Autism is a prenatal disorder: Evidence from late gestation brain overgrowth / Frédérique BONNET-BRILHAULT in Autism Research, 11-12 (December 2018)  

Public ISBD [article]  inAutism Research > 11-12 (December 2018) . - p.1635-1642 Titre : Autism is a prenatal disorder: Evidence from late gestation brain overgrowth Type de document : Texte imprimé et/ou numérique Auteurs : Frédérique BONNET-BRILHAULT, Auteur ; T. A. RAJERISON, Auteur ; C. PAILLET, Auteur ; M. GUIMARD-BRUNAULT, Auteur ; A. SABY, Auteur ; L. PONSON, Auteur ; G. TRIPI, Auteur ; J. MALVY, Auteur ; S. ROUX, Auteur Article en page(s) : p.1635-1642 Langues : Anglais (eng) Mots-clés : brain growth  head circumference  neurodevelopmental disorder  ultrasound Index. décimale : PER Périodiques Résumé : This retrospective study aimed to specify the critical period for atypical brain development in individuals with autism spectrum disorder (ASD) using prenatal and postnatal head growth parameters. The sample consisted of 80 Caucasian, unrelated, idiopathic patients with ASD born after 1995. Fetal ultrasound parameters (head circumference [HC], abdominal circumference, and femur length) were obtained during the second and third trimesters of gestation. HC at birth and postnatal parameters at 12 and 24 months of age were also collected. Head overgrowth, assessed by HC, was highlighted during the second (20-26 weeks of amenorrhea) and third (28-36 weeks of amenorrhea) trimesters. Normal growth of body fetal parameters indicated that head overgrowth was not because of overall body overgrowth. Moreover, postnatal results replicated previously and reported head overgrowth. A critical time window for atypical brain development in autism is hypothesized to begin from the 22nd week of amenorrhea. This period is critical for cortical lamination and glial activation. A pathophysiological cascade is suggested with interactions between candidate genes and environmental factors. Autism Research 2018, 11: 1635-1642. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: It is now widely acknowledged in the scientific community, that autism is a neurodevelopmental disorder. Recent evidence from animal and pathological studies has implicated the in utero period. However, the precise time of onset of abnormal brain development remains unknown. This retrospective study reports novel findings, identifying an atypical head growth trajectory in children with autism, during the in utero period (after the 22nd week of amenorrhea). In the same children, postnatal head overgrowth was also observed. Late gestation is identified as a critical period for atypical brain development underlying autism symptoms. En ligne : http://dx.doi.org/10.1002/aur.2036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=372 [article] Autism is a prenatal disorder: Evidence from late gestation brain overgrowth [Texte imprimé et/ou numérique] / Frédérique BONNET-BRILHAULT, Auteur ; T. A. RAJERISON, Auteur ; C. PAILLET, Auteur ; M. GUIMARD-BRUNAULT, Auteur ; A. SABY, Auteur ; L. PONSON, Auteur ; G. TRIPI, Auteur ; J. MALVY, Auteur ; S. ROUX, Auteur . - p.1635-1642. Langues : Anglais (eng) in Autism Research > 11-12 (December 2018) . - p.1635-1642 Mots-clés : brain growth  head circumference  neurodevelopmental disorder  ultrasound Index. décimale : PER Périodiques Résumé : This retrospective study aimed to specify the critical period for atypical brain development in individuals with autism spectrum disorder (ASD) using prenatal and postnatal head growth parameters. The sample consisted of 80 Caucasian, unrelated, idiopathic patients with ASD born after 1995. Fetal ultrasound parameters (head circumference [HC], abdominal circumference, and femur length) were obtained during the second and third trimesters of gestation. HC at birth and postnatal parameters at 12 and 24 months of age were also collected. Head overgrowth, assessed by HC, was highlighted during the second (20-26 weeks of amenorrhea) and third (28-36 weeks of amenorrhea) trimesters. Normal growth of body fetal parameters indicated that head overgrowth was not because of overall body overgrowth. Moreover, postnatal results replicated previously and reported head overgrowth. A critical time window for atypical brain development in autism is hypothesized to begin from the 22nd week of amenorrhea. This period is critical for cortical lamination and glial activation. A pathophysiological cascade is suggested with interactions between candidate genes and environmental factors. Autism Research 2018, 11: 1635-1642. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: It is now widely acknowledged in the scientific community, that autism is a neurodevelopmental disorder. Recent evidence from animal and pathological studies has implicated the in utero period. However, the precise time of onset of abnormal brain development remains unknown. This retrospective study reports novel findings, identifying an atypical head growth trajectory in children with autism, during the in utero period (after the 22nd week of amenorrhea). In the same children, postnatal head overgrowth was also observed. Late gestation is identified as a critical period for atypical brain development underlying autism symptoms. En ligne : http://dx.doi.org/10.1002/aur.2036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=372

Emotional prosodic change detection in autism Spectrum disorder: an electrophysiological investigation in children and adults / J. CHARPENTIER in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 28 p. Titre : Emotional prosodic change detection in autism Spectrum disorder: an electrophysiological investigation in children and adults Type de document : Texte imprimé et/ou numérique Auteurs : J. CHARPENTIER, Auteur ; K. KOVARSKI, Auteur ; Emmanuelle HOUY-DURAND, Auteur ; J. MALVY, Auteur ; A. SABY, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Marianne LATINUS, Auteur ; Marie GOMOT, Auteur Année de publication : 2018 Article en page(s) : 28 p. Langues : Anglais (eng) Mots-clés : Adults  Autism spectrum disorder  Change detection  Children  Eeg  Emotion  Mismatch negativity (MMN)  Prosody Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical behaviors in social environments and in reaction to changing events. While this dyad of symptoms is at the core of the pathology along with atypical sensory behaviors, most studies have investigated only one dimension. A focus on the sameness dimension has shown that intolerance to change is related to an atypical pre-attentional detection of irregularity. In the present study, we addressed the same process in response to emotional change in order to evaluate the interplay between alterations of change detection and socio-emotional processing in children and adults with autism. METHODS: Brain responses to neutral and emotional prosodic deviancies (mismatch negativity (MMN) and P3a, reflecting change detection and orientation of attention toward change, respectively) were recorded in children and adults with autism and in controls. Comparison of neutral and emotional conditions allowed distinguishing between general deviancy and emotional deviancy effects. Moreover, brain responses to the same neutral and emotional stimuli were recorded when they were not deviants to evaluate the sensory processing of these vocal stimuli. RESULTS: In controls, change detection was modulated by prosody: in children, this was characterized by a lateralization of emotional MMN to the right hemisphere, and in adults, by an earlier MMN for emotional deviancy than for neutral deviancy. In ASD, an overall atypical change detection was observed with an earlier MMN and a larger P3a compared to controls suggesting an unusual pre-attentional orientation toward any changes in the auditory environment. Moreover, in children with autism, deviancy detection depicted reduced MMN amplitude. In addition in children with autism, contrary to adults with autism, no modulation of the MMN by prosody was present and sensory processing of both neutral and emotional vocal stimuli appeared atypical. CONCLUSIONS: Overall, change detection remains altered in people with autism. However, differences between children and adults with ASD evidence a trend toward normalization of vocal processing and of the automatic detection of emotion deviancy with age. En ligne : http://dx.doi.org/10.1186/s11689-018-9246-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Emotional prosodic change detection in autism Spectrum disorder: an electrophysiological investigation in children and adults [Texte imprimé et/ou numérique] / J. CHARPENTIER, Auteur ; K. KOVARSKI, Auteur ; Emmanuelle HOUY-DURAND, Auteur ; J. MALVY, Auteur ; A. SABY, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Marianne LATINUS, Auteur ; Marie GOMOT, Auteur . - 2018 . - 28 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 28 p. Mots-clés : Adults  Autism spectrum disorder  Change detection  Children  Eeg  Emotion  Mismatch negativity (MMN)  Prosody Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical behaviors in social environments and in reaction to changing events. While this dyad of symptoms is at the core of the pathology along with atypical sensory behaviors, most studies have investigated only one dimension. A focus on the sameness dimension has shown that intolerance to change is related to an atypical pre-attentional detection of irregularity. In the present study, we addressed the same process in response to emotional change in order to evaluate the interplay between alterations of change detection and socio-emotional processing in children and adults with autism. METHODS: Brain responses to neutral and emotional prosodic deviancies (mismatch negativity (MMN) and P3a, reflecting change detection and orientation of attention toward change, respectively) were recorded in children and adults with autism and in controls. Comparison of neutral and emotional conditions allowed distinguishing between general deviancy and emotional deviancy effects. Moreover, brain responses to the same neutral and emotional stimuli were recorded when they were not deviants to evaluate the sensory processing of these vocal stimuli. RESULTS: In controls, change detection was modulated by prosody: in children, this was characterized by a lateralization of emotional MMN to the right hemisphere, and in adults, by an earlier MMN for emotional deviancy than for neutral deviancy. In ASD, an overall atypical change detection was observed with an earlier MMN and a larger P3a compared to controls suggesting an unusual pre-attentional orientation toward any changes in the auditory environment. Moreover, in children with autism, deviancy detection depicted reduced MMN amplitude. In addition in children with autism, contrary to adults with autism, no modulation of the MMN by prosody was present and sensory processing of both neutral and emotional vocal stimuli appeared atypical. CONCLUSIONS: Overall, change detection remains altered in people with autism. However, differences between children and adults with ASD evidence a trend toward normalization of vocal processing and of the automatic detection of emotion deviancy with age. En ligne : http://dx.doi.org/10.1186/s11689-018-9246-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

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