Face processing in 22q11.2 deletion syndrome: atypical development and visual scanning alterations / A. ZAHARIA in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 26 p. Titre : Face processing in 22q11.2 deletion syndrome: atypical development and visual scanning alterations Type de document : Texte imprimé et/ou numérique Auteurs : A. ZAHARIA, Auteur ; M. SCHNEIDER, Auteur ; B. GLASER, Auteur ; M. FRANCHINI, Auteur ; S. MENGHETTI, Auteur ; M. SCHAER, Auteur ; M. DEBBANE, Auteur ; S. ELIEZ, Auteur Année de publication : 2018 Article en page(s) : 26 p. Langues : Anglais (eng) Mots-clés : Configural face processing  Eye-tracking  Featural face processing  Neurodevelopmental disorders  Social difficulties Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research links social difficulties to atypical face exploration in 22q11.2 deletion syndrome (22q11.2DS). Two types of face processing are distinguished: configural (CFP) and featural (FFP). CFP develops later in life and plays an important role in face and emotion recognition abilities. Recent studies reported atypical development of CFP in several neurodevelopmental disorders. Taking previous reports of atypical face exploration one step further, our study aims at characterizing face processing in children and adolescents with 22q11.2DS. First, we sought to identify biases in the first two fixation positions on faces and to detect differences between CFP and FFP in 22q11.2DS using eye-tracking technology. Second, we investigated the developmental trajectories of CFP and FFP using accuracy data from follow-up evaluation. METHODS: Seventy-five individuals with 22q11.2DS and 84 typically developed (TD) individuals (aged 6-21 years) completed a discrimination task ("Jane task") inducing CFP and FFP in an eye-tracking setting. Thirty-six individuals with 22q11DS and 30 TD from our sample completed a longitudinal follow-up evaluation. RESULTS: Findings revealed that individuals with 22q11.2DS demonstrate an early bias toward the mouth region during the initial fixations on the faces and reduced flexibility exploration of the faces, with a reduced number of transitions between faces and longer fixations compared to the TD group. Further, scanpaths did not differ between CFP and FFP in the 22q11.2DS group. Longitudinal analysis of accuracy data provided evidence for atypical development of CFP in 22q11.2DS. CONCLUSIONS: The current study brings new evidence of altered face exploration in 22q11.2DS and identifies developmental mechanisms that may contribute to difficulties impacting social interactions in the syndrome. En ligne : http://dx.doi.org/10.1186/s11689-018-9245-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Face processing in 22q11.2 deletion syndrome: atypical development and visual scanning alterations [Texte imprimé et/ou numérique] / A. ZAHARIA, Auteur ; M. SCHNEIDER, Auteur ; B. GLASER, Auteur ; M. FRANCHINI, Auteur ; S. MENGHETTI, Auteur ; M. SCHAER, Auteur ; M. DEBBANE, Auteur ; S. ELIEZ, Auteur . - 2018 . - 26 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 26 p. Mots-clés : Configural face processing  Eye-tracking  Featural face processing  Neurodevelopmental disorders  Social difficulties Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research links social difficulties to atypical face exploration in 22q11.2 deletion syndrome (22q11.2DS). Two types of face processing are distinguished: configural (CFP) and featural (FFP). CFP develops later in life and plays an important role in face and emotion recognition abilities. Recent studies reported atypical development of CFP in several neurodevelopmental disorders. Taking previous reports of atypical face exploration one step further, our study aims at characterizing face processing in children and adolescents with 22q11.2DS. First, we sought to identify biases in the first two fixation positions on faces and to detect differences between CFP and FFP in 22q11.2DS using eye-tracking technology. Second, we investigated the developmental trajectories of CFP and FFP using accuracy data from follow-up evaluation. METHODS: Seventy-five individuals with 22q11.2DS and 84 typically developed (TD) individuals (aged 6-21 years) completed a discrimination task ("Jane task") inducing CFP and FFP in an eye-tracking setting. Thirty-six individuals with 22q11DS and 30 TD from our sample completed a longitudinal follow-up evaluation. RESULTS: Findings revealed that individuals with 22q11.2DS demonstrate an early bias toward the mouth region during the initial fixations on the faces and reduced flexibility exploration of the faces, with a reduced number of transitions between faces and longer fixations compared to the TD group. Further, scanpaths did not differ between CFP and FFP in the 22q11.2DS group. Longitudinal analysis of accuracy data provided evidence for atypical development of CFP in 22q11.2DS. CONCLUSIONS: The current study brings new evidence of altered face exploration in 22q11.2DS and identifies developmental mechanisms that may contribute to difficulties impacting social interactions in the syndrome. En ligne : http://dx.doi.org/10.1186/s11689-018-9245-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Symptom trajectories in the first 18 months and autism risk in a prospective high-risk cohort / Lonnie ZWAIGENBAUM in Journal of Child Psychology and Psychiatry, 62-12 (December 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1435-1443 Titre : Symptom trajectories in the first 18 months and autism risk in a prospective high-risk cohort Type de document : Texte imprimé et/ou numérique Auteurs : Lonnie ZWAIGENBAUM, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; Lori-Ann R. SACREY, Auteur ; M. FRANCHINI, Auteur ; Susan E. BRYSON, Auteur ; T. VAILLANCOURT, Auteur ; V. ARMSTRONG, Auteur ; E. DUKU, Auteur ; P. SZATMARI, Auteur ; W. ROBERTS, Auteur ; C. RONCADIN, Auteur Article en page(s) : p.1435-1443 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology  Autistic Disorder  Child  Child, Preschool  Cohort Studies  Humans  Infant  Prospective Studies  Siblings  Autism spectrum disorder  early detection  high-risk studies  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Although early autism spectrum disorder (ASD) detection strategies tend to focus on differences at a point in time, behavioral symptom trajectories may also be informative. METHODS: Developmental trajectories of early signs of ASD were examined in younger siblings of children diagnosed with ASD (n?=?499) and infants with no family history of ASD (n?=?177). Participants were assessed using the Autism Observation Scale for Infants (AOSI) from 6 to 18?months. Diagnostic outcomes were determined at age 3?years blind to previous assessments. RESULTS: Semiparametric group-based modeling using AOSI scores identified three distinct trajectories: Group 1 ('Low', n?=?435, 64.3%) was characterized by a low level and stable evolution of ASD signs, group 2 ('Intermediate', n?=?180, 26.6%) had intermediate and stable levels, and group 3 ('Inclining', n?=?61, 9.3%) had higher and progressively elevated levels of ASD signs. Among younger siblings, ASD rates at age 3 varied by trajectory of early signs and were highest in the Inclining group, membership in which was highly specific (94.5%) but poorly sensitive (28.5%) to ASD. Children with ASD assigned to the inclining trajectory had more severe symptoms at age 3, but developmental and adaptive functioning did not differ by trajectory membership. CONCLUSIONS: These prospective data emphasize variable early-onset patterns and the importance of a multipronged approach to early surveillance and screening for ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13417 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Symptom trajectories in the first 18 months and autism risk in a prospective high-risk cohort [Texte imprimé et/ou numérique] / Lonnie ZWAIGENBAUM, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; Lori-Ann R. SACREY, Auteur ; M. FRANCHINI, Auteur ; Susan E. BRYSON, Auteur ; T. VAILLANCOURT, Auteur ; V. ARMSTRONG, Auteur ; E. DUKU, Auteur ; P. SZATMARI, Auteur ; W. ROBERTS, Auteur ; C. RONCADIN, Auteur . - p.1435-1443. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1435-1443 Mots-clés : Autism Spectrum Disorder/epidemiology  Autistic Disorder  Child  Child, Preschool  Cohort Studies  Humans  Infant  Prospective Studies  Siblings  Autism spectrum disorder  early detection  high-risk studies  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Although early autism spectrum disorder (ASD) detection strategies tend to focus on differences at a point in time, behavioral symptom trajectories may also be informative. METHODS: Developmental trajectories of early signs of ASD were examined in younger siblings of children diagnosed with ASD (n?=?499) and infants with no family history of ASD (n?=?177). Participants were assessed using the Autism Observation Scale for Infants (AOSI) from 6 to 18?months. Diagnostic outcomes were determined at age 3?years blind to previous assessments. RESULTS: Semiparametric group-based modeling using AOSI scores identified three distinct trajectories: Group 1 ('Low', n?=?435, 64.3%) was characterized by a low level and stable evolution of ASD signs, group 2 ('Intermediate', n?=?180, 26.6%) had intermediate and stable levels, and group 3 ('Inclining', n?=?61, 9.3%) had higher and progressively elevated levels of ASD signs. Among younger siblings, ASD rates at age 3 varied by trajectory of early signs and were highest in the Inclining group, membership in which was highly specific (94.5%) but poorly sensitive (28.5%) to ASD. Children with ASD assigned to the inclining trajectory had more severe symptoms at age 3, but developmental and adaptive functioning did not differ by trajectory membership. CONCLUSIONS: These prospective data emphasize variable early-onset patterns and the importance of a multipronged approach to early surveillance and screening for ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13417 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Variability in Verbal and Nonverbal Communication in Infants at Risk for Autism Spectrum Disorder: Predictors and Outcomes / M. FRANCHINI in Journal of Autism and Developmental Disorders, 48-10 (October 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3417-3431 Titre : Variability in Verbal and Nonverbal Communication in Infants at Risk for Autism Spectrum Disorder: Predictors and Outcomes Type de document : Texte imprimé et/ou numérique Auteurs : M. FRANCHINI, Auteur ; E. DUKU, Auteur ; V. ARMSTRONG, Auteur ; Jessica BRIAN, Auteur ; Susan E. BRYSON, Auteur ; N. GARON, Auteur ; W. ROBERTS, Auteur ; C. RONCADIN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; I. M. SMITH, Auteur Article en page(s) : p.3417-3431 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Infant siblings  Group-based trajectory model  Vocabulary development  Gesture development Index. décimale : PER Périodiques Résumé : Early communication impairment is among the most-reported first concerns in parents of young children with autism spectrum disorder (ASD). Using a parent-report questionnaire, we derived trajectory groups for early language and gesture acquisition in siblings at high risk for ASD and in children at low risk, during their first 2 years of life. Developmental skills at 6 months were associated with trajectory group membership representing growth in receptive language and gestures. Behavioral symptoms also predicted gesture development. All communication measures were strongly related to clinical and developmental outcomes. Trajectory groups further indicated slowest language/gesture acquisition in infants with later ASD diagnoses, in particular when associated with language delay. Overall, our results confirm considerable variability in communication development in high-risk infants. En ligne : https://doi.org/10.1007/s10803-018-3607-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Variability in Verbal and Nonverbal Communication in Infants at Risk for Autism Spectrum Disorder: Predictors and Outcomes [Texte imprimé et/ou numérique] / M. FRANCHINI, Auteur ; E. DUKU, Auteur ; V. ARMSTRONG, Auteur ; Jessica BRIAN, Auteur ; Susan E. BRYSON, Auteur ; N. GARON, Auteur ; W. ROBERTS, Auteur ; C. RONCADIN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; I. M. SMITH, Auteur . - p.3417-3431. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3417-3431 Mots-clés : Autism spectrum disorder  Infant siblings  Group-based trajectory model  Vocabulary development  Gesture development Index. décimale : PER Périodiques Résumé : Early communication impairment is among the most-reported first concerns in parents of young children with autism spectrum disorder (ASD). Using a parent-report questionnaire, we derived trajectory groups for early language and gesture acquisition in siblings at high risk for ASD and in children at low risk, during their first 2 years of life. Developmental skills at 6 months were associated with trajectory group membership representing growth in receptive language and gestures. Behavioral symptoms also predicted gesture development. All communication measures were strongly related to clinical and developmental outcomes. Trajectory groups further indicated slowest language/gesture acquisition in infants with later ASD diagnoses, in particular when associated with language delay. Overall, our results confirm considerable variability in communication development in high-risk infants. En ligne : https://doi.org/10.1007/s10803-018-3607-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

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