Early behavioral and physiological markers of social anxiety in infants with fragile X syndrome / Conner J. BLACK in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Early behavioral and physiological markers of social anxiety in infants with fragile X syndrome Type de document : texte imprimé Auteurs : Conner J. BLACK, Auteur ; Abigail L. HOGAN, Auteur ; Kayla D. SMITH, Auteur ; Jane E. ROBERTS, Auteur Langues : Anglais (eng) Mots-clés : Anxiety  Attention  Autism Spectrum Disorder  Behavior  Biomarkers  Female  Fragile X Syndrome  Humans  Infant  Male  Fragile X syndrome  Physiology  Respiratory sinus arrhythmia  Social anxiety  Social behavioral inhibition Index. décimale : PER Périodiques Résumé : BACKGROUND: Social anxiety is highly prevalent in neurotypical children and children with fragile X syndrome (FXS). FXS is a genetic syndrome that is characterized by intellectual disability and an increased risk for autism spectrum disorder. If social anxiety is left untreated, negative outcomes are highly prevalent later in life. However, early detection of social anxiety is challenging as symptoms are often subtle or absent very early in life. Given the prevalence and impairment associated with childhood social anxiety, efforts have accelerated to identify risk markers of anxiety. A cluster of early features of anxiety have been identified including elevated behavioral inhibition, attentional biases, and physiological dysregulation that index early emerging markers of social anxiety. Infants with FXS provide a unique opportunity to study the earlier predictors of social anxiety. The current study utilized a multi-method approach to investigate early markers of social anxiety in 12-month-old infants with FXS. METHOD: Participants included 32 infants with FXS and 41 low-risk controls, all approximately 12 months old. Parent-reported social behavioral inhibition was recorded from the Infant Behavior Questionnaire (IBQ-R). Direct observations of behavioral inhibition and attention were measured during a stranger approach task with respiratory sinus arrhythmia collected simultaneously. RESULTS: Parent-reported social behavioral inhibition was not significantly different between groups. In contrast, direct observations suggested that infants with FXS displayed elevated behavioral inhibition, increased attention towards the stranger, and a blunted respiratory sinus arrhythmia response. CONCLUSIONS: Findings suggest that infants with FXS show both behavioral and physiological markers of social anxiety at 12 months old using a biobehavioral approach with multiple sources of input. Results highlight the importance of a multi-method approach to understanding the complex early emergent characteristics of anxiety in infants with FXS. En ligne : https://dx.doi.org/10.1186/s11689-021-09356-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Early behavioral and physiological markers of social anxiety in infants with fragile X syndrome [texte imprimé] / Conner J. BLACK, Auteur ; Abigail L. HOGAN, Auteur ; Kayla D. SMITH, Auteur ; Jane E. ROBERTS, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Anxiety  Attention  Autism Spectrum Disorder  Behavior  Biomarkers  Female  Fragile X Syndrome  Humans  Infant  Male  Fragile X syndrome  Physiology  Respiratory sinus arrhythmia  Social anxiety  Social behavioral inhibition Index. décimale : PER Périodiques Résumé : BACKGROUND: Social anxiety is highly prevalent in neurotypical children and children with fragile X syndrome (FXS). FXS is a genetic syndrome that is characterized by intellectual disability and an increased risk for autism spectrum disorder. If social anxiety is left untreated, negative outcomes are highly prevalent later in life. However, early detection of social anxiety is challenging as symptoms are often subtle or absent very early in life. Given the prevalence and impairment associated with childhood social anxiety, efforts have accelerated to identify risk markers of anxiety. A cluster of early features of anxiety have been identified including elevated behavioral inhibition, attentional biases, and physiological dysregulation that index early emerging markers of social anxiety. Infants with FXS provide a unique opportunity to study the earlier predictors of social anxiety. The current study utilized a multi-method approach to investigate early markers of social anxiety in 12-month-old infants with FXS. METHOD: Participants included 32 infants with FXS and 41 low-risk controls, all approximately 12 months old. Parent-reported social behavioral inhibition was recorded from the Infant Behavior Questionnaire (IBQ-R). Direct observations of behavioral inhibition and attention were measured during a stranger approach task with respiratory sinus arrhythmia collected simultaneously. RESULTS: Parent-reported social behavioral inhibition was not significantly different between groups. In contrast, direct observations suggested that infants with FXS displayed elevated behavioral inhibition, increased attention towards the stranger, and a blunted respiratory sinus arrhythmia response. CONCLUSIONS: Findings suggest that infants with FXS show both behavioral and physiological markers of social anxiety at 12 months old using a biobehavioral approach with multiple sources of input. Results highlight the importance of a multi-method approach to understanding the complex early emergent characteristics of anxiety in infants with FXS. En ligne : https://dx.doi.org/10.1186/s11689-021-09356-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Restricted and Repetitive Behaviors in Males and Females with Fragile X Syndrome: Developmental Trajectories in Toddlers Through Young Adults / Lauren J. MOSKOWITZ in Journal of Autism and Developmental Disorders, 50-11 (November 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.3957-3966 Titre : Restricted and Repetitive Behaviors in Males and Females with Fragile X Syndrome: Developmental Trajectories in Toddlers Through Young Adults Type de document : texte imprimé Auteurs : Lauren J. MOSKOWITZ, Auteur ; Elizabeth A. WILL, Auteur ; Conner J. BLACK, Auteur ; Jane E. ROBERTS, Auteur Article en page(s) : p.3957-3966 Langues : Anglais (eng) Mots-clés : Developmental trajectory  Fragile X syndrome  Repetitive behavior  Restricted interests  Self-injurious behavior  Sensory motor behaviors Index. décimale : PER Périodiques Résumé : There is limited research on the trajectory of restricted and repetitive behaviors (RRBs) in fragile X syndrome (FXS), with previous studies only examining males and/or examining RRBs as a unitary construct rather than delineating subtypes of RRBs. Thus, we described the trajectory of five subtypes of RRBs in 153 males and females with FXS (aged 1-18 years) with repeated measurement over time (445 total assessments). Multilevel modeling was used to test age-related differences in RRB subtypes between males and females with FXS, controlling for nonverbal IQ. Results showed that lower-order Sensory-Motor behaviors decreased over time for both males and females, while there was no significant change in the higher-order RRBs. The trajectory between males and females differed for Self-Injury. En ligne : http://dx.doi.org/10.1007/s10803-020-04459-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Restricted and Repetitive Behaviors in Males and Females with Fragile X Syndrome: Developmental Trajectories in Toddlers Through Young Adults [texte imprimé] / Lauren J. MOSKOWITZ, Auteur ; Elizabeth A. WILL, Auteur ; Conner J. BLACK, Auteur ; Jane E. ROBERTS, Auteur . - p.3957-3966. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.3957-3966 Mots-clés : Developmental trajectory  Fragile X syndrome  Repetitive behavior  Restricted interests  Self-injurious behavior  Sensory motor behaviors Index. décimale : PER Périodiques Résumé : There is limited research on the trajectory of restricted and repetitive behaviors (RRBs) in fragile X syndrome (FXS), with previous studies only examining males and/or examining RRBs as a unitary construct rather than delineating subtypes of RRBs. Thus, we described the trajectory of five subtypes of RRBs in 153 males and females with FXS (aged 1-18 years) with repeated measurement over time (445 total assessments). Multilevel modeling was used to test age-related differences in RRB subtypes between males and females with FXS, controlling for nonverbal IQ. Results showed that lower-order Sensory-Motor behaviors decreased over time for both males and females, while there was no significant change in the higher-order RRBs. The trajectory between males and females differed for Self-Injury. En ligne : http://dx.doi.org/10.1007/s10803-020-04459-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

The effect of anxiety and autism symptom severity on restricted and repetitive behaviors over time in children with fragile X syndrome / Lauren J. MOSKOWITZ in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : The effect of anxiety and autism symptom severity on restricted and repetitive behaviors over time in children with fragile X syndrome Type de document : texte imprimé Auteurs : Lauren J. MOSKOWITZ, Auteur ; Elizabeth A. WILL, Auteur ; Conner J. BLACK, Auteur ; Jane E. ROBERTS, Auteur Langues : Anglais (eng) Mots-clés : Humans  Fragile X Syndrome/complications/physiopathology  Male  Female  Child  Autism Spectrum Disorder/complications/physiopathology  Anxiety/etiology  Severity of Illness Index  Longitudinal Studies  Child, Preschool  Stereotyped Behavior/physiology  Adolescent  Comorbidity  Anxiety  Autism  Compulsive behavior  Fragile X syndrome  Restricted interests  Restricted repetitive behaviors  Ritualistic/sameness behavior  Self-injurious behaviors  Sensory-motor behaviors Index. décimale : PER Périodiques Résumé : BACKGROUND: Restricted and repetitive behaviors (RRBs) are highly prevalent and reduce function in individuals with fragile X syndrome (FXS). As transdiagnostic features of intellectual disability, elevated rates of RRBs in FXS could represent various underlying known co-occurring conditions in FXS such as anxiety or autism spectrum disorder (ASD), yet this distinction has not been investigated. Further, delineating whether RRBs are more indicative of anxiety or ASD in FXS may clarify phenotypic profiles within FXS and improve differential assessment. METHODS: We longitudinally examined the potentially independent or multiplicative effect of ASD and anxiety symptom severity on RRBs in 60 children with FXS. Anxiety was measured using the Child Behavior Checklist (CBCL), ASD severity was measured using the Childhood Autism Rating Scale (CARS), and RRBs were measured using the Repetitive Behavior Scale - Revised (RBS-R). We estimated a series of moderated regression models with anxiety and ASD symptoms at the initial assessment (Time 1) as predictors of RRBs at the outcome assessment two years later (Time 2), along with an anxiety-by-ASD interaction term to determine the potential multiplicative effect of these co-occurring conditions on RRBs. RESULTS: Results identified a significant interaction between ASD and anxiety symptom severity at the initial assessment that predicted elevated sensory-motor RRBs two years later. Increased sensory-motor RRBs were predicted by elevated ASD symptoms only when anxiety symptom severity was low. Likewise, increased sensory-motor RRBs were predicted by elevated anxiety symptoms only when ASD symptom severity was low. Interestingly, this relationship was isolated to Sensory-Motor RRBs, with evidence that it could also apply to total RRBs. CONCLUSIONS: Findings suggest that ASD and anxiety exert independent and differential effects on Sensory-Motor RRBs when at high severity levels and a multiplicative effect when at moderate levels, which has important implications for early and targeted interventions. En ligne : https://dx.doi.org/10.1186/s11689-024-09569-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] The effect of anxiety and autism symptom severity on restricted and repetitive behaviors over time in children with fragile X syndrome [texte imprimé] / Lauren J. MOSKOWITZ, Auteur ; Elizabeth A. WILL, Auteur ; Conner J. BLACK, Auteur ; Jane E. ROBERTS, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Fragile X Syndrome/complications/physiopathology  Male  Female  Child  Autism Spectrum Disorder/complications/physiopathology  Anxiety/etiology  Severity of Illness Index  Longitudinal Studies  Child, Preschool  Stereotyped Behavior/physiology  Adolescent  Comorbidity  Anxiety  Autism  Compulsive behavior  Fragile X syndrome  Restricted interests  Restricted repetitive behaviors  Ritualistic/sameness behavior  Self-injurious behaviors  Sensory-motor behaviors Index. décimale : PER Périodiques Résumé : BACKGROUND: Restricted and repetitive behaviors (RRBs) are highly prevalent and reduce function in individuals with fragile X syndrome (FXS). As transdiagnostic features of intellectual disability, elevated rates of RRBs in FXS could represent various underlying known co-occurring conditions in FXS such as anxiety or autism spectrum disorder (ASD), yet this distinction has not been investigated. Further, delineating whether RRBs are more indicative of anxiety or ASD in FXS may clarify phenotypic profiles within FXS and improve differential assessment. METHODS: We longitudinally examined the potentially independent or multiplicative effect of ASD and anxiety symptom severity on RRBs in 60 children with FXS. Anxiety was measured using the Child Behavior Checklist (CBCL), ASD severity was measured using the Childhood Autism Rating Scale (CARS), and RRBs were measured using the Repetitive Behavior Scale - Revised (RBS-R). We estimated a series of moderated regression models with anxiety and ASD symptoms at the initial assessment (Time 1) as predictors of RRBs at the outcome assessment two years later (Time 2), along with an anxiety-by-ASD interaction term to determine the potential multiplicative effect of these co-occurring conditions on RRBs. RESULTS: Results identified a significant interaction between ASD and anxiety symptom severity at the initial assessment that predicted elevated sensory-motor RRBs two years later. Increased sensory-motor RRBs were predicted by elevated ASD symptoms only when anxiety symptom severity was low. Likewise, increased sensory-motor RRBs were predicted by elevated anxiety symptoms only when ASD symptom severity was low. Interestingly, this relationship was isolated to Sensory-Motor RRBs, with evidence that it could also apply to total RRBs. CONCLUSIONS: Findings suggest that ASD and anxiety exert independent and differential effects on Sensory-Motor RRBs when at high severity levels and a multiplicative effect when at moderate levels, which has important implications for early and targeted interventions. En ligne : https://dx.doi.org/10.1186/s11689-024-09569-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

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