder and are believed to often underlie commonly seen problems with aggression, depression, and anxiety. The Emotional Awareness and Skills Enhancement program was developed to reduce emotion regulation impairment and thereby improve behavioral disturbance, via mindfulness. Emotional Awareness and Skills Enhancement consists of a 16-week individual therapy treatment targeting emotion regulation impairments among individuals with autism spectrum disorder. We describe the conceptual framework and development of the program and present data on feasibility and preliminary efficacy from a pilot trial. The Emotional Awareness and Skills Enhancement manual was developed using a participatory action framework, based on emotion regulation research specific to autism spectrum disorder and input from individuals with autism spectrum disorder, therapists, and parents of children with autism spectrum disorder. Emotional Awareness and Skills Enhancement was piloted in a two-site open trial with 20 participants with autism spectrum disorder (12-17 years old, confirmed autism spectrum disorder diagnosis, IQ > 80).Outcome data support program feasibility and acceptability to participants, as well as significant improvement in emotion regulation impairments and related concerns.Findings offer preliminary support for both the feasibility and clinical effectiveness of the Emotional Awareness and Skills Enhancement program. En ligne : http://dx.doi.org/10.1177/1362361318810709 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401

Predicting aggression to others in youth with autism using a wearable biosensor / M. S. GOODWIN in Autism Research, 12-8 (August 2019)  

Public ISBD [article]  inAutism Research > 12-8 (August 2019) . - p.1286-1296 Titre : Predicting aggression to others in youth with autism using a wearable biosensor Type de document : Texte imprimé et/ou numérique Auteurs : M. S. GOODWIN, Auteur ; C. A. MAZEFSKY, Auteur ; S. IOANNIDIS, Auteur ; D. ERDOGMUS, Auteur ; M. SIEGEL, Auteur Article en page(s) : p.1286-1296 Langues : Anglais (eng) Mots-clés : aggression  autism spectrum disorder  autonomic nervous system  biosensing techniques  inpatients Index. décimale : PER Périodiques Résumé : Unpredictable and potentially dangerous aggressive behavior by youth with Autism Spectrum Disorder (ASD) can isolate them from foundational educational, social, and familial activities, thereby markedly exacerbating morbidity and costs associated with ASD. This study investigates whether preceding physiological and motion data measured by a wrist-worn biosensor can predict aggression to others by youth with ASD. We recorded peripheral physiological (cardiovascular and electrodermal activity) and motion (accelerometry) signals from a biosensor worn by 20 youth with ASD (ages 6-17 years, 75% male, 85% minimally verbal) during 69 independent naturalistic observation sessions with concurrent behavioral coding in a specialized inpatient psychiatry unit. We developed prediction models based on ridge-regularized logistic regression. Our results suggest that aggression to others can be predicted 1 min before it occurs using 3 min of prior biosensor data with an average area under the curve of 0.71 for a global model and 0.84 for person-dependent models. The biosensor was well tolerated, we obtained useable data in all cases, and no users withdrew from the study. Relatively high predictive accuracy was achieved using antecedent physiological and motion data. Larger trials are needed to further establish an ideal ratio of measurement density to predictive accuracy and reliability. These findings lay the groundwork for the future development of precursor behavior analysis and just-in-time adaptive intervention systems to prevent or mitigate the emergence, occurrence, and impact of aggression in ASD. Autism Res 2019, 12: 1286-1296. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Unpredictable aggression can create a barrier to accessing community, therapeutic, medical, and educational services. The present study evaluated whether data from a wearable biosensor can be used to predict aggression to others by youth with autism spectrum disorder (ASD). Results demonstrate that aggression to others can be predicted 1 min before it occurs with high accuracy, laying the groundwork for the future development of preemptive behavioral interventions and just-in-time adaptive intervention systems to prevent or mitigate the emergence, occurrence, and impact of aggression to others in ASD. En ligne : http://dx.doi.org/10.1002/aur.2151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Predicting aggression to others in youth with autism using a wearable biosensor [Texte imprimé et/ou numérique] / M. S. GOODWIN, Auteur ; C. A. MAZEFSKY, Auteur ; S. IOANNIDIS, Auteur ; D. ERDOGMUS, Auteur ; M. SIEGEL, Auteur . - p.1286-1296. Langues : Anglais (eng) in Autism Research > 12-8 (August 2019) . - p.1286-1296 Mots-clés : aggression  autism spectrum disorder  autonomic nervous system  biosensing techniques  inpatients Index. décimale : PER Périodiques Résumé : Unpredictable and potentially dangerous aggressive behavior by youth with Autism Spectrum Disorder (ASD) can isolate them from foundational educational, social, and familial activities, thereby markedly exacerbating morbidity and costs associated with ASD. This study investigates whether preceding physiological and motion data measured by a wrist-worn biosensor can predict aggression to others by youth with ASD. We recorded peripheral physiological (cardiovascular and electrodermal activity) and motion (accelerometry) signals from a biosensor worn by 20 youth with ASD (ages 6-17 years, 75% male, 85% minimally verbal) during 69 independent naturalistic observation sessions with concurrent behavioral coding in a specialized inpatient psychiatry unit. We developed prediction models based on ridge-regularized logistic regression. Our results suggest that aggression to others can be predicted 1 min before it occurs using 3 min of prior biosensor data with an average area under the curve of 0.71 for a global model and 0.84 for person-dependent models. The biosensor was well tolerated, we obtained useable data in all cases, and no users withdrew from the study. Relatively high predictive accuracy was achieved using antecedent physiological and motion data. Larger trials are needed to further establish an ideal ratio of measurement density to predictive accuracy and reliability. These findings lay the groundwork for the future development of precursor behavior analysis and just-in-time adaptive intervention systems to prevent or mitigate the emergence, occurrence, and impact of aggression in ASD. Autism Res 2019, 12: 1286-1296. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Unpredictable aggression can create a barrier to accessing community, therapeutic, medical, and educational services. The present study evaluated whether data from a wearable biosensor can be used to predict aggression to others by youth with autism spectrum disorder (ASD). Results demonstrate that aggression to others can be predicted 1 min before it occurs with high accuracy, laying the groundwork for the future development of preemptive behavioral interventions and just-in-time adaptive intervention systems to prevent or mitigate the emergence, occurrence, and impact of aggression to others in ASD. En ligne : http://dx.doi.org/10.1002/aur.2151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Problem Behaviors in Autism Spectrum Disorder: Association with Verbal Ability and Adapting/Coping Skills / D. L. WILLIAMS in Journal of Autism and Developmental Disorders, 48-11 (November 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3668-3677 Titre : Problem Behaviors in Autism Spectrum Disorder: Association with Verbal Ability and Adapting/Coping Skills Type de document : Texte imprimé et/ou numérique Auteurs : D. L. WILLIAMS, Auteur ; M. SIEGEL, Auteur ; C. A. MAZEFSKY, Auteur Article en page(s) : p.3668-3677 Langues : Anglais (eng) Mots-clés : Autism inpatient collection (AIC)  Autism spectrum disorder (ASD)  Challenging behavior  Communication  Coping skills  Psychiatric inpatients Index. décimale : PER Périodiques Résumé : Data from the Autism Inpatient Collection was used to examine the relationship between problem behaviors and verbal ability, which have generally, though not universally, been highly associated. In a comparison of 169 minimally-verbal and 177 fluently-verbal 4 to 20-year-old psychiatric inpatients with ASD, the severity of self-injurious behavior, stereotyped behavior, and irritability (including aggression and tantrums) did not significantly differ, when controlling for age and NVIQ. Verbal ability was not strongly related to the severity of problem behaviors. However, lower adapting/coping scores were significantly associated with increasing severity of each type of problem behavior, even when accounting for verbal ability. Interventions to develop adapting/coping mechanisms may be important for mitigation of problem behaviors across the spectrum of individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3179-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Problem Behaviors in Autism Spectrum Disorder: Association with Verbal Ability and Adapting/Coping Skills [Texte imprimé et/ou numérique] / D. L. WILLIAMS, Auteur ; M. SIEGEL, Auteur ; C. A. MAZEFSKY, Auteur . - p.3668-3677. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3668-3677 Mots-clés : Autism inpatient collection (AIC)  Autism spectrum disorder (ASD)  Challenging behavior  Communication  Coping skills  Psychiatric inpatients Index. décimale : PER Périodiques Résumé : Data from the Autism Inpatient Collection was used to examine the relationship between problem behaviors and verbal ability, which have generally, though not universally, been highly associated. In a comparison of 169 minimally-verbal and 177 fluently-verbal 4 to 20-year-old psychiatric inpatients with ASD, the severity of self-injurious behavior, stereotyped behavior, and irritability (including aggression and tantrums) did not significantly differ, when controlling for age and NVIQ. Verbal ability was not strongly related to the severity of problem behaviors. However, lower adapting/coping scores were significantly associated with increasing severity of each type of problem behavior, even when accounting for verbal ability. Interventions to develop adapting/coping mechanisms may be important for mitigation of problem behaviors across the spectrum of individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3179-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Processing Speed is Impaired in Adults with Autism Spectrum Disorder, and Relates to Social Communication Abilities / Sarah M. HAIGH in Journal of Autism and Developmental Disorders, 48-8 (August 2018)  

Permalink

Rates of Co-occurring Psychiatric Disorders in Autism Spectrum Disorder Using the Mini International Neuropsychiatric Interview / M. G. MOSNER in Journal of Autism and Developmental Disorders, 49-9 (September 2019)  

Permalink

Risk Factors for Self-injurious Behavior in an Inpatient Psychiatric Sample of Children with Autism Spectrum Disorder: A Naturalistic Observation Study / B. L. HANDEN in Journal of Autism and Developmental Disorders, 48-11 (November 2018)  

Permalink

The combined impact of social support and perceived stress on quality of life in adults with autism spectrum disorder and without intellectual disability / Lauren BISHOP-FITZPATRICK in Autism, 22-6 (August 2018)  

Permalink

The emotion dysregulation inventory: Psychometric properties and item response theory calibration in an autism spectrum disorder sample / C. A. MAZEFSKY in Autism Research, 11-6 (June 2018)  

Permalink

Verbal Ability and Psychiatric Symptoms in Clinically Referred Inpatient and Outpatient Youth with ASD / M. D. LERNER in Journal of Autism and Developmental Disorders, 48-11 (November 2018)  

Permalink

---

1 (1 - 11 / 11)