Evidence of a reduced role for circumscribed interests in the social attention patterns of children with Autism Spectrum Disorder / Z. AMBARCHI in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3999-4011 Titre : Evidence of a reduced role for circumscribed interests in the social attention patterns of children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Z. AMBARCHI, Auteur ; K. A. BOULTON, Auteur ; R. THAPA, Auteur ; E. E. THOMAS, Auteur ; M. M. DEMAYO, Auteur ; N. J. SASSON, Auteur ; I. B. HICKIE, Auteur ; Adam J. GUASTELLA, Auteur Article en page(s) : p.3999-4011 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Reduced social attention is characteristic of Autism Spectrum Disorder (ASD). It has been suggested to result from an early onset and excessive influence of circumscribed interests (CIs) on gaze behaviour, compared to typically developing (TYP) individuals. To date, these findings have been mixed. The current eye-tracking study utilised a visual preference paradigm to investigate the influence of CI versus non-CI objects on attention patterns in children with ASD (aged 3-12 years, n=37) and their age-matched TYP peers (n=30). Compared to TYP, social and object attention was reduced in the ASD group irrespective of the presence of CIs. Results suggest a reduced role for CIs and extend recent evidence of atypical attention patterns across social and non-social domains in ASD. En ligne : https://doi.org/10.1007/s10803-022-05638-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Evidence of a reduced role for circumscribed interests in the social attention patterns of children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Z. AMBARCHI, Auteur ; K. A. BOULTON, Auteur ; R. THAPA, Auteur ; E. E. THOMAS, Auteur ; M. M. DEMAYO, Auteur ; N. J. SASSON, Auteur ; I. B. HICKIE, Auteur ; Adam J. GUASTELLA, Auteur . - p.3999-4011. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3999-4011 Index. décimale : PER Périodiques Résumé : Reduced social attention is characteristic of Autism Spectrum Disorder (ASD). It has been suggested to result from an early onset and excessive influence of circumscribed interests (CIs) on gaze behaviour, compared to typically developing (TYP) individuals. To date, these findings have been mixed. The current eye-tracking study utilised a visual preference paradigm to investigate the influence of CI versus non-CI objects on attention patterns in children with ASD (aged 3-12 years, n=37) and their age-matched TYP peers (n=30). Compared to TYP, social and object attention was reduced in the ASD group irrespective of the presence of CIs. Results suggest a reduced role for CIs and extend recent evidence of atypical attention patterns across social and non-social domains in ASD. En ligne : https://doi.org/10.1007/s10803-022-05638-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Machine Learning Differentiation of Autism Spectrum Sub-Classifications / R. THAPA in Journal of Autism and Developmental Disorders, 54-11 (November)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-11 (November) . - p.4216-4231 Titre : Machine Learning Differentiation of Autism Spectrum Sub-Classifications Type de document : Texte imprimé et/ou numérique Auteurs : R. THAPA, Auteur ; A. GARIKIPATI, Auteur ; M. CIOBANU, Auteur ; N. P. SINGH, Auteur ; E. BROWNING, Auteur ; J. DECURZIO, Auteur ; G. BARNES, Auteur ; F. A. DINENNO, Auteur ; Q. MAO, Auteur ; R. DAS, Auteur Article en page(s) : p.4216-4231 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Disorders on the autism spectrum have characteristics that can manifest as difficulties with communication, executive functioning, daily living, and more. These challenges can be mitigated with early identification. However, diagnostic criteria has changed from DSM-IV to DSM-5, which can make diagnosing a disorder on the autism spectrum complex. We evaluated machine learning to classify individuals as having one of three disorders of the autism spectrum under DSM-IV, or as non-spectrum. En ligne : https://doi.org/10.1007/s10803-023-06121-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 [article] Machine Learning Differentiation of Autism Spectrum Sub-Classifications [Texte imprimé et/ou numérique] / R. THAPA, Auteur ; A. GARIKIPATI, Auteur ; M. CIOBANU, Auteur ; N. P. SINGH, Auteur ; E. BROWNING, Auteur ; J. DECURZIO, Auteur ; G. BARNES, Auteur ; F. A. DINENNO, Auteur ; Q. MAO, Auteur ; R. DAS, Auteur . - p.4216-4231. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-11 (November) . - p.4216-4231 Index. décimale : PER Périodiques Résumé : Disorders on the autism spectrum have characteristics that can manifest as difficulties with communication, executive functioning, daily living, and more. These challenges can be mitigated with early identification. However, diagnostic criteria has changed from DSM-IV to DSM-5, which can make diagnosing a disorder on the autism spectrum complex. We evaluated machine learning to classify individuals as having one of three disorders of the autism spectrum under DSM-IV, or as non-spectrum. En ligne : https://doi.org/10.1007/s10803-023-06121-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537

Reduced heart rate variability in adults with autism spectrum disorder / R. THAPA in Autism Research, 12-6 (June 2019)  

Public ISBD [article]  inAutism Research > 12-6 (June 2019) . - p.922-930 Titre : Reduced heart rate variability in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : R. THAPA, Auteur ; Gail A. ALVARES, Auteur ; T. A. ZAIDI, Auteur ; E. E. THOMAS, Auteur ; I. B. HICKIE, Auteur ; S. H. PARK, Auteur ; A. J. GUASTELLA, Auteur Année de publication : 2019 Article en page(s) : p.922-930 Langues : Anglais (eng) Mots-clés : autonomic nervous system  biological marker  heart rate variability  mental health  parasympathetic nervous system  social development  sympathetic nervous system Index. décimale : PER Périodiques Résumé : A growing body of research has suggested heart rate variability (HRV) may be reduced in autism spectrum disorder (ASD) in comparison to neurotypical cohorts. While there have been several studies investigating HRV in children diagnosed with ASD, few studies have been conducted in adults. The objective of the current study was to investigate autonomic nervous system activity as assessed by HRV in adults diagnosed with ASD. We hypothesized that adults with ASD would show a reduction in HRV compared to neurotypical participants. Participants diagnosed with ASD (n = 55) were recruited from the Autism Clinic for Translational Research at the Brain and Mind Centre (University of Sydney) between 2013 and 2017. Neurotypical participants were recruited from advertisements and online media. Resting state heart rate was measured for 5 min while participants sat in an upright position. Results showed there was an overall significant difference in resting-state HRV between adults diagnosed with ASD compared to the neurotypical control group. Logarithmically transformed high frequency (HF) and root mean square of successive differences were particularly decreased in the ASD group, suggesting lower parasympathetic activity. The use of psychotropic medications and comorbidities were associated with reductions in low frequency of HRV. Our data suggest an overall dysregulation in resting autonomic activity in adults with ASD. This may represent an important physiological mechanism leading to potential cardiovascular risk in ASD, which warrants further investigation. Autism Res 2019, 12: 922-930. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: ASD is commonly associated with a range of physical and mental health comorbidities. Autonomic disruptions underlying reductions in heart rate variability (HRV) have been linked to a range of mental and physical health conditions. We assessed resting-state HRV in adults diagnosed with ASD in comparison to healthy individuals. Our results showed reduced heart rate variability in people diagnosed with ASD compared to adults without ASD. These findings implicate a role for autonomic activity as a potentially modifiable risk factor for ASD. En ligne : https://dx.doi.org/10.1002/aur.2104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] Reduced heart rate variability in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / R. THAPA, Auteur ; Gail A. ALVARES, Auteur ; T. A. ZAIDI, Auteur ; E. E. THOMAS, Auteur ; I. B. HICKIE, Auteur ; S. H. PARK, Auteur ; A. J. GUASTELLA, Auteur . - 2019 . - p.922-930. Langues : Anglais (eng) in Autism Research > 12-6 (June 2019) . - p.922-930 Mots-clés : autonomic nervous system  biological marker  heart rate variability  mental health  parasympathetic nervous system  social development  sympathetic nervous system Index. décimale : PER Périodiques Résumé : A growing body of research has suggested heart rate variability (HRV) may be reduced in autism spectrum disorder (ASD) in comparison to neurotypical cohorts. While there have been several studies investigating HRV in children diagnosed with ASD, few studies have been conducted in adults. The objective of the current study was to investigate autonomic nervous system activity as assessed by HRV in adults diagnosed with ASD. We hypothesized that adults with ASD would show a reduction in HRV compared to neurotypical participants. Participants diagnosed with ASD (n = 55) were recruited from the Autism Clinic for Translational Research at the Brain and Mind Centre (University of Sydney) between 2013 and 2017. Neurotypical participants were recruited from advertisements and online media. Resting state heart rate was measured for 5 min while participants sat in an upright position. Results showed there was an overall significant difference in resting-state HRV between adults diagnosed with ASD compared to the neurotypical control group. Logarithmically transformed high frequency (HF) and root mean square of successive differences were particularly decreased in the ASD group, suggesting lower parasympathetic activity. The use of psychotropic medications and comorbidities were associated with reductions in low frequency of HRV. Our data suggest an overall dysregulation in resting autonomic activity in adults with ASD. This may represent an important physiological mechanism leading to potential cardiovascular risk in ASD, which warrants further investigation. Autism Res 2019, 12: 922-930. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: ASD is commonly associated with a range of physical and mental health comorbidities. Autonomic disruptions underlying reductions in heart rate variability (HRV) have been linked to a range of mental and physical health conditions. We assessed resting-state HRV in adults diagnosed with ASD in comparison to healthy individuals. Our results showed reduced heart rate variability in people diagnosed with ASD compared to adults without ASD. These findings implicate a role for autonomic activity as a potentially modifiable risk factor for ASD. En ligne : https://dx.doi.org/10.1002/aur.2104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder / Marilena M. DEMAYO in Journal of Autism and Developmental Disorders, 52-3 (March 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1211-1222 Titre : The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Marilena M. DEMAYO, Auteur ; I. POKORSKI, Auteur ; Y. J. C. SONG, Auteur ; R. THAPA, Auteur ; S. PATEL, Auteur ; Zahava AMBARCHI, Auteur ; D. SOLIGO, Auteur ; I. SADELI, Auteur ; E. E. THOMAS, Auteur ; I. B. HICKIE, Auteur ; A. J. GUASTELLA, Auteur Article en page(s) : p.1211-1222 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Brain  Child  Child, Preschool  Feasibility Studies  Humans  Magnetic Resonance Imaging/methods  Autism spectrum disorders  Biomarkers  Brain function  Brain structure  Clinical trial  Interventions–pharmacologic  Magnetic resonance imaging  Neuroimaging  Pre-school children  School-age children Index. décimale : PER Périodiques Résumé : There is an increasing interest in using magnetic resonance imaging (MRI) as a tool for precision medicine in autism spectrum disorder (ASD). This study investigated the feasibility of MRI scanning in a large comprehensive, inclusive and test heavy clinical trial for children (aged 3-12 years) with ASD, without functioning constraints for participation. Of the 71 participants enrolled who consented to the MRI, 24 participants (38%) successfully completed an MRI scan at baseline along with other assessments. This scanning followed a familiarization procedure at two preceding visits. At post-treatment, 21 participants successfully completed the MRI scan. This study highlights the challenge of completing MRI assessments in ASD populations when conducted as one of a number of tests in a clinical trial. En ligne : http://dx.doi.org/10.1007/s10803-021-05028-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Marilena M. DEMAYO, Auteur ; I. POKORSKI, Auteur ; Y. J. C. SONG, Auteur ; R. THAPA, Auteur ; S. PATEL, Auteur ; Zahava AMBARCHI, Auteur ; D. SOLIGO, Auteur ; I. SADELI, Auteur ; E. E. THOMAS, Auteur ; I. B. HICKIE, Auteur ; A. J. GUASTELLA, Auteur . - p.1211-1222. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1211-1222 Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Brain  Child  Child, Preschool  Feasibility Studies  Humans  Magnetic Resonance Imaging/methods  Autism spectrum disorders  Biomarkers  Brain function  Brain structure  Clinical trial  Interventions–pharmacologic  Magnetic resonance imaging  Neuroimaging  Pre-school children  School-age children Index. décimale : PER Périodiques Résumé : There is an increasing interest in using magnetic resonance imaging (MRI) as a tool for precision medicine in autism spectrum disorder (ASD). This study investigated the feasibility of MRI scanning in a large comprehensive, inclusive and test heavy clinical trial for children (aged 3-12 years) with ASD, without functioning constraints for participation. Of the 71 participants enrolled who consented to the MRI, 24 participants (38%) successfully completed an MRI scan at baseline along with other assessments. This scanning followed a familiarization procedure at two preceding visits. At post-treatment, 21 participants successfully completed the MRI scan. This study highlights the challenge of completing MRI assessments in ASD populations when conducted as one of a number of tests in a clinical trial. En ligne : http://dx.doi.org/10.1007/s10803-021-05028-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

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