Altered functional resting-state hypothalamic connectivity and abnormal pituitary morphology in children with Prader-Willi syndrome / Akvile LUKOSHE in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.12 Titre : Altered functional resting-state hypothalamic connectivity and abnormal pituitary morphology in children with Prader-Willi syndrome Type de document : texte imprimé Auteurs : Akvile LUKOSHE, Auteur ; Suzanne E. VAN DIJK, Auteur ; Gerbrich E. VAN DEN BOSCH, Auteur ; Aad VAN DER LUGT, Auteur ; Tiffany C. WHITE, Auteur ; Anita C. HOKKEN-KOELEGA, Auteur Article en page(s) : p.12 Langues : Anglais (eng) Mots-clés : 15q11-q13  Functional resting-state connectivity  Hypothalamus  Neurodevelopmental disorders  Pituitary gland  Prader-Willi syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND: Prader-Willi syndrome (PWS) is a complex neurodevelopmental disorder, characterized by endocrine problems and hyperphagia, indicating hypothalamic-pituitary dysfunction. However, few studies have explored the underlying neurobiology of the hypothalamus and its functional connectivity with other brain regions. Thus, the aim of this study was to examine the anatomical differences of the hypothalamus, mammillary bodies, and pituitary gland as well as resting state functional connectivity of the hypothalamus in children with PWS. METHODS: Twenty-seven children with PWS (13 DEL, 14 mUPD) and 28 typically developing children were included. Manual segmentations by a blinded investigator were performed to determine the volumes of the hypothalamus, mammillary bodies, and pituitary gland. In addition, brain-wide functional connectivity analysis was performed using the obtained masks of the hypothalamus. RESULTS: Children with PWS showed altered resting state functional connectivity between hypothalamus and right and left lateral occipital complex, compared to healthy controls. In addition, children with PWS had on average a 50% smaller pituitary volume, an irregular shape of the pituitary, and a longer pituitary stalk. Pituitary volume did not increase in volume during puberty in PWS. No volumetric differences in the hypothalamus and mammillary bodies were found. In all subjects, the posterior pituitary bright spot was observed. CONCLUSIONS: We report altered functional hypothalamic connectivity with lateral occipital complexes in both hemispheres, which are implicated in response to food and reward system, and absence of connectivity might therefore at least partially contribute to the preoccupation with food in PWS. En ligne : http://dx.doi.org/10.1186/s11689-017-9188-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 [article] Altered functional resting-state hypothalamic connectivity and abnormal pituitary morphology in children with Prader-Willi syndrome [texte imprimé] / Akvile LUKOSHE, Auteur ; Suzanne E. VAN DIJK, Auteur ; Gerbrich E. VAN DEN BOSCH, Auteur ; Aad VAN DER LUGT, Auteur ; Tiffany C. WHITE, Auteur ; Anita C. HOKKEN-KOELEGA, Auteur . - p.12. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.12 Mots-clés : 15q11-q13  Functional resting-state connectivity  Hypothalamus  Neurodevelopmental disorders  Pituitary gland  Prader-Willi syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND: Prader-Willi syndrome (PWS) is a complex neurodevelopmental disorder, characterized by endocrine problems and hyperphagia, indicating hypothalamic-pituitary dysfunction. However, few studies have explored the underlying neurobiology of the hypothalamus and its functional connectivity with other brain regions. Thus, the aim of this study was to examine the anatomical differences of the hypothalamus, mammillary bodies, and pituitary gland as well as resting state functional connectivity of the hypothalamus in children with PWS. METHODS: Twenty-seven children with PWS (13 DEL, 14 mUPD) and 28 typically developing children were included. Manual segmentations by a blinded investigator were performed to determine the volumes of the hypothalamus, mammillary bodies, and pituitary gland. In addition, brain-wide functional connectivity analysis was performed using the obtained masks of the hypothalamus. RESULTS: Children with PWS showed altered resting state functional connectivity between hypothalamus and right and left lateral occipital complex, compared to healthy controls. In addition, children with PWS had on average a 50% smaller pituitary volume, an irregular shape of the pituitary, and a longer pituitary stalk. Pituitary volume did not increase in volume during puberty in PWS. No volumetric differences in the hypothalamus and mammillary bodies were found. In all subjects, the posterior pituitary bright spot was observed. CONCLUSIONS: We report altered functional hypothalamic connectivity with lateral occipital complexes in both hemispheres, which are implicated in response to food and reward system, and absence of connectivity might therefore at least partially contribute to the preoccupation with food in PWS. En ligne : http://dx.doi.org/10.1186/s11689-017-9188-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350

Assessment of racial and ethnic bias in autism spectrum disorder prevalence estimates from a US surveillance system / Pamela IMM in Autism, 23-8 (November 2019)  

Public ISBD [article]  inAutism > 23-8 (November 2019) . - p.1927-1935 Titre : Assessment of racial and ethnic bias in autism spectrum disorder prevalence estimates from a US surveillance system Type de document : texte imprimé Auteurs : Pamela IMM, Auteur ; Tiffany C. WHITE, Auteur ; Maureen S. DURKIN, Auteur Article en page(s) : p.1927-1935 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  epidemiology  health disparities  prevalence Index. décimale : PER Périodiques Résumé : This study assessed potential under-ascertainment of autism spectrum disorder due to missing administrative information for Hispanic and non-Hispanic Black children within the Autism and Developmental Disabilities Monitoring Network. We analyzed data from two Network sites (Colorado and Wisconsin) for surveillance years 2012 and 2014 to determine whether children excluded from autism spectrum disorder prevalence estimates due to missing residency and other information differed from those included by race and ethnicity. We used multiple approaches to impute missing information to evaluate impacts on racial and ethnic disparities in autism spectrum disorder prevalence. Compared with confirmed autism spectrum disorder cases, those excluded due to missing residency were more than twice as likely to be Hispanic (19% vs 44%; p < 0.002), yet the number of cases excluded due to missing residency information was too small to account for prevalence differences. Confirmation of autism spectrum disorder case status was more likely for children with relevant health records than for those with school records only. Moreover, relevant health records were more likely to be missing for Black and Hispanic children than for White children. Observed disparities in autism spectrum disorder prevalence were not accounted for by missing demographic data, but may reflect disparities in healthcare access for developmental evaluations. En ligne : http://dx.doi.org/10.1177/1362361319827510 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=407 [article] Assessment of racial and ethnic bias in autism spectrum disorder prevalence estimates from a US surveillance system [texte imprimé] / Pamela IMM, Auteur ; Tiffany C. WHITE, Auteur ; Maureen S. DURKIN, Auteur . - p.1927-1935. Langues : Anglais (eng) in Autism > 23-8 (November 2019) . - p.1927-1935 Mots-clés : autism spectrum disorders  epidemiology  health disparities  prevalence Index. décimale : PER Périodiques Résumé : This study assessed potential under-ascertainment of autism spectrum disorder due to missing administrative information for Hispanic and non-Hispanic Black children within the Autism and Developmental Disabilities Monitoring Network. We analyzed data from two Network sites (Colorado and Wisconsin) for surveillance years 2012 and 2014 to determine whether children excluded from autism spectrum disorder prevalence estimates due to missing residency and other information differed from those included by race and ethnicity. We used multiple approaches to impute missing information to evaluate impacts on racial and ethnic disparities in autism spectrum disorder prevalence. Compared with confirmed autism spectrum disorder cases, those excluded due to missing residency were more than twice as likely to be Hispanic (19% vs 44%; p < 0.002), yet the number of cases excluded due to missing residency information was too small to account for prevalence differences. Confirmation of autism spectrum disorder case status was more likely for children with relevant health records than for those with school records only. Moreover, relevant health records were more likely to be missing for Black and Hispanic children than for White children. Observed disparities in autism spectrum disorder prevalence were not accounted for by missing demographic data, but may reflect disparities in healthcare access for developmental evaluations. En ligne : http://dx.doi.org/10.1177/1362361319827510 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=407

Brain morphology, autistic traits, and polygenic risk for autism: A population-based neuroimaging study / Silvia ALEMANY in Autism Research, 14-10 (October 2021)  

Public ISBD [article]  inAutism Research > 14-10 (October 2021) . - p.2085-2099 Titre : Brain morphology, autistic traits, and polygenic risk for autism: A population-based neuroimaging study Type de document : texte imprimé Auteurs : Silvia ALEMANY, Auteur ; Elisabet BLOK, Auteur ; Philip R. JANSEN, Auteur ; Ryan L. MUETZEL, Auteur ; Tiffany C. WHITE, Auteur Article en page(s) : p.2085-2099 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging/genetics  Autistic Disorder/diagnostic imaging/genetics  Brain/diagnostic imaging  Child  Humans  Magnetic Resonance Imaging  Neuroimaging  autism  cortical thickness  genetics  gyrification  surface area Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with widespread brain alterations. Previous research in our group linked autistic traits with altered gyrification, but without pronounced differences in cortical thickness. Herein, we aim to replicate and extend these findings using a larger and older sample. Additionally, we examined whether (a) brain correlates of autistic traits were associated with polygenic risk scores (PRS) for ASD, and (b) autistic traits are related with brain morphological changes over time in a subset of children with longitudinal data available. The sample included 2400 children from the Generation R cohort. Autistic traits were measured using the Social Responsiveness Scale (SRS) at age 6 years. Gyrification, cortical thickness, surface area, and global morphological measures were obtained from high-resolution structural MRI scans at ages 9-to-12 years. We performed multiple linear regression analyses on a vertex-wise level. Corresponding regions of interest were tested for association with PRS. Results showed that autistic traits were related to (a) lower gyrification in the lateral occipital and the superior and inferior parietal lobes, (b) lower cortical thickness in the superior frontal region, and (c) lower surface area in inferior temporal and rostral middle frontal regions. PRS for ASD and longitudinal analyses showed significant associations that did not survive correction for multiple testing. Our findings support stability in the relationship between higher autistic symptoms and lower gyrification and smaller surface areas in school-aged children. These relationships remained when excluding ASD cases, providing neurobiological evidence for the extension of autistic traits into the general population. LAY SUMMARY: We found that school-aged children with higher levels of autistic traits had smaller total brain volume, cerebellum, cortical thickness, and surface area. Further, we also found differences in the folding patterns of the brain (gyrification). Overall, genetic susceptibility for autism spectrum disorders was not related to these brain regions suggesting that other factors could be involved in their origin. These results remained significant when excluding children with a diagnosis of ASD, providing support for the extension of the relationship between autistic traits and brain findings into the general population. En ligne : http://dx.doi.org/10.1002/aur.2576 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Brain morphology, autistic traits, and polygenic risk for autism: A population-based neuroimaging study [texte imprimé] / Silvia ALEMANY, Auteur ; Elisabet BLOK, Auteur ; Philip R. JANSEN, Auteur ; Ryan L. MUETZEL, Auteur ; Tiffany C. WHITE, Auteur . - p.2085-2099. Langues : Anglais (eng) in Autism Research > 14-10 (October 2021) . - p.2085-2099 Mots-clés : Autism Spectrum Disorder/diagnostic imaging/genetics  Autistic Disorder/diagnostic imaging/genetics  Brain/diagnostic imaging  Child  Humans  Magnetic Resonance Imaging  Neuroimaging  autism  cortical thickness  genetics  gyrification  surface area Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with widespread brain alterations. Previous research in our group linked autistic traits with altered gyrification, but without pronounced differences in cortical thickness. Herein, we aim to replicate and extend these findings using a larger and older sample. Additionally, we examined whether (a) brain correlates of autistic traits were associated with polygenic risk scores (PRS) for ASD, and (b) autistic traits are related with brain morphological changes over time in a subset of children with longitudinal data available. The sample included 2400 children from the Generation R cohort. Autistic traits were measured using the Social Responsiveness Scale (SRS) at age 6 years. Gyrification, cortical thickness, surface area, and global morphological measures were obtained from high-resolution structural MRI scans at ages 9-to-12 years. We performed multiple linear regression analyses on a vertex-wise level. Corresponding regions of interest were tested for association with PRS. Results showed that autistic traits were related to (a) lower gyrification in the lateral occipital and the superior and inferior parietal lobes, (b) lower cortical thickness in the superior frontal region, and (c) lower surface area in inferior temporal and rostral middle frontal regions. PRS for ASD and longitudinal analyses showed significant associations that did not survive correction for multiple testing. Our findings support stability in the relationship between higher autistic symptoms and lower gyrification and smaller surface areas in school-aged children. These relationships remained when excluding ASD cases, providing neurobiological evidence for the extension of autistic traits into the general population. LAY SUMMARY: We found that school-aged children with higher levels of autistic traits had smaller total brain volume, cerebellum, cortical thickness, and surface area. Further, we also found differences in the folding patterns of the brain (gyrification). Overall, genetic susceptibility for autism spectrum disorders was not related to these brain regions suggesting that other factors could be involved in their origin. These results remained significant when excluding children with a diagnosis of ASD, providing support for the extension of the relationship between autistic traits and brain findings into the general population. En ligne : http://dx.doi.org/10.1002/aur.2576 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Childhood sleep disturbances and white matter microstructure in preadolescence / Tessa A. MULDER in Journal of Child Psychology and Psychiatry, 60-11 (November 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-11 (November 2019) . - p.1242-1250 Titre : Childhood sleep disturbances and white matter microstructure in preadolescence Type de document : texte imprimé Auteurs : Tessa A. MULDER, Auteur ; Desana KOCEVSKA, Auteur ; Ryan L. MUETZEL, Auteur ; Maria Elisabeth KOOPMAN-VERHOEFF, Auteur ; Manon H.J. HILLEGERS, Auteur ; Tiffany C. WHITE, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : p.1242-1250 Langues : Anglais (eng) Mots-clés : Dti  Sleep problems  repeated measurements  white matter microstructure Index. décimale : PER Périodiques Résumé : BACKGROUND: Sleep problems occur in up to 30% of children and have been associated with adverse developmental outcomes. However, due to a lack of longitudinal neuroimaging studies, the neurobiological changes that may underlie some of these associations have remained unclear. This study explored the association between sleep problems during childhood and white matter (WM) microstructure in preadolescence. METHODS: Children from the population-based birth cohort, the Generation R Study, who had repeatedly assessed sleep problems between 1.5 and 10 years of age and a MRI scan at age 10 (N = 2,449), were included. Mothers reported on their child's sleep problems using the Child Behavior Checklist (CBCL 1.5-5) when children were 1.5, 3, and 6 years of age. At age 2, mothers completed very similar questions. At age 10, both children and their mothers reported on sleep problems. We used whole-brain and tract-specific fractional anisotropy (FA) and mean diffusivity (MD) values obtained through diffusion tensor imaging as measures of WM microstructure. RESULTS: Childhood sleep problems at 1.5, 2, and 6 years of age were associated with less WM microstructural integrity (approximately 0.05 SD lower global FA score per 1-SD sleep problems). In repeated-measures analyses, children with more sleep problems (per 1-SD) at baseline had lower FA values at age 10 in particular in the corticospinal tract (-0.12 SD, 95% CI:-0.20;-0.05), the uncinate fasciculus (-0.12 SD, 95% CI:-0.19;-0.05), and the forceps major (-0.11 SD, 95% CI:-0.18;-0.03), although effect estimates across the tracts did not differ substantially. CONCLUSIONS: Childhood sleep disturbances are associated with less WM microstructural integrity in preadolescence. Our results show that early neurodevelopment may be a period of particular vulnerability to sleep problems. This study cannot demonstrate causality but suggests that preventive interventions addressing sleep problems should be further explored to test whether they impact adverse neurodevelopment. En ligne : http://dx.doi.org/10.1111/jcpp.13085 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Childhood sleep disturbances and white matter microstructure in preadolescence [texte imprimé] / Tessa A. MULDER, Auteur ; Desana KOCEVSKA, Auteur ; Ryan L. MUETZEL, Auteur ; Maria Elisabeth KOOPMAN-VERHOEFF, Auteur ; Manon H.J. HILLEGERS, Auteur ; Tiffany C. WHITE, Auteur ; Henning TIEMEIER, Auteur . - p.1242-1250. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-11 (November 2019) . - p.1242-1250 Mots-clés : Dti  Sleep problems  repeated measurements  white matter microstructure Index. décimale : PER Périodiques Résumé : BACKGROUND: Sleep problems occur in up to 30% of children and have been associated with adverse developmental outcomes. However, due to a lack of longitudinal neuroimaging studies, the neurobiological changes that may underlie some of these associations have remained unclear. This study explored the association between sleep problems during childhood and white matter (WM) microstructure in preadolescence. METHODS: Children from the population-based birth cohort, the Generation R Study, who had repeatedly assessed sleep problems between 1.5 and 10 years of age and a MRI scan at age 10 (N = 2,449), were included. Mothers reported on their child's sleep problems using the Child Behavior Checklist (CBCL 1.5-5) when children were 1.5, 3, and 6 years of age. At age 2, mothers completed very similar questions. At age 10, both children and their mothers reported on sleep problems. We used whole-brain and tract-specific fractional anisotropy (FA) and mean diffusivity (MD) values obtained through diffusion tensor imaging as measures of WM microstructure. RESULTS: Childhood sleep problems at 1.5, 2, and 6 years of age were associated with less WM microstructural integrity (approximately 0.05 SD lower global FA score per 1-SD sleep problems). In repeated-measures analyses, children with more sleep problems (per 1-SD) at baseline had lower FA values at age 10 in particular in the corticospinal tract (-0.12 SD, 95% CI:-0.20;-0.05), the uncinate fasciculus (-0.12 SD, 95% CI:-0.19;-0.05), and the forceps major (-0.11 SD, 95% CI:-0.18;-0.03), although effect estimates across the tracts did not differ substantially. CONCLUSIONS: Childhood sleep disturbances are associated with less WM microstructural integrity in preadolescence. Our results show that early neurodevelopment may be a period of particular vulnerability to sleep problems. This study cannot demonstrate causality but suggests that preventive interventions addressing sleep problems should be further explored to test whether they impact adverse neurodevelopment. En ligne : http://dx.doi.org/10.1111/jcpp.13085 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Disparities in autism spectrum disorder diagnoses among 8-year-old children in Colorado: Who are we missing? / Trenesha L. HILL in Autism, 25-1 (January 2021)  

Public ISBD [article]  inAutism > 25-1 (January 2021) . - p.102-113 Titre : Disparities in autism spectrum disorder diagnoses among 8-year-old children in Colorado: Who are we missing? Type de document : texte imprimé Auteurs : Trenesha L. HILL, Auteur ; Tiffany C. WHITE, Auteur ; Bruno J. ANTHONY, Auteur ; Judy REAVEN, Auteur ; Bryn HARRIS, Auteur ; Nuri M. REYES, Auteur ; Laura G. ANTHONY, Auteur Article en page(s) : p.102-113 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  early diagnosis  health disparities  missed diagnosis Index. décimale : PER Périodiques Résumé : Although autism can be reliably diagnosed as early as 2 years of age, many children are not diagnosed with autism until much later. We analyzed data to determine why many of the 8-year-old children who resided in Colorado and were identified as having autism through a review of their health and/or educational records did not have a documented clinical diagnosis of autism and were not eligible for special education services under an autism eligibility. We found that children who did not have a documented clinical diagnosis of autism and were not eligible for special education services under an autism eligibility were more likely to be female, aggressive, and argumentative. They had a poorer quality of information in their records and were less likely to have had a developmental regression, sleep problems, or an autism screener or diagnostic measure in their records. These results suggest that the symptoms characteristic of autism among this group of children may have been attributed to another disorder and that clinicians may be able to recognize autism more readily in children with more functional impairment and those who experience a developmental regression. We also discovered that differences in symptom presentations among children who had a documented clinical diagnosis of autism and/or were eligible for special education services under an autism eligibility were associated with different ages at autism diagnosis. En ligne : http://dx.doi.org/10.1177/1362361320950058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Disparities in autism spectrum disorder diagnoses among 8-year-old children in Colorado: Who are we missing? [texte imprimé] / Trenesha L. HILL, Auteur ; Tiffany C. WHITE, Auteur ; Bruno J. ANTHONY, Auteur ; Judy REAVEN, Auteur ; Bryn HARRIS, Auteur ; Nuri M. REYES, Auteur ; Laura G. ANTHONY, Auteur . - p.102-113. Langues : Anglais (eng) in Autism > 25-1 (January 2021) . - p.102-113 Mots-clés : autism spectrum disorder  early diagnosis  health disparities  missed diagnosis Index. décimale : PER Périodiques Résumé : Although autism can be reliably diagnosed as early as 2 years of age, many children are not diagnosed with autism until much later. We analyzed data to determine why many of the 8-year-old children who resided in Colorado and were identified as having autism through a review of their health and/or educational records did not have a documented clinical diagnosis of autism and were not eligible for special education services under an autism eligibility. We found that children who did not have a documented clinical diagnosis of autism and were not eligible for special education services under an autism eligibility were more likely to be female, aggressive, and argumentative. They had a poorer quality of information in their records and were less likely to have had a developmental regression, sleep problems, or an autism screener or diagnostic measure in their records. These results suggest that the symptoms characteristic of autism among this group of children may have been attributed to another disorder and that clinicians may be able to recognize autism more readily in children with more functional impairment and those who experience a developmental regression. We also discovered that differences in symptom presentations among children who had a documented clinical diagnosis of autism and/or were eligible for special education services under an autism eligibility were associated with different ages at autism diagnosis. En ligne : http://dx.doi.org/10.1177/1362361320950058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Divergent structural brain abnormalities between different genetic subtypes of children with Prader-Willi syndrome / Akvile LUKOSHE in Journal of Neurodevelopmental Disorders, 5-1 (December 2013)  

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A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder / Philip SHAW in Journal of Child Psychology and Psychiatry, 59-10 (October 2018)  

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A prospective study of fetal head growth, autistic traits and autism spectrum disorder / Laura M.E. BLANKEN in Autism Research, 11-4 (April 2018)  

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The bidirectional association between sleep problems and autism spectrum disorder: a population-based cohort study / Maria E. VERHOEFF in Molecular Autism, 9 (2018)  

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