Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence / Edward D. BARKER in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.1145-1156 Titre : Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Edward D. BARKER, Auteur ; Charlotte A. M. CECIL, Auteur ; E. WALTON, Auteur ; L. C. HOUTEPEN, Auteur ; T. G. O'CONNOR, Auteur ; A. DANESE, Auteur ; Sara R. JAFFEE, Auteur ; S. K. G. JENSEN, Auteur ; C. PARIANTE, Auteur ; W. MCARDLE, Auteur ; T. R. GAUNT, Auteur ; C. L. RELTON, Auteur ; S. ROBERTS, Auteur Article en page(s) : p.1145-1156 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7-15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7-15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health. En ligne : http://dx.doi.org/10.1017/s0954579418000330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence [Texte imprimé et/ou numérique] / Edward D. BARKER, Auteur ; Charlotte A. M. CECIL, Auteur ; E. WALTON, Auteur ; L. C. HOUTEPEN, Auteur ; T. G. O'CONNOR, Auteur ; A. DANESE, Auteur ; Sara R. JAFFEE, Auteur ; S. K. G. JENSEN, Auteur ; C. PARIANTE, Auteur ; W. MCARDLE, Auteur ; T. R. GAUNT, Auteur ; C. L. RELTON, Auteur ; S. ROBERTS, Auteur . - p.1145-1156. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.1145-1156 Index. décimale : PER Périodiques Résumé : In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7-15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7-15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health. En ligne : http://dx.doi.org/10.1017/s0954579418000330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Intergenerational impacts of trauma and hardship through parenting / S. K. G. JENSEN in Journal of Child Psychology and Psychiatry, 62-8 (August 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-8 (August 2021) . - p.989-999 Titre : Intergenerational impacts of trauma and hardship through parenting Type de document : Texte imprimé et/ou numérique Auteurs : S. K. G. JENSEN, Auteur ; V. SEZIBERA, Auteur ; S. M. MURRAY, Auteur ; Robert T. BRENNAN, Auteur ; Theresa S. BETANCOURT, Auteur Article en page(s) : p.989-999 Langues : Anglais (eng) Mots-clés : Emotional Regulation  Emotions  Humans  Mental Health  Parenting  Stress Disorders, Post-Traumatic  emotional dysregulation  internalising disorder  post-traumatic stress disorder  trauma Index. décimale : PER Périodiques Résumé : BACKGROUND: Millions of people worldwide experience severe trauma in their lifetime. Trauma has immediate and long-term effects on emotional wellbeing. Moreover, the experiences of one generation may influence subsequent generations via social and biological pathways. Poor mental health and emotion dysregulation associated with trauma may affect parenting behaviours, which may have long-lasting effects on children's development. METHODS: We use longitudinal data from a unique sample of 732 caregivers of children aged 6-36 months living in extremely poor rural households in Rwanda to examine associations of caregiver lifetime trauma, recent daily hardships, mental health, and emotion dysregulation with parenting behaviours reflecting parental acceptance and rejection of their offspring. RESULTS: Cumulative trauma exposure (? = .234, p < .001) and recent daily hardships (? = .323, p < .001) are associated with higher levels of internalising symptoms. Trauma (? = .257, p < .001) and daily hardships (? = .323, p < 0.001) are also associated with post-traumatic stress disorder (PTSD) symptoms. Internalising symptoms predict more rejection (? = .177, p = .001), but show no association with acceptance. Caregiver PTSD symptoms predict more rejection (? = .277, p < .001) and less acceptance (? = -.190, p = .003). Both internalising symptoms (? = .557, p < .001) and PTSD symptoms (? = .606, p < .001) are strongly associated with poor emotion regulation. Indirect effects suggest that caregiver trauma and hardships affect parenting indirectly via elevated caregiver internalising symptoms and PTSD and that some of these effects are accounted for by emotion dysregulation. CONCLUSIONS: Caregiver internalising and PTSD symptoms are important mechanisms through which caregiver trauma and hardship affect parenting behaviours. Emotion dysregulation is a shared mechanism linking caregivers' mental health problems with parenting behaviours that reflect acceptance and rejection of the child. Emotion regulation is indicated as a key target for prevention of adverse effects of caregiver trauma on mental health and child wellbeing. En ligne : http://dx.doi.org/10.1111/jcpp.13359 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Intergenerational impacts of trauma and hardship through parenting [Texte imprimé et/ou numérique] / S. K. G. JENSEN, Auteur ; V. SEZIBERA, Auteur ; S. M. MURRAY, Auteur ; Robert T. BRENNAN, Auteur ; Theresa S. BETANCOURT, Auteur . - p.989-999. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-8 (August 2021) . - p.989-999 Mots-clés : Emotional Regulation  Emotions  Humans  Mental Health  Parenting  Stress Disorders, Post-Traumatic  emotional dysregulation  internalising disorder  post-traumatic stress disorder  trauma Index. décimale : PER Périodiques Résumé : BACKGROUND: Millions of people worldwide experience severe trauma in their lifetime. Trauma has immediate and long-term effects on emotional wellbeing. Moreover, the experiences of one generation may influence subsequent generations via social and biological pathways. Poor mental health and emotion dysregulation associated with trauma may affect parenting behaviours, which may have long-lasting effects on children's development. METHODS: We use longitudinal data from a unique sample of 732 caregivers of children aged 6-36 months living in extremely poor rural households in Rwanda to examine associations of caregiver lifetime trauma, recent daily hardships, mental health, and emotion dysregulation with parenting behaviours reflecting parental acceptance and rejection of their offspring. RESULTS: Cumulative trauma exposure (? = .234, p < .001) and recent daily hardships (? = .323, p < .001) are associated with higher levels of internalising symptoms. Trauma (? = .257, p < .001) and daily hardships (? = .323, p < 0.001) are also associated with post-traumatic stress disorder (PTSD) symptoms. Internalising symptoms predict more rejection (? = .177, p = .001), but show no association with acceptance. Caregiver PTSD symptoms predict more rejection (? = .277, p < .001) and less acceptance (? = -.190, p = .003). Both internalising symptoms (? = .557, p < .001) and PTSD symptoms (? = .606, p < .001) are strongly associated with poor emotion regulation. Indirect effects suggest that caregiver trauma and hardships affect parenting indirectly via elevated caregiver internalising symptoms and PTSD and that some of these effects are accounted for by emotion dysregulation. CONCLUSIONS: Caregiver internalising and PTSD symptoms are important mechanisms through which caregiver trauma and hardship affect parenting behaviours. Emotion dysregulation is a shared mechanism linking caregivers' mental health problems with parenting behaviours that reflect acceptance and rejection of the child. Emotion regulation is indicated as a key target for prevention of adverse effects of caregiver trauma on mental health and child wellbeing. En ligne : http://dx.doi.org/10.1111/jcpp.13359 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

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