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Auteur Roseriet BEIJERS |
Documents disponibles écrits par cet auteur (3)
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Effects of daily full-term infant skin-to-skin contact on behavior and cognition at age three - secondary outcomes of a randomized controlled trial / Nicole RHEINHEIMER in Journal of Child Psychology and Psychiatry, 64-1 (January 2023)
[article]
Titre : Effects of daily full-term infant skin-to-skin contact on behavior and cognition at age three - secondary outcomes of a randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Nicole RHEINHEIMER, Auteur ; Roseriet BEIJERS, Auteur ; Nina BRUINHOF, Auteur ; Kelly H. M COOIJMANS, Auteur ; Carolina DE WEERTH, Auteur Article en page(s) : p.136-144 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Daily skin-to-skin contact (SSC) during early infancy fosters the long-term development of children born preterm. This is the first randomized controlled trial assessing the potential beneficial effects of daily SSC on executive functioning and socio-emotional behavior of children born full-term. Whether children of mothers who experienced prenatal stress and anxiety benefitted more from SSC was also explored. Methods Pregnant women (N=116) were randomly assigned to a SSC or care-as-usual (CAU) condition. Women in the SSC condition were instructed to perform one hour of SSC daily from birth until postnatal week five. Prenatal stress was measured with questionnaires on general and pregnancy-specific stress and anxiety completed by the mothers in gestational week 37. At child age three, mothers filled in questionnaires on children's executive functioning, and externalizing and internalizing behavior. Analyses were performed in an intention-to-treat (ITT), per-protocol, and dose-response approach. Netherlands Trial Register: NL5591. Results In the ITT approach, fewer internalizing (95% CI=0.11-1.00, U=2148.50, r=.24, p=.001) and externalizing (95% CI=0.04-2.62, t=2.04, d=0.38, p=.04) problems were reported in the SSC condition compared to the CAU condition. Multivariate analyses of variance did not show group differences on executive functioning. Additional analyses of covariance showed no moderations by maternal prenatal stress. Conclusions Current findings indicate that early daily SSC in full-term infants may foster children's behavioral development. Future replications, including behavioral observations of child behavior to complement maternal reports, are warranted. En ligne : https://doi.org/10.1111/jcpp.13679 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.136-144[article] Effects of daily full-term infant skin-to-skin contact on behavior and cognition at age three - secondary outcomes of a randomized controlled trial [Texte imprimé et/ou numérique] / Nicole RHEINHEIMER, Auteur ; Roseriet BEIJERS, Auteur ; Nina BRUINHOF, Auteur ; Kelly H. M COOIJMANS, Auteur ; Carolina DE WEERTH, Auteur . - p.136-144.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.136-144
Index. décimale : PER Périodiques Résumé : Background Daily skin-to-skin contact (SSC) during early infancy fosters the long-term development of children born preterm. This is the first randomized controlled trial assessing the potential beneficial effects of daily SSC on executive functioning and socio-emotional behavior of children born full-term. Whether children of mothers who experienced prenatal stress and anxiety benefitted more from SSC was also explored. Methods Pregnant women (N=116) were randomly assigned to a SSC or care-as-usual (CAU) condition. Women in the SSC condition were instructed to perform one hour of SSC daily from birth until postnatal week five. Prenatal stress was measured with questionnaires on general and pregnancy-specific stress and anxiety completed by the mothers in gestational week 37. At child age three, mothers filled in questionnaires on children's executive functioning, and externalizing and internalizing behavior. Analyses were performed in an intention-to-treat (ITT), per-protocol, and dose-response approach. Netherlands Trial Register: NL5591. Results In the ITT approach, fewer internalizing (95% CI=0.11-1.00, U=2148.50, r=.24, p=.001) and externalizing (95% CI=0.04-2.62, t=2.04, d=0.38, p=.04) problems were reported in the SSC condition compared to the CAU condition. Multivariate analyses of variance did not show group differences on executive functioning. Additional analyses of covariance showed no moderations by maternal prenatal stress. Conclusions Current findings indicate that early daily SSC in full-term infants may foster children's behavioral development. Future replications, including behavioral observations of child behavior to complement maternal reports, are warranted. En ligne : https://doi.org/10.1111/jcpp.13679 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder / Lawrence M. CHEN in Development and Psychopathology, 32-5 (December 2020)
[article]
Titre : Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence M. CHEN, Auteur ; Marieke S. TOLLENAAR, Auteur ; Shantala A. HARI DASS, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Irina POKHVISNEVA, Auteur ; Helene GAUDREAU, Auteur ; Carine PARENT, Auteur ; Josie DIORIO, Auteur ; Lisa M. MCEWEN, Auteur ; Julia L. MACISAAC, Auteur ; Michael S. KOBOR, Auteur ; Roseriet BEIJERS, Auteur ; Carolina DE WEERTH, Auteur ; Patricia P. SILVEIRA, Auteur ; Sherif KARAMA, Auteur ; Michael J. MEANEY, Auteur ; Kieran J. O'DONNELL, Auteur Article en page(s) : p.1810-1821 Langues : Anglais (eng) Mots-clés : *Attention Deficit Disorder with Hyperactivity/genetics Child Depression/genetics Female Genomics Humans Mental Health Mothers Pregnancy *adhd *child development *gene by environment (GxE) *perinatal mental health *polygenic risk score Index. décimale : PER Périodiques Résumé : Maternal antenatal depression strongly influences child mental health but with considerable inter-individual variation that is, in part, linked to genotype. The challenge is to effectively capture the genotypic influence. We outline a novel approach to describe genomic susceptibility to maternal antenatal depression focusing on child emotional/behavioral difficulties. Two cohorts provided measures of maternal depression, child genetic variation, and child mental health symptoms. We constructed a conventional polygenic risk score (PRS) for attention-deficit/hyperactivity disorder (ADHD) (PRSADHD) that significantly moderated the association between maternal antenatal depression and internalizing problems at 60 months (p = 2.94 × 10-4, R2 = .18). We then constructed an interaction PRS (xPRS) based on a subset of those single nucleotide polymorphisms from the PRSADHD that most accounted for the moderation of the association between maternal antenatal depression and child outcome. The interaction between maternal antenatal depression and this xPRS accounted for a larger proportion of the variance in child emotional/behavioral problems than models based on any PRSADHD (p = 5.50 × 10-9, R2 = .27), with similar findings in the replication cohort. The xPRS was significantly enriched for genes involved in neuronal development and synaptic function. Our study illustrates a novel approach to the study of genotypic moderation on the impact of maternal antenatal depression on child mental health and highlights the utility of the xPRS approach. These findings advance our understanding of individual differences in the developmental origins of mental health. En ligne : http://dx.doi.org/10.1017/s0954579420001418 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437
in Development and Psychopathology > 32-5 (December 2020) . - p.1810-1821[article] Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Lawrence M. CHEN, Auteur ; Marieke S. TOLLENAAR, Auteur ; Shantala A. HARI DASS, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Irina POKHVISNEVA, Auteur ; Helene GAUDREAU, Auteur ; Carine PARENT, Auteur ; Josie DIORIO, Auteur ; Lisa M. MCEWEN, Auteur ; Julia L. MACISAAC, Auteur ; Michael S. KOBOR, Auteur ; Roseriet BEIJERS, Auteur ; Carolina DE WEERTH, Auteur ; Patricia P. SILVEIRA, Auteur ; Sherif KARAMA, Auteur ; Michael J. MEANEY, Auteur ; Kieran J. O'DONNELL, Auteur . - p.1810-1821.
Langues : Anglais (eng)
in Development and Psychopathology > 32-5 (December 2020) . - p.1810-1821
Mots-clés : *Attention Deficit Disorder with Hyperactivity/genetics Child Depression/genetics Female Genomics Humans Mental Health Mothers Pregnancy *adhd *child development *gene by environment (GxE) *perinatal mental health *polygenic risk score Index. décimale : PER Périodiques Résumé : Maternal antenatal depression strongly influences child mental health but with considerable inter-individual variation that is, in part, linked to genotype. The challenge is to effectively capture the genotypic influence. We outline a novel approach to describe genomic susceptibility to maternal antenatal depression focusing on child emotional/behavioral difficulties. Two cohorts provided measures of maternal depression, child genetic variation, and child mental health symptoms. We constructed a conventional polygenic risk score (PRS) for attention-deficit/hyperactivity disorder (ADHD) (PRSADHD) that significantly moderated the association between maternal antenatal depression and internalizing problems at 60 months (p = 2.94 × 10-4, R2 = .18). We then constructed an interaction PRS (xPRS) based on a subset of those single nucleotide polymorphisms from the PRSADHD that most accounted for the moderation of the association between maternal antenatal depression and child outcome. The interaction between maternal antenatal depression and this xPRS accounted for a larger proportion of the variance in child emotional/behavioral problems than models based on any PRSADHD (p = 5.50 × 10-9, R2 = .27), with similar findings in the replication cohort. The xPRS was significantly enriched for genes involved in neuronal development and synaptic function. Our study illustrates a novel approach to the study of genotypic moderation on the impact of maternal antenatal depression on child mental health and highlights the utility of the xPRS approach. These findings advance our understanding of individual differences in the developmental origins of mental health. En ligne : http://dx.doi.org/10.1017/s0954579420001418 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? / Roseriet BEIJERS ; Kieran J. O?DONNELL ; Carolina DE WEERTH ; Marieke S. TOLLENAAR in Development and Psychopathology, 36-2 (May 2024)
[article]
Titre : Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? Type de document : Texte imprimé et/ou numérique Auteurs : Roseriet BEIJERS, Auteur ; Kieran J. O?DONNELL, Auteur ; Carolina DE WEERTH, Auteur ; Marieke S. TOLLENAAR, Auteur Article en page(s) : p.967-978 Langues : Anglais (eng) Mots-clés : NR3C1 externalizing internalizing maternal sensitivity methylation Index. décimale : PER Périodiques Résumé : The early caregiving environment can have lasting effects on child mental health. Animal models suggest that glucocorticoid receptor gene (NR3C1) DNA methylation plays a mediating role in linking more responsive caregiving to improved behavioral outcomes by its impact on the stress regulatory system. In this longitudinal study, we examined whether children?s NR3C1 methylation levels mediate an effect of maternal sensitivity in infancy on levels of child internalizing and externalizing behavior in a community sample. Maternal sensitivity of 145 mothers was rated at infant age 5 weeks, 12 months, and 30 months by observing mother-infant interactions. Buccal DNA methylation was assessed in the same children at age 6 years and maternal-reported internalizing and externalizing behavior was assessed at age 6 and 10 years. Higher sensitivity at age 5 weeks significantly predicted lower DNA methylation levels at two NR3C1 CpG loci, although methylation levels at these loci did not mediate an effect of maternal sensitivity on levels of child internalizing and externalizing behavior. Overall, the study provides evidence that maternal sensitivity in early infancy is associated with DNA methylation levels at loci involved in stress regulation, but the significance of this finding for child mental health remains unclear. En ligne : https://dx.doi.org/10.1017/S0954579423000226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528
in Development and Psychopathology > 36-2 (May 2024) . - p.967-978[article] Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? [Texte imprimé et/ou numérique] / Roseriet BEIJERS, Auteur ; Kieran J. O?DONNELL, Auteur ; Carolina DE WEERTH, Auteur ; Marieke S. TOLLENAAR, Auteur . - p.967-978.
Langues : Anglais (eng)
in Development and Psychopathology > 36-2 (May 2024) . - p.967-978
Mots-clés : NR3C1 externalizing internalizing maternal sensitivity methylation Index. décimale : PER Périodiques Résumé : The early caregiving environment can have lasting effects on child mental health. Animal models suggest that glucocorticoid receptor gene (NR3C1) DNA methylation plays a mediating role in linking more responsive caregiving to improved behavioral outcomes by its impact on the stress regulatory system. In this longitudinal study, we examined whether children?s NR3C1 methylation levels mediate an effect of maternal sensitivity in infancy on levels of child internalizing and externalizing behavior in a community sample. Maternal sensitivity of 145 mothers was rated at infant age 5 weeks, 12 months, and 30 months by observing mother-infant interactions. Buccal DNA methylation was assessed in the same children at age 6 years and maternal-reported internalizing and externalizing behavior was assessed at age 6 and 10 years. Higher sensitivity at age 5 weeks significantly predicted lower DNA methylation levels at two NR3C1 CpG loci, although methylation levels at these loci did not mediate an effect of maternal sensitivity on levels of child internalizing and externalizing behavior. Overall, the study provides evidence that maternal sensitivity in early infancy is associated with DNA methylation levels at loci involved in stress regulation, but the significance of this finding for child mental health remains unclear. En ligne : https://dx.doi.org/10.1017/S0954579423000226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528