Medical Aspects of Autism / Pauline A. FILIPEK

Public ISBD contenu dans Handbook of Autism and Pervasive Developmental Disorders : Volume One / Fred R. VOLKMAR Titre : Medical Aspects of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Pauline A. FILIPEK, Auteur Année de publication : 2005 Importance : p.534-581 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=380 contenu dans Handbook of Autism and Pervasive Developmental Disorders : Volume One / Fred R. VOLKMAR Medical Aspects of Autism [Texte imprimé et/ou numérique] / Pauline A. FILIPEK, Auteur . - 2005 . - p.534-581. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=380

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Motor stereotypies and volumetric brain alterations in children with Autistic Disorder / Sylvie GOLDMAN in Research in Autism Spectrum Disorders, 7-1 (January 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-1 (January 2013) . - p.82-92 Titre : Motor stereotypies and volumetric brain alterations in children with Autistic Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sylvie GOLDMAN, Auteur ; Liam M. O’BRIEN, Auteur ; Pauline A. FILIPEK, Auteur ; Isabelle RAPIN, Auteur ; Martha R. HERBERT, Auteur Année de publication : 2013 Article en page(s) : p.82-92 Langues : Anglais (eng) Mots-clés : Structural imaging  Volumetric brain analysis  Videotape scoringMotor stereotypies  Autistic Disorder Index. décimale : PER Périodiques Résumé : Motor stereotypies are defined as patterned, repetitive, purposeless movements. These stigmatizing motor behaviors represent one manifestation of the third core criterion for an Autistic Disorder (AD) diagnosis, and are becoming viewed as potential early markers of autism. Moreover, motor stereotypies might be a tangible expression of the underlying neurobiology of this neurodevelopmental disorder. In this study, we videoscored stereotypies recorded during semi-structured play sessions from school age children with AD. We examined the effect of severity and persistence over time of stereotypies on brain volumetric changes. Our findings confirmed that the brain volume of school age children with AD is, on average, larger than that of age-matched typically developing children. However, we have failed to detect any sign of volumetric differences in brain regions thought to be particularly linked to the pathophysiology of stereotypies. This negative finding may suggest that, at least with respect to motor stereotypies, functional rather than structural alterations might be the underpinning of these disruptive motor manifestations of autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.07.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Motor stereotypies and volumetric brain alterations in children with Autistic Disorder [Texte imprimé et/ou numérique] / Sylvie GOLDMAN, Auteur ; Liam M. O’BRIEN, Auteur ; Pauline A. FILIPEK, Auteur ; Isabelle RAPIN, Auteur ; Martha R. HERBERT, Auteur . - 2013 . - p.82-92. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.82-92 Mots-clés : Structural imaging  Volumetric brain analysis  Videotape scoringMotor stereotypies  Autistic Disorder Index. décimale : PER Périodiques Résumé : Motor stereotypies are defined as patterned, repetitive, purposeless movements. These stigmatizing motor behaviors represent one manifestation of the third core criterion for an Autistic Disorder (AD) diagnosis, and are becoming viewed as potential early markers of autism. Moreover, motor stereotypies might be a tangible expression of the underlying neurobiology of this neurodevelopmental disorder. In this study, we videoscored stereotypies recorded during semi-structured play sessions from school age children with AD. We examined the effect of severity and persistence over time of stereotypies on brain volumetric changes. Our findings confirmed that the brain volume of school age children with AD is, on average, larger than that of age-matched typically developing children. However, we have failed to detect any sign of volumetric differences in brain regions thought to be particularly linked to the pathophysiology of stereotypies. This negative finding may suggest that, at least with respect to motor stereotypies, functional rather than structural alterations might be the underpinning of these disruptive motor manifestations of autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.07.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

Neuroimaging in the Developmental Disorders: The State of the Science / Pauline A. FILIPEK in Journal of Child Psychology and Psychiatry, 40-1 (January 1999)

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 40-1 (January 1999) . - p.113-128 Titre : Neuroimaging in the Developmental Disorders: The State of the Science Type de document : Texte imprimé et/ou numérique Auteurs : Pauline A. FILIPEK, Auteur Année de publication : 1999 Article en page(s) : p.113-128 Langues : Anglais (eng) Mots-clés : Brain imaging  development  autism Index. décimale : PER Périodiques Résumé : The developmental disorders of childhood—autistic, developmental language, reading (dyslexia), and attention deficit-hyperactivity disorders—manifest with deficits in the traditional behavioral domains of cognition, language, visual-spatial function, attention, and socialization. However, none of these disorders has been associated with characteristic discrete focal lesions or recognized encephaloclastic processes. Developmental cognitive neuroscientists must therefore begin with the spectrum of sometimes divergent behaviors occurring within these disorders and work backward in an attempt to identify the responsible anomalous neural systems. Since the advent of “brain imaging” two decades ago, much effort has focused on identifying brain-behavior correlates in these disorders. The results of these neuropathologic, structural, and functional neuroimaging studies are presented and the reasons for the often divergent findings are discussed. As we approach the end of the Decade of the Brain, current neuroimaging techniques give us the technology for the first time to apply a fundamental cognitive approach to brain-behavior relationships in the developmental disorders, to eliminate the conglomeration of “apples and camels” phenomenon. Researchers are working together to create comparable protocols and to adhere to methods that can be replicated across sites. The future prospects for a greater understanding of the developmental disorders are now much brighter with neuroimaging technology. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124 [article] Neuroimaging in the Developmental Disorders: The State of the Science [Texte imprimé et/ou numérique] / Pauline A. FILIPEK, Auteur . - 1999 . - p.113-128. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 40-1 (January 1999) . - p.113-128 Mots-clés : Brain imaging  development  autism Index. décimale : PER Périodiques Résumé : The developmental disorders of childhood—autistic, developmental language, reading (dyslexia), and attention deficit-hyperactivity disorders—manifest with deficits in the traditional behavioral domains of cognition, language, visual-spatial function, attention, and socialization. However, none of these disorders has been associated with characteristic discrete focal lesions or recognized encephaloclastic processes. Developmental cognitive neuroscientists must therefore begin with the spectrum of sometimes divergent behaviors occurring within these disorders and work backward in an attempt to identify the responsible anomalous neural systems. Since the advent of “brain imaging” two decades ago, much effort has focused on identifying brain-behavior correlates in these disorders. The results of these neuropathologic, structural, and functional neuroimaging studies are presented and the reasons for the often divergent findings are discussed. As we approach the end of the Decade of the Brain, current neuroimaging techniques give us the technology for the first time to apply a fundamental cognitive approach to brain-behavior relationships in the developmental disorders, to eliminate the conglomeration of “apples and camels” phenomenon. Researchers are working together to create comparable protocols and to adhere to methods that can be replicated across sites. The future prospects for a greater understanding of the developmental disorders are now much brighter with neuroimaging technology. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124

Role of parental occupation in autism spectrum disorder diagnosis and severity / Aisha S. DICKERSON in Research in Autism Spectrum Disorders, 8-9 (September 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-9 (September 2014) . - p.997-1007 Titre : Role of parental occupation in autism spectrum disorder diagnosis and severity Type de document : Texte imprimé et/ou numérique Auteurs : Aisha S. DICKERSON, Auteur ; Deborah A. PEARSON, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur ; Pauline A. FILIPEK, Auteur Article en page(s) : p.997-1007 Langues : Anglais (eng) Mots-clés : Autism  Diagnosis  Severity  Risk  Occupation  Parents Index. décimale : PER Périodiques Résumé : Abstract Some have suggested that parents of children with autism spectrum disorder (ASD) may present with less recognizable autistic-like phenotypic characteristics, leading them to highly systemizing occupations. Using secondary analysis of data from two previous studies of children with ASD, we tested associations between parental occupations and ASD diagnosis and the association of parental occupational characteristics on ASD severity. We found that fathers in healthcare (P lt; 0.01) and finance (P = 0.03) were more likely to have children with ASD. Additionally, joint effects of parental technical occupations were associated with communication (P lt; 0.01) and social impairment (P = 0.04). These results support that a “broader phenotype” and possible assortative mating in adults with autistic-like characteristics might contribute to intergenerational transmission and having offspring with greater ASD severity. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.05.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 [article] Role of parental occupation in autism spectrum disorder diagnosis and severity [Texte imprimé et/ou numérique] / Aisha S. DICKERSON, Auteur ; Deborah A. PEARSON, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur ; Pauline A. FILIPEK, Auteur . - p.997-1007. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-9 (September 2014) . - p.997-1007 Mots-clés : Autism  Diagnosis  Severity  Risk  Occupation  Parents Index. décimale : PER Périodiques Résumé : Abstract Some have suggested that parents of children with autism spectrum disorder (ASD) may present with less recognizable autistic-like phenotypic characteristics, leading them to highly systemizing occupations. Using secondary analysis of data from two previous studies of children with ASD, we tested associations between parental occupations and ASD diagnosis and the association of parental occupational characteristics on ASD severity. We found that fathers in healthcare (P lt; 0.01) and finance (P = 0.03) were more likely to have children with ASD. Additionally, joint effects of parental technical occupations were associated with communication (P lt; 0.01) and social impairment (P = 0.04). These results support that a “broader phenotype” and possible assortative mating in adults with autistic-like characteristics might contribute to intergenerational transmission and having offspring with greater ASD severity. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.05.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238

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