Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD / A. LENARTOWICZ in Journal of Child Psychology and Psychiatry, 60-8 (August 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-8 (August 2019) . - p.917-926 Titre : Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD Type de document : Texte imprimé et/ou numérique Auteurs : A. LENARTOWICZ, Auteur ; H. TRUONG, Auteur ; G. C. SALGARI, Auteur ; R. M. BILDER, Auteur ; J. MCGOUGH, Auteur ; J. T. MCCRACKEN, Auteur ; S. K. LOO, Auteur Article en page(s) : p.917-926 Langues : Anglais (eng) Mots-clés : Adhd  Eeg  academic achievement  alpha oscillations  maintenance  visual attention  working memory Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with working memory (WM) deficits. However, WM is a multiprocess construct that can be impaired through several pathways, leaving the source of WM impairments in ADHD unresolved. In this study, we aim to replicate, in an independent sample, previously reported deficits in component processes of WM deficits in ADHD and expand to consider their implications for neurocognitive outcomes. METHODS: In 119 children (7-14 years old, 85 with ADHD), we used electroencephalography measures to quantify component processes during performance of a spatial working memory task. We quantified stimulus encoding using alpha range (8-12 Hz) power; vigilance by the P2 event-related potential to cues; and WMmaintenance by occipital-alpha and frontal-theta (4-7 Hz) power. These measures were evaluated against metrics of executive function, ADHD symptoms, and academic achievement. RESULTS: Encoding alpha-power decreases and cue P2 amplitude were attenuated in ADHD, whereas occipital-alpha power during maintenance was significantly greater in ADHD, consistent with a compensatory response to weak encoding. Weak alpha modulation during encoding was associated with poorer reading comprehension and executive function, as well as enhanced ADHD symptoms. Previously reported effects in frontal-theta power failed to replicate. CONCLUSIONS: Stimulus encoding, a component process of WM coupled to alpha modulation, is impaired in ADHD, and, unlike WM maintenance or vigilance processes, has implications outside of the laboratory via a relationship with executive function, and, to a weaker extent, reading comprehension. En ligne : http://dx.doi.org/10.1111/jcpp.13042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404 [article] Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD [Texte imprimé et/ou numérique] / A. LENARTOWICZ, Auteur ; H. TRUONG, Auteur ; G. C. SALGARI, Auteur ; R. M. BILDER, Auteur ; J. MCGOUGH, Auteur ; J. T. MCCRACKEN, Auteur ; S. K. LOO, Auteur . - p.917-926. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-8 (August 2019) . - p.917-926 Mots-clés : Adhd  Eeg  academic achievement  alpha oscillations  maintenance  visual attention  working memory Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with working memory (WM) deficits. However, WM is a multiprocess construct that can be impaired through several pathways, leaving the source of WM impairments in ADHD unresolved. In this study, we aim to replicate, in an independent sample, previously reported deficits in component processes of WM deficits in ADHD and expand to consider their implications for neurocognitive outcomes. METHODS: In 119 children (7-14 years old, 85 with ADHD), we used electroencephalography measures to quantify component processes during performance of a spatial working memory task. We quantified stimulus encoding using alpha range (8-12 Hz) power; vigilance by the P2 event-related potential to cues; and WMmaintenance by occipital-alpha and frontal-theta (4-7 Hz) power. These measures were evaluated against metrics of executive function, ADHD symptoms, and academic achievement. RESULTS: Encoding alpha-power decreases and cue P2 amplitude were attenuated in ADHD, whereas occipital-alpha power during maintenance was significantly greater in ADHD, consistent with a compensatory response to weak encoding. Weak alpha modulation during encoding was associated with poorer reading comprehension and executive function, as well as enhanced ADHD symptoms. Previously reported effects in frontal-theta power failed to replicate. CONCLUSIONS: Stimulus encoding, a component process of WM coupled to alpha modulation, is impaired in ADHD, and, unlike WM maintenance or vigilance processes, has implications outside of the laboratory via a relationship with executive function, and, to a weaker extent, reading comprehension. En ligne : http://dx.doi.org/10.1111/jcpp.13042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404

In Search of Biomarkers for Autism Spectrum Disorder / Marta DEL VALLE RUBIDO in Autism Research, 11-11 (November 2018)  

Public ISBD [article]  inAutism Research > 11-11 (November 2018) . - p.1567-1579 Titre : In Search of Biomarkers for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Marta DEL VALLE RUBIDO, Auteur ; J. T. MCCRACKEN, Auteur ; E. HOLLANDER, Auteur ; F. SHIC, Auteur ; J. NOELDEKE, Auteur ; Lauren BOAK, Auteur ; O. KHWAJA, Auteur ; S. SADIKHOV, Auteur ; P. FONTOURA, Auteur ; D. UMBRICHT, Auteur Article en page(s) : p.1567-1579 Langues : Anglais (eng) Mots-clés : biomarker  eye movement  olfactory  social cognition Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) lacks validated measures of core social functions across development stages suitable for clinical trials. We assessed the concurrent validity between ASD clinical measures and putative biomarkers of core deficits, and their feasibility of implementation in human studies. Datasets from two adult ASD studies were combined (observational study [n = 19] and interventional study baseline data [n = 19]). Potential biomarkers included eye-tracking, olfaction, and auditory and visual emotion recognition assessed via the Affective Speech Recognition test (ASR) and Reading-the-Mind-in-the-Eyes Test (RMET). Current functioning was assessed with intelligence quotient (IQ), adaptive skill testing, and behavioral ratings. Autism severity was determined by the Autism Diagnostic Observation Scale-2 and Social Communication Interaction Test (SCIT). Exploratory measures showed varying significant associations across ASD severity, adaptive skills, and behavior. Eye tracking endpoints showed little relationship to adaptive ability but correlated with severity and behavior. ASR scores significantly correlated with most adaptive behavior domains, as well as severity. Olfaction predicted visual and auditory emotion recognition. SCIT scores related moderately to multiple severity domains, and was the only measure not related with IQ. RMET accuracy was less related to ASD features. Eye tracking, SCIT, and ASR showed high test-retest reliability. We documented associations of proximal biomarkers of social functioning with multiple ASD dimensions. With the exception of SCIT, most correlations were modest, limiting utility as proxy measures of social communication. Feasibility and reliability were high for eye-tracking, ASR, and SCIT. Overall, several novel experimental paradigms showed potential as social biomarkers or surrogate markers in ASD. Autism Research 2018, 11: 1567-1579. (c) 2018 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: More accurate measurements of treatment effects are needed to help the development of new drug treatments for autism spectrum disorders (ASD). This study evaluates the relationship between assessments designed to measure behaviors associated with social communication and cognition in ASD with clinical and diagnostic assessments of symptom severity as well as their implementation. The assessments including eye-tracking, auditory and visual social stimuli recognition, and olfaction identification showed potential for use in the evaluation of treatments for social difficulties in ASD. En ligne : http://dx.doi.org/10.1002/aur.2026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] In Search of Biomarkers for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Marta DEL VALLE RUBIDO, Auteur ; J. T. MCCRACKEN, Auteur ; E. HOLLANDER, Auteur ; F. SHIC, Auteur ; J. NOELDEKE, Auteur ; Lauren BOAK, Auteur ; O. KHWAJA, Auteur ; S. SADIKHOV, Auteur ; P. FONTOURA, Auteur ; D. UMBRICHT, Auteur . - p.1567-1579. Langues : Anglais (eng) in Autism Research > 11-11 (November 2018) . - p.1567-1579 Mots-clés : biomarker  eye movement  olfactory  social cognition Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) lacks validated measures of core social functions across development stages suitable for clinical trials. We assessed the concurrent validity between ASD clinical measures and putative biomarkers of core deficits, and their feasibility of implementation in human studies. Datasets from two adult ASD studies were combined (observational study [n = 19] and interventional study baseline data [n = 19]). Potential biomarkers included eye-tracking, olfaction, and auditory and visual emotion recognition assessed via the Affective Speech Recognition test (ASR) and Reading-the-Mind-in-the-Eyes Test (RMET). Current functioning was assessed with intelligence quotient (IQ), adaptive skill testing, and behavioral ratings. Autism severity was determined by the Autism Diagnostic Observation Scale-2 and Social Communication Interaction Test (SCIT). Exploratory measures showed varying significant associations across ASD severity, adaptive skills, and behavior. Eye tracking endpoints showed little relationship to adaptive ability but correlated with severity and behavior. ASR scores significantly correlated with most adaptive behavior domains, as well as severity. Olfaction predicted visual and auditory emotion recognition. SCIT scores related moderately to multiple severity domains, and was the only measure not related with IQ. RMET accuracy was less related to ASD features. Eye tracking, SCIT, and ASR showed high test-retest reliability. We documented associations of proximal biomarkers of social functioning with multiple ASD dimensions. With the exception of SCIT, most correlations were modest, limiting utility as proxy measures of social communication. Feasibility and reliability were high for eye-tracking, ASR, and SCIT. Overall, several novel experimental paradigms showed potential as social biomarkers or surrogate markers in ASD. Autism Research 2018, 11: 1567-1579. (c) 2018 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: More accurate measurements of treatment effects are needed to help the development of new drug treatments for autism spectrum disorders (ASD). This study evaluates the relationship between assessments designed to measure behaviors associated with social communication and cognition in ASD with clinical and diagnostic assessments of symptom severity as well as their implementation. The assessments including eye-tracking, auditory and visual social stimuli recognition, and olfaction identification showed potential for use in the evaluation of treatments for social difficulties in ASD. En ligne : http://dx.doi.org/10.1002/aur.2026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Overweight and obese status in children with autism spectrum disorder and disruptive behavior / K. K. CRIADO in Autism, 22-4 (May 2018)  

Public ISBD [article]  inAutism > 22-4 (May 2018) . - p.450-459 Titre : Overweight and obese status in children with autism spectrum disorder and disruptive behavior Type de document : Texte imprimé et/ou numérique Auteurs : K. K. CRIADO, Auteur ; W. G. SHARP, Auteur ; C. E. MCCRACKEN, Auteur ; O. DE VINCK-BAROODY, Auteur ; L. DONG, Auteur ; Michael G. AMAN, Auteur ; C. J. MCDOUGLE, Auteur ; J. T. MCCRACKEN, Auteur ; L. EUGENE ARNOLD, Auteur ; C. WEITZMAN, Auteur ; J. M. LEVENTHAL, Auteur ; B. VITIELLO, Auteur ; Lawrence SCAHILL, Auteur Article en page(s) : p.450-459 Langues : Anglais (eng) Mots-clés : National Health and Nutrition Examination Surveys  prevalence  risperidone Index. décimale : PER Périodiques Résumé : Overweight and obesity are common in pediatric populations. Children with autism spectrum disorder and disruptive behavior may be at higher risk. This study examined whether children with autism spectrum disorder and disruptive behavior are more likely to be overweight or obese than matched controls. Baseline data from medication-free children with autism spectrum disorder who participated in trials conducted by the Research Units on Pediatric Psychopharmacology Autism Network (N = 276) were compared to 544 control children from the National Health and Nutrition Examination Survey database matched on age, sex, race, parent education, and era of data collection. The mean age of the children with autism spectrum disorder was 7.9 +/- 2.6 years; 84.4% were males. In the autism spectrum disorder group, the prevalence was 42.4% for overweight and 21.4% for obesity compared to 26.1% for overweight and 12.0% for obesity among controls (p < 0.001 for each contrast). Within the autism spectrum disorder sample, obesity was associated with minority status and lower daily living skills. These findings suggest that children with autism spectrum disorder and disruptive behavior are at increased risk for obesity and underscore the need for weight management interventions in this population. En ligne : http://dx.doi.org/10.1177/1362361316683888 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=361 [article] Overweight and obese status in children with autism spectrum disorder and disruptive behavior [Texte imprimé et/ou numérique] / K. K. CRIADO, Auteur ; W. G. SHARP, Auteur ; C. E. MCCRACKEN, Auteur ; O. DE VINCK-BAROODY, Auteur ; L. DONG, Auteur ; Michael G. AMAN, Auteur ; C. J. MCDOUGLE, Auteur ; J. T. MCCRACKEN, Auteur ; L. EUGENE ARNOLD, Auteur ; C. WEITZMAN, Auteur ; J. M. LEVENTHAL, Auteur ; B. VITIELLO, Auteur ; Lawrence SCAHILL, Auteur . - p.450-459. Langues : Anglais (eng) in Autism > 22-4 (May 2018) . - p.450-459 Mots-clés : National Health and Nutrition Examination Surveys  prevalence  risperidone Index. décimale : PER Périodiques Résumé : Overweight and obesity are common in pediatric populations. Children with autism spectrum disorder and disruptive behavior may be at higher risk. This study examined whether children with autism spectrum disorder and disruptive behavior are more likely to be overweight or obese than matched controls. Baseline data from medication-free children with autism spectrum disorder who participated in trials conducted by the Research Units on Pediatric Psychopharmacology Autism Network (N = 276) were compared to 544 control children from the National Health and Nutrition Examination Survey database matched on age, sex, race, parent education, and era of data collection. The mean age of the children with autism spectrum disorder was 7.9 +/- 2.6 years; 84.4% were males. In the autism spectrum disorder group, the prevalence was 42.4% for overweight and 21.4% for obesity compared to 26.1% for overweight and 12.0% for obesity among controls (p < 0.001 for each contrast). Within the autism spectrum disorder sample, obesity was associated with minority status and lower daily living skills. These findings suggest that children with autism spectrum disorder and disruptive behavior are at increased risk for obesity and underscore the need for weight management interventions in this population. En ligne : http://dx.doi.org/10.1177/1362361316683888 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=361

Predictors of Caregiver Strain for Parents of Children with Autism Spectrum Disorder / Jessica BRADSHAW in Journal of Autism and Developmental Disorders, 51-9 (September 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3039-3049 Titre : Predictors of Caregiver Strain for Parents of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jessica BRADSHAW, Auteur ; S. GILLESPIE, Auteur ; C. MCCRACKEN, Auteur ; B. H. KING, Auteur ; J. T. MCCRACKEN, Auteur ; C. R. JOHNSON, Auteur ; L. LECAVALIER, Auteur ; T. SMITH, Auteur ; N. SWIEZY, Auteur ; Karen E. BEARSS, Auteur ; L. SIKICH, Auteur ; C. DONNELLY, Auteur ; E. HOLLANDER, Auteur ; C. J. MCDOUGLE, Auteur ; Lawrence SCAHILL, Auteur Article en page(s) : p.3039-3049 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Caregivers  Child  Family  Humans  Parents  Surveys and Questionnaires  Autism spectrum disorder  Caregiver strain  Disruptive behavior  Stress  Wellbeing Index. décimale : PER Périodiques Résumé : Parents of children with autism spectrum disorder (ASD) face higher levels of caregiver strain compared to parents of children with other disabilities. This study examined child clinical features that predict high levels of caregiver strain for 374 parents of children with ASD. Caregiver strain was measured using the Caregiver Strain Questionnaire (CGSQ) objective, subjective internalized, and subjective externalized subscales. Confirmatory factor analysis indicated an acceptable fit for the original CGSQ three-factor solution. The strongest child predictors across CGSQ subscales were: disruptive behavior for objective strain, autism severity and disruptive behavior for subjective internalized strain, and oppositional behavior and hyperactivity for subjective externalized strain. Individualized interventions that attend to specific elements of parental strain may reduce strain and improve family wellbeing. En ligne : http://dx.doi.org/10.1007/s10803-020-04625-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Predictors of Caregiver Strain for Parents of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Jessica BRADSHAW, Auteur ; S. GILLESPIE, Auteur ; C. MCCRACKEN, Auteur ; B. H. KING, Auteur ; J. T. MCCRACKEN, Auteur ; C. R. JOHNSON, Auteur ; L. LECAVALIER, Auteur ; T. SMITH, Auteur ; N. SWIEZY, Auteur ; Karen E. BEARSS, Auteur ; L. SIKICH, Auteur ; C. DONNELLY, Auteur ; E. HOLLANDER, Auteur ; C. J. MCDOUGLE, Auteur ; Lawrence SCAHILL, Auteur . - p.3039-3049. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3039-3049 Mots-clés : Autism Spectrum Disorder  Caregivers  Child  Family  Humans  Parents  Surveys and Questionnaires  Autism spectrum disorder  Caregiver strain  Disruptive behavior  Stress  Wellbeing Index. décimale : PER Périodiques Résumé : Parents of children with autism spectrum disorder (ASD) face higher levels of caregiver strain compared to parents of children with other disabilities. This study examined child clinical features that predict high levels of caregiver strain for 374 parents of children with ASD. Caregiver strain was measured using the Caregiver Strain Questionnaire (CGSQ) objective, subjective internalized, and subjective externalized subscales. Confirmatory factor analysis indicated an acceptable fit for the original CGSQ three-factor solution. The strongest child predictors across CGSQ subscales were: disruptive behavior for objective strain, autism severity and disruptive behavior for subjective internalized strain, and oppositional behavior and hyperactivity for subjective externalized strain. Individualized interventions that attend to specific elements of parental strain may reduce strain and improve family wellbeing. En ligne : http://dx.doi.org/10.1007/s10803-020-04625-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

What's missing in autism spectrum disorder motor assessments? / R. B. WILSON in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 33 p. Titre : What's missing in autism spectrum disorder motor assessments? Type de document : Texte imprimé et/ou numérique Auteurs : R. B. WILSON, Auteur ; J. T. MCCRACKEN, Auteur ; Nicole J. RINEHART, Auteur ; S. S. JESTE, Auteur Année de publication : 2018 Article en page(s) : 33 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Motor assessments  Motor function  Quantitative motor measures Index. décimale : PER Périodiques Résumé : BACKGROUND: Motor delays and impairments in autism spectrum disorders (ASD) are extremely common and often herald the emergence of pervasive atypical development. Clinical accounts of ASD and standardized measures of motor function have identified deficits in multiple motor domains. However, literature describing frequently used standardized motor assessments in children with ASD, their test properties, and their limitations are sparse. METHODS: We systematically reviewed the literature to identify the most frequently used standardized motor assessments used to evaluate children with ASD from infancy to early childhood. All assessments included were required to possess reference norms, evaluate more than one motor domain, and have undergone some degree of validation. RESULTS: We identified six frequently used standardized measures of motor function per our inclusion and exclusion criteria. We investigated and described in detail the psychometric properties of these assessments, their utility for use with children with ASD, and their individual and overall strengths and limitations. The global strengths of these assessments are the ability to identify early development delays and differences in fine and gross motor function in children with ASD. Global limitations of these studies are lack of validation in individuals with ASD and scoring systems that often miss specific and subtle abnormalities. CONCLUSIONS: Standardized assessments of motor function have provided valuable information on motor impairments in ASD. However, significant limitations remain in the use of these measures in children with ASD. Moving forward, it is imperative that standardized measures of motor function receive greater validation testing in children with ASD to assess their potential application given the clinical heterogeneity of this condition. In addition, utilizing quantitative measures of motor function should allow for evaluation and comparison of individuals with ASD across the lifespan with varying cognitive and behavioral abilities. En ligne : http://dx.doi.org/10.1186/s11689-018-9257-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] What's missing in autism spectrum disorder motor assessments? [Texte imprimé et/ou numérique] / R. B. WILSON, Auteur ; J. T. MCCRACKEN, Auteur ; Nicole J. RINEHART, Auteur ; S. S. JESTE, Auteur . - 2018 . - 33 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 33 p. Mots-clés : Autism spectrum disorder  Motor assessments  Motor function  Quantitative motor measures Index. décimale : PER Périodiques Résumé : BACKGROUND: Motor delays and impairments in autism spectrum disorders (ASD) are extremely common and often herald the emergence of pervasive atypical development. Clinical accounts of ASD and standardized measures of motor function have identified deficits in multiple motor domains. However, literature describing frequently used standardized motor assessments in children with ASD, their test properties, and their limitations are sparse. METHODS: We systematically reviewed the literature to identify the most frequently used standardized motor assessments used to evaluate children with ASD from infancy to early childhood. All assessments included were required to possess reference norms, evaluate more than one motor domain, and have undergone some degree of validation. RESULTS: We identified six frequently used standardized measures of motor function per our inclusion and exclusion criteria. We investigated and described in detail the psychometric properties of these assessments, their utility for use with children with ASD, and their individual and overall strengths and limitations. The global strengths of these assessments are the ability to identify early development delays and differences in fine and gross motor function in children with ASD. Global limitations of these studies are lack of validation in individuals with ASD and scoring systems that often miss specific and subtle abnormalities. CONCLUSIONS: Standardized assessments of motor function have provided valuable information on motor impairments in ASD. However, significant limitations remain in the use of these measures in children with ASD. Moving forward, it is imperative that standardized measures of motor function receive greater validation testing in children with ASD to assess their potential application given the clinical heterogeneity of this condition. In addition, utilizing quantitative measures of motor function should allow for evaluation and comparison of individuals with ASD across the lifespan with varying cognitive and behavioral abilities. En ligne : http://dx.doi.org/10.1186/s11689-018-9257-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

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