Additive interaction between birth asphyxia and febrile seizures on autism spectrum disorder: a population-based study / Yi MAO in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 17p. Titre : Additive interaction between birth asphyxia and febrile seizures on autism spectrum disorder: a population-based study Type de document : Texte imprimé et/ou numérique Auteurs : Yi MAO, Auteur ; Xindi LIN, Auteur ; Yuhan WU, Auteur ; Jiayi LU, Auteur ; Jiayao SHEN, Auteur ; Shaogen ZHONG, Auteur ; Xingming JIN, Auteur ; Jun MA, Auteur Article en page(s) : 17p. Langues : Anglais (eng) Mots-clés : Child  Humans  Child, Preschool  Autism Spectrum Disorder/epidemiology  Seizures, Febrile/epidemiology  Cross-Sectional Studies  Asphyxia  China/epidemiology  Autism spectrum disorder  Birth asphyxia  Children  Epidemiological study  Febrile seizures  Interaction effect Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder that can significantly impact an individual's ability to socially integrate and adapt. It's crucial to identify key factors associated with ASD. Recent studies link both birth asphyxia (BA) and febrile seizures (FS) separately to higher ASD prevalence. However, investigations into the interplay of BA and FS and its relationship with ASD are yet to be conducted. The present study mainly focuses on exploring the interactive effect between BA and FS in the context of ASD. METHODS: Utilizing a multi-stage stratified cluster sampling, we initially recruited 84,934 Shanghai children aged 3-12 years old from June 2014 to June 2015, ultimately including 74,251 post-exclusion criteria. A logistic regression model was conducted to estimate the interaction effect after controlling for pertinent covariates. The attributable proportion (AP), the relative excess risk due to interaction (RERI), the synergy index (SI), and multiplicative-scale interaction were computed to determine the interaction effect. RESULTS: Among a total of 74,251 children, 192 (0.26%) were diagnosed with ASD. The adjusted odds ratio for ASD in children with BA alone was 3.82 (95% confidence interval [CI] 2.42-6.02), for FS alone 3.06 (95%CI 1.48-6.31), and for comorbid BA and FS 21.18 (95%CI 9.10-49.30), versus children without BA or FS. The additive interaction between BA and FS showed statistical significance (P < 0.001), whereas the multiplicative interaction was statistically insignificant (P > 0.05). LIMITATIONS: This study can only demonstrate the relationship between the interaction of BA and FS with ASD but cannot prove causation. Animal brain experimentation is necessary to unravel its neural mechanisms. A larger sample size, ongoing monitoring, and detailed FS classification are needed for confirming BA-FS interaction in ASD. CONCLUSION: In this extensive cross-sectional study, both BA and FS were significantly linked to ASD. The coexistence of these factors was associated with an additive increase in ASD prevalence, surpassing the cumulative risk of each individual factor. En ligne : https://dx.doi.org/10.1186/s13229-024-00596-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Additive interaction between birth asphyxia and febrile seizures on autism spectrum disorder: a population-based study [Texte imprimé et/ou numérique] / Yi MAO, Auteur ; Xindi LIN, Auteur ; Yuhan WU, Auteur ; Jiayi LU, Auteur ; Jiayao SHEN, Auteur ; Shaogen ZHONG, Auteur ; Xingming JIN, Auteur ; Jun MA, Auteur . - 17p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 17p. Mots-clés : Child  Humans  Child, Preschool  Autism Spectrum Disorder/epidemiology  Seizures, Febrile/epidemiology  Cross-Sectional Studies  Asphyxia  China/epidemiology  Autism spectrum disorder  Birth asphyxia  Children  Epidemiological study  Febrile seizures  Interaction effect Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder that can significantly impact an individual's ability to socially integrate and adapt. It's crucial to identify key factors associated with ASD. Recent studies link both birth asphyxia (BA) and febrile seizures (FS) separately to higher ASD prevalence. However, investigations into the interplay of BA and FS and its relationship with ASD are yet to be conducted. The present study mainly focuses on exploring the interactive effect between BA and FS in the context of ASD. METHODS: Utilizing a multi-stage stratified cluster sampling, we initially recruited 84,934 Shanghai children aged 3-12 years old from June 2014 to June 2015, ultimately including 74,251 post-exclusion criteria. A logistic regression model was conducted to estimate the interaction effect after controlling for pertinent covariates. The attributable proportion (AP), the relative excess risk due to interaction (RERI), the synergy index (SI), and multiplicative-scale interaction were computed to determine the interaction effect. RESULTS: Among a total of 74,251 children, 192 (0.26%) were diagnosed with ASD. The adjusted odds ratio for ASD in children with BA alone was 3.82 (95% confidence interval [CI] 2.42-6.02), for FS alone 3.06 (95%CI 1.48-6.31), and for comorbid BA and FS 21.18 (95%CI 9.10-49.30), versus children without BA or FS. The additive interaction between BA and FS showed statistical significance (P < 0.001), whereas the multiplicative interaction was statistically insignificant (P > 0.05). LIMITATIONS: This study can only demonstrate the relationship between the interaction of BA and FS with ASD but cannot prove causation. Animal brain experimentation is necessary to unravel its neural mechanisms. A larger sample size, ongoing monitoring, and detailed FS classification are needed for confirming BA-FS interaction in ASD. CONCLUSION: In this extensive cross-sectional study, both BA and FS were significantly linked to ASD. The coexistence of these factors was associated with an additive increase in ASD prevalence, surpassing the cumulative risk of each individual factor. En ligne : https://dx.doi.org/10.1186/s13229-024-00596-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Copy number variation and neural pathway analysis of children with autism spectrum disorder from a large Han Chinese population-based cross-sectional study / You YANG in Research in Autism Spectrum Disorders, 51 (July 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 51 (July 2018) . - p.66-74 Titre : Copy number variation and neural pathway analysis of children with autism spectrum disorder from a large Han Chinese population-based cross-sectional study Type de document : Texte imprimé et/ou numérique Auteurs : You YANG, Auteur ; Zhijuan JIN, Auteur ; Jian WANG, Auteur ; Shijian LIU, Auteur ; Hong HUANG, Auteur ; Xingming JIN, Auteur Article en page(s) : p.66-74 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Copy number variations (CNVs)  Microarray diagnostic testing  Pathway analysis  Han Chinese Index. décimale : PER Périodiques Résumé : Certain genetic events can be attributed to copy number variations (CNVs). A population in Shanghai, China was screened for autism spectrum disorder (ASD), and their CNV characteristics and possible associations with neural pathways were analyzed. A multi-stage stratified cluster sampling method was used to evaluate 3- to 12-year-old children from the general population who were in kindergarten and primary school in Shanghai. DNA samples were obtained from 133 ASD cases from preparatory ASD screening. An Affymetrix Cytoscan 750k array was used for copy number variant detection. Among the 711 children who had positive results on a survey completed by both their parents and teachers, a total of 663 (93.2%) children underwent diagnostic evaluation. Of these, 203 children were confirmed to have ASD, including 163 (80.3%) children from special education schools, 29 (14.3%) children from general kindergartens, and 11 (5.4%) children from general primary schools. Final consent had been given for blood collection, and 15 CNVs that may contribute to ASD in 133 cases were identified. The mean ages at which the ASD children with and without pathogenic CNVs (pCNVs) began to speak were 45.6 months and 29.2 months, respectively (t?=?2.452, P?=?0.016), and the ages of walking alone were 33.9 months and 17.5 months, respectively (t?=?5.376, P? En ligne : https://doi.org/10.1016/j.rasd.2018.04.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=362 [article] Copy number variation and neural pathway analysis of children with autism spectrum disorder from a large Han Chinese population-based cross-sectional study [Texte imprimé et/ou numérique] / You YANG, Auteur ; Zhijuan JIN, Auteur ; Jian WANG, Auteur ; Shijian LIU, Auteur ; Hong HUANG, Auteur ; Xingming JIN, Auteur . - p.66-74. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 51 (July 2018) . - p.66-74 Mots-clés : Autism spectrum disorder (ASD)  Copy number variations (CNVs)  Microarray diagnostic testing  Pathway analysis  Han Chinese Index. décimale : PER Périodiques Résumé : Certain genetic events can be attributed to copy number variations (CNVs). A population in Shanghai, China was screened for autism spectrum disorder (ASD), and their CNV characteristics and possible associations with neural pathways were analyzed. A multi-stage stratified cluster sampling method was used to evaluate 3- to 12-year-old children from the general population who were in kindergarten and primary school in Shanghai. DNA samples were obtained from 133 ASD cases from preparatory ASD screening. An Affymetrix Cytoscan 750k array was used for copy number variant detection. Among the 711 children who had positive results on a survey completed by both their parents and teachers, a total of 663 (93.2%) children underwent diagnostic evaluation. Of these, 203 children were confirmed to have ASD, including 163 (80.3%) children from special education schools, 29 (14.3%) children from general kindergartens, and 11 (5.4%) children from general primary schools. Final consent had been given for blood collection, and 15 CNVs that may contribute to ASD in 133 cases were identified. The mean ages at which the ASD children with and without pathogenic CNVs (pCNVs) began to speak were 45.6 months and 29.2 months, respectively (t?=?2.452, P?=?0.016), and the ages of walking alone were 33.9 months and 17.5 months, respectively (t?=?5.376, P? En ligne : https://doi.org/10.1016/j.rasd.2018.04.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=362

Risk factors for ASD / Yuanyuan LIN in Journal of Autism and Developmental Disorders, 53-8 (August 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2954-2963 Titre : Risk factors for ASD Type de document : Texte imprimé et/ou numérique Auteurs : Yuanyuan LIN, Auteur ; Guanghai WANG, Auteur ; You YANG, Auteur ; Xingming JIN, Auteur ; Hong HUANG, Auteur ; Yiwen ZHANG, Auteur ; Zhijuan JIN, Auteur Article en page(s) : p.2954-2963 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that brings heavy burdens to families and the society. This case-control study explored risk factors for ASD based on 74,252 children aged 3-12 years who were recruited from general education kindergartens, primary schools, and special education schools in Shanghai, China. One hundred ninety-two children were identified with ASD according to the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition. Male sex, the presence of anoxia or asphyxia at birth, artificial feeding, adverse maternal psychological status, complications during pregnancy and higher paternal education were associated with ASD even after controlling for age, residential district, family history of mental disorders, parental personality, and amount of daily TV viewing. En ligne : https://doi.org/10.1007/s10803-022-05603-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Risk factors for ASD [Texte imprimé et/ou numérique] / Yuanyuan LIN, Auteur ; Guanghai WANG, Auteur ; You YANG, Auteur ; Xingming JIN, Auteur ; Hong HUANG, Auteur ; Yiwen ZHANG, Auteur ; Zhijuan JIN, Auteur . - p.2954-2963. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2954-2963 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that brings heavy burdens to families and the society. This case-control study explored risk factors for ASD based on 74,252 children aged 3-12 years who were recruited from general education kindergartens, primary schools, and special education schools in Shanghai, China. One hundred ninety-two children were identified with ASD according to the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition. Male sex, the presence of anoxia or asphyxia at birth, artificial feeding, adverse maternal psychological status, complications during pregnancy and higher paternal education were associated with ASD even after controlling for age, residential district, family history of mental disorders, parental personality, and amount of daily TV viewing. En ligne : https://doi.org/10.1007/s10803-022-05603-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

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