A Causal and Mediation Analysis of the Comorbidity Between Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) / Elena SOKOLOVA in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1595-1604 Titre : A Causal and Mediation Analysis of the Comorbidity Between Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) Type de document : texte imprimé Auteurs : Elena SOKOLOVA, Auteur ; Anoek M. OERLEMANS, Auteur ; Nanda N. ROMMELSE, Auteur ; Perry GROOT, Auteur ; Catharina A. HARTMAN, Auteur ; Jeffrey C. GLENNON, Auteur ; Tom CLAASSEN, Auteur ; Tom HESKES, Auteur ; Jan K. BUITELAAR, Auteur Article en page(s) : p.1595-1604 Langues : Anglais (eng) Mots-clés : ADHD  ASD  Inattention  Social interaction  Comorbidity Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and Attention-deficit/hyperactivity disorder (ADHD) are often comorbid. The purpose of this study is to explore the relationships between ASD and ADHD symptoms by applying causal modeling. We used a large phenotypic data set of 417 children with ASD and/or ADHD, 562 affected and unaffected siblings, and 414 controls, to infer a structural equation model using a causal discovery algorithm. Three distinct pathways between ASD and ADHD were identified: (1) from impulsivity to difficulties with understanding social information, (2) from hyperactivity to stereotypic, repetitive behavior, (3) a pairwise pathway between inattention, difficulties with understanding social information, and verbal IQ. These findings may inform future studies on understanding the pathophysiological mechanisms behind the overlap between ASD and ADHD. En ligne : http://dx.doi.org/10.1007/s10803-017-3083-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] A Causal and Mediation Analysis of the Comorbidity Between Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) [texte imprimé] / Elena SOKOLOVA, Auteur ; Anoek M. OERLEMANS, Auteur ; Nanda N. ROMMELSE, Auteur ; Perry GROOT, Auteur ; Catharina A. HARTMAN, Auteur ; Jeffrey C. GLENNON, Auteur ; Tom CLAASSEN, Auteur ; Tom HESKES, Auteur ; Jan K. BUITELAAR, Auteur . - p.1595-1604. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1595-1604 Mots-clés : ADHD  ASD  Inattention  Social interaction  Comorbidity Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and Attention-deficit/hyperactivity disorder (ADHD) are often comorbid. The purpose of this study is to explore the relationships between ASD and ADHD symptoms by applying causal modeling. We used a large phenotypic data set of 417 children with ASD and/or ADHD, 562 affected and unaffected siblings, and 414 controls, to infer a structural equation model using a causal discovery algorithm. Three distinct pathways between ASD and ADHD were identified: (1) from impulsivity to difficulties with understanding social information, (2) from hyperactivity to stereotypic, repetitive behavior, (3) a pairwise pathway between inattention, difficulties with understanding social information, and verbal IQ. These findings may inform future studies on understanding the pathophysiological mechanisms behind the overlap between ASD and ADHD. En ligne : http://dx.doi.org/10.1007/s10803-017-3083-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders / Jordan M. RAMSEY in Molecular Autism, (August 2013)  

Public ISBD [article]  inMolecular Autism > (August 2013) . - 18 p. Titre : Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders Type de document : texte imprimé Auteurs : Jordan M. RAMSEY, Auteur ; Paul C. GUEST, Auteur ; Jantine A.C. BROEK, Auteur ; Jeffrey C. GLENNON, Auteur ; Nanda N. ROMMELSE, Auteur ; Barbara FRANKE, Auteur ; Hassan RAHMOUNE, Auteur ; Jan K. BUITELAAR, Auteur ; Sabine BAHN, Auteur Année de publication : 2013 Article en page(s) : 18 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorders (ASDs) are neurodevelopmental conditions with symptoms manifesting before the age of 3, generally persisting throughout life and affecting social development and communication. Here, we have investigated changes in protein biomarkers in blood during childhood and adolescent development. Methods We carried out a multiplex immunoassay profiling analysis of serum samples from 37 individuals with a diagnosis of ASD and their matched, non-affected siblings, aged between 4 and 18 years, to identify molecular pathways affected over the course of ASDs. Results This analysis revealed age-dependent differences in the levels of 12 proteins involved in inflammation, growth and hormonal signaling. Conclusions These deviations in age-related molecular trajectories provide further insight into the progression and pathophysiology of the disorder and, if replicated, may contribute to better classification of ASD individuals, as well as to improved treatment and prognosis. The results also underline the importance of stratifying and analyzing samples by age, especially in ASD and potentially other developmental disorders. En ligne : http://dx.doi.org/10.1186/2040-2392-4-27 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 [article] Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders [texte imprimé] / Jordan M. RAMSEY, Auteur ; Paul C. GUEST, Auteur ; Jantine A.C. BROEK, Auteur ; Jeffrey C. GLENNON, Auteur ; Nanda N. ROMMELSE, Auteur ; Barbara FRANKE, Auteur ; Hassan RAHMOUNE, Auteur ; Jan K. BUITELAAR, Auteur ; Sabine BAHN, Auteur . - 2013 . - 18 p. Langues : Anglais (eng) in Molecular Autism > (August 2013) . - 18 p. Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorders (ASDs) are neurodevelopmental conditions with symptoms manifesting before the age of 3, generally persisting throughout life and affecting social development and communication. Here, we have investigated changes in protein biomarkers in blood during childhood and adolescent development. Methods We carried out a multiplex immunoassay profiling analysis of serum samples from 37 individuals with a diagnosis of ASD and their matched, non-affected siblings, aged between 4 and 18 years, to identify molecular pathways affected over the course of ASDs. Results This analysis revealed age-dependent differences in the levels of 12 proteins involved in inflammation, growth and hormonal signaling. Conclusions These deviations in age-related molecular trajectories provide further insight into the progression and pathophysiology of the disorder and, if replicated, may contribute to better classification of ASD individuals, as well as to improved treatment and prognosis. The results also underline the importance of stratifying and analyzing samples by age, especially in ASD and potentially other developmental disorders. En ligne : http://dx.doi.org/10.1186/2040-2392-4-27 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211

Practitioner Review: Psychological treatments for children and adolescents with conduct disorder problems – a systematic review and meta-analysis / M. J. BAKKER in Journal of Child Psychology and Psychiatry, 58-1 (January 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.4-18 Titre : Practitioner Review: Psychological treatments for children and adolescents with conduct disorder problems – a systematic review and meta-analysis Type de document : texte imprimé Auteurs : M. J. BAKKER, Auteur ; C. U. GREVEN, Auteur ; Jan K. BUITELAAR, Auteur ; Jeffrey C. GLENNON, Auteur Article en page(s) : p.4-18 Langues : Anglais (eng) Mots-clés : Psychological  meta-analysis  treatment  conduct disorder  aggression Index. décimale : PER Périodiques Résumé : Background This meta-analysis evaluates the efficacy of nonpharmacological treatments for conduct disorder (CD) problems in children and adolescents, based on child, parent and teacher report. Methods PubMed, PsycINFO and EMBASE were searched for peer-reviewed articles published between January 1970 and March 2015. Main inclusion criteria were nonpharmacological treatment, participants younger than 18 years, clinical CD problems/diagnosis, randomized controlled trials and inclusion of at least one CD problem-related outcome. Treatment efficacy is expressed in effect sizes (ESs) calculated for each rater (parent, teacher, self and blinded observer). Results Of 1,549 articles retrieved, 17 (published between June 2004 and January 2014) describing 19 interventions met the inclusion criteria. All studies used psychological treatments; only three studies included a blinded observer to rate CD problems. Most studies were of very poor to fair quality. ESs were significant but small for parent-reported outcomes (0.36, 95% CI = 0.27–0.47), teacher-reported outcomes (0.26, 95% CI = 0.12–0.49) and blinded observer outcomes (0.26, 95% CI = 0.06–0.47), and they were nonsignificant for self-reported outcomes (−0.01, 95% CI = −0.25 to 0.23). Comorbidity, gender, age, number of sessions, duration, intervention type, setting, medication use or dropout percentage did not influence the effect of treatment. Conclusions Psychological treatments have a small effect in reducing parent-, teacher- and observer-rated CD problems in children and adolescents with clinical CD problems/diagnosis. There is not enough evidence to support one specific psychological treatment over another. Future studies should investigate the influence of participant characteristics (e.g. age of CD onset), use more homogeneous outcome measures and allow better evaluation of study quality. Many reports failed to provide detailed information to allow optimization of psychological treatment strategies. En ligne : http://dx.doi.org/10.1111/jcpp.12590 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Practitioner Review: Psychological treatments for children and adolescents with conduct disorder problems – a systematic review and meta-analysis [texte imprimé] / M. J. BAKKER, Auteur ; C. U. GREVEN, Auteur ; Jan K. BUITELAAR, Auteur ; Jeffrey C. GLENNON, Auteur . - p.4-18. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.4-18 Mots-clés : Psychological  meta-analysis  treatment  conduct disorder  aggression Index. décimale : PER Périodiques Résumé : Background This meta-analysis evaluates the efficacy of nonpharmacological treatments for conduct disorder (CD) problems in children and adolescents, based on child, parent and teacher report. Methods PubMed, PsycINFO and EMBASE were searched for peer-reviewed articles published between January 1970 and March 2015. Main inclusion criteria were nonpharmacological treatment, participants younger than 18 years, clinical CD problems/diagnosis, randomized controlled trials and inclusion of at least one CD problem-related outcome. Treatment efficacy is expressed in effect sizes (ESs) calculated for each rater (parent, teacher, self and blinded observer). Results Of 1,549 articles retrieved, 17 (published between June 2004 and January 2014) describing 19 interventions met the inclusion criteria. All studies used psychological treatments; only three studies included a blinded observer to rate CD problems. Most studies were of very poor to fair quality. ESs were significant but small for parent-reported outcomes (0.36, 95% CI = 0.27–0.47), teacher-reported outcomes (0.26, 95% CI = 0.12–0.49) and blinded observer outcomes (0.26, 95% CI = 0.06–0.47), and they were nonsignificant for self-reported outcomes (−0.01, 95% CI = −0.25 to 0.23). Comorbidity, gender, age, number of sessions, duration, intervention type, setting, medication use or dropout percentage did not influence the effect of treatment. Conclusions Psychological treatments have a small effect in reducing parent-, teacher- and observer-rated CD problems in children and adolescents with clinical CD problems/diagnosis. There is not enough evidence to support one specific psychological treatment over another. Future studies should investigate the influence of participant characteristics (e.g. age of CD onset), use more homogeneous outcome measures and allow better evaluation of study quality. Many reports failed to provide detailed information to allow optimization of psychological treatment strategies. En ligne : http://dx.doi.org/10.1111/jcpp.12590 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Self-initiations in young children with autism during Pivotal Response Treatment with and without robot assistance / Manon W. P. DE KORTE in Autism, 24-8 (November 2020)  

Public ISBD [article]  inAutism > 24-8 (November 2020) . - p.2117-2128 Titre : Self-initiations in young children with autism during Pivotal Response Treatment with and without robot assistance Type de document : texte imprimé Auteurs : Manon W. P. DE KORTE, Auteur ; Iris VAN DEN BERK-SMEEKENS, Auteur ; Martine VAN DONGEN-BOOMSMA, Auteur ; Iris J OOSTERLING, Auteur ; Jenny C. DEN BOER, Auteur ; Emilia I. BARAKOVA, Auteur ; Tino LOURENS, Auteur ; Jan K. BUITELAAR, Auteur ; Jeffrey C. GLENNON, Auteur ; Wouter G. STAAL, Auteur Article en page(s) : p.2117-2128 Langues : Anglais (eng) Mots-clés : *Pivotal Response Treatment  *autism spectrum disorders  *robot-assisted intervention  *self-initiations Index. décimale : PER Périodiques Résumé : The initiation of social interaction is often defined as a core deficit of autism spectrum disorder. Optimizing these self-initiations is therefore a key component of Pivotal Response Treatment, an established intervention for children with autism spectrum disorder. However, little is known about the development of self-initiations during intervention and whether this development can be facilitated by robot assistance within Pivotal Response Treatment. The aim of this study was to (1) investigate the effect of Pivotal Response Treatment and robot-assisted Pivotal Response Treatment on self-initiations (functional and social) of young children with autism spectrum disorder over the course of intervention and (2) explore the relation between development in self-initiations and additional gains in general social-communicative skills. Forty-four children with autism spectrum disorder (aged 3-8 years) were included in this study. Self-initiations were assessed during parent-child interaction videos of therapy sessions and coded by raters who did not know which treatment (Pivotal Response Treatment or robot-assisted Pivotal Response Treatment) the child received. General social-communicative skills were assessed before start of the treatment, after 10 and 20 weeks of intervention and 3 months after the treatment was finalized. Results showed that self-initiations increased in both treatment groups, with the largest improvements in functional self-initiations in the group that received robot-assisted Pivotal Response Treatment. Increased self-initiations were related to higher parent-rated social awareness 3 months after finalizing the treatment. En ligne : http://dx.doi.org/10.1177/1362361320935006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Self-initiations in young children with autism during Pivotal Response Treatment with and without robot assistance [texte imprimé] / Manon W. P. DE KORTE, Auteur ; Iris VAN DEN BERK-SMEEKENS, Auteur ; Martine VAN DONGEN-BOOMSMA, Auteur ; Iris J OOSTERLING, Auteur ; Jenny C. DEN BOER, Auteur ; Emilia I. BARAKOVA, Auteur ; Tino LOURENS, Auteur ; Jan K. BUITELAAR, Auteur ; Jeffrey C. GLENNON, Auteur ; Wouter G. STAAL, Auteur . - p.2117-2128. Langues : Anglais (eng) in Autism > 24-8 (November 2020) . - p.2117-2128 Mots-clés : *Pivotal Response Treatment  *autism spectrum disorders  *robot-assisted intervention  *self-initiations Index. décimale : PER Périodiques Résumé : The initiation of social interaction is often defined as a core deficit of autism spectrum disorder. Optimizing these self-initiations is therefore a key component of Pivotal Response Treatment, an established intervention for children with autism spectrum disorder. However, little is known about the development of self-initiations during intervention and whether this development can be facilitated by robot assistance within Pivotal Response Treatment. The aim of this study was to (1) investigate the effect of Pivotal Response Treatment and robot-assisted Pivotal Response Treatment on self-initiations (functional and social) of young children with autism spectrum disorder over the course of intervention and (2) explore the relation between development in self-initiations and additional gains in general social-communicative skills. Forty-four children with autism spectrum disorder (aged 3-8 years) were included in this study. Self-initiations were assessed during parent-child interaction videos of therapy sessions and coded by raters who did not know which treatment (Pivotal Response Treatment or robot-assisted Pivotal Response Treatment) the child received. General social-communicative skills were assessed before start of the treatment, after 10 and 20 weeks of intervention and 3 months after the treatment was finalized. Results showed that self-initiations increased in both treatment groups, with the largest improvements in functional self-initiations in the group that received robot-assisted Pivotal Response Treatment. Increased self-initiations were related to higher parent-rated social awareness 3 months after finalizing the treatment. En ligne : http://dx.doi.org/10.1177/1362361320935006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

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