15 recherche sur le mot-clé 'Brain imaging'

Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants / D. A. GHEORGHE in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.822-830 Titre : Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants Type de document : Texte imprimé et/ou numérique Auteurs : D. A. GHEORGHE, Auteur ; C. LI, Auteur ; J. GALLACHER, Auteur ; S. BAUERMEISTER, Auteur Article en page(s) : p.822-830 Langues : Anglais (eng) Mots-clés : Adverse Childhood Experiences  Aged  Aged, 80 and over  Biological Specimen Banks  Brain/diagnostic imaging  Humans  Middle Aged  Retrospective Studies  Spouse Abuse  United Kingdom/epidemiology  Brain imaging  adversity  early life experience  large data Index. décimale : PER Périodiques Résumé : BACKGROUND: Adversity experiences (AEs) are major risk factors for psychiatric illness, and ample evidence suggests that adversity-related changes in brain structure enhance this vulnerability. To achieve greater understanding of the underlying biological pathways, increased convergence among findings is needed. Suggested future directions may benefit from the use of large population samples which may contribute to achieving this goal. We addressed mechanistic pathways by investigating the associations between multiple brain phenotypes and retrospectively reported AEs in early life (child adversity) and adulthood (partner abuse) in a large population sample, using a cross-sectional approach. METHODS: The UK Biobank resource was used to access imaging-derived phenotypes (IDPs) from 6,751 participants (aged: M = 62.1, SD = 7.2, range = 45-80), together with selected reports of childhood AEs and adult partner abuse. Principal component analysis was used to reduce the dimensionality of the data prior to multivariate tests. RESULTS: The data showed that participants who reported experiences of childhood emotional abuse ('felt hated by family member as a child') had smaller cerebellar and ventral striatum volumes. This result was also depicted in a random subset of participants; however, we note small effect sizes ( ?p2 ( ) < .01), suggestive of modest biological changes. CONCLUSIONS: Using a large population cohort, this study demonstrates the value of big datasets in the study of adversity and using automatically preprocessed neuroimaging phenotypes. While retrospective and cross-sectional characteristics limit interpretation, this study demonstrates that self-perceived adversity reports, however nonspecific, may still expose neural consequences, identifiable with increased statistical power. En ligne : http://dx.doi.org/10.1111/jcpp.13298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants [Texte imprimé et/ou numérique] / D. A. GHEORGHE, Auteur ; C. LI, Auteur ; J. GALLACHER, Auteur ; S. BAUERMEISTER, Auteur . - p.822-830. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.822-830 Mots-clés : Adverse Childhood Experiences  Aged  Aged, 80 and over  Biological Specimen Banks  Brain/diagnostic imaging  Humans  Middle Aged  Retrospective Studies  Spouse Abuse  United Kingdom/epidemiology  Brain imaging  adversity  early life experience  large data Index. décimale : PER Périodiques Résumé : BACKGROUND: Adversity experiences (AEs) are major risk factors for psychiatric illness, and ample evidence suggests that adversity-related changes in brain structure enhance this vulnerability. To achieve greater understanding of the underlying biological pathways, increased convergence among findings is needed. Suggested future directions may benefit from the use of large population samples which may contribute to achieving this goal. We addressed mechanistic pathways by investigating the associations between multiple brain phenotypes and retrospectively reported AEs in early life (child adversity) and adulthood (partner abuse) in a large population sample, using a cross-sectional approach. METHODS: The UK Biobank resource was used to access imaging-derived phenotypes (IDPs) from 6,751 participants (aged: M = 62.1, SD = 7.2, range = 45-80), together with selected reports of childhood AEs and adult partner abuse. Principal component analysis was used to reduce the dimensionality of the data prior to multivariate tests. RESULTS: The data showed that participants who reported experiences of childhood emotional abuse ('felt hated by family member as a child') had smaller cerebellar and ventral striatum volumes. This result was also depicted in a random subset of participants; however, we note small effect sizes ( ?p2 ( ) < .01), suggestive of modest biological changes. CONCLUSIONS: Using a large population cohort, this study demonstrates the value of big datasets in the study of adversity and using automatically preprocessed neuroimaging phenotypes. While retrospective and cross-sectional characteristics limit interpretation, this study demonstrates that self-perceived adversity reports, however nonspecific, may still expose neural consequences, identifiable with increased statistical power. En ligne : http://dx.doi.org/10.1111/jcpp.13298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Connecting the dots: social networks in the classroom and white matter connections in the brain / Rosa H. MULDER in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1622-1630 Titre : Connecting the dots: social networks in the classroom and white matter connections in the brain Type de document : Texte imprimé et/ou numérique Auteurs : Rosa H. MULDER, Auteur ; Monica LOPEZ-VICENTE, Auteur ; Andrea P. CORTES HIDALGO, Auteur ; Lisa R. STEENKAMP, Auteur ; Berna GUROÄŽLU, Auteur ; Henning TIEMEIER, Auteur ; Ryan L. MUETZEL, Auteur Article en page(s) : p.1622-1630 Langues : Anglais (eng) Mots-clés : Child  Humans  White Matter/diagnostic imaging  Diffusion Tensor Imaging  Cross-Sectional Studies  Brain/diagnostic imaging  Social Networking  Bullying behavior  Generation R Study  brain imaging  peer acceptance  peer rejection  peer victimization  white matter microstructure Index. décimale : PER Périodiques Résumé : BACKGROUND: Peer connections in school classrooms play an important role in social-emotional development and mental health. However, research on the association between children's peer relationships and white matter connections in the brain is scarce. We studied associations between peer relationships in the classroom and white matter structural connectivity in a pediatric population-based sample. METHODS: Bullying and victimization, as well as rejection and acceptance, were assessed in classrooms in 634 children at age 7. White matter microstructure (fractional anisotropy (FA), mean diffusivity (MD)) was measured with diffusion tensor imaging at age 10. We examined global metrics of white matter microstructure and used Tract-Based Spatial Statistics (TBSS) for voxel-wise associations. RESULTS: Peer victimization was associated with higher global FA and lower global MD and peer rejection was associated with lower global MD; however, these associations did not remain after multiple testing correction. Voxel-wise TBSS results for peer victimization and rejection were in line with global metrics both in terms of direction and spatial extent of the associations, with associated voxels (p(FWE) <.05) observed throughout the brain (including corpus callosum, corona radiata, sagittal stratum and superior longitudinal fasciculi). CONCLUSIONS: Although based only on cross-sectional data, the findings could indicate accelerated white matter microstructure maturation in certain brain areas of children who are victimized or rejected more often. However, repeated measurements are essential to unravel this complex interplay of peer connections, maturation and brain development over time. En ligne : http://dx.doi.org/10.1111/jcpp.13647 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Connecting the dots: social networks in the classroom and white matter connections in the brain [Texte imprimé et/ou numérique] / Rosa H. MULDER, Auteur ; Monica LOPEZ-VICENTE, Auteur ; Andrea P. CORTES HIDALGO, Auteur ; Lisa R. STEENKAMP, Auteur ; Berna GUROÄŽLU, Auteur ; Henning TIEMEIER, Auteur ; Ryan L. MUETZEL, Auteur . - p.1622-1630. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1622-1630 Mots-clés : Child  Humans  White Matter/diagnostic imaging  Diffusion Tensor Imaging  Cross-Sectional Studies  Brain/diagnostic imaging  Social Networking  Bullying behavior  Generation R Study  brain imaging  peer acceptance  peer rejection  peer victimization  white matter microstructure Index. décimale : PER Périodiques Résumé : BACKGROUND: Peer connections in school classrooms play an important role in social-emotional development and mental health. However, research on the association between children's peer relationships and white matter connections in the brain is scarce. We studied associations between peer relationships in the classroom and white matter structural connectivity in a pediatric population-based sample. METHODS: Bullying and victimization, as well as rejection and acceptance, were assessed in classrooms in 634 children at age 7. White matter microstructure (fractional anisotropy (FA), mean diffusivity (MD)) was measured with diffusion tensor imaging at age 10. We examined global metrics of white matter microstructure and used Tract-Based Spatial Statistics (TBSS) for voxel-wise associations. RESULTS: Peer victimization was associated with higher global FA and lower global MD and peer rejection was associated with lower global MD; however, these associations did not remain after multiple testing correction. Voxel-wise TBSS results for peer victimization and rejection were in line with global metrics both in terms of direction and spatial extent of the associations, with associated voxels (p(FWE) <.05) observed throughout the brain (including corpus callosum, corona radiata, sagittal stratum and superior longitudinal fasciculi). CONCLUSIONS: Although based only on cross-sectional data, the findings could indicate accelerated white matter microstructure maturation in certain brain areas of children who are victimized or rejected more often. However, repeated measurements are essential to unravel this complex interplay of peer connections, maturation and brain development over time. En ligne : http://dx.doi.org/10.1111/jcpp.13647 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Girls' brain structural connectivity in late adolescence relates to history of depression symptoms / Rajpreet CHAHAL in Journal of Child Psychology and Psychiatry, 61-11 (November 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1224-1233 Titre : Girls' brain structural connectivity in late adolescence relates to history of depression symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Rajpreet CHAHAL, Auteur ; David G. WEISSMAN, Auteur ; Scott MAREK, Auteur ; Shawn A. RHOADS, Auteur ; Alison E. HIPWELL, Auteur ; Erika E. FORBES, Auteur ; Kate KEENAN, Auteur ; Amanda E. GUYER, Auteur Article en page(s) : p.1224-1233 Langues : Anglais (eng) Mots-clés : Adolescence  brain imaging  connectomics  depression  development Index. décimale : PER Périodiques Résumé : BACKGROUND: Girls' depressive symptoms typically increase in adolescence, with individual differences in course and severity being key risk factors for impaired emotional functioning in young adulthood. Given the continued brain white matter (WM) maturation that occurs in adolescence, the present study tested whether structural connectivity patterns in late adolescence are associated with variation in the course of depression symptom severity throughout adolescence. METHOD: Participants were girls (N = 115) enrolled in a multiyear prospective cohort study of risk for depression. Initial depression severity (intercept) at age 10 and change in severity (linear slope) across ages 10-19 were examined in relation to WM tractography collected at age 19. Network-based statistic analyses were used to identify clusters showing variation in structural connectivity in association with depressive symptom intercept, slope, and their interaction. RESULTS: Higher initial depressive severity and steeper positive slope (separately) were associated with greater structural connectivity between temporal, subcortical socioaffective, and occipital regions. Intercept showed more connectivity associations than slope. The interaction effect indicated that higher initial symptom severity and a steeper negative slope (i.e., alleviating symptoms) were related to greater connectivity between cognitive control regions. Moderately severe symptoms that worsened over time were followed by greater connectivity between self-referential and cognitive regions (e.g., posterior cingulate and frontal gyrus). CONCLUSIONS: Higher depressive symptom severity in early adolescence and increasing symptom severity over time may forecast structural connectivity differences in late adolescence, particularly in pathways involving cognitive and emotion-processing regions. Understanding how clinical course relates to neurobiological correlates may inform new treatment approaches to adolescent depression. En ligne : http://dx.doi.org/10.1111/jcpp.13184 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Girls' brain structural connectivity in late adolescence relates to history of depression symptoms [Texte imprimé et/ou numérique] / Rajpreet CHAHAL, Auteur ; David G. WEISSMAN, Auteur ; Scott MAREK, Auteur ; Shawn A. RHOADS, Auteur ; Alison E. HIPWELL, Auteur ; Erika E. FORBES, Auteur ; Kate KEENAN, Auteur ; Amanda E. GUYER, Auteur . - p.1224-1233. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1224-1233 Mots-clés : Adolescence  brain imaging  connectomics  depression  development Index. décimale : PER Périodiques Résumé : BACKGROUND: Girls' depressive symptoms typically increase in adolescence, with individual differences in course and severity being key risk factors for impaired emotional functioning in young adulthood. Given the continued brain white matter (WM) maturation that occurs in adolescence, the present study tested whether structural connectivity patterns in late adolescence are associated with variation in the course of depression symptom severity throughout adolescence. METHOD: Participants were girls (N = 115) enrolled in a multiyear prospective cohort study of risk for depression. Initial depression severity (intercept) at age 10 and change in severity (linear slope) across ages 10-19 were examined in relation to WM tractography collected at age 19. Network-based statistic analyses were used to identify clusters showing variation in structural connectivity in association with depressive symptom intercept, slope, and their interaction. RESULTS: Higher initial depressive severity and steeper positive slope (separately) were associated with greater structural connectivity between temporal, subcortical socioaffective, and occipital regions. Intercept showed more connectivity associations than slope. The interaction effect indicated that higher initial symptom severity and a steeper negative slope (i.e., alleviating symptoms) were related to greater connectivity between cognitive control regions. Moderately severe symptoms that worsened over time were followed by greater connectivity between self-referential and cognitive regions (e.g., posterior cingulate and frontal gyrus). CONCLUSIONS: Higher depressive symptom severity in early adolescence and increasing symptom severity over time may forecast structural connectivity differences in late adolescence, particularly in pathways involving cognitive and emotion-processing regions. Understanding how clinical course relates to neurobiological correlates may inform new treatment approaches to adolescent depression. En ligne : http://dx.doi.org/10.1111/jcpp.13184 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

Annotation: MRI Neuroimaging of Childhood Psychiatric Disorders: A Selective Review / Stephan ELIEZ in Journal of Child Psychology and Psychiatry, 41-6 (September 2000)

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 41-6 (September 2000) . - p.679-694 Titre : Annotation: MRI Neuroimaging of Childhood Psychiatric Disorders: A Selective Review Type de document : Texte imprimé et/ou numérique Auteurs : Stephan ELIEZ, Auteur ; Allan L. REISS, Auteur Année de publication : 2000 Article en page(s) : p.679-694 Langues : Anglais (eng) Mots-clés : ADD/ADHD  autistic disorder  brain imaging  depression  schizophrenia  Tourette syndrome Index. décimale : PER Périodiques Résumé : Over the past 10 years, innovations in physics and computer science have promoted magnetic resonance imaging (MRI) as an essential tool for investigating the biological substrates of psychiatric disorders. Requiring no radiation exposure, MRI is now the preferred imaging technique for pediatric populations. However, the rapid technical advances in MRI pulse sequences, data processing, and analysis have made it increasingly complex for clinicians to compare and critically evaluate MRI research studies. This paper selectively reviews MRI research on five psychiatric conditions occurring in childhood or adolescence: ADHD, autism, childhood-onset schizophrenia, Tourette syndrome, and early-onset depression. The selection of papers reviewed was based on four criteria: the originality of the idea underlying the paper, the quality of the sample and methodologies used, the presence of controversial findings in the paper, and whether the paper was a clear illustration of specific methodological strengths or weaknesses. The tlwo goals of this review paper are to update clinicians on morphometric brain imaging in child psychiatry and the methodological issues pertaining to image acquisition and analysis, and to promote critical reading of future MRI studies. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125 [article] Annotation: MRI Neuroimaging of Childhood Psychiatric Disorders: A Selective Review [Texte imprimé et/ou numérique] / Stephan ELIEZ, Auteur ; Allan L. REISS, Auteur . - 2000 . - p.679-694. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 41-6 (September 2000) . - p.679-694 Mots-clés : ADD/ADHD  autistic disorder  brain imaging  depression  schizophrenia  Tourette syndrome Index. décimale : PER Périodiques Résumé : Over the past 10 years, innovations in physics and computer science have promoted magnetic resonance imaging (MRI) as an essential tool for investigating the biological substrates of psychiatric disorders. Requiring no radiation exposure, MRI is now the preferred imaging technique for pediatric populations. However, the rapid technical advances in MRI pulse sequences, data processing, and analysis have made it increasingly complex for clinicians to compare and critically evaluate MRI research studies. This paper selectively reviews MRI research on five psychiatric conditions occurring in childhood or adolescence: ADHD, autism, childhood-onset schizophrenia, Tourette syndrome, and early-onset depression. The selection of papers reviewed was based on four criteria: the originality of the idea underlying the paper, the quality of the sample and methodologies used, the presence of controversial findings in the paper, and whether the paper was a clear illustration of specific methodological strengths or weaknesses. The tlwo goals of this review paper are to update clinicians on morphometric brain imaging in child psychiatry and the methodological issues pertaining to image acquisition and analysis, and to promote critical reading of future MRI studies. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125

Annual Research Review: All mothers are not created equal: neural and psychobiological perspectives on mothering and the importance of individual differences / Jennifer BARRETT in Journal of Child Psychology and Psychiatry, 52-4 (April 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.368-397 Titre : Annual Research Review: All mothers are not created equal: neural and psychobiological perspectives on mothering and the importance of individual differences Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer BARRETT, Auteur ; Alison S. FLEMING, Auteur Année de publication : 2011 Article en page(s) : p.368-397 Langues : Anglais (eng) Mots-clés : Adversity  maternal depression  brain imaging  parenting  mothers Index. décimale : PER Périodiques Résumé : Quality of mothering relies on the integrity of multiple physiological and behavioral systems and on two maternal factors, one proximal and one distal, that have a great impact on how a mother mothers: postpartum depression and early experiences. To mother appropriately requires the action of systems that regulate sensation, perception, affect, reward, executive function, motor output and learning. When a mother is at risk to engage in less than optimal mothering, such as when she is depressed or has experienced adversity in childhood, the function of many or all of maternal and related systems may be affected. In this paper, we will review what is currently known about the biological basis of mothering, with attention to literature on hormones but with a particular focus on recent advances in the fields of functional neuroimaging. Instead of discussing strictly ‘maternal’ brain imaging studies, we instead use a systems approach to survey important findings relevant to brain systems integral to and/or strongly related to the mothering experience: (a) social behavior; (b) reward and affect; (c) executive function; and (d) maternal behavior. We find that there are many commonalities in terms of the brain regions identified across these systems and, as we would expect, all are sensitive to the influence of, or function differently in the context of, depression and adverse early experience. It is likely that the similarity and cross-talk between maternal, affect and stress systems, observed behaviorally, hormonally and in the context of brain function, allows for mood disturbance and early adverse experiences to have a significant impact on the quality of mothering and the motivation to mother. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02306.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 [article] Annual Research Review: All mothers are not created equal: neural and psychobiological perspectives on mothering and the importance of individual differences [Texte imprimé et/ou numérique] / Jennifer BARRETT, Auteur ; Alison S. FLEMING, Auteur . - 2011 . - p.368-397. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.368-397 Mots-clés : Adversity  maternal depression  brain imaging  parenting  mothers Index. décimale : PER Périodiques Résumé : Quality of mothering relies on the integrity of multiple physiological and behavioral systems and on two maternal factors, one proximal and one distal, that have a great impact on how a mother mothers: postpartum depression and early experiences. To mother appropriately requires the action of systems that regulate sensation, perception, affect, reward, executive function, motor output and learning. When a mother is at risk to engage in less than optimal mothering, such as when she is depressed or has experienced adversity in childhood, the function of many or all of maternal and related systems may be affected. In this paper, we will review what is currently known about the biological basis of mothering, with attention to literature on hormones but with a particular focus on recent advances in the fields of functional neuroimaging. Instead of discussing strictly ‘maternal’ brain imaging studies, we instead use a systems approach to survey important findings relevant to brain systems integral to and/or strongly related to the mothering experience: (a) social behavior; (b) reward and affect; (c) executive function; and (d) maternal behavior. We find that there are many commonalities in terms of the brain regions identified across these systems and, as we would expect, all are sensitive to the influence of, or function differently in the context of, depression and adverse early experience. It is likely that the similarity and cross-talk between maternal, affect and stress systems, observed behaviorally, hormonally and in the context of brain function, allows for mood disturbance and early adverse experiences to have a significant impact on the quality of mothering and the motivation to mother. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02306.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119

Annual Research Review: Current limitations and future directions in MRI studies of child- and adult-onset developmental psychopathologies / Guillermo HORGA in Journal of Child Psychology and Psychiatry, 55-6 (June 2014)  

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Neural correlates of language variability in preschool-aged boys with autism spectrum disorder / Letitia R. NAIGLES in Autism Research, 10-6 (June 2017)  

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Neuroimaging in the Developmental Disorders: The State of the Science / Pauline A. FILIPEK in Journal of Child Psychology and Psychiatry, 40-1 (January 1999)

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Research Review: Emanuel Miller Memorial Lecture 2012 – Neuroscientific studies of intervention for language impairment in children: interpretive and methodological problems / Dorothy V. M. BISHOP in Journal of Child Psychology and Psychiatry, 54-3 (March 2013)  

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Annual Research Review: Threats to the validity of child psychiatry and psychology / Michael RUTTER in Journal of Child Psychology and Psychiatry, 57-3 (March 2016)  

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